Registration Procedure Research Articles

Advances and Perspectives in the Use of Biocontrol Agents against Fungal Plant Diseases

The use of synthetic fungicides to control fungal diseases has growing limitations due to eco-toxicological risks. Therefore, it is necessary to replace or integrate high risk chemicals with safer tools for human health and environment. Consequently, research on the selection, evaluation, characterization, and use of biocontrol agents (BCAs) has consistently increased in the last decades. BCA formulates, particularly in some countries, are still scarce in coping with the growing demand for their use in sustainable agricultural management. To foster development and utilization of new effective bioformulates, there is a need to optimize BCA activity, to share knowledge on their formulation processes and to simplify the registration procedures. Studies based on new molecular tools can significantly contribute to achieve such objectives. The present review provides the state of the art on biocontrol of fungal plant diseases with special emphasis on (i) features of the most studied BCAs; (ii) key strategies to optimize selection and use of BCAs (iii); mechanisms of action of the main BCAs; (iv) molecular tools and metagenomic studies in the selection and use of BCAs; (v) main issues and constraints in the registration and commercialization of BCAs, and (vi) perspectives in the biocontrol of fungal plant diseases.

Fast and Accurate Registration of Terrestrial Point Clouds Using a Planar Approximation of Roof Features

3D reconstructed models are becoming more diffused daily, especially in the Cultural Heritage field. These geometric models are typically obtained from elaborating a 3D point cloud. A significant limit in using these methods is the realignment of different point clouds acquired from different acquisitions, particularly for those whose dimensions are millions of points. Although several methodologies have tried to propose a solution for this necessity, none of these seems to solve definitively the problems related to the realignment of large point clouds. This paper presents a new and innovative procedure for the fine registration of large point clouds. The method performs an alignment by using planar approximations of roof features, taking the roof’s extension into account. It looks particularly suitable for the alignment of large point clouds acquired in urban and archaeological environments. The proposed methodology is compared in terms of accuracy and time with a standard photogrammetric reconstruction based on Ground Control Points (GCPs) and other ones, aligned by the Iterative Closest Point method (ICP) and markers. The results evidence the excellent performance of the methodology, which could represent an alternative for aligning extensive photogrammetric reconstructions without the use of GCPs.

OVERVIEW OF SERVICE ADMINISTRATION CONDITIONS BPJS OUTCOME PATIENTS AT X JOMBANG HOSPITAL

The administrative requirements for registration of outpatients specifically for BPJS users, must be brought in full when visiting a hospital for a health check. The problem is from the number of 8 patients who visited the hospital including 2 patients who did not bring a control letter, 2 patients did not bring a photocopy of their ID card, 3 patients did not bring a photocopy of BPJS, and 1 patient came who had not been scheduled for control. The purpose of this study was to determine the suitability of the administrative requirements for outpatient registration of BPJS users at Hospital X Jombang. Descriptive research method with a cross sectional approach, the variables are policy regulations, standard operating procedures, administrative completeness of patient registration. The population of BPJS outpatients is 26,654, the sample is 30 by quota sampling and 1 respondent is the Head of Medical Records. As a result, policies and standard operating procedures have been implemented, administrative compliance is not complete, such as a control letter (20%), photocopy of ID card (56.7%), and photocopy of BPJS (53.3%). The conclusion is that the implementation of the outpatient registration procedure for BPJS users at Hospital X Jombang is not in accordance with the rules, because the patient administration requirements are not complete. This can cause the waiting time for the destination poly to be longer and hamper the service process at the patient registration area and cancel BPJS claims at the hospital. Suggestions for making information facilities related to completeness for outpatient registration requirements.

