Innovative Research Articles

Current Models of Innovation and Market Strategies in Pharmaceutical Development: A Comprehensive Review

This paper examines innovative models and market strategies in the pharmaceutical industry, highlighting how these innovations shape drug development, market dynamics, and public health outcomes. Pharmaceutical innovation spans product enhancements, process efficiencies, and organizational and marketing transformations, all aimed at improving patient outcomes and healthcare access. The methodology explored comprehensive literature review, focusing on recent developments in pharmaceutical innovation, drug marketing practices, and regulatory frameworks. Primary sources include scholarly articles from Google Scholar, ResearchGate, Scopus, and Web of Science, as well as industry reports and case studies from leading pharmaceutical firms. Key strategies explored include product and process innovations that make medications more effective and accessible, as well as open innovation models, which promote collaboration and cost-sharing in research. The review underscores the ethical and regulatory complexities of the industry, from patient-centered marketing to the rise of biosimilars. Future directions in pharmaceutical innovation, such as artificial intelligence and precision medicine, are presented as transformative tools for advancing personalized healthcare. These advancements reflect the sector's ongoing response to regulatory demands, economic pressures, and global health challenges, positioning the pharmaceutical industry as a crucial driver of public health and economic sustainability.

Model‐Based Exploration of Web Guiding Behavior for a Novel Battery Cell Stacking Process

Innovative production processes are required to meet the rapidly growing demand for batteries and the associated material trends. In particular, the process step of stack assembly using new machine concepts promises a high potential for optimization. However, these concepts are untested in practice. The use of digital models makes it possible to develop corresponding optimization approaches. This article presents the development of a model for the web guiding systems of electrodes and its integration into an overall machine model for a novel machine concept. Finally, optimization approaches are identified by determining appropriate controller parameters for the web guiding systems.

Durable polymer composites preparation with oxy-delignified banana fiber for automotive parts: A study on mechanical and thermal properties

An innovative process route has been developed to produce modified banana fiber that are used as reinforcement in polypropylene composites for automotive parts. Banana fiber (BF) is modified through, Alkaline peroxide (APF), and oxygen delignification (ODF) treatment to obtain better adhesion and enhanced thermo-mechanical properties. The fiber-reinforced polymer (FRP) composites (10–30 % loading), were prepared through a specified configuration in a co-rotating twin screw extruder followed by injection molding. The results show that the ODF treatment with a 15 % NaOH concentration resulted in an 11-kappa number, which was lower than APF and untreated fiber. The highest improvement in tensile (31.27 ± 2.56) and flexural strength (44.880 ± 1.05 MPa) was achieved for ODF polymer composite and were 20.40 % and 35.6 % higher compared to the untreated fiber. The addition of natural fiber decreased the melt flow index to 7.56 gm/10 min with a slight decrease in hydrophilicity. The thermal stability was increased with enhanced melting, crystallization temperatures, and surface morphology.

Determining the Effect of Feedback Quality on User Engagement on Online Idea Crowdsourcing Platforms Using an AI model

The success of idea crowdsourcing platforms relies on fostering a collaborative environment that encourages active user participation, measured by the quality and quantity of contributions and interactions. However, understanding the impact of peer interactions on user engagement and the innovation process remains challenging. While previous studies have focused on sentiment analysis, the contextual interpretation of peer feedback and its effects on engagement and innovation have yet to be explored. To address this knowledge gap, we propose a feature-based AI model that categorizes peer feedback based on its quality and polarity. Our model achieves 96% accuracy in identifying feedback quality (constructive vs. non-constructive and toxic vs. non-toxic) and feedback polarity (negative vs. positive). This contextual feedback categorization provides a foundation for quantitatively analyzing the impacts of feedback on user engagement and the innovation process. Our results show that positive and constructive peer feedback has a significantly positive effect, while toxic and negative peer feedback has a significantly negative impact on the process of idea generation, idea evaluation, and idea selection. Our results also indicate that inexperienced users are more susceptible to toxic feedback than experienced users. Based on these findings, we suggest a recommendation and reward system for incentivizing constructive feedback and preventing toxic feedback.

