With the ongoing process of globalization and the rapid expansion of the global economy, the proliferation of coastal constructions and infrastructures has witnessed a notable surge. These structures often encounter a confluence of environmental stressors in practical engineering, including cyclic fatigue loading, chloride salt erosion, and freeze-thaw cycles. These synergistic factors accelerate concrete’s failure, resulting in accelerated deterioration and significantly reduced durability. A comprehensive understanding of the damage characteristics of concrete materials in offshore environments, under the multi-factor coupled action of freeze-thaw phenomena, along with an assessment of their residual strength, is crucial for the development of relevant structural analysis and lifetime prediction models. To address this, twenty-seven dedicated specimens were designed and fabricated for this investigation. They were employed to scrutinize the residual strength of concrete under the combined influences of fatigue, freeze-thaw, and chloride penetration. Nine distinct multi-factor coupling actions were meticulously devised and characterized by different parameters. Following the multi-factor coupling action, tests were conducted to assess the residual flexural and compressive strengths, as well as the chloride ion content near the specimen edges. The findings revealed a substantial negative correlation between the residual flexural and compressive strengths with both the number of freeze-thaw cycles and fatigue loading iterations. In contrast, chloride ion concentration and the stress level of fatigue loading (stress ratio: 0.1–0.3) exhibited a comparatively marginal influence. Despite the relatively short test duration, it was evident that both freeze-thaw cycles and fatigue loading exerted a discernible promotional effect on chloride ion ingress in the concrete of the specimens.