Assessment of Regulatory requirements and filing procedure of Drug Master File for Brazil, Europe and South Africa

A Drug Master File is a record that consists of detailed, correct data approximately an Active Pharmaceutical Ingredient (API) or Dosage Form of a Finished Product (FP). It is a classified document containing thorough, accurate, and up-to-date information regarding the active medicinal ingredient and medicament. A DMF is divided into two sections: (a) Open part (the Applicant's Part), which includes all of the details needed to determine the quality of a product. And (b) the Closed Part (Restricted Part). The Restricted Part (Closed Part) comprises openly undisclosed manufacturing method knowledge only given to authorized individuals. This compilation aims to offer a comparison of DMF regulatory necessities in addition to the exact data for the registration of lively pharmaceutical ingredients (API) for common drugs in various regulatory governments, including EUROPE (EDQM, EMA), BRAZIL (ANVISA), and SOUTH AFRICA (SAHPRA). This review will provide information on the differences and similarities in the DMF filing requirements in EUROPE, BRAZIL, and SOUTH AFRICA. The regulatory criteria for API registration vary by jurisdiction. Despite the existence and widespread adoption of an ICH-CTD standard format, there are also some limitations. There are a few particular requirements set provided to drug authorities along with the submission. The registration procedure is a regulatory undertaking that permits a person/organization/sponsor/innovator to get permission to participate in the regulation process for fetching marketing authorization/approval.

Analysis on the registration and review system of emergency medical devices in China and abroad in the context of COVID-19

Objective
 In the context of COVID-19, the domestic and foreign demand for emergency medical devices, such as medical masks and protective suits, is surging, and it is urgent to complete the registration and review of emergency medical devices with high efficiency and quality, which requires a mature and perfect registration and review system as the support. This paper aims to compare and analyze the domestic and foreign registration and review system of emergency medical device, summarize the good experience, and provide feasible suggestions for improving China's emergency medical device registration and review system.
 Method
 USA, Canada, Japan and the European Union were selected to make a comparative analysis with China from the aspects of legal system and emergency registration and review procedure by literature research, comparative analysis and other theoretical methods.
 Results
 The legal system and review mechanism of emergency medical device registration in China have been relatively perfect, but the safety and risk balance mechanism and the comprehensiveness of emergency management measures need to be further improved.
 Conclusion
 On the basis of maintaining its own institutional advantages, China should learn from foreign experience to further optimize the registration and review system of emergency medical devices, so as to improve the ability of response and implementation of China in public health emergencies.

Special Provisions for the Medicines Registration Procedure in Response to Economic Restrictions Imposed on the Russian Federation

The economic sanctions imposed on the Russian Federation in 2022 create a potential risk of shortages or absence of a range of medicines demanded by the Russian healthcare system. The article describes the legislative measures by the Russian Government aimed at prevention of inventory shortages of medicinal products and, in particular, the special requirements to expert evaluation and registration of the medicines that could be affected by the risk. The article pays special attention to the time frames of assessment and registration procedures.

Circulation of orphan drugs within the Eurasian economic union: problems and solutions

INTRODUCTION. One of the socially significant directions in the development of pharmaceutical products is the provision of high-quality, effective and safe medicines intended for the treatment of orphan (rare) diseases among the population of the Member States of the Union. The availability of medicinal products for such patients suffering from such diseases should be regulated by state incentives for the development and launch of orphan drugs from do- mestic manufacturers through the updating and timely updating of regulatory legal acts in the field of marketing authorization (MA) of medicinal products, as well as providing benefits when initiating the registration process. AIM. To assess the prospects and possibilities of putting orphan drugs into circulation within the framework of the Eurasian Economic Union for domestic manufacturers. MATERIALS AND METHODS. The study materials were available publications in peer-reviewed journals on thematic queries based on keywords of the se- lected topic, official websites, regulatory legal acts, regulating the procedure for registering medicinal products in the Eurasian Economic Union and the Russian Federation. RESULTS AND DISCUSSION. A review of national legislation on MA and regulation of the circulation of orphan drugs revealed several critical problems that prevent domestic manu- facturers from introducing drugs of this group to the pharmaceutical market of the Eurasian Economic Union, such as lack of regulation of the list of orphan drugs and a simplified registration procedure in the custom territory of the Eurasian Economic Union, complexity procedures for assigning an orphan drug status, etc. Imperfections in the regulatory regulation of these issues predetermine problems in drug provision for patients with orphan diseases in the Eurasian Economic Union. Conclusion. A review of the problems and possibilities of putting orphan drugs into circulation by domestic manufacturers needs to improve legal regulation both at the level of the Russian Federation and within the legal framework of the Eurasian space.

