BACKGROUND:The importance of studying the growth and development processes of the child population is due to the significance of the pre-clinical approach aimed at primary disease prevention. AIM:To provide the constituent entities of the Russian Federation with standards for the physical development of children and adolescents aged 7–17years. MATERIAL AND METHODS:An analytical study was conducted, big data from the database “Physical Development of Children, Adolescents, and Youth of the Russian Federation in 2000–2021” were analyzed, containing 395,956observations of physical development (length and body weight indicators) of children, adolescents, and young people living in 49constituent entities of the Russian Federation. Priority was given to research in the constituent entities for which regional standards had never been developed or for which they were developed 15–20years or more ago. As a result, at least 2constituent entities were analyzed in each federal district. Big data processing using machine learning was carried out on the basis of the PostgreSQL database. A web application was created that implemented the functions of tabular display of data, construction of histograms with the ability to select parameters and subsequent data publication on the map of the Russian Federation. RESULTS:In Russia at the beginning of the 21st century, the characteristics of physical development of students living in different constituent entities of the Russian Federation were established, which allowed us to talk about the presence of “regional scenarios” that must be taken into account when developing standards. At the age of 15, the range of average values of growth indicators for boys in the constituent entities ranged from 161.70±0.20cm in the Kursk Region to 174.55±0.40cm in the Krasnodar Territory (the difference was 12.85cm, p=0.001), for girls— from 154.60±0.50cm in the Republic of Tyva to 165.69±0.55cm in St.Petersburg (the difference was 11.09cm, p=0.001). The range of body weight of 15-year-old boys in the regions was from 50.17±0.70kg in the Kursk region to 66.00±0.80kg in the Khabarovsk region (difference 15.83kg, p=0.001), girls— from 46.90±0.60kg in the Chelyabinsk region to 58.40±0.70kg in the Khabarovsk region (difference 8.50kg, p=0.001). CONCLUSION:40regional standards for the physical development of the child population have been developed in a standardized manner, which allows taking into account regional characteristics and makes it possible to use them in practical healthcare in the constituent entities of the Russian Federation.