This research explores the impact of humanitarian architecture in designing an orphanage for vulnerable children in Yaoundé, Cameroon. In a context where millions of children are affected by social, economic, and political crises, particularly in Sub- Saharan Africa, humanitarian architecture emerges as a viable response to ensure their protection and well-being. The literature review highlights the key principles of humanitarian architecture, such as user-centered design, the use of local and sustainable materials, and the creation of resilient spaces in times of crisis. Through case studies, including projects in Burkina Faso and Mali, this research examines how architectural approaches can be integrated into educational and care facilities to improve the living environment of vulnerable children. The work concludes with design proposals for an orphanage in Yaoundé, focusing on adaptation to the local climate, material sustainability, and community participation, aiming to strengthen the resilience and autonomy of children.