Попытка классификации новых российский партий

The purpose of this paper is to determine which new Russian political parties, which completed the procedure of registration in 2020, can act as “spoilers” for the opposition parties in the Parliament, In order to achieve this goal, the author has undertaken an attempt to provide classification for the new political parties basing on the approach that was taken by famous Russian political scientists A.Lyubarev and M. Volkhina. This approach was employed by Lyubarev and Volkhina in their research, where they offered their classification of small Russian political parties that were set up after 2021. The output of the research and analysis clearly states that all new Russian political parties possess certain features that are typical for political technologies. However, it would be an exaggeration to assert that every new Russian political party has been designed as a “spoiler” for a specific political party in the Russian Parliament.

Role & Responsibilities of Notary in Implementation of Association Registration Through the Online Legal Entity Administration System

This study aims to analyze: 1) The procedure for registering associations is through the online Legal Entity Administration System. 2) The role and responsibilities of a notary in carrying out the registration of associations through the online Legal Entity Administration System. The approach method in this research is a sociological juridical approach. The data used are primary data and secondary data obtained through interviews and literature study, data analysis was carried out in a descriptive analytical manner. The results of the study concluded: 1). The association registration procedure through the online Legal Entity Administration System is uncomplicated. The procedure begins with an application for ordering the name of the association through SABH www.ahu.go.id, then the application for legalization of the association's legal entity must be submitted by a notary with supporting documents submitted electronically. Supporting documents in the form of an electronic statement from the applicant. A statement letter containing the completeness of the association's establishment documents from the applicant. The Ministerial Decree concerning the legalization of the legal entity association is issued no later than 14 days. The period of time is calculated from the date of the statement of no objection from the Minister. The fee for ordering the name of the association is IDR 100,000, -, while for the ratification of the establishment of the association of IDR 250.000,-. 2). The role of the notary in carrying out the registration of associations through the online legal entity administration system is to order names and register the ratification of the association to the minister through the SABH. Notaries have an important role in managing the legal entity of the Association. People who need the legal entity ratification of the Association cannot access the SABH directly but must go through a Notary who has been registered in the SABH. This is because the notary plays a role in carrying out statutory orders so that the interests of the parties do not violate the law.

Performance barriers of Civil Registration System in Bihar: An exploratory study.

Vital statistics generated by the Civil Registration System (CRS) are essential for developing healthcare interventions at all administrative levels. Bihar had one of the lowest levels of mortality registration among India's states. This study investigates CRS's performance barriers from the perspective of CRS staff and community members in Bihar. We conducted a primary qualitative survey in the two districts of Bihar during February-March 2020 with CRS staff (n = 15) and community members (n = 90). We purposively selected the Patna and Vaishali districts of Bihar for the survey. Thematic analysis was done to identify the pattern across the data using the Atlas-ti software. Most participants showed a good understanding of registration procedures and birth and death registration benefits. The perceived need for death registration is lower than birth registration. Birth registration was higher among female children than male children. We found that most participants did not report children or adult female death due to lack of financial or property-related benefits. Most participants faced challenges in reporting birth and death due to poor delivery of services at the registration centres, higher indirect opportunity cost, and demand of bribes by the CRS staff for providing certificates. We found a lack of adequate investment, shortage of dedicated staff, and limited computer and internet services at the registration centres. Poor data on birth and death registration could lead decision-makers to target health services inappropriately. Strengthening health institutions' linkage with the registration centres, mobile registration in far-flung areas and regular CRS staff training could increase death registration levels. An adequate awareness campaign on the benefits of birth and death registration is required to increase the reporting of vital events.

