Prism-based Surface Plasmon Resonance Sensors Research Articles

Multi-Disease Detection Using a Prism-Based Surface Plasmon Resonance Sensor: A TMM and FEM Approach.

This research introduces a surface plasmon resonance (SPR)-based biosensor with multilayered structures for telecommunication wavelength in order to detect multiple diseases. The malaria and the chikungunya viruses are taken into account and the presence of these viruses are determined by examining several blood components in healthy and affected phases. Here, two distinct configurations (Al-BTO-Al-MoS2 and Cu-BTO-Cu-MoS2) are proposed and contrasted for the detection of numerous viruses. The performance characteristics of this work have been analyzed using Transfer Matrix Method (TMM) method and Finite Element Method (FEM) method under angle interrogation technique. From the TMM and FEM solutions, it is evident that the Al-BTO-Al-MoS2 structure provides the highest sensitivities of ~270 deg./RIU for malaria and ~262 deg./RIU for chikungunya viruses, with satisfactory detection accuracy of ~1.10 for malaria, ~1.64 for chikungunya, and quality factor of ~204.40 for malaria, ~208.20 for chikungunya. In addition, the Cu-BTO-Cu MoS2 structure offers the highest sensitivities of ~310 deg./RIU for malaria and ~298 deg./RIU for chikungunya, with satisfactory detection accuracy of ~0.40 for malaria, ~0.58 for chikungunya, and quality factor of ~89.85 for malaria, ~86.38 for chikungunya viruses. Therefore, the performance of the proposed sensors is analyzed using two distinct methods and gives around similar results. In a sum, this research could be utilized as a theoretical foundation and first step in the development of a real sensor.

High Performance Bimetallic(Cu-Co) Surface Plasmon Resonance Sensor using Hybrid Configuration of 2D Materials

The performance of prism-based surface plasmon resonance sensor utilizing kretschmann configuration composed of thin metallic (Cu–Co) film coated with 2D material such as BP/Graphene layer is investigated theoretically based on angular interrogation method. It is observed that optimizing the thickness of bimetallic (Cu–Co) and BP/Graphene layers, the sensitivity of the sensor improved greatly and still can maintain its minimum reflectivity and line width of the SPR reflectivity curve. We also observed that addition of BP/ Graphene over the bimetallic layer, its further enhanced the sensitivity. Numerical results shows that sensitivity as high as 504deg/RIU is achieved for the well optimized bimetallic configuration consist of 45nm of Cu and 10nm of Co thickness for the analyte refractive indices ranging from 1.330 - 1.335.

Modeling of a novel K5 prism-based surface Plasmon resonance sensor for urea detection employing Aluminum arsenide

Modeling of a novel K5 prism-based surface Plasmon resonance sensor for urea detection employing Aluminum arsenide

Study of CuS Thin Films Deposited by PLD Simulated for Prism Based SPR Sensor

Copper Sulfide CuS thin film was prepared using pulsed laser deposition PLD technique and characterized by X-ray and SEM. The optical, structural, and morphological properties are examined at different energies 500 mJ, 600 mJ, 700 mJ, and 800 mJ. The best result was 600 mJ which annealed at various annealing temperatures 300°C, 350°C, 400°C, and 450°C. The effect of thermal annealing on CuS thin film was examined X-ray and SEM. CuS Film was simulated using a prism-based SPR optical sensor. This paper introduces the optical test study of CuS thin film deposited by pulsed laser deposition technique on the quartz substrate and supported by theoretical application study under the effect of surface plasmon resonance (SPR). In this research field, the optical and morphological characteristics of the CuS thin film were deposited by PLD at different laser energies. The annealing process was applied for better-deposited thin-film; the XRD results, SEM images, transmittance T%, and energy gap Eg were analyzed thoroughly and compared to evaluate the thin-film. This effort was made in an in-depth analysis of CuS thin film deposited by PLD on the quartz substrate and applied theoretically in surface plasmon application.

