Prime Type Research Articles

Recent developments in cardiovascular stem cells.

Heart failure, a common consequence of ischemic heart disease, is a major cause of morbidity and mortality in the world.1–3 Pharmacological treatment with β-blockers and inhibitors of the renin–angiotensin–aldosterone system has improved the clinical outcomes in patients with heart failure.4–7 Likewise, mechanical unloading with left ventricular assist devices and resynchronization therapy have led to partial reversal of cardiac structural and molecular remodeling and symptomatic improvement.8–10 Despite these remarkable advances, however, mortality and morbidity of patients with heart failure, with or without reduced ejection fraction remains high.1,2 Moreover, heart transplantation, while an effective option, is available only for a selected number of patients and is not without considerable negative consequences.11 Furthermore, gene therapy still remains in early investigational stages and not yet ready for clinical applications.12 The high residual mortality and morbidity of patients with heart failure might be inherent to the shortcomings of the current therapeutic approaches, as none directly targets the underlying causal problem in heart failure, that is, loss of or intrinsically dysfunctional myocytes. Consequently, novel therapeutic approaches are necessary to further improve the clinical outcomes in patients with heart failure. The heart is considered, by and large, a terminally differentiated organ with a limited intrinsic regenerative capacity that alone is insufficient to compensate for the pathological loss of cardiac myocytes during the postnatal period.13–15 The discovery of cardiac progenitor cells (CPCs) in the heart more than a decade ago along with the recent data showing that the existing myocytes undergo a gradual turnover have raised the potentials for regenerative cardiac repair.16,17 Likewise, the discovery of mesenchymal stem cells (MSCs), which was thought to have the potential to differentiate to cardiac myocytes, but yet to proven, or enhance …

Late bilinguals see a scan in scannerAND in scandal: dissecting formal overlap from morphological priming in the processing of derived words

Masked priming research with late (non-native) bilinguals has reported facilitation effects following morphologically derived prime words (scanner – scan). However, unlike for native speakers, there are suggestions that purely orthographic prime-target overlap (scandal – scan) also produces priming in non-native visual word recognition. Our study directly compares orthographically related and derived prime-target pairs. While native readers showed morphological but not formal overlap priming, the two prime types yielded the same magnitudes of facilitation for non-natives. We argue that early word recognition processes in a non-native language are more influenced by surface-form properties than in one's native language.

Haptic recognition of familiar objects: examining lateralization of specificity effects.

Previous research has found evidence in favor of two subsystems underlying object recognition: an abstract-category subsystem that mainly works in the left hemisphere (LH) and a specific-exemplar subsystem that mainly works in the right hemisphere (RH). This asymmetry has been observed in both the visual and auditory domains by means of long-term repetition priming experiments. This study explored whether this asymmetrical pattern extends to the haptic domain through an experiment in which 30 right-handed participants (24 women) ages 18 to 38 years could identify familiar objects with a single hand. The procedure included two blocks of trials, the study (presentation of primes) and the test phase (presentation of targets), separated by a short distractor task. Of interest was if repetition of the same exemplar object (e.g., the same cigarette lighter) produced more priming than repetition of a different exemplar of the same object category (e.g., a different cigarette lighter), and, crucially, if this hypothetical same-exemplar advantage (specificity) was larger when objects were identified with the left hand (RH). An ANOVA was performed on RTs with priming type (same-exemplar primed, different-exemplar primed and unprimed) and hand (left, right) as within-participants factors. Results showed a main effect of priming type due to a same-exemplar advantage (shorter RTs) both for the left and the right hand, but a non-significant interaction between specificity effects and hands.

One version of direct response priming requires automatization of the relevant associations but not awareness of the prime.

Priming is the influence of one event on performance during a second event. One type of priming is known as semantic priming because it biases interpretation of the subsequent stimulus. Another type, direct response priming, biases responding directly without semantic mediation. Research reviewed in this article indicates that two versions of the second type, direct response priming, can be distinguished. One version, explicit priming, requires awareness of the prime. The other version, associative response priming, occurs even if the prime is masked and not phenomenally visible. This version, which is attributed to associations relating specific sensory events to movements of particular muscles, is enabled only if the association has previously been automatized by brief practice in which the to-be-primed response is made to the stimulus that subsequently appears as the prime. Associative response priming can be explained by a simple stimulus-response interpretation; other varieties of priming are more theoretically challenging.