Implemention of Innovative Process Analytical Technologies to Characterize Critical Quality Attributes of Co‐Formulated Monoclonal Antibody Products

ABSTRACTCharacterizing co‐formulated monoclonal antibodies (mAbs) poses significant challenges in the pharmaceutical industry. Due to the high structural similarity of the mAbs, traditional analytical methods, compounded by the lengthy method development process, hinder product development and manufacturing efficiency. There is increasing critical need in the pharmaceutical industry to streamline analytical approaches, minimizing time and resources, ensuring a rapid clinical entry and cost‐effective manufacturing. This study investigates the application of process analytical technologies (PAT) to address such challenges. Our investigation introduces two complementary technologies, on‐line ultra‐performance liquid chromatography (online UPLC) and multimode fluorescence spectroscopy (MMFS), as potential PAT tools tailored for characterizing critical quality attributes (CQA) in co‐formulated mAb products. Specifically, the CQAs under evaluation include the total protein concentration of the mAbs within the co‐formulation and the ratio of mAb A to mAb B. Online UPLC enables direct and automated measurement of the CQAs through physical separation, while MMFS determines them in a non‐destructive and more swift manner based on chemometric modeling. We demonstrate these technologies' comparable performance to conventional methods, alongside substantial benefits such as reduced analytical turnaround time and decreased laboratory efforts. Ultimately, integrating them as innovative PAT tools expedites the delivery of therapeutic solutions to patients and enhances manufacturing efficiency, aligning with the imperative for swift translation of scientific discoveries into clinical benefits.

Incremental and Radical Innovations that Contribute to the Survival of Small Businesses in Environments of Crisis

This paper examines the influence of incremental and radical innovations on the survival capacity of micro and small companies (MSE) in contexts of economic crisis.State of the art on innovation points to a lack of a specific methodology to segregate incremental and radical innovation in MSEs. Identifying such a method allows for action to promote innovation in such more assertive companies, contributing to the survival of companies in the most adverse moments, such as crises.In this sense, a methodology was developed to identify the type and degree of innovation based on the level of innovation in the sector of activity and was applied to a sample of 60 companies in the textile retail sector. The dependent variable was business survival, measured by the continuity or cessation of activity in 2020. The estimate of the probability of survival was carried out using a binary logistic regression model.The dimensions of incremental innovation, which are the most common in the business environment, did not significantly affect survival. The dimensions of radical innovation, which imply deeper and more disruptive changes in the business model, had a positive impact. significant impact on survival in all cases. The most complex actions in the Solutions dimension increased the chances of survival by 42%; improving Processes by 39%; and innovation in the Square by 38%. These findings suggest that small businesses that adopt radical innovations have greater adaptability and resilience to adverse situations.

Machine Vision AI in Railroad Safety: Advanced Inspection Techniques

This article explores the transformative impact of machine vision AI in railroad safety, focusing on advanced inspection techniques. It examines the integration of technologies such as line scan cameras, LiDAR, and IoT sensors in enabling comprehensive 360-degree inspections of railway infrastructure and rolling stock. The article discusses key innovations in continuous monitoring, data processing, and AI-driven analysis, highlighting their potential to significantly enhance defect detection accuracy, reduce maintenance costs, and prevent accidents. Real-world applications in structural integrity assessment and overhead line inspection are presented, along with an analysis of current challenges and future developments in the field. The article underscores the paradigm shift from reactive to proactive maintenance strategies, promising a safer and more efficient future for rail transport.

Approach to Weighting the Success Criteria of Toll Road Project of Government Cooperation with Business Entities Procurement Model

In providing funding for toll road development projects, many developing countries are im-plementing PPP pro-curement schemes including Indonesia. This funding scheme is believed to be an innovative procurement process model and has good prospects for the future of the construc-tion industry in the world. However, in its implementation, the Indonesian government is currently faced with various problems that have the potential to have a negative impact on the management and development of toll roads in Indo-nesia. Therefore, the main objective of this research is to develop a method of evaluating the success of PPP-themed toll road projects and determining the current and future strategy of PPP-themed toll road development projects. Methodology This research, using an exploratory sequential mixed methods approach, involves four stages of research. Through a Systematic Literature Review (SLR) of reputable scientific journals from various countries, a questionnaire survey was developed. The survey results were analyzed using multivariate statistical methods with the help of Par-tial Least square analysis software (PLS-SEM), analytical hierarchy process (AHP) and Relative Importance Index (RII) methods. The results of this research found 20 critical success indicators and four dimensions of project success. This study produces a new way to assess the success of PPP-themed toll road projects that is very important and can inspire the government in making policies, legislation and regulations as well as innovative strategies in develop-ing PPP-themed toll roads.

