Scope Of Procedures Research Articles

Trifluoromethyl Vinamidinium Salt as a Promising Precursor for Fused β-Trifluoromethyl Pyridines

An efficient chlorotrimethylsilane-promoted synthetic protocol for the preparation of functionalized fused β-trifluoromethyl pyridines by cyclization of electron-rich aminoheterocycles or substituted anilines with a trifluoromethyl vinamidinium salt was developed. The efficient and scalable approach for producing represented trifluoromethyl vinamidinium salt demonstrated huge prospects for further use. The structure specificities of the trifluoromethyl vinamidinium salt and their impact on the reaction progress were determined. The procedure's scope and alternative ways of the reaction were investigated. The possibility of increasing the reaction scale up to 50 g and further modification of obtained products was shown. A minilibrary of potential fragments for 19F NMR-based fragment-based drug discovery (FBDD) was synthesized.

The Role of Summary Judgment in Commercial Law

This article considers the historical development of the summary judgment procedure, both in England and in New Zealand, for the purpose of highlighting the commercial imperatives underlying the procedure's genesis. It goes on to discuss the modern role played by summary judgment, by reference to two recent decisions that illustrate the tensions associated with expanding the procedure's scope into previously unheralded areas of the law. It concludes that commercial parties should rigorously consider whether their dispute is capable of being determined by summary judgment, but that this should not be understood as lessening the standard required to be met before judgment will be granted.