Prime Time Research Articles

Therapy with mesenchymal stem cell transplantation in multiple sclerosis ready for prime time: Commentary

Therapy with mesenchymal stem cell transplantation in multiple sclerosis ready for prime time: Commentary

Therapy with mesenchymal stem cell transplantation in multiple sclerosis is ready for prime time: No

Therapy with mesenchymal stem cell transplantation in multiple sclerosis is ready for prime time: No

AJS-1 Tumor-agnostic drug development: Ready for Prime Time

Cancer care and clinical research continue to rapidly move in the direction of personalized care with precision medicines. The molecular alterations found within many cancers is often more critical to therapy selection than the site of origin. The ability to molecularly profile tumors has established that each patient’s cancer is unique, biology is destiny, and tumor heterogeneity is a reality. The utilization of liquid biopsies has facilitated the process of assessing for mutations, and this modality is moving quickly into strategies around monitoring for residual disease and detecting cancers very early.

Diet as a treatment for inflammatory bowel disease: is it ready for prime time?

Diet remains an important topic for patients with inflammatory bowel disease (IBD), yet few guidelines for dietary recommendations exist. There is a growing interest in the use of diet as treatment or adjuvant therapy for both ulcerative colitis and Crohn's disease. Here, we highlight the latest evidence on the use of diet for treatment of symptoms, active disease and maintenance of remission in ulcerative colitis and Crohn's disease. The Crohn's Disease Exclusion Diet (CDED) and the Specific Carbohydrate Diet (SCD) are studied diets that have gained popularity, but there is growing interest in the use and efficacy of less restrictive diets such as the Mediterranean diet. Recent data suggest healthful dietary patterns alone, with an emphasis on whole foods that are high in vegetable fibre and that promote less consumption of ultra-processed foods may also help achieve remission in patients with ulcerative colitis and Crohn's disease. In this review, we summarize the literature on diet as treatment for IBD. We highlight the latest clinical dietary studies, randomized clinical trials, as well as new and emerging diets for the treatment of IBD.

Determination of Optimum PGPB-Priming Protocol on Germination and Seedling Growth in Lentil

Plant growth promoting bacterias (PGPBs) can be described as bacterial strains increasing water and nutrient uptake, gaining nitrogen and phosphorus to plants by biological nitrogen fixation and phosphate mineralization, promoting plant growth and enabling to improve the tolerance to stress factors due to mechanisms as secretion of various phytohormones, vitamins and growth regulators, restriction of ethylene synthesis with ACC deaminase activity, decreasing of pathogen damage by the secret of antibiotic and fungicidal compounds. This study was carried out in a laboratory of Field crops in Siirt University under controlled conditions. The 2 original bacterial strains (KF3B and KF63C) and 5 different priming times (control, 1, 2, 4 and 6 h) were applied on the Fırat-87 lentil variety. The study was laid out in a completely randomized design with 3 replications. It was aimed with this study that investigating effects based on bacterial biodiversity and priming time on germination characteristics and seedling growth in lentils. According to results, biodiversity-induced differences were observed in germination percentage, seedling fresh weight, seedling dry weight, seedling length and seedling vigor index while priming time significantly affected all investigated parameters except for germination percentage. However, the interaction of strains and priming times did not lead to any significant differences in traits. In conclusion, microbial diversity and priming time have a critical role on successful of the priming technique. Optimum priming time for lentils was determined as 4 hours. Besides, the strain of KF63C had a noteworthy stimulative effect on especially seedling growth in the experiment.

Reflections, Impact and Future Recommendations Following ‘Prime Time of Life’ – an Online 12-week Multimodal Physical Activity and Health Education Programme for Middle Aged and Older Adults in Laois

Article: Reflections, Impact and Future Recommendations Following ‘Prime Time of Life’ – an Online 12-week Multimodal Physical Activity and Health Education Programme for Middle Aged and Older Adults in Laois

Digital Health-Enabled Clinical Trials in Stroke: Ready for Prime Time?