MIC gene polymorphism and haplotype diversity in Zhuang nationality of Southern China

Zhuang ethnic minority is the largest minority group in China. Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Zhuang population of 209 unrelated individuals. Using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (PCR-SBT), 13 MICA-sequence alleles and 5 MICA-STR alleles, as well as 11 MICB alleles were detected, among which MICA∗010, MICA∗A5 and MICB∗005:02 were the most frequent alleles. Linkage disequilibria was investigated and the most common two-locus haplotypes were MICB∗005:02-MICA∗010 and MICB∗014-MICA∗045. These results suggest informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in Zhuang population.

The temporal dynamics of visual object priming

Priming reflects an important means of learning that is mediated by implicit memory. Importantly, priming occurs for previously viewed objects (item-specific priming) and their category relatives (category-wide priming). Two distinct neural mechanisms are known to mediate priming, including the sharpening of a neural object representation and the retrieval of stimulus–response mappings. Here, we investigated whether the relationship between these neural mechanisms could help explain why item-specific priming generates faster responses than category-wide priming. Participants studied pictures of everyday objects, and then performed a difficult picture identification task while we recorded event-related potentials (ERP). The identification task gradually revealed random line segments of previously viewed items (Studied), category exemplars of previously viewed items (Exemplar), and items that were not previously viewed (Unstudied). Studied items were identified sooner than Unstudied items, showing evidence of item-specific priming, and importantly Exemplar items were also identified sooner than Unstudied items, showing evidence of category-wide priming. Early activity showed sustained neural suppression of parietal activity for both types of priming. However, these neural suppression effects may have stemmed from distinct processes because while category-wide neural suppression was correlated with priming behavior, item-specific neural suppression was not. Late activity, examined with response-locked ERPs, showed additional processes related to item-specific priming including neural suppression in occipital areas and parietal activity that was correlated with behavior. Together, we conclude that item-specific and category-wide priming are mediated by separate, parallel neural mechanisms in the context of the current paradigm. Temporal differences in behavior are determined by the timecourses of these distinct processes.

On the effect of subliminal priming on subjective perception of images: a machine learning approach.

The research presented in this article investigates the influence of subliminal prime words on peoples' judgment about images, through electroencephalograms (EEGs). In this cross domain priming paradigm, the participants are asked to rate how much they like the stimulus images, on a 7-point Likert scale, after being subliminally exposed to masked lexical prime words, with EEG recorded simultaneously. Statistical analysis tools are used to analyze the effect of priming on behavior, and machine learning techniques to infer the primes from EEGs. The experiment reveals strong effects of subliminal priming on the participants' explicit rating of images. The subjective judgment affected by the priming makes visible change in event-related potentials (ERPs); results show larger ERP amplitude for the negative primes compared with positive and neutral primes. In addition, Support Vector Machine (SVM) based classifiers are proposed to infer the prime types from the average ERPs, which yields a classification rate of 70%.

Implicit death primes increase alcohol consumption.

The authors examined whether priming thoughts of death are associated with increases in alcohol consumption. Research assistants handed out fliers that were stacked in a random order to pedestrians walking through campus (N = 377). These fliers served to remind them of either their death or of an aversive condition unrelated to death (severe back pain), which served as the control. Then they were solicited to purchase an alcoholic or nonalcoholic beverage. The authors used a 2 × 2 log-linear analysis, with type of prime (death-pain) and beverage type (alcoholic-nonalcoholic) as the independent variables and consumption (yes-no) as the outcome measure (11.9% of the total sample consumed a beverage). RESULTS revealed that a greater percentage of students who received the death prime consumed alcohol (36.59%) versus students in the pain prime condition (8.94%), G²(4, N = 377) = 64.8, p < .001, W = .41. The type of prime (death-pain) did not influence the consumption of nonalcoholic beverages. The current research indicates that death-related concerns may play a role in increasing the consumption of alcoholic beverages.

