In this paper, the feedback load reduction problem in wireless systems based on orthogonal frequency division multiplexing (OFDM) is investigated and an opportunistic feedback scheme (OFS) is proposed. The key idea behind OFS is that only the key channel gains which can significantly affect the system throughput are fed back to the BS. Firstly, the key channel gains are proved to belong to a channel gain interval. Secondly, a statistical method is proposed to estimate the channel gain interval. Thirdly, the opportunistic feedback scheme is formulated and the feedback load of OFS is analyzed. The advantage of OFS is threefold: the first is OFS can work in both OFDM-based multicast system and OFDM-based unicast system. The second is the channel fading type of the BS-user link is not required, which is more realistic. The third is OFS can get better feedback load performance compared with other schemes, while achieving almost the same throughput performance compared with that of full feedback scheme.