As stroke continues to represent a major global health care problem, advancing our knowledge of new effective and safe stroke interventions represents a public health priority. The identification of these therapies requires the conduct of high-quality and well-powered randomized clinical trials. Despite its potential to inform clinical practice, traditional randomized clinical trial models have their drawbacks, including elevated costs, long completion times, failure to recruit the target sample sizes, lack of diversity, and complex operational procedures. Therefore, improving the participants' experience and trials' overall efficiency constitutes an important unmet need. Innovative models such as virtual and decentralized patient-centric trials have been proposed as a valuable strategy in this pursuit. In this narrative review, we discuss the limitations of traditional randomized clinical trial models and present the concept, advantages, and challenges of decentralized digitally enabled approaches to the conduct of stroke clinical trials.

Electronic Monitoring of Patient-Reported Outcomes—Ready for Prime Time?

Electronic Monitoring of Patient-Reported Outcomes—Ready for Prime Time?

Not Ready for Prime Time: Financial Reporting Quality After SPAC Mergers

We examine the financial reporting quality of special purpose acquisition corporations (SPACs) following a successful merger. We compare a sample of SPACs with completed mergers from 2006 to 2020 to initial public offering (IPO) firms in the same industry covering the same period. Compared with similar IPO firms, SPACs are more likely to restate their financial statements and have internal control weaknesses. We also find that SPACs are more likely to file untimely financial statements, amend previously issued filings, and have comment letters that go more rounds with the Securities and Exchange Commission. This lower reporting quality also results in less informative earnings to investors. Our evidence corroborates concerns from the media, accounting firms, and regulators that SPACs exhibit low financial reporting quality in comparison with IPOs. This paper was accepted by Suraj Srinivasan, accounting.

A Comparison of Water Imbibition and Controlled Deterioration in Five Orthodox Species

Orthodox seeds deteriorate even when stored in the best of conditions; hence, it is very important to monitor germination in stored seeds. To assess orthodox seed deterioration, a germination test is usually employed. This study assessed and compared seed deterioration in five orthodox species using electrolyte leakage and Fourier transform infrared spectroscopy (FTIR). The study also compared water imbibition by the test orthodox seeds. To achieve this, the seeds from three wild (Bolusanthus speciosus; Combretum erythrophyllum; Erythrina caffra) and two agricultural (Pisum sativum and Cucurbita pepo) species were imbibed between 20 layers of single-ply paper towel. The other set was subjected to controlled deterioration at 40 °C and 100% relative humidity for 32 d, with samples taken for germination and electrolyte leakage measurement at 4 d intervals. FTIR measurements were performed at 0, 20, and 32 d of controlled deterioration. The results indicated that there were some significant interspecies differences in the imbibition times and seed water contents but these were not large. In all species, uptake of water was complete between about 15 and 25 h. The wild species showed higher sensitivity to controlled deterioration. Complete loss of germinability occurred much earlier in the wild species (20 d in B. speciosus and E. caffra, and 16 d in Co. erythrophyllum) compared with 36 d for the agricultural species P. sativum and Cu. pepo. There was a negative correlation between electrolyte leakage and seed germination in all wild and agricultural species. A strong positive correlation was observed between the time of controlled deterioration, electrolyte leakage, and FTIR transmission in all the species. While controlled deterioration may help in decisions relating to the storage of orthodox seeds, the water imbibition results from this study will help to set the priming time of the species. The study reaffirms electrolyte leakage as an indicator of seed viability in P. sativum and Cu. pepo; it also recommends the use of electrolyte leakage as an indicator of seed deterioration in B. speciosus, Co. erythrophyllum, and E. caffra. The study also recommends FTIR as a tool for monitoring the germination of stored seeds of all the test species.

Analysis of Social Reality of Spousal Relationship Depicted in Pakistan Television Prime time Dramas

The main focus of this study is placed on depiction of spousal relationship in prime time dramas of Pakistani television channel. In order to collect a quantitative baseline information on the topic, the study utilized message system analysis of the social reality of spousal relationship portrayed in prime time dramas of Pakistani television channel. For probability sampling, a 6-day week was constructed from July 2020-June 2021. The results of analysis revealed that Pakistani prime time dramas show both healthy and unhealthy aspects of spousal relationship. However, unhealthy aspects are shown more frequently than the positive aspects. The present study also concluded that sacrifice, lies, fraud, materialism, criticism and selfishness were more frequently depicted with respect to wives while support, dominance, aggression, infidelity, relationship commitment and romantic gestures were associated with husbands.

Endoscopic submucosal dissection in the duodenum: Ready for prime time?