Analysis of Factors Affecting the Level of Patient Satisfaction on the Mobile JKN Registration Procedure at Public Health Center Guluk-Guluk Sumenep Regency

Patient's assessment of the services of health workers is based on the patient's experience. The patient experience aspect can be interpreted as a treatment or action from a nurse who is currently or has been undergoing, felt and borne by someone who uses health services.The purpose of this study is to analyze influence service quality, perception and response time to level of satisfaction with the Mobile JKN registration procedure at the Guluk-guluk Health Center, Sumenep Regency. The design of this research is an observational quantitative research with a cross sectional approach with the focus of the research being directed at analyzinginfluence service quality, perception and response time to level of satisfaction with the Mobile JKN registration procedure at the Guluk-guluk Health Center, Sumenep Regency. The total population is 134 respondents and a sample of 105 respondents is taken by using Simple Random Sampling technique. The results showed that most of the respondents had good service quality category as many as 58 respondents (55%). Most respondents have a good category perception as many as 58 respondents (55%). Most of the respondents have a fast response time category as many as 92 respondents (87.6%). Most of the respondents have a satisfied category of satisfaction as many as 60 respondents (57.1%). Based on the results of Multiple Linear Regression analysis shows that with a p-value of 0.000 <0.05 then H1 is accepted so it can be concluded that there is a simultaneous influenceservice quality, perception and response time to the level of satisfaction with the Mobile JKN registration procedure at the Guluk-guluk Public Health Center, Sumenep Regency with an effect of 81.2%. It is expected that respondents can provide constructive input and criticism so that the services provided can be in accordance with what is expected.

A NEW MONUMENTARY TREE ON TEKKE MOUNTAIN, MERSIN: BOYLU ARDIÇ (JUNIPERUS EXCELSA M. BIEB.)

Monumental trees are the memory of history, they can be defined as living things that exceed the usual measures of their own kind, have a special place in the folklore, culture and history of the region where they are located, and build a bridge between the past and the future. Today, many studies are carried out on the registration, protection and transfer of monumental trees to future generations, and these studies are extremely important. In this context; In 2015, during the Wildlife Monitoring and Follow-up studies carried out in the Cennetdere Wildlife Development Area (YHGS), which is among the registered and protected areas within the scope of duty of the "Ministry of Agriculture and Forestry, Nature Conservation and National Parks" 7th Regional Directorate – Mersin Branch Directorate, Juniperus excelsa M. Bieb. (Boylu ardıç) individual, which is thought to have the status of Monumental Tree, was identified on the summit of Teke Mountain in Cocakdere region. The dimensional characteristics of this tree (diameter ≅ 3 m; circumference ≅9.5 m and height ≅17 m) showed that it had a monumental quality. The Juniper excelsa detected in its natural distribution area should be considered as a contribution to the monumental tree existence of Mersin province and the registration procedures as a dimensional monumental tree should be carried out by the relevant institution immediately.

INCORPORATION OF COMPANIES IN SERBIA - THE SCOPE OF PRESENCE OF ELECTRONIC AND TRADITIONAL PROCEDURES

Increasing the investment activity of the existing companies and stimulating the incorporation of new companies is one of the factors of economic development. Many factors determine the scope of economic activity in a country, one of them is the procedure for incorporating economic entities. If we start from the assumption that the investor, domestic or foreign, has assessed the possibility of profiting in a specific economic environment, the first step in the realization of their business idea is the incorporation of their company. The legislation in Serbia provides an opportunity for a significant part of the procedure for incorporating business entities to be conducted electronically. Using this opportunity implies the knowledge of several laws related to the procedure for incorporation registration, as well as mastering new e-methods of communicating and running business. In this paper, we point out the normative solutions related to the e-registration of companies in Serbia and the problems in the practice that the founders encounter. E-registration of business entities entails the understanding of numerous e-instruments such as: e-documents, qualified e-signature, e-address, user applications, qualified e-time stamp and others. Memorandum of Association and other acts can be made in written or e-form, so the question arises whether all documents when forming a company can be in e-form and how an e-document can be materialized without losing legal force. Another legal obligation in our country, for some companies, is the e-records of beneficial owners. We will deal with these and other practical issues that the founders of companies in Serbia face in this paper.

