Accounting for water stress-induced tree mortality in forest productivity models remains a challenge due to uncertainty in stress tolerance of tree populations. In this study, logistic regression models were developed to assess species-specific relationships between probability of mortality (Pm ) and drought, drawing on 8.1 million observations of change in vital status (m) of individual trees across North America. Drought was defined by standardized (relative) values of soil water content (Ws,z ) and reference evapotranspiration (ETr,z ) at each field plot. The models additionally tested for interactions between the water-balance variables, aridity class of the site (AC), and estimated tree height (h). Considering drought improved model performance in 95 (80) per cent of the 64 tested species during calibration (cross-validation). On average, sensitivity to relative drought increased with site AC (i.e. aridity). Interaction between water-balance variables and estimated tree height indicated that drought sensitivity commonly decreased during early height development and increased during late height development, which may reflect expansion of the root system and decreasing whole-plant, leaf-specific hydraulic conductance, respectively. Across North America, predictions suggested that changes in the water balance caused mortality to increase from 1.1%yr-1 in 1951 to 2.0% yr-1 in 2014 (a net change of 0.9±0.3% yr-1 ). Interannual variation in mortality also increased, driven by increasingly severe droughts in 1988, 1998, 2006, 2007 and 2012. With strong confidence, this study indicates that water stress is a common cause of tree mortality. With weak-to-moderate confidence, this study strengthens previous claims attributing positive trends in mortality to increasing levels of water stress. This 'learn-as-we-go' approach - defined by sampling rare drought events as they continue to intensify - will help to constrain the hydraulic limits of dominant tree species and the viability of boreal and temperate forest biomes under continued climate change.