Problem statement. The present-day realities show that the design of buildings and structures with regard to possible local collapses of their bearing structures is becoming more and more realistic and thus an increasingly urgent challenge. The need to solve this issue is an important component in ensuring the safety of buildings and structures under operational and emergency loads. Local destruction is interpreted as a global result that can lead to the destruction of the entire frame or a significant part of it and cause loss of life. The peculiarity of calculations for progressive collapse of steel-framed buildings is that, unlike monolithic reinforced concrete, in a steel frame, the nodes of connection of elements are usually hinged, and this can lead to transformation of the structural scheme into a geometrically variable structural scheme. In this case, structural failure may occur not due to loss of material strength, but due to loss of load-bearing capacity of the structural connection joints. The purpose of the article is to analyse the main specific peculiarities occurring in the design (reinforcement) of industrial buildings with steel frames, considering the possibility of their local destruction. Conclusion. The article considers some problems that need to be solved during the designing or reconstructioning industrial buildings with a steel frame, the operation of which may be associated with some local destruction of the bearing structures. Prospective constructive ways of effectively solving these problems are presented.