We analyze the relationships between country culture and country regulatory structure pertaining to information privacy concerns (IPC) in the context of social media applications. Drawing on prior research we develop a framework that integrates country culture and country regulatory structure and use it as the basis for a study that contrasts samples of 1086 professionals drawn from four countries – United States, United Kingdoms, India and Hong Kong – to assess effects of national culture and of a nation’s regulatory structure on IPC, attitudinal beliefs about information privacy and professionals’ behavioral reactions to IPC. We find that country culture has a strong bearing on explaining differences in individuals’ IPC concerns, attitudinal beliefs about privacy, and behavioral reactions to privacy much more than does country regulatory structure. Country culture remains a significant factor in the management of information privacy. The results also show that country regulatory structure remains deficient in allaying individuals’ concerns pertaining to information privacy.