Blockchain-Based Reliable Framework for Land Registration Information System

One of the biggest problems in India is the land/property disputes for the land proprietorship issues. The main reason behind it could be the number of intermediaries in the process of land registry, which creates doubtful transactions and non-clarity of title. Maintaining transparency and tamper-proof of land titles are the challenging task, while data are moving through a number of channels. By using blockchain technology, one can solve these issues during land proprietorship transfer. This paper explains complexities in the present land registration procedure and how to resolve these issues by using blockchain technology. Furthermore, the paper provides a reliable framework configuration utilizing blockchain technology for the supports of the land proprietorship transfer in the nation. The proposed framework will remove the intermediaries and minimize the cause of fraud in the process. Using the framework, the land titles are unique and give valid and decisive authority to proprietorship.

Fast, accurate and robust registration of multiple depth sensors without need for RGB and IR images

Registration is an essential prerequisite for many applications when a multiple-camera setup is used. Due to the noise in depth images, registration procedures for depth sensors frequently rely on the detection of a target object in color or infrared images. However, this prohibits use cases where color and infrared images are not available or where there is no mapping between the pixels of different image types, e.g., due to separate sensors or different projections. We present our novel registration method that requires only the point cloud resulting from the depth image of each camera. For feature detection, we propose a combination of a custom-designed 3D registration target and an algorithm that is able to reliably detect that target and its features in noisy point clouds. Our evaluation indicates that our lattice detection is very robust (with a precision of more than 0.99) and very fast (on average about 20 ms with a single core). We have also compared our registration method with known methods: Our registration method achieves an accuracy of 1.6 mm at a distance of 2 m using only the noisy depth image, while the most accurate registration method achieves an accuracy of 0.7 mm requiring both the infrared and depth image.

Implementing robotic process automation to improve operational efficiency in the health-care sector

Robotic Process Automation (RPA) is a technique that is rapidly being utilised as a tool to automate, maintain, analyse, and update existing databases in a cost-effective and error-free manner. The majority of healthcare procedures are the same. As a result, deploying Automation solutions in the healthcare industry pays off handsomely for the firm. The Patient Registration procedure is one of the best application reasons for RPA adoption. As requested by the hospital, collect information from patients. Finally, all of the patient's records should be integrated and updated in one location. Manually performing these activities takes a long time and can result in a lot of human mi stakes. Patients must also wait in line to submit their applications if they are done manually. RPA in Patient Register will not only speed up and streamline the process, but it will also improve customer satisfaction and provide a competitive advantage. As a result, a healthcare bot can take over such routine activities from a human staff, allowing them to focus on more important diagnostic and analytical tasks. In addition, an RPA database may be utilised to schedule doctor's visits and deliver all pertinent information to the doctor with a single click.

3DupIC: An Underwater Scan Matching Method for Three-Dimensional Sonar Registration

This work presents a six degrees of freedom probabilistic scan matching method for registration of 3D underwater sonar scans. Unlike previous works, where local submaps are built to overcome measurement sparsity, our solution develops scan matching directly from the raw sonar data. Our method, based on the probabilistic Iterative Correspondence (pIC), takes measurement uncertainty into consideration while developing the registration procedure. A new probabilistic sensor model was developed to compute the uncertainty of each scan measurement individually. Initial displacement guesses are obtained from a probabilistic dead reckoning approach, also detailed in this document. Experiments, based on real data, demonstrate superior robustness and accuracy of our method with respect to the popular ICP algorithm. An improved trajectory is obtained by integration of scan matching updates in the localization data fusion algorithm, resulting in a substantial reduction of the original dead reckoning drift.

