Prior Experiments Research Articles

Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress.

Melanin is a complex pigment that is found in various fungal species and is associated with a multitude of protective functions against environmental stresses. In Cryptococcus neoformans, melanin is synthesized from exogenous substrate and deposited in the cell wall. Although melanin is often cited as a protector against mechanical stress, there is a paucity of direct experimental data supporting this claim. To probe whether melanin enhances cellular strength, we used ultrasonic cavitation and French cell press pressure to stress cryptococcal cells and then measured changes in cellular morphology and fragmentation for melanized and nonmelanized C. neoformans cells. Melanized yeast cells exhibited lower rates of fragmentation and greater cell areas than did nonmelanized yeast cells after sonication or French press passage. When subjected to French press passage, both melanized and nonmelanized cells exhibited responses that were dependent on their culture age. Our results indicate that melanization protects against some of the morphological changes, such as fragmentation and cellular shrinkage, that are initiated by mechanical energy derived from either sonic cavitation or French press passage, thus supporting the notion that this pigment provides mechanical strength for fungal cell walls. IMPORTANCE Melanin was shown in prior microbiological experiments to be associated with protection against environmental stressors, and it has often been cited as being associated with mechanical stress protection. However, there is a lack of direct experimentation to confirm this claim. We examined the responses of melanized and nonmelanized C. neoformans cells to sonication and French press passage, and we report differences in outcomes depending not only on melanization status but also on culture age. Such findings have important implications for the design and interpretation of laboratory experiments involving C. neoformans. In addition, the elucidation of some of the mechanical properties of melanin promotes further research into fungal melanin applications in health care and industry.

Feature Aggregation with Two‐Layer Ensemble Framework for Multilingual Speech Emotion Recognition

In this study, we present a framework for improving the accuracy of speech emotion recognition in a multilingual environment. In our prior experiments, where machine learning (ML) models were trained to predict emotions in Korean and then tested in English, as well as vice versa, we observed a dependency on language in emotion recognition, resulting in poor accuracy. We suspect that this may be related to the spectral differences in certain emotions between Korean and English and to the tendency for different formant values to have different acoustic frequencies. For this study, we investigated several different methods, including models with mixed databases, a single database, and bagging, boosting, and voting ML algorithms. Finally, we developed a framework consisting of two branches: one for the aggregation of high‐dimensional features from multilingual data and one for a two‐layered ensemble framework for emotion classification. In the ensemble framework for Korean and English (EF‐KEN), features are extracted and ensemble models are trained, boosted, and evaluated by applying them to different spoken languages (English and Korean). The final experimental result demonstrates a meaningful improvement in an environment with two different languages.

Reactions of Thorium Oxide Clusters with Water: The Effects of Oxygen Content.

Thorium oxide has many important applications in industry. In this article, theoretical calculations have been carried out to explore the hydrolysis reactions of the ThOn (n=1-3) clusters. The reaction mechanisms of the O-deficient ThO and the O-rich ThO3 are compared with the stoichiometric ThO2 . The theoretical results show good agreement with the prior experiments. It is shown that the hydrolysis mainly occurred on the singlet potential surface. The overall reactions consist of two hydrolysis steps which are all favourable in energy. The effects of oxygen content on the hydrolysis are elucidated. Interestingly, among them, the peroxo group O2 2- in ThO3 is converted to the HOO- ligand, behaving like the terminal O2- in the hydrolysis which is transformed into the HO- groups. In addition, natural bond orbital (NBO) analyses were employed to further understand the bonding of the pertinent species and to interpret the differences in hydrolysis.

Computational investigation of vertical upflow boiling of liquid nitrogen and effects of bubble collision dispersion force

The present study investigates the performance of 2-D axisymmetric computational fluid dynamics (CFD) in predicting boiling characteristics of liquid nitrogen flowing vertically upwards along a uniformly heated circular tube. Investigation of the popular Volume of Fluid (VOF) model reveals (a) inaccurate surface tension calculation which degrades interface tracking, and (b) under-representation of bubble-to-bubble interaction, which stems from the innate nature of employing a single momentum equation in VOF. To alleviate VOF shortcomings, Coupled Level Set VOF (CLSVOF) is adopted in ANSYS FLUENT, including a user defined function to account for the crucial effects of bubble collision dispersion force. The CFD simulation results are validated against wall temperature and volume fraction results from prior benchmark experiments corresponding to four different wall heat flux conditions at nearly identical mass velocities. Predictions are also provided for axial variations of interfacial flow pattern, fluid temperature, and fluid velocity, flow characteristics that are very difficult to measure in cryogenic experiments. The CFD simulation results are shown to be highly accurate at predicting the nucleate boiling portion of the flow boiling curve.