Priming from Others' Observed or Simulated Responses

We discuss a novel form of priming that (a) involves the activation of embodied as well as mental representations in the perceiver and (b) is caused by the observation or simulation of the belief, attitude, emotion, or behavior of one or more other people. As in any form of priming, the representation, once activated, may have effects on the perceiver's own responses. We focus on effects of simulating another person's or group's responses, which give rise to a form of priming that can occur without observation of or communication from the other. Theoretical considerations predict that this type of priming will be moderated by self–other overlap between the perceiver and the other, and will have greater effects on implicit or timepressured responses than on more explicit, deliberative responses. Laboratory findings offer preliminary evidence for this form of priming, and recent thinking in cultural psychology converges by proposing that an individual's judgments and behavior are often driven not by that in...

Effects of subliminal affective priming on occupational gender stereotypes

We investigated the effects of subliminal affective priming on implicit and explicit occupational gender stereotypes and their correspondence. First, we manipulated 3 types of affective priming (positive, neutral, and negative) and utilized the Implicit Association Test to find that positively affective priming decreased, and negatively affective priming increased, implicit occupational gender stereotyping at the subliminal level. We then measured participants' explicit occupational gender stereotypes and found that, at the subliminal level, positive affective priming deterred, and negative affective priming enhanced, explicit occupational gender stereotypes. Also, in the condition of subliminal affective priming, implicit and explicit occupational gender stereotypes were not significantly related and affect did not moderate the correspondence between them. In sum, our results showed that affect moderated both implicit and explicit occupational gender stereotypes in the condition of subliminal affective priming, but did not moderate the correspondence between them.

A behavioral database for masked form priming

Reading involves a process of matching an orthographic input with stored representations in lexical memory. The masked priming paradigm has become a standard tool for investigating this process. Use of existing results from this paradigm can be limited by the precision of the data and the need for cross-experiment comparisons that lack normal experimental controls. Here, we present a single, large, high-precision, multicondition experiment to address these problems. Over 1,000 participants from 14 sites responded to 840 trials involving 28 different types of orthographically related primes (e.g., castfe-CASTLE) in a lexical decision task, as well as completing measures of spelling and vocabulary. The data were indeed highly sensitive to differences between conditions: After correction for multiple comparisons, prime type condition differences of 2.90 ms and above reached significance at the 5% level. This article presents the method of data collection and preliminary findings from these data, which included replications of the most widely agreed-upon differences between prime types, further evidence for systematic individual differences in susceptibility to priming, and new evidence regarding lexical properties associated with a target word's susceptibility to priming. These analyses will form a basis for the use of these data in quantitative model fitting and evaluation and for future exploration of these data that will inform and motivate new experiments.

Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.

BackgroundTissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown.ResultsHere we showed that a single intramuscular acid injection induced a priming effect on muscle nociceptors of mice. The primed muscle nociceptors were plastic and permitted the development of long-lasting chronic hyperalgesia induced by a second acid insult. The plastic changes of muscle nociceptors were modality-specific and required the activation of acid-sensing ion channel 3 (ASIC3) or transient receptor potential cation channel V1 (TRPV1). Activation of ASIC3 was associated with increased activity of tetrodotoxin (TTX)-sensitive voltage-gated sodium channels but not protein kinase Cϵ (PKCϵ) in isolectin B4 (IB4)-negative muscle nociceptors. In contrast, increased activity of TTX-resistant voltage-gated sodium channels with ASIC3 or TRPV1 activation in NaV1.8-positive muscle nociceptors was required for the development of chronic hyperalgesia. Accordingly, compared to wild type mice, NaV1.8-null mice showed briefer acid-induced hyperalgesia (5 days vs. >27 days).ConclusionASIC3 activation may manifest a new type of nociceptor priming in IB4-negative muscle nociceptors. The activation of ASIC3 and TRPV1 as well as enhanced NaV1.8 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

Investigating Thought Disorder in Schizophrenia: Evidence for Pathological Activation

