As a stable material at high temperatures, the presence of cracks and other defects greatly reduces the performance of quasicrystals (QCs). The plane thermoelastic problem of one-dimensional hexagonal quasicrystals (1DHQ) non-periodic plane containing a nano-open crack is analyzed using surface elasticity theory. The closed form solutions are obtained to describe the thermoelastic field corresponding to the nano-crack by the Fourier integral transformation technique. The analytical solutions of the thermal stress intensity factors (TSIFs) and the strain energy density factor (SEDF) at the crack tip are derived explicitly. The influence of the applied loads, the surface effects and the multi-field coupling effects on the TSIFs and SEDF are discussed. The numerical results reveal that the surface effects have an obvious impact on TSIFs with small applied loads, and the surface effects will inhibit the propagation of nano-open cracks. The research results of this study provide some reliable theoretical references for the development of nano-QCs.