Healing through helping: an experimental investigation of kindness, social activities, and reappraisal as well-being interventions

ABSTRACT Social connection is vital to well-being and is often impaired among individuals with anxiety or depressive disorders, yet CBT techniques may be ineffective at improving social connection (Hofmann et al., 2014). Acts of kindness may more effectively improve social connection and related dimensions of well-being than prevailing CBT techniques. In this study, we randomly assigned individuals with elevated anxiety or depression symptoms (N = 122) to engage in acts of kindness (AK), social activities (SA), or thought records, i.e., cognitive reappraisal (CR). Multilevel modeling revealed that improvement was greater in the AK group than the CR and SA groups for social connection, and improvement was greater in the AK group than the CR group for depression/anxiety symptoms and life satisfaction. Time-lagged analyses indicated that public self-absorption mediated the effects of AK. These results converge with prior experiments to demonstrate the advantages of acts of kindness over prevailing CBT techniques.

Transitions between field emission and vacuum breakdown in nanoscale gaps

The continuing reduction in device size motivates a more fundamental understanding of breakdown and electron emission for nanoscale gaps. While prior experiments have separately studied breakdown and electron emission in vacuum gaps, no study has comprehensively examined the transitions between these mechanisms. In this study, we measure the current-voltage (I−V) curves for electrodes with different emitter widths for 20–800 nm gaps at vacuum (∼1 μTorr) to measure breakdown voltage and assess electron emission behavior. The breakdown voltage Vb increases linearly with increasing gap distance from ∼15 V at 20 nm to ∼220 V at 300 nm and remains nearly constant for larger gaps; Vb does not depend strongly on the emitter width. Breakdown can proceed directly from the field emission regime. Nexus theory, which predicts transitions between space-charge limited current (SCLC) and field emission (FE), shows that the experimental conditions are in the Fowler–Nordheim regime and within a factor of 0.7 to the FE-SCLC transition. We also present the results of electrode damage by emission current-induced heating to explain the flattening of Vb at larger gaps that was absent in previous experiments for similar gap distances at atmospheric pressure.

Controls of crystal shape on degassing mechanisms in crystal-rich magmas with rhyolitic groundmass melts

Understanding the mechanical effects of crystals on degassing kinetics and permeability development in silicic magmas is important for modeling eruptions and examining first order controls on eruption style. We conducted high-pressure-high-temperature isothermal decompression experiments to investigate the role of crystal shape on permeability development and pore pathway geometry. Experiments were performed on hydrous rhyolitic glass (76.3 wt.% SiO2) seeded with variable amounts of equant (aspect ratio ∼1.8 ± 0.6) corundum crystals and elongate (aspect ratio ∼10 ± 5.5) wollastonite crystals to approximate natural phenocryst and microphenocryst/microlite populations, respectively. We measured total porosity, connected pore volume and permeability directly from the experimental charges by applying Archimedes' principle to determine bulk density, helium-pycnometry to measure connected porosity, and a custom-made permeameter to measure permeability. The experimental samples developed permeability at a critical melt porosity (ϕc-melt, above which degassing is enhanced due to bubble coalescence) of ∼55 vol.% vesicles for the corundum experiments and ∼48 vol.% for the wollastonite-bearing experiments; these values are considerably lower than the ϕc-melt>63 vol.% for prior crystal-free experiments (Lindoo et al., 2016; deGraffenried et al., 2019). Critical porosity is reduced when crystals comprise at least ∼20 vol.%, regardless of shape. Connected porosity increases and average bubble size decreases with increasing abundance of elongate wollastonite crystals, explained by the onset of yield strength behavior induced by loosely touching crystal frameworks that form at decreasing crystallinities with increasing elongation of crystals comprising the network. When the population of high-aspect-ratio crystals reaches random loose packing, the resulting reduction in interstitial melt available for unimpeded bubble expansion forces the bubbles to connect at lower total vesicularity. It therefore seems likely that crystal-bearing intermediate magmas experience an abrupt increase in degassing efficiency when crystallinity attains random loose packing. In hydrous magmas, the efficiency of decompression-driven degassing and resulting formation of anisotropic groundmass crystals is controlled by magma composition and decompression rate. Enhanced gas loss in slowly ascending (and crystallizing) magma may aid the development of dense conduit plugs, thus increasing the possibility of violent Vulcanian explosions.