Science and Innovation Management: Sustainable Development Goals 8 and 9 as Challenges for Poland

This manuscript continues the series of research publications on Sustainable Development Goals 8 and 9 (SDGs 8 and 9). Innovations play an essential role in the global and national economies, as they contribute to the growth of economic productivity, the creation of new products, services, and jobs, and improve the quality of life. In the context of innovation, economy and artificial intelligence (AI) are the ideological and technological components of the innovation process. The authors hypothesized that the Polish system for assessing the importance of scientific economic journals is ineffective for social development and for creating an innovation-based economy. The research methods are a scientometric analysis of 795,070 scientific sources by the keywords “Economy” and “Artificial Intelligence”, a bibliometric analysis of 219,739 sources by the keywords “Economy”, “Economic productivity”, and “Innovation”, correlation analysis, and testing statistical hypotheses. The study led to the adoption of an alternative statistical hypothesis, which is a strong confirmation of the basic hypothesis. A new model for assessing the weight of scientific journals was created based on the existing system. Two management recommendations were formulated in the rules for determining the weight of journals. The high R2 value indicates that the new model effectively predicts the result. The correlation coefficient of the weight of journals in the new model is more than 98%. When verifying statistical hypotheses, a high significance level of 99.0 was used. The study’s practical significance is in the movement of Polish science to a leading place in the world market of scientific products.

PROGRESSO DA TECNOLOGIA NOS ESPAÇOS PEDAGÓGICO

Currently, innovation in the teaching-learning process is needed for education to be successfully carried out in educational spaces. Therefore, the main objective of this work is to present a discussion about the teaching and learning process between technologies, methodological innovations and interactivity, bringing examples of innovative methodologies that have changed the educational context. It is known that educational institutions that do not invest in technologies and new methodologies do not attract students to study and, as a consequence, do not advance in relation to those that invest. The methodology used in this study was a bibliographical research carried out on academic sites such as SciELO and Google Scholar with authors of articles and websites between the years 2011 and 2021. In view of what was researched, it is possible to consider that, at present, institutions need to reinvent and, for that, it is necessary to use technologies and new methodologies having as reference schools that have changed their curriculum and methodology, such as the Marist school in Brasília, which makes technology a teaching-learning methodology using instruments and tools that increase and facilitate interaction, providing a more pleasant and attractive learning and teaching.

Mergers and Licensing With Horizontal Differentiation

ABSTRACTWe consider a research laboratory that owns a patented process innovation and two firms producing differentiating goods in a Bertrand setting. The laboratory considers the possibility to license the innovation as an outsider patentee or to merge with one of the firms in the industry, becoming an incumbent patentee. Licensing takes place through observable two‐part tariff contracts. We show that the merger is profitable only for small innovations and increases social welfare for both small and large innovations. Even though we allow the royalty to be higher than the size of the innovation, and opposite to the result in a Cournot setting, we find a region where the merger is both profitable and welfare improving. This occurs only for small innovations and sufficiently differentiated goods. The same result arises for consumer surplus which allows us to derive the optimal merger policy: compared with Cournot competition, a Bertrand setting calls for a more lenient merger policy.

The Role of Industrial Design for the Sustainable Disaster Management in Türkiye

This article aims to discuss the contributions of the industrial design discipline to the development of new product and service systems for sustainable and effective disaster management in Turkey. For this reason, the article focuses on innovative process activities such as design and R&D carried out by the Turkish NGO-affiliated Shelter Systems Company, a major player in disaster response and one of the largest shelter system manufacturers in Europe. This research explores the roles of the industrial design discipline in innovation processes, as well as the organizational characteristics of the innovation activities carried out in the Shelter Systems Company. Within the scope of the case study, a business process analysis was conducted to understand the role of design in the creative process activities of the Shelter Systems Company and the natural workflow of the design processes. The research demonstrated that the Shelter Systems Company has recently shifted to income-generating activities that support social entrepreneurship, aiming to transform these efforts into social benefits. However, the main process activities of the Shelter Systems Company are primarily manufacturing orientated. Its industrial design capacity is limited, its inovation process is closed to external influences, and its horizontal collaborations for open information sharing with external organisations and stakeholders are restricted. Based on the findings, this research proposes strategies to make industrial design more effective in the innovative process activities of the Shelter Systems Company in disaster management.

