Purpose Despite technology transfer being emphasised in most public policy documents globally, it is not always clear how its effectiveness plays out in developing and emerging economies. This paper aims to bridge this gap by providing a systematic understanding of the processes of technology transfer, the antecedents and determinants, and finally how to measure its effectiveness, particularly in technologically dependent and emerging economies. Design/methodology/approach The paper puts forward a modified contingent effectiveness model of technology transfer based on Bozeman (2000) and Bozeman et al. (2015) and adapts it to incorporate the characteristics of emerging economies. Four major elements of technology transfer are discussed, namely, transfer object, actor characteristics, transfer environment, local environment and how they interact to determine effectiveness. Thereafter, the study shifts its focus to India’s evolving science technology and innovation (STI) ecosystem and discuss the current status, structure and major stakeholders associated with technology transfer. The study also reflects upon the challenges that inhibit effective technology transfer in India. In the last part, the study offers policy recommendations for improving the effectiveness of technology transfer, keeping in view India’s sustainable developmental goals. Findings A significant distinction of the conceptual model from its predecessors lies in its examination of the four dimensions of technology transfer effectiveness through the lens of developing and emerging economies, keeping in mind the inherent strengths, weaknesses and STI practices of the attendant local economy. As a novel contribution, the paper also discusses India’s evolving STI ecosystem backed by recent policy initiatives on technology transfer and the major stakeholders involved. Originality/value The paper constructs a modified contingent effectiveness model of technology transfer with particular emphasis on emerging economies. It also provides a comprehensive overview of India’s complex STI and technology transfer ecosystem, the challenges involved and offers recommendations for policy intervention.