The Role of Public-private Partnerships In Land Administration

The earth occupies a special place among the living material conditions of man and is a necessary condition for the existence of society. Thus, it is important to see how effectively the natural, agricultural and economic potential of the land will be used. Unfortunately, under the conditions of the agrarian reform, the possibilities of rational land use were not properly taken into account and, consequently, it was not possible to achieve satisfactory results. It is known that land, as a spatial basis for the location and operation of productive forces, plays an important role in all areas, but it is especially important in agriculture, where land is an instrument of labor and an object of labor. The administration of land, as an important natural resource and a key factor of production is a task of political and socio-economic importance for the country. International experience shows that the necessary condition for the development of an effective market economy is active cooperation between state authorities and business. In the process of institutionalization, this cooperation took on the character of a public-private partnership (PPP) and was renamed public-private partnership. The public-private partnership is a framework that recognizes and structures the role of government in fulfilling its social responsibilities, successfully reforming the sector and implementing public investment, and at the same time integrates the private sector into these processes. Public-private partnerships are vital to economic development as engagement, participation and collaboration contribute to more effective laws and policies. Public-private partnerships in land administration bring flexible and customer-oriented land registration services and significantly improve land registration procedures. In addition, PPP brings a higher level of service delivery, cost-effectiveness, and reduced investment risks to participating parties. Keywords: Land Administration, Public-Private Partnership, Blockchain.

Problems of criminal responsibility for violation of patient rights in the field of conducting clinacal trials of drugs

The article is devoted to the problem of criminal liability for violation of patients' rights in the field of clinical trials of medicines.
 The norms formulated in Articles 141 and 321-2 of the Criminal Code (hereinafter - the CC) of Ukraine are studied. It is established that the name of Art. 141 of the Criminal Code of Ukraine is unfounded in terms of the rules of legislative technique. The ambiguity of the phrase " violation of the patient's rights" does not reflect the content set forth in the disposition of Art. 141 of the Criminal Code of Ukraine prohibition. The list of patient rights is quite wide. However, the disposition of the article prohibits only three types of violations of patients 'rights, which can occur only in one of the possible areas of violations of patients' rights, namely in the field of clinical trials of medicines. In particular, liability is provided for: 1) for conducting clinical trials of drugs without the written consent of the patient or his legal representative; 2) for conducting clinical trials of medicinal products in relation to a minor; 3) for conducting clinical trials of drugs against incapacitated. In this case, liability arises only in the event of socially dangerous consequences (death of the patient or other serious consequences).
 Article 321-2 of the Criminal Code of Ukraine “Violation of the established procedure for pre-clinical studies, clinical trials and state registration of medicinal products” also provides for liability for violation of the procedure for clinical trials of medicinal products, but without causing death, other serious consequences (Part 1 and 2 Article 321-2 of the Criminal Code of Ukraine). However, sanctions under Art. 141 and Part 1 of Art. 321-2 of the Criminal Code of Ukraine are the same, and under Part 2 of Art. 321-2 of the Criminal Code of Ukraine - stricter.
 It is established that in part 3 of Art. 321-2 of the Criminal Code of Ukraine actually provides for liability for the same actions as in Art. 141 of the Criminal Code of Ukraine. However, the punishment under Part 3 of Art. 321-2 is much stricter than under Art. 141 of the Criminal Code of Ukraine. Emphasis is placed on the fact that there is competition between norms, in which more socially dangerous acts (which are provided for in Article 141) are punished less severely.
 Soundly the expediency of removing Art. 141 of the Criminal Code of Ukraine with the Criminal Code of Ukraine, as well as differentiation under Art. 321-2 of the Criminal Code of Ukraine liability for an act that is in gross violation of the order of clinical trials of drugs, led to the death of the patient.

STATE REGISTRATION OF RELIGIOUS ORGANIZATIONS IN UKRAINE

The article considers the issue of the creation and registration of religious organizations and the acquisition of the status of a legal entity. The main problems faced by religious organizations in the process of state recognition are considered. The methods of state registration of religious organizations depending on their type are described, the powers of regional and central executive bodies regarding the legal recognition of religious organizations are outlined. Proposals have been made to amend the current legislation to create a transparent process for registering religious organizations. The article defines religious organizations in Ukraine such as religious communities, centers, administrations, monasteries, church unions, missions, theological educational institutions, organizations, and associations. As the registration procedure of religious organizations has two stages of registration in Ukraine, the article describes in detail each of the stages of state registration of religious organizations. The article describes the state benefits that religious organizations in Ukraine can receive after obtaining the status of a legal entity.