BackgroundPrevious research has yielded evidence for enhanced semantic priming in formal thought-disordered schizophrenia patients, a result that fits well with the hypothesis of disinhibited processes of spreading activation in this population. ObjectiveThe current study examined whether hyper priming among schizophrenia patients is an outcome of further spreading of activation of a node or a result of farther activation of nodes in the semantic network. We also try to shed light on the fate of this activation. MethodsThe present study tested this hypothesis by using semantic and identical priming in two different experiments. SOA (stimulus onset asynchrony) was manipulated (240 ms vs. 740 ms) within block. It is assumed that among healthy individuals, performance relies on a balance between activation and inhibition processes, contrary to in schizophrenic individuals. In order to examine this hypothesis, we compared formal thought-disordered schizophrenia patients, non thought-disordered schizophrenia patients, and healthy controls. ResultsFor thought-disordered schizophrenia patients, we found a large positive semantic effect and identical priming effect (129 ms and 154 ms, respectively) only with short SOA. SOA and type of priming did not modulate priming effects in the control groups. ConclusionsThis result supports the claim that there is a lack of inhibitory processes among thought-disordered patients. Hyper priming in the thought-disorder group may be an outcome of hyper activation followed by rapid decay below baseline threshold.

Priming effects under continuous flash suppression: An examination on subliminal bottom‐up processing

AbstractBinocular rivalry is a bistable perception that occurs when two dissimilar stimuli are presented to each eye. Recent studies have demonstrated that the reaction time to target words under binocular rivalry was shortened when semantically related prime words were presented supraliminally (Costello, Jiang, Baartman, McGlennen, &amp; He, 2009). We investigated whether three types of priming (repetition, semantic, and cross‐script) occurred from the prime words presented under binocular rivalry, by using continuous flash suppression paradigm (Tsuchiya, Koch, Gilroy, &amp; Blake, 2006). The prime words presented to the suppressed eye invoked repetition and cross‐script priming, but not semantic priming. The results suggested that the stimuli presented to the suppressed eye underwent shape and phonological level processing, but not semantic level processing.

Is the Masked Priming Same-Different Task a Pure Measure of Prelexical Processing?

To study prelexical processes involved in visual word recognition a task is needed that only operates at the level of abstract letter identities. The masked priming same-different task has been purported to do this, as the same pattern of priming is shown for words and nonwords. However, studies using this task have consistently found a processing advantage for words over nonwords, indicating a lexicality effect. We investigated the locus of this word advantage. Experiment 1 used conventional visually-presented reference stimuli to test previous accounts of the lexicality effect. Results rule out the use of different strategies, or strength of representations, for words and nonwords. No interaction was shown between prime type and word type, but a consistent word advantage was found. Experiment 2 used novel auditorally-presented reference stimuli to restrict nonword matching to the sublexical level. This abolished scrambled priming for nonwords, but not words. Overall this suggests the processing advantage for words over nonwords results from activation of whole-word, lexical representations. Furthermore, the number of shared open-bigrams between primes and targets could account for scrambled priming effects. These results have important implications for models of orthographic processing and studies that have used this task to investigate prelexical processes.

Design and operation of ARGONTUBE: a 5 m long drift liquid argon TPC

The Liquid Argon Time Projection Chamber (LArTPC) is a prime type of detector for future large-mass neutrino observatories and proton decay searches. In this paper we present the design and operation, as well as experimental results from ARGONTUBE, a LArTPC being operated at the AEC-LHEP, University of Bern. The main goal of this detector is to prove the feasibility of charge drift over very long distances in liquid argon. Many other aspects of the LArTPC technology are also investigated, such as a voltage multiplier to generate high voltage in liquid argon (Greinacher circuit), a cryogenic purification system and the application of multi-photon ionization of liquid argon by a UV laser. For the first time, tracks induced by cosmic muons and UVlaser beam pulses have been observed and studied at drift distances of up to 5 m, the longest reached to date.

Contrast and Congruence Effects in Affective Priming of Words and Melodies

We examined possible congruence and contrast effects during affective priming of linguistic and musical stimuli. In Experiment 1, when two words were presented auditorily, participants judged the affective content of the second item (happy or sad) faster when the affects matched (congruency), as expected. In Experiment 2, however, a contrast effect was observed with melodies, with slower responses in the matched conditions. In Experiment 3, two words, two melodies, or one of each were presented. A congruency effect was observed when the target was a musical stimulus (regardless of the prime type) but a contrast effect was observed when the target was a linguistic stimulus (again, regardless of the prime type). The results show that affective properties can influence the priming in both music and language. However, such priming is sensitive to the type of task, and strategic/expectancy effects play a large role when stimulus types are mixed.