A Synthesis of the Dibble et al. Controlled Experiments into the Mechanics of Lithic Production

Abstract Archaeologists have explored a wide range of topics regarding archaeological stone tools and their connection to past human lifeways through experimentation. Controlled experimentation systematically quantifies the empirical relationships among different flaking variables under a controlled and reproducible setting. This approach offers a platform to generate and test hypotheses about the technological decisions of past knappers from the perspective of basic flaking mechanics. Over the past decade, Harold Dibble and colleagues conducted a set of controlled flaking experiments to better understand flake variability using mechanical flaking apparatuses and standardized cores. Results of their studies underscore the dominant impact of exterior platform angle and platform depth on flake size and shape and have led to the synthesis of a flake formation model, namely the EPA-PD model. However, the results also illustrate the complexity of the flake formation process through the influence of other parameters such as core surface morphology and force application. Here we review the work of Dibble and colleagues on controlled flaking experiments by summarizing their findings to date. Our goal is to synthesize what was learned about flake variability from these controlled experiments to better understand the flake formation process. With this paper, we are including all of the data produced by these prior experiments and an explanation of the data in the Supplementary Information.

Chronic lipopolysaccharide impairs motivation when delivered to the ventricles, but not when delivered peripherally in male rats

Increased neuroinflammation relative to controls is observed in major depression. Moreover, depressive disorders are significantly elevated in conditions which increase neuroinflammation (e.g., brain injury, Parkinson's disease, Alzheimer's disease). To better understand the relationship between neuroinflammation and depression, additional research is needed. The current set of studies made use of the progressive ratio (PR) task in male rats, a stable measure of motivation which can be evaluated daily and thus is ideally suited for examining a potential role for chronic neuroinflammation in depressive-like behavior. Lipopolysaccharide (LPS) was used to induce an inflammatory response. Experiment 1 confirmed prior acute LPS administration experiments for sensitivity of the PR task, with a large effect at 2 mg/kg, a partial effect at 1 mg/kg, and no effect at 0.5 mg/kg. Experiment 2 evaluated a dose-response of continuous s.c. LPS infusion but found no significant elevation in brain cytokines after 14 days at any doses of 0.1, 0.5, 1, or 2 mg/kg/week. Experiment 3 assessed motivation during continuous s.c. infusion of a large 5 mg/kg/week LPS dose and found no significant impairments in motivation, but transient decreases in rates of lever pressing (i.e., only motoric deficits). Experiment 4 measured motivation during continuous ICV infusion of 10.5 μg/kg/week LPS and found significantly decreased motivation without changes to rates of lever pressing (i.e., only motivational deficits). Together these results suggest that the PR task is efficient for evaluating models of chronic inflammation, and that the adaptive response to chronic LPS exposure, even when delivered centrally, may necessitate alternative strategies for generating long-term neuroinflammation.

Performance Analysis of Electromyogram Signal Compression Sampling in a Wireless Body Area Network.

The rapid growth in demand for portable and intelligent hardware has caused tremendous pressure on signal sampling, transfer, and storage resources. As an emerging signal acquisition technology, compressed sensing (CS) has promising application prospects in low-cost wireless sensor networks. To achieve reduced energy consumption and maintain a longer acquisition duration for high sample rate electromyogram (EMG) signals, this paper comprehensively analyzes the compressed sensing method using EMG. A fair comparison is carried out on the performances of 52 ordinary wavelet sparse bases and five widely applied reconstruction algorithms at different compression levels. The experimental results show that the db2 wavelet basis can sparse EMG signals so that the compressed EMG signals are reconstructed properly, thanks to its low percentage root mean square distortion (PRD) values at most compression ratios. In addition, the basis pursuit (BP) reconstruction algorithm can provide a more efficient reconstruction process and better reconstruction performance by comparison. The experiment records and comparative analysis screen out the suitable sparse bases and reconstruction algorithms for EMG signals, acting as prior experiments for further practical applications and also a benchmark for future academic research.

