Multidisciplinary reliability design optimization is considered an effective method for solving complex product design optimization problems under the influence of uncertainty factors; however, the high computational cost seriously affects its application in practice. As an important part of multidisciplinary reliability design optimization, multidisciplinary reliability analysis plays a direct leading role in its computational efficiency. At present, multidisciplinary reliability analysis under mixed uncertainty is still nested or sequential execution mode, which leads to the problem of poor disciplinary autonomy and inefficiency in the reliability analysis of complex products. To this end, a multidisciplinary reliability assessment method integrating deep neural networks and probabilistic computational models under mixed uncertainty is proposed for the problem of multidisciplinary reliability analysis under mixed uncertainty. The method considers the stochastic-interval-fuzzy uncertainty, decouples the nested multidisciplinary probability analysis, multidisciplinary likelihood analysis, and multidisciplinary interval analysis, uses deep neural networks to extract subdisciplinary high-dimensional features, and fuses them with probabilistic computational models. Moreover, the whole system is divided into several independent subsystems, then the collected reliability data are classified, and the fault data are attributed to each subsystem. Meanwhile, the environmental conditions of the system are considered, and the corresponding environmental factors are added as input neurons along with each subsystem. In this paper, the effectiveness of the proposed method is verified on numerical calculations and real inverter power failure data.