Sensitivity enhancement of surface plasmon resonance sensor using Al–Au–BaTiO3–Graphene layers

The performance of prism-based surface plasmon resonance sensor utilizing new sensing configuration composed of thin metallic (Al–Au) film coated with a thin layer of BaTiO3is investigated theoretically based on angular interrogation method. It is observed that optimizing the thickness of bimetallic (Al–Au) and BaTiO3 layers, the sensitivity of the sensor improved greatly and still can maintain its minimum reflectivity and linewidth of the SPR reflectivity curve. We also observed addition of dual layer of graphene on BaTiO3 further enhanced the sensitivity. The sensitivity of the proposed sensor is found to be 227 deg/RIU, and the FWHM of resonance curve is observed to be 4.47 deg for the thickness of 28 nm of Al, 8 nm of Au and 10 nm of BaTiO3added with double layer of graphene.

Highly sensitive antimonene-coated black phosphorous-based surface plasmon-resonance biosensor for DNA hybridization: design and numerical analysis

The design of an ultrasensitive surface plasmon resonance (SPR) sensor for the detection of deoxyribose nucleic acid (DNA) hybridization is highly desirable for biomedical applications. We have proposed an SPR sensor architecture (Prism-SF10/Al/Si/BP/Antimonene/phosphate buffer saline solution) and performed its numerical analysis for DNA hybridization using angular interrogation at 633 nm. Antimonene is used as a biorecognition element layer for better attachment of single stranded (ss), i.e., ss probe DNA on its surface, due to its higher binding energy for ssDNA (even greater than graphene). Silicon and black phosphorous are utilized to enhance the electromagnetic field at the sensing layer interface. Aluminum is used as an surface plasmon active metal and it also improves the quality factor. Remarkable sensitivity (202.37 deg / refractive index unit) is attained for this work, which is greater than any other SF10 prism-based SPR sensor proposed to date. The performance of the SPR biosensor is meticulously evaluated as limit-of-detection (0.0028 nM) and figure-of-merit (0.037 nM − 1) with respect to the concentration of complementary target ssDNA in the sensing medium. This versatile biosensor shows great application to detect deadly diseases via DNA hybridization in the biomedical field if developed as an SPR chip for experimental verification.

Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID-19 SARS-CoV-2 Spike Protein.

The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID‐19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID‐19 SARS‐CoV‐2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism‐based SPR sensor has an incremental sensitivity of 111.11 deg RIU−1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth.

An Open-Source Simulator Applied to Prism Coupling Sensors Based on Kretschmann's Configuration

In this letter, we present an open-source simulator applied to design and to analyze prism coupling sensors considering surface plasmon resonance (SPR) effect based on Kretschmann's configuration. The open-source simulator is called Sim-SPR and takes into account principles of software engineering. For comparison purposes and to validate our results, we considered two simulation tools already consolidated in the literature and performed an experimental setup for detecting resonant angle in a prism-based SPR sensor. The sensor design was based on optical prism (BK7 glass) as well as Au thin film. The results show that Sim-SPR provides reflectance curves that present a minimum in the resonance condition, resulting in a good agreement when compared with simulation and experimental data. Sim-SPR provides new insights and it has great promise for possible applications in the field of biosensors.

Simultaneous measurement of refractive index and temperature for prism-based surface plasmon resonance sensors.

A detailed theoretical model is provided to analyze the effects of temperature on prism-based surface plasmon resonance (SPR) sensors, including temperature dependence of the metal and prism. A complete sensitivity matrix simultaneously measures variations in refractive index (RI) and temperatures using measurements at two wavelengths for the angular-interrogation mode, or at two angles of incidence for the wavelength-interrogation mode. Correction of matrix coefficients improves accuracy of the two modes. Validation is performed using a self-designed wavelength SPR system with an adjustable incident angle perform. This method provides a new way to detect the RI and may lead to the better design and fabrication of prism-based SPR sensors.

Theoretical study on negative permittivity of the material producing sharp surface plasmon resonance dips

Using theoretical simulations for optical fiber surface plasmon resonance (SPR) sensors and prism-based SPR sensors coated with negative permittivity material (NPM), we investigated the effect of the permittivity of NPM on the transmitted spectrum of optical fiber SPR sensors and the reflected spectrum of prism-based SPR sensors and then obtained optimum permittivity of the NPM, which can excite the sharpest SPR spectrum in the white light region (400–900 nm).

