This study identifies a large cohort of HIV-infected adolescents cared for in a multidisciplinary program. Since the subjects were selected because of their risk of HIV-infection, differences between the HIV-positive and -negative groups were minimized. Rates of STDs, drug use, and prior sexual abuse were much higher in both groups than those reported in population-based studies of adolescents; thus, behavior profiles can play a role in identifying high-risk adolescents. In adolescents, sexual behavior and sexual identity are often not the same, and thus AIDS prevention programs designed for the homosexual community are often not recognized as relevant by adolescents engaging in same-sex encounters. Virtually all HIV-positive females in this study apparently contracted HIV through heterosexual intercourse. None of the females were able to consistently convince their partners to use a condom. The majority of the HIV-positive adolescents reported more than 10 life-time sexual partners. There was a strong association between crack/cocaine use and increased numbers of sexual partners, termed "survival-sex." Traditional safer-sex messages are unlikely to reach teens attempting to survive on the street. Comprehensive drug treatment programs must be developed as a component of HIV prevention in adolescents. Medically, 80% of seropositive adolescents were asymptomatic by history and physical, yet by CD4 counts, nearly half were eligible for antiretroviral treatment. Adequate referral sources for comprehensive medical care should be linked to HIV counseling and testing programs for youth. After being informed of their seropositivity, most adolescents assumed they were going to die within a year. With a realistic message of hope, many of the adolescents were able to make positive changes in their lives, and the HIV infection became an organizing force in their lives.