Lattice Boltzmann very large eddy simulations of a turbulent flow over covered and uncovered cavities

Microphone measurements in a closed test section wind tunnel are affected by turbulent boundary layer (TBL) pressure fluctuations. These fluctuations are mitigated by placing the microphones at the bottom of cavities, usually covered with a thin, acoustically transparent material. Prior experiments showed that the cavity geometry affects the propagation of TBL pressure fluctuations toward the bottom. However, the relationship between the cavity geometry and the flowfield within the cavity is not well understood. Therefore, a very large-eddy simulation was performed using the lattice Boltzmann method. A cylindrical, a countersunk and a conical cavity are simulated with and without a fine wire-cloth cover, which is modeled as a porous medium governed by Darcy's law. Adding a countersink to an uncovered cylindrical cavity is found to mitigate the transport of turbulent structures across the bottom by shifting the recirculation pattern away from the cavity bottom. Covering the cavities nearly eliminates this source of hydrodynamic pressure fluctuations. The eddies within the boundary layer, which convect over the cover, generate a primarily acoustic pressure field inside the cavities and thus suggesting that the pressure fluctuations within covered cavities can be modeled acoustically. As the cavity diameter increases compared to the eddies' integral length scale, the amount of energy in the cut-off modes increases with respect to the cut-on modes. Since cut-off modes decay as they propagate into the cavity, more attenuation is seen. The results are in agreement with experimental evidence.

Inhibition in discriminated operant learning: Tests of response-specificity after feature-negative and extinction learning.

Six experiments with rats examined the nature of inhibition learned in an operant feature-negative (FN) discrimination. The results of prior experiments that examined instrumental extinction rather than FN learning suggest that inhibition can be very specific to the inhibited response. In Experiment 1, we trained lever-press and chain-pull responses in separate but parallel FN discriminations (AR1+, ABR1-, CR2+, and CDR2-) and then tested both inhibitors (B and D) with both responses. Of primary interest was the extent to which the inhibitors suppressed the response they were trained with (same-response inhibition) versus the other response (cross-response inhibition). We found that cross-response inhibition was robust and essentially equal to same-response inhibition. Experiment 2 replicated this result and confirmed stronger inhibition after FN learning than after a differential inhibition procedure (AR1+, BR1-, CR2+, and DR2-). There was also little evidence that cross-response inhibition was due to a demonstrable competing response. Experiment 3 found that cross-response inhibition did not depend on having the two responses reinforced by a common outcome. Experiments 4 and 5 then found that cross-response inhibition depended substantially (though not completely) on the transfer target response having been trained in its own FN discrimination. However, Experiment 6 found that inhibition after instrumental extinction (as opposed to FN learning) was still highly response-specific when the transferred-to response had been trained in an FN discrimination. The overall results suggest that the characteristics of inhibition in instrumental extinction and FN learning differ and that transfer of FN inhibition across responses depends at least partly on previous "inhibitability" of the target response. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Free Riding and Workplace Democracy—Heterogeneous Task Preferences and Sorting

A novel laboratory experiment is used to show that mismatching between task preferences and task assignment strongly undermines worker performance and leads to free riding in teams. Unlike prior experiments using real effort tasks, task preferences are elicited from all workers. Under team-based remuneration (revenue sharing), free riding is significant, but this effect is largely driven by those working on undesired tasks. Workers’ endogenous sorting into tasks improves productivity as it mitigates task mismatching although workers’ task selection per se has only small effects on work performance and effort provisions beyond the positive sorting effects. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: This work was supported by Independent Research Fund Denmark [Grant 4182-00163]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4556 .

Calculation and Measurement of Salt Loading in Metal–Organic Frameworks

The inclusion of salts within the pores of metal–organic frameworks (MOFs) has been shown to increase the ionic conductivities of the salt ions relative to that of the bulk salt, raising the possibility that salt/MOF composites could be used as solid electrolytes. The present study explores the mechanism by which the inclusion of ionic liquids (ILs) occurs in MOFs and the mass loadings that can be achieved. Simulated annealing simulations and cyclic differential scanning calorimetry (DSC) experiments are used to investigate the loading of tetraethylammonium bis(trifluoromethylsulfonyl)-imide ([NEt4][TFSI]) salt in three different UiO-6x MOFs: UiO-66, UiO-67, and a defective form of UiO-66 containing missing linkers. Good agreement is achieved between the predicted loadings and those measured experimentally. An analysis of the spatial distribution of salt ions within the MOF pores as a function of loading shows that repulsive anion–anion and cation–cation electrostatic interactions contribute to the upper limit of loading. The surface area and void fraction of the MOFs approach zero at the maximum loading, suggesting that the ions completely fill the MOF pores. The absence of free volume at the maximum loading is proposed as an explanation for the decrease in conductivity observed in prior experiments; hence, conductivity will be maximized for loadings that do not fill the MOF pores. Finally, the surface area and pore volume of the empty MOFs are shown to be good predictors of the maximum salt loading.