Pengembangan Buku Interaktif 3D Audio Visual pada Materi Tutorial Pengembangan Media Pembelajaran Berbasis Studi Kasus Adaptif untuk Peningkatan Kompetensi Keterampilan Mahasiswa PPG Seni Budaya

This study aims to develop a 3D audio-visual interactive book on tutorial materials for developing adaptive case-based learning media to enhance the skill competencies of PPG Art and Culture students. The methodology includes needs analysis, interactive book design, and effectiveness evaluation. This interactive book is designed to provide an immersive and comprehensive learning experience through the use of 3D and audio-visual technology. The results indicate that this interactive book significantly improves students' understanding and skills in developing adaptive, case-based learning media. Evaluations through surveys and in-depth interviews confirm that the book is effective in supporting a more innovative and interactive learning process. This study makes a significant contribution to the development of modern and relevant learning materials in contemporary education.

Comprehensive Review and Future Research Directions on ICT Standardisation

Standardisation has become imperative to retaining order and development in modern society. The simplest actions, such as train timings and the width of the railroad, would be very difficult to achieve without Standardisation. Standardisation also solves problems, such as the use of mobile devices, which requires travel abroad when out of range. We perform a large-scale quantitative analysis for papers dealing with (1) standards and (2) Information and communications technology (ICT) data in three important databases, namely Web of Science, IEEE Explore, and ACM digital library, in this paper. These three databases presented 216 articles that were divided into five categories: standard-related review and survey studies, information management across hardware and software standards, energy management standards, machine learning model classification performance, privacy-aware software system standards, and health information and communications technology standards. This paper discusses how Standardisation facilitates the planning of the entire research and innovation process by encouraging discussions regarding the specific outputs the research aims to achieve. The paper further illustrates that references related to standardisation within the call topics act as a crucial motivating factor in the decision to adopt standardisation. In conclusion, our contribution provides a better understanding of standards in peer-reviewed publications and an essential foundation for future research. In addition, we demonstrate that standards play an important role in innovation.

How incentive alignment along the supply chain fosters incremental innovation: evidence from defence performance-based contracts

PurposeTo investigate how providers of product-service bundles design and manage their contracts with upstream suppliers to incentivise incremental innovation for the benefit of their downstream customers, who contract the provider based on performance.Design/methodology/approachAn embedded multiple-case study was conducted to examine elements of a European jet fighter’s manufacturing and after-sales supply chain. The embedded cases concern provider contracts with first-tier suppliers of product and service offerings. Data collection involved 21 semi-structured interviews, documents and other secondary data sources. Data analysis was informed by agency theory to assess the effectiveness of contract design and management in delivering incremental innovation and to identify related contracting strategies.FindingsWe identify four strategies for fostering incremental innovation in contracts between providers and their first-tier suppliers. These include two contract design strategies, i.e. reducing goal incongruence and addressing information asymmetry; and two contract management strategies, i.e. reducing outcome uncertainty and promoting inter-firm integration between providers and sub-suppliers.Practical implicationsThe research offers managerial guidelines regarding how providers can design and manage their tier-one supplier contracts to achieve incremental innovation. These include encouraging early supplier involvement, using focussed KPIs in contracts, and managing product and service-offering suppliers differently.Originality/valueThe research shows the contingent effect during contract design and management of a sub-supplier’s product vs. service offering, which, in turn, impacts incremental innovation. We also find that using focussed key performance indicators in sub-supplier contracts can be effective in improving product and service quality.

Unlocking glycerol Potential: Novel pathway for hydrogen production and Value-Added chemicals

In the global fight against climate change, the bio-based supply chain represents an interesting solution as it offers the potential to produce high-value-added products and bioenergy through the utilization of waste and by-products. In this work, a new route is proposed for the conversion of bio-based glycerol to H2/CO2 and high value-added liquid and solid products. The innovative process used pure or crude glycerol or ethanol-glycerol mixture along with water and sodium metaborate as reagents at 300 °C under discontinuous conditions. The gas stream consists mainly of hydrogen, followed by biogenic CO2 (31–54 %), CO (4–13 %) and CH4 in traces. The presence of water in the tested crude glycerol improved the hydrogen selectivity to 55 %. Characterization of the liquid reaction products revealed the synthesis of products such as 1,2-propanediol, propanoic acid, acetic acid, cyclopentenones and cyclic diglycerol. In the solid phase, an aliphatic hydrocarbon resin with oxygenated carbon along the saturated chain and an aromatic cluster were also characterized by NMR, FTIR and TG analyses. Based on these findings, the global reaction route to the general reaction products was proposed.