조선시대 우의(雨衣) 연구

This study tried to get a deeper understanding of the characteristics of raincoats in Joseon by searching through historic records: the Annals of Joseon(朝鮮王朝實錄), personal or official records, paintings, etc. The time range of the research covers the entire period of Joseon. There were two prime types of raincoats: Saui, a cyperus coat, and Yusam(油衫), an oilcloth coat. The study proceeded as follows: 1) Identifying the people who wore the coats as well as the time period, 2) Figuring out the shapes and materials of those raincoats, 3) Postulating the reasons for the upward trend in popularity of a certain type as well as the eventual downward trend. Those research efforts revealed the following: 1) In the early Joseon, from royals to commoners, people wore Saui. But as time passed valuation about Saui might have become degraded. Eventually it became regarded as a farmer`s smock in the 19th Century. 2) Yusam might not have been worn in the early Joseon. It was developed and spread after the middle of 17th Century. It was for soldiers and nobles, especially travelers, but by the end of the Joseon period, it was also used by commoners. 3) Saui was made of cyperus, but Yusam was made of oiled paper, cotton or silk. Those shapes were similar to a Western cloak. The analysis of the research findings led to following conclusions: 1) Around the middle of Joseon, people started to wear Yusam after the introduction of a Chinese version of it. 2) Yusam might have become popular in Joseon because of the social and cultural implications. At that time, people had pride in their culture and thought that real experiences and travels were important. 3) As people became fond of Yusam more, then Saui`s popularity fell.

A study of the effect of auditory prime type on emotional facial expression recognition

&#x0D; &#x0D; &#x0D; Background: In this study, we investigated the influence of two types of emotional auditory primes - vocalizations and pseudoutterances - on the ability to judge a subsequently presented emotional facial expression in an event-related potential (ERP) study using the facial-affect decision task. We hypothesized that accuracy would be greater for congruent trials than for incongruent trials. This is due to the possibility that a congruent prime would allow the listener to implicitly identify the particular emotion of the face more effectively. We also hypothesized that the normal priming effect would be observed in the N400 for both prime types, i.e. a greater negativity for incongruent trials than for congruent trials.&#x0D; Methods: Emotional primes (vocalization or pseudoutterance) were presented to participants who were then asked to make a judgment regarding whether or not a facial expression conveyed an emotion. Behavioural data on participant accuracy and experimental electroencephalogram (EEG) data were collected and subsequently analyzed for six participants.&#x0D; Results: Behavioural results showed that participants were more accurate in judging faces when primed with vocalizations than pseudoutterances. ERP results revealed that a normal priming effect was observed for vocalizations in the 150 msec - 250 msec temporal window – where greater negativities were produced during incongruent trials than during congruent trials – whereas the reverse effect was observed for pseudoutterances. Few participants were tested (n = 7). Hence, this study is a pilot study preceding a further study conducted with a greater sample size (n = 25) and slight modifications in the methodology (such as the duration of auditory primes.)&#x0D; Conclusions: Vocalizations showed the expected priming effect of greater negativities for incongruent trials than for congruent trials, while pseudoutterances unexpectedly showed the opposite effect. These results suggest that vocalizations may provide more prosodic information in a shorter time and thereby generate the expected congruency effect.&#x0D; &#x0D; &#x0D;

Priming lexical em crianças fluentes e com gagueira do desenvolvimento

To examine the possible relationship between lexical variables (categorization and naming) and developmental stuttering. Thirty Brazilian Portuguese speaking children with ages ranging from 7 to 9 years and 11 months participated in the study. We applied a lexical priming paradigm to experimentally investigate whether children with developmental stuttering (Research Group) differed from their fluent peers (Control Group), with respect to reaction time in three conditions - control (without prime); semantically related prime, and semantically independent prime - of two experimental tasks: categorization and naming of the target stimulus. No difference between groups was observed in reaction time on the categorization task. However, there was a condition effect showing that, for both groups, reaction time was shorter in the semantically related prime condition when compared to the no prime condition. In the naming task, a between-group difference was observed in reaction time, indicating a longer reaction time in the Research Group than the Control Group. There was no condition effect on naming, i.e. the Research Group showed slower reaction time regardless of prime type. The results confirm the hypothesis that, in children with developmental stuttering, readiness in motor programming of speech is slowed when compared to fluent children. There is no difference between groups when the lexical function does not require speech readiness.