Tyrosyl-DNA phosphodiesterase 1 excises the 3′-DNA-ALKBH1 cross-link and its application for 3′-DNA-ALKBH1 cross-link characterization by LC-MS/MS

The apurinic/apyrimidinic (abasic, AP) site is one of the most abundant DNA lesions. Previous studies by others demonstrated that human AlkB homologue 1 (ALKBH1) catalyzes the DNA strand incision at an AP site, resulting in suicidal cross-linking of the enzyme to the 3′-DNA end. Prior site-directed mutagenesis experiments had reported that Cys129 of ALKBH1 is the predominant nucleophile that conjugates to the C3′ position of the incised AP site, 3′-phospho-α,β-unsaturated aldehyde (3′-PUA), to form a 3′-PUA-ALKBH1 cross-link. However, direct evidence to support this mechanism was lacking. The 3′-PUA-ALKBH1 cross-link is so far the only adduct that has been found to form via a Michael addition reaction between a protein and 3′-PUA. It is unclear whether and how this type of cross-link is repaired. In this study, we first demonstrated that the 3′-PUA-ALKBH1 cross-link is fairly stable under physiological temperature and pH as only ~10% of the adduct decomposed after a 3-day incubation. Using a gel-based assay with an aldehyde-reacting probe, we demonstrated that the 3′-PUA-ALKBH1 cross-link has a free aldehyde group that is in line with the Michael addition mechanism. Moreover, we found that the 3′-PUA-ALKBH1 cross-link can be excised by human tyrosyl-DNA phosphodiesterase 1 (TDP1) and the removal efficiency is significantly enhanced if the adduct is pre-digested by trypsin. Notably, we employed TDP1 as a molecular tool to homogeneously release the cross-linked peptides from DNA to facilitate liquid chromatography tandem mass spectrometry analysis, and demonstrated that Cys129 and Cys371 of ALKBH1 cross-link to 3′-PUA.

Experimental achievement and signatures of ignition at the National Ignition Facility.

An inertial fusion implosion on the National Ignition Facility, conducted on August 8, 2021 (N210808), recently produced more than a megajoule of fusion yield and passed Lawson's criterion for ignition [Phys. Rev. Lett. 129, 075001 (2022)10.1103/PhysRevLett.129.075001]. We describe the experimental improvements that enabled N210808 and present the first experimental measurements from an igniting plasma in the laboratory. Ignition metrics like the product of hot-spot energy and pressure squared, in the absence of self-heating, increased by ∼35%, leading to record values and an enhancement from previous experiments in the hot-spot energy (∼3×), pressure (∼2×), and mass (∼2×). These results are consistent with self-heating dominating other power balance terms. The burn rate increases by an order of magnitude after peak compression, and the hot-spot conditions show clear evidence for burn propagation into the dense fuel surrounding the hot spot. These novel dynamics and thermodynamic properties have never been observed on prior inertial fusion experiments.

A visco-hyperelastic constitutive model of human periodontal ligament and the verification with finite element method

The scientific basis of orthodontics is physics and Newtonian mechanics applied to the tooth-periodontal ligament-bone biologic system. The mechanical response of the periodontal ligament (PDL) to forces has a significant impact on bone remodelling and tooth movement. At the early stages, orthodontists mainly evaluated the PDL mechanical properties by in vitro experiments, which guided the use of forces in the orthodontic process. With the development of computers, finite element (FE) methods were increasingly used in the study of orthodontics. The phenomena and results of PDL mechanical tests are abstracted into constitutive equations. The identified constitutive equations are then implemented in finite element software. The finite element method could be used to simulate in vitro and in vivo experiments and predict the response of PDL under various complex working conditions. A visco-hyperelastic constitutive model is proposed and implemented in finite element technique based on prior static mechanical experiments of human PDL. Some complex experimental conditions are simulated to discuss the properties of the constitutive model.

