In the era of Big Data, where vast datasets fuel innovation across industries, the paramount concern remains safeguarding individual privacy. This article explores how statistical approaches ensure data confidentiality amidst the proliferation of digital information. Differential privacy techniques introduce calibrated noise to protect identities while preserving data utility, crucial for compliance and trust in data-driven decision-making. Secure Multiparty Computation (MPC) enables collaborative analysis without exposing raw data, supporting privacy in sectors like healthcare and finance. Privacy-preserving data mining techniques integrate encryption and anonymization to extract insights while shielding sensitive information. Anonymization and de-identification methods further bolster privacy by masking identifiable data, essential for adhering to stringent regulations like GDPR and HIPAA. As data generation escalates, advancing these statistical methods is essential for maintaining privacy integrity in the evolving landscape of Big Data applications. Keywords: Big Data, Privacy, Statistical approaches, Differential privacy, Secure multiparty computation.