Prism-Based Surface Plasmon Resonance for Dual-Parameter Sensing

A simple method to construct a dual-channel in a prism-based surface plasmon resonance sensor for dual-parameter monitoring is proposed. The metal layer (sensing area), attached to the prism, is half-covered with a polymer in order to generate two individual sensing sections. In this paper, eight different sensor structures (prism/metal/polymer) were analyzed. The prisms are made of NSK16 or SF10 glass and coated with gold or silver films. Half section of the metal films is covered with Polydimethylsiloxane (PDMS) or Poly-methyl methacrylate. The sensor is based on angle interrogation, the laser beam is aligned to be incident upon the interface of the bare and polymer sections. The resonance conditions are different at each pad, due to the refractive index (RI) mismatch, thus the intensity of the reflected signal presents a pair of well-defined resonance dips in series. The sensitivity of these dips to RI and temperature (T) changes was numerically analyzed. Finally, to demonstrate the feasibility to monitor RI and T, simultaneously, a surface plasmon resonance sensor was constructed using a NSK16 glass prism coated with a thin gold film, which was half-covered with PDMS.

Enhancing angular sensitivity of plasmonic nanostructures using mode transition in hexagonal gold nanohole arrays

We presented a surface plasmon resonance (SPR) sensor with an angular sensitivity up to 440 deg/RIU by using (±1,∓1) mode on a hexagonal gold nanohole array. The large-area gold nanohole arrays were fabricated by thermal-annealing template-stripping method with 180-nm-hole diameter and 600-nm period. A flat dispersion curve deviated from Bragg condition for (±1,∓1) mode occurred when incident angle was larger than 20°. The finite-difference time-domain calculations verified that plasmonic mode changed from surface plasmon mode to cavity mode in nanoholes. Such mode transition resulted in the large change of dispersion curve. The angular sensitivity of the (±1,∓1) mode near the transition band was 6.2 times higher than surface plasmon mode under Bragg condition and 4.5 times higher than prism-based SPR sensors at 850nm wavelength. Biosensing experiments for antigen-antibody interactions verified the surface binding sensitivity was higher than prism-based SPR machine.

An SPR-based sensor with an extremely large dynamic range of refractive index measurements in the visible region

A promising GaP prism-based surface plasmon resonance sensor in the Kretschmann configuration with an extremely large dynamic range of refractive index detection is proposed. The prism base is coated with a gold layer and then a thin layer of silicon. The sensor is studied theoretically in terms of sensitivity and detection accuracy. The proposed sensor shows the potential of sensing media with a refractive index varying from gaseous to very dense liquid with appreciably high sensitivity.

Rapid and highly sensitive detection using Fano resonances in ultrathin plasmonic nanogratings

We developed a nanoplasmonic sensor platform employing the extraordinary optical properties of one-dimensional nanogratings patterned on 30 nm-thick ultrathin Ag films. Excitation of Fano resonances in the ultrathin Ag nanogratings results in transmission spectra with high amplitude, large contrast, and narrow bandwidth, making them well-suited for rapid and highly sensitive sensing applications. The ultrathin nanoplasmonic sensor chip was integrated with a polydimethylsiloxane microfluidic channel, and the measured refractive index resolution was found to be 1.46 × 10−6 refractive index units with a high temporal resolution of 1 s. This compares favorably with commercial prism-based surface plasmon resonance sensors, but is achieved using a more convenient collinear transmission geometry and a significantly smaller sensor footprint of 50 × 50 μm2. In addition, an order-of-magnitude improvement in the temporal and spatial resolutions was achieved relative to state-of-the-art nanoplasmonic sensors, for comparable detection resolutions.

Surface plasmon resonance hydrogen sensor based on metallic grating with high sensitivity

High sensitivity is obtained at larger resonant incident angle if negative diffraction order of metallic grating is used to excite the surface plasmon. A highly sensitive grating-based surface plasmon resonance (SPR) sensor is designed for the hydrogen detection. A thin palladium (Pd) film deposited on the grating surface is used as transducer. The influences of grating period and the thickness of Pd on the performance of sensor are investigated using rigorous coupled-wave analysis (RCWA) method. The sensitivity as well as the width of the SPR curves and reflective amplitude is considered simultaneously for designing the grating-based SPR hydrogen sensor, and a set of optimized structural parameters is presented. The performance of grating-based SPR sensor is also compared with that of conventional prism-based SPR sensor.