Endoscopic submucosal dissection in the duodenum: Ready for prime time?

Wrenching Torque

Wrenching Torque

코로나19 전후 스마트폰에 의한 여가식민화 현상의 심화

The purpose of this study is to compare the proportion of the time spent on smartphones in South Korean’s leisure life from the perspective on colonization of leisure and explore its implications before and after COVID-19. In other words, analyzing data of ‘The National Leisure Activity Survey’ and ‘The Korean Media Panel Survey’ from 2019 to 2020, this study intended to examine whether the proportion and influence of smartphones in South Korean’s leisure time have increased since the outbreak of COVID-19. The key findings are as follows. Firstly, compared to the period before COVID-19, leisure time increased on both weekdays and holidays, and the time to use smart devices including smartphones during leisure time also increased. Second, it was found that the percentage of time spent using smart devices during leisure time has increased by nearly 20% since COVID-19, accounting for more than half of leisure time. In particular, teenagers accounted for 80% and those in their 20s and 30s accounted for more than 70%. Third, the number of smartphone users increased in most time windows measured in every 15 minutes for 24 hours a day except for sleep time. Fourth, when smartphones were used simultaneously with other media, the number of users increased the most from 7 p.m. to 10 p.m. called ‘Prime Time’, which is assumed to be due to the increase in the number of people watching TV and using smartphones at the same time. Lastly, Though TV still accounted for a large part of our leisure time, it is found that smartphone is the medium that controls the rhythm of our daily lives. Taken as a whole, the deepening of colonization of leisure by smartphones after COVID-19 has been verified. In this vein, we suggested that future studies should be conducted critically in consideration of the economic and technical systems related to smartphones, such as platforms and algorithms that induce excessive use of smartphones.

LEGAL AND BUSINESS STUDY STOP PRESS EARLY WARNING TSUNAMI AT PRIME TIME ON INEWS

<span class="fontstyle0">Early warning tsunami iis the right of every citizen to know, guaranteed by the 1945 Constitution, and the Regulation of the Minister of Communication and Information No. 20/2006. The Minister of Communication and Informatics clearly states that broadcast media are obliged to broadcast Stop pressing contains early warning tsunami after the earthquake disaster. The impression took at least 30 seconds, with a high tone. This is the dilemma of broadcast media managers. Namely showing Stop press as a statutory obligation when the zone prime time television. During this time duration prime time the price is very expensive. However, Inews still prioritizes the interests of the community, by broadcasting Stop pressing,<br />should reduce the duration. This is part of the responsibility and protection of legal rights for the community. In addition, Inews does not want to receive criminal sanctions, just for not broadcasting Stop pressing early warning tsunamis.</span> <br /><br />

DUNAV MOST – THE BRIDGE OF THE TIME OF TRANSITION (DISCUSSIONS ABOUT A BULGARIAN TV SHOW)

The article is focused on one of the most popular Bulgarian TV shows – Dunav Most and the debates about it. The main method is content analysis of newspaper articles and their language in an attempt at explaining the characteristics of the mass media strategies and public speech in the time of transition. Since its broadcasting in November 1999 the TV show has provoked lengthy discussions in some of the most popular newspapers. Journalists have criticized the movie project and the author of the first published article even insisted “Stop the series immediately”. The motivation was that 67 percent of the audience did not like the discussed product of the Bulgarian National Television. The team that created the film was criticized about its many weaknesses – the movie makers tried to tell many stories in a short time and none of the them is finished, there are many erotic scenes (even homosexual ones), which provoke the public moral code, the language is the language of the streets. The whole story is “seamed” from newspaper titles, talking about murders, robberies, rapes and violence – the critics wrote. The conclusions were that it could not be broadcasted in the prime time. The accusations in the newspapers were very serious and the critics blamed the film crew about the usage of vulgar scenes and figures of speech in order to attract the public. The analysis shows that they speculated with the public expectations, using language full of stereotypes and sexist vocabulary – the figurative language that the audience recognizes and fully understands.

Multi-Modality Imaging for Prevention of Coronary Artery Disease and Myocardial Infarction in the General Population: Ready for Prime Time?