Benchmarking iSALE and CTH Shock Physics Codes to In Situ High‐Velocity Impact Experiments Into Fe‐Ni Targets

AbstractCratering is a prominent evolutionary process on asteroids. Crater morphologies, regolith generation, bulk fracturing and projectile implantation are all examples of asteroidal surface evolution resulting from impact processes. The characterization of these processes on metal‐rich bodies has become a priority due to the upcoming NASA Psyche mission, poised to study the likely metal‐rich 225‐km main belt asteroid, (16) Psyche. Small‐scale impact experiments into metals (e.g., iron, aluminum, copper, steel) have shown that crater morphologies into these materials are different than rocky targets—exhibiting notable distinctive features such as raised, sharp rims, and deeper cavities. In this work, we determine strength constants for different metals used in prior impact experiments, namely manufactured Fe‐Ni materials and the Gibeon iron meteorite at 77 K. These parameters have been used as inputs for the Johnson and Cook (1983) strength model in a suite of numerical simulations reproducing impact experiments. Using the Johnson and Cook strength model and our laboratory‐derived material constants, we find that it is possible to closely match small‐scale experimental crater diameters and depths using iSALE and CTH shock physics codes.

Use of a human patient simulator for apnea studies: a preliminary in vitro trial.

BackgroundModern human patient simulators (HPSs) could be used for researching critical scenarios such as apnea oxygenation. We aimed to study the use of a high-fidelity HPS to assess prolonged apnea using various oxygenation strategies with a simple high-flow nasal cannula (15 L/min).MethodsAn experimental simulation study using an HPS (CAE Healthcare™) was conducted after obtaining approval from the Institutional Review Board. The HPS responded according to real-time physiologically modeled responses to external gases, such as oxygen (O2). Apnea experiments were performed with different physiological settings, such as shunt fraction (5%) and O2 consumption (250, 500, and 750 ml/min). The following four apnea experiments were conducted: no oxygenation (NO), apnea oxygenation alone (AO), preoxygenation alone (PO), and para-oxygenation (PAO). The time to 92%, 75%, and 50% saturation was recorded. Alveolar and arterial gas levels were recorded till 50% saturation.ResultsAt 250 ml/min, PO (1121 s) and PAO (1274.5 s) had a significantly longer time to 50% saturation (400% increase) compared to NO (222.5 s) and AO (239 s). A similar trend was observed for the time to 92% and 75% saturation. At higher O2 consumption rates, a shorter time to desaturation was observed.ConclusionsApnea trends in the HPS correlated with similar prior human experiments. AO without preoxygenation was found to provide no additional benefit. Preoxygenation with high-flow O2 via nasal cannula prolonged the time to desaturation in the PAO more than PO scenario. Therefore, HPSs can be used in future studies where patient safety is a concern.

Wind-induced changes to shoaling surface gravity wave shape

Unforced shoaling waves experience growth and changes to wave shape. Similarly, wind-forced waves on a flat-bottom likewise experience growth/decay and changes to wave shape. However, the combined effect of shoaling and wind-forcing on wave shape, particularly relevant in the near-shore environment, has not yet been investigated theoretically. Here, we consider small-amplitude, shallow-water solitary waves propagating up a gentle, planar bathymetry forced by a weak, Jeffreys-type wind-induced surface pressure. We derive a variable-coefficient Korteweg-de Vries-Burgers (vKdV-B) equation governing the wave profile's evolution and solve it numerically using a Runge-Kutta third-order finite difference solver. The simulations run until convective prebreaking -- a Froude number limit appropriate to the order of the vKdV-B equation. Offshore winds weakly enhance the ratio of prebreaking height to depth as well as prebreaking wave slope. Onshore winds have a strong impact on narrowing the wave peak, and wind also modulates the rear shelf formed behind the wave. Furthermore, wind strongly affects the width of the prebreaking zone, with larger effects for smaller beach slopes. After converting our pressure magnitudes to physically realistic wind speeds, we observe qualitative agreement with prior laboratory and numerical experiments on breakpoint location. Additionally, our numerical results have qualitatively similar temporal wave shape to shoaling and wind-forced laboratory observations, suggesting that the vKdV-B equation captures the essential aspects of wind-induced effects on shoaling wave shape. Finally, we isolate the wind's effect by comparing the wave profiles to the unforced case. This reveals that the numerical results are approximately a superposition of a solitary wave, a shoaling-induced shelf, and a wind-induced, bound, dispersive, and decaying tail.