Integrating Sustainability Goals into Innovation at Henkel

PRACTITIONER TAKEAWAYS To be meaningful, sustainability assessments need to account for the whole product life cycle. This requires strong partnerships with suppliers, customers, and end users, beginning already in the new product development cycle. Culture is an essential ingredient: We need to ensure that sustainability is not just a checklist but a core value for our employees and our business. Innovation and product management are both part of the product life cycle: How we assess sustainability impact for a new product in development needs to be consistent with how that product will be assessed once it is fully commercial. The methodology a company uses in its innovation process cannot be different from the one it uses in product line management.

An innovative thermal simulation study of microstructure improvement by delay forging during solidification

The solid fraction at the beginning of the forging process is an important factor affecting the performance of the casting-forging integrated forming, which is an innovative and efficient process. The solid fraction depends on the delayed forging time during the casting-forging integrated forming. This paper investigates the effect of delayed forging time on the microstructure of aluminum alloy forged during solidification using an innovative physical simulation method. In this work, a solidification-forging device compatible with the Gleeble system has been developed. Then, experiments were conducted at various delayed forging time. Temperature and force data were collected using the Gleeble system for analysis. Microstructural evolution was investigated using methods including Optical Microscopy (OM), Scanning Electron Microscopy (SEM), Electron Backscattered Diffraction (EBSD), and Three Dimensional Computed Tomography (3D-CT). The results demonstrate that with the extension of the delayed forging time, the grain size of the alloy decreases gradually, and the coarse dendrite structure changes to the rose-shaped grains, and the local misorientation in the grain increases. Moreover, the effect of forging under different forging time on the casting defects of the alloy is studied. When the forging delay is extended to 8 s, the forging promotes the porosity caused by the liquid phase convection. However, with further extension of forging delay, the reduction of the liquid phase and the fracture of dendrites lead to the complexity of liquid phase channels, resulting in the increase of porosity. Additionally, forging near solidification can close shrinkage porosity.

HBIM for conservation and valorization of structural heritage: The Stylite Tower at Umm ar-Rasas, Jordan

The Heritage Building Information Modeling (HBIM) is a consistent approach to support the multidisciplinary process of knowledge, conservation, and valorization of the historical building heritage, exploiting the combination of advanced 3D modelling and heterogeneous informative data. In the present paper, a highly customized HBIM workflow is developed for the enhancement and conservation of the byzantine Stylite Tower in the Jordan archaeological site of Umm ar-Rasas. The case study is considered a benchmark to test the effectiveness and the scalability of the proposed methodology for the broader set of ancient structures located in archaeological sites. The proposed HBIM process has a dual aim: the organization of heterogeneous and fragmented sources concerning the history and the actual state maintenance of the Tower and the development of a flexible tool to perform fast qualitative and quantitative analysis oriented towards conservation and management projects. The small scale of the structure and an innovative semi-automatic modelling process based on visual coding allowed for a stone-by-stone segmentation of the Tower. The model procedure is based on an information management workflow based on CIDOC-CRM ontology and the interchange format Industry Foundation Classes to ensure interoperability, developing an open-access interactive visualization of the model of the Tower, embedding organized document sources. The proposed HBIM model can also be a valuable tool for enhanced monument fruition and dissemination activities of the structure.

Investigation into the purification and regeneration of rare earth polishing powder waste via continuous solid-phase conversion

The concentration of rare earth elements (lanthanum, cerium, and praseodymium) within rare earth polishing powder waste (REPPW) typically exceeds 50 %, with the majority of impurities comprised of silicon and aluminum-related compounds. Transforming REPPW into recycled rare earth polishing powders that adhere to polishing standards in an eco-friendly and economically viable way presents a significant challenge in the industry. Traditional acid or alkaline processes predominantly recover rare earth elements as oxides, which are underutilized due to their high costs. Considering the varying forms of impurities and rare earth compounds found in REPPW, this research introduces a novel physicochemical decontamination and continuous chemical transformation process aimed at producing regenerated rare earth polishing powders. Under optimal conditions, the physicochemical two-step decontamination process achieved a rare earth recovery rate surpassing 92 %, while silicon and aluminum removal rates reached 86.12 %. During the continuous chemical transformation of REPPW, the rare earth phases in an alkaline setting followed the sequence REOF (CeO2) → RE(OH)3 → RECO3OH→RECO3F→CeLa2O3F3(CeO2), which not only facilitated phase reorganization but also enhanced the particle surface structure. Notably, these chemical transformations did not disrupt the rare earth distribution; instead, they indirectly boosted product purity and uniformly dispersed within the regenerated polishing powder particles, thereby improving polishing efficiency. Consequently, the adoption of this innovative regeneration process for polishing powders holds substantial importance for the sustainable utilization of rare earth resources.