Background: The healthcare landscape requires integrating traditional principles with evidence-based practices. This study addresses the vital need to assess and enhance Evidence-Based Decision-Making (EBDM) understanding among students in homeopathic medicine. Challenge: Homeopathic medicine, rooted in tradition, must align with modern healthcare standards emphasizing evidence-based approaches. Bridging this gap is crucial for optimizing patient outcomes and maintaining the relevance of homeopathic practices. Objective: This study aimed to scrutinize the comprehension and implementation of EBDM among undergraduate homeopathic medical students. Identifying discrepancies in perception and actual understanding, the goal was to outline interventions enhancing EBM competence and harmonizing traditional and evidence-based practices. Methodology: Using a cross-sectional design, data were collected through a questionnaire distributed via Google Forms. 203 undergraduate students from Vinayaka Mission’s Homoeopathic Medical College participated, providing insights into their EBDM grasp, ability to discern reliable evidence sources, understanding of research study designs, and self-reported EBM practices. Expected results: Initial analyses reveal a misalignment between perceived and actual understanding of EBDM concepts. Academic progression correlates with increased use of evidence-based resources and improved statistical literacy. Barriers include resource constraints, insufficient critical appraisal skills, and time limitations. Facilitators include user-friendly resources, institutional policies, curriculum integration, and mentor support. Anticipated outcomes stress the need for tailored educational interventions, enhancing EBM competence, and integrating EBM principles into traditional homeopathic practice.