Cardiovascular disease (CVD) remains a leading cause of death and disability worldwide. Acute myocardial infarction (AMI) causes irreversible myocardial damage, heart failure, life-threatening arrythmias and sudden cardiac death (SCD), and is a main driver of CVD mortality and morbidity. To control the forecasted increase in CVD burden for both the individual and society, improved strategies for the prevention of AMI and SCD are required. Current prevention of AMI and SCD is directed towards risk-modifying interventions, guided by risk assessment using clinical risk prediction scores (CRPSs) and the coronary artery calcium score (CACS). Early detection of more advanced coronary artery disease (CAD), beyond risk assessment by CRPSs or CACS, is a promising strategy to allow personalized treatment for the improved prevention of AMI and SCD in the general population. We review evidence for further testing, beyond CRPSs and CACS, and therapies focusing on promising targets, including subclinical obstructive CAD, high-risk plaques, and silent myocardial ischemia. We also evaluate the potential of multi-modality imaging to enhance the conduction of adequately powered trials to provide high-quality evidence on the impact of add-on tests and therapies in the prevention of AMI and SCD in asymptomatic individuals. To conclude, we discuss the occurrence of AMI and SCD in individuals currently estimated to be at “low-risk” by the current strategy based on CRPSs, and methods to improve prevention of AMI and SCD in this “low-risk” population.

Is It Prime Time for Statin Therapy in Psoriasis?

It has been over a decade and a half since the first large-scale study of the accelerated risk of myocardial infarction in psoriasis (Gelfand et al., 2006). Since then, a broad range of scientific approaches has determined that psoriasis itself is associated with a higher-risk subclinical vascular disease (Naik et al., 2015), high-risk coronary plaque (Lerman et al., 2017), and major adverse cardiovascular (CV) events (Mehta et al., 2010) and mortality (Noe et al., 2018). Although these studies have established that the risk of CV disease (CVD) is independent of traditional CV risk factors, psoriasis also has complex interactions with metabolic disease.

Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time?

We review the clinical benefits of altering myocardial substrate metabolism in heart failure. Modulation of cardiac substrates (fatty acid, glucose, or ketone metabolism) offers a wide range of therapeutic possibilities which may be applicable to heart failure. Augmenting ketone oxidation seems to offer great promise as a new therapeutic modality in heart failure. The heart has long been recognized as metabolic omnivore, meaning it can utilize a variety of energy substrates to maintain adequate ATP production. The adult heart uses fatty acid as a major fuel source, but it can also derive energy from other substrates including glucose and ketone, and to some extent pyruvate, lactate, and amino acids. However, cardiomyocytes of the failing heart endure remarkable metabolic remodeling including a shift in substrate utilization and reduced ATP production, which account for cardiac remodeling and dysfunction. Research to understand the implication of myocardial metabolic perturbation in heart failure has grown in recent years, and this has raised interest in targeting myocardial substrate metabolism for heart failure therapy. Due to the interdependency between different pathways, the main therapeutic metabolic approaches include inhibiting fatty acid uptake/fatty acid oxidation, reducing circulating fatty acid levels, increasing glucose oxidation, and augmenting ketone oxidation.

Autologous Immune Cell-Based Regenerative Therapies to Treat Vasculogenic Erectile Dysfunction: Is the Immuno-Centric Revolution Ready for the Prime Time?

About 35% of patients affected by erectile dysfunction (ED) do not respond to oral phosphodiesterase-5 inhibitors (PDE5i) and more severe vasculogenic refractory ED affects diabetic patients. Innovative approaches, such as regenerative therapies, including stem cell therapy (SCT) and platelet-rich plasma (PRP), are currently under investigation. Recent data point out that the regenerative capacity of stem cells is strongly influenced by local immune responses, with macrophages playing a pivotal role in the injury response and as a coordinator of tissue regeneration, suggesting that control of the immune response could be an appealing approach in regenerative medicine. A new generation of autologous cell therapy based on immune cells instead of stem cells, which could change regenerative medicine for good, is discussed. Increasing safety and efficacy data are coming from clinical trials using peripheral blood mononuclear cells to treat no-option critical limb ischemia and diabetic foot. In this review, ongoing phase 1/phase 2 stem cell clinical trials are discussed. In addition, we examine the mechanism of action and rationale, as well as propose a new generation of regenerative therapies, evolving from typical stem cell or growth factor to immune cell-based medicine, based on autologous peripheral blood mononuclear cells (PBMNC) concentrates for the treatment of ED.