Primary Skeletal Muscle Lymphoma Research Articles

A case of primary skeletal muscle lymphoma mimicking cellulitis

Primary skeletal muscle lymphoma is a rare entity. Their presentation can be easily confused with a wide variety of inflammatory conditions, neoplasia as well as infectious diseases. We came across a 65-year-old lady who presented to us with complains of pain and swelling in the right thigh, leg and foot and fever-on and off for 20 days. She was initially managed elsewhere on the line of cellulitis with incision and drainage of right leg 15 days back but there had been no clinical improvement. We took her detailed history and examined her thoroughly. Relevant blood investigations were sent. However, the clinical examination findings and history were suggestive of an infective cause, blood investigations were suggestive of an acute inflammatory pathology, whereas radiological investigations (NCCT and X-ray) and cytological investigations (FNAC) which were performed at the previous place of treatment were inconclusive. We then did a CE-MRI of the right lower limb which showed centrally necrotic, enhancing mass lesion involving peroneal muscles with multiple enlarged inguinal and popliteal lymph nodes. Based on this finding, biopsy was performed and specimen was sent for histopathological examination which revealed “malignant small round cell tumor”. Immunohistochemistry was then done and tumor cells were found to be positive for vimentin, LCA, CD20 and negative for PANCK and CD3. Based on the above findings it was diagnosed as “non-hodgkin’s lymphoma (NHL) B-cell type” of right leg. Considering the confusing clinical presentation of this entity and inconclusiveness of blood and basic radiological investigations, lesions of extremities presenting with features of cellulitis must be carefully assessed.

A case of primary soft-tissue lymphoma of the lower extremity complicated with bacterial infection in a patient with acquired immunodeficiency syndrome

A patient with primary skeletal muscle lymphoma underwent plain and contrast-enhanced computed tomography (CT) and a pathologic diagnosis was made. The affected muscles were diffusely swollen, with recognizable outlines and clear borders. Contrast-enhanced CT showed mild-to-moderate enhancement, and the spaces surrounding the muscle and subcutaneous fat were narrowed and blurred. Primary skeletal muscle lymphoma is relatively rare and not very specific in its imaging manifestations. The final diagnosis depends on a biopsy of the lesion and immunohistochemistry.

A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA

Primary extranodal non-Hodgkin's lymphoma (eNHL) usually presents at an early stage, as an extranodal organ involvement along with draining lymph nodes only or the predominant site is extranodal. As an eNHL, primary skeletal muscle lymphoma is very rare. The usual clinical picture is local swelling and pain with or without systemic symptoms. MRI features are distinctive and FDG-PET/CT may help to evaluate the stage and monitor the response to the treatment. A 56-year-old male, presented with a one-month history of swelling and pain on his left ankle. There was no history of trauma or any physical strain. A mass lesion was palpated on the calcaneus bone. MRI showed diffuse muscle involvement. The clinical picture was not consistent with infection or hematoma. The blood cell count and biochemical investigations were within normal limits. Serology for hepatitis B, C and HIV were negative. Biopsy was decided. Histological examination revealed CD19, CD20, bcl-2 and bcl-6 positive B-cell lymphoma with a Ki67 proliferation index of 95%. Myc, bcl-2, and bcl-6 gene rearrangements were not detected. Diffuse large B cell lymphoma was diagnosed. FDG-PET/CT showed lesions in multiple regions only limited to skeletal muscles but no other organ involvement. He had no adverse risk factors but bulky lesion (11cm sized lesion). After 6 courses of R-CHOP protocol, he had complete anatomic and metabolic response. Healthy skeletal muscles do not have lymphatic system. Lymphomatous involvement of muscles occurs by 3 pathways as dissemination via the haematogenous or lymphatic pathway, extension from adjacent organs, such as the bones or lymph nodes, and de novo primary extranodal disease. Most of the histology primary skeletal lymphomas have the aggressive B-cell immunophenoty. In general, treatment is similar to nodal lymphomas. In conclusion, we aimed to contribute in experience with this rare eNHL type.

Primary Skeletal Muscle Lymphoma Disguised as Non-Resolving Cellulitis and Deep Venous Thrombosis: A Case Report and Literature Review

Primary Skeletal Muscle Lymphoma Disguised as Non-Resolving Cellulitis and Deep Venous Thrombosis: A Case Report and Literature Review

Primary Non-Hodgkin’s lymphoma originating from the masseter muscle

Recently, as we experienced a case of extranodal NHL originating from the masseter musclecompletely cured by chemotherapy with radiotherapy, we present the clinical, US, CT, andMR imaging findings in additional one case of biopsy-proved extranodal NHL (NK/T celllymphoma) involving predominantly the masseter muscle also review thoroughly our collectedcases of primary non-Hodgkin’s lymphoma involving the muscles of mastication and facialexpression. On the basis of our comprehensive review, we suggest two conclusions. First, primarymuscle lymphoma particularly originating from muscles of mastication and facial expression isextremely rare, but primary muscle lymphoma should be considered in the differential diagnosisof muscular masses. Second, primary muscle lymphoma particularly originating from muscles ofmastication and facial expression has similar clinical and radiological characteristics to primaryskeletal muscle lymphoma involving other sites. However, the prognosis is more favorablein primary muscle lymphoma originating from muscles of mastication and facial expressioncompared to primary skeletal muscle lymphoma involving other sites.
 Bangladesh Journal of Medical Science Vol.20(1) 2021 p.181-186

Primary skeletal muscle lymphoma: A case report.

Primary lymphomas of the bone or skeletal muscle are rare. Three mechanisms of lymphomatous involvement of the muscle have been described, namely direct invasion from adjacent involved lymph nodes or bone, metastatic spread and, least commonly, primary muscle lymphoma. We herein present a rare case of primary mucle non-Hodgkin lymphoma with a description if the associated clinicopathological findings and a review of the relevant literature. A 41-year-old female patient was referred to our hospital with a painful mass in the right lower extremity. Following resection and histopathological examination, a diffuse large B-cell lymphoma originating from the muscle with cutaneous and subcutanenous infiltration was diagnosed. The patient received chemotherapy with six cycles of cyclophosphamide, hydroxydaunomycin, oncovin and prednisone (CHOP regimen) and a complete radiological response was achieved after six cycles of treatment.

Long Term Survival of Primary Skeletal Muscle Lymphoma in a Miniature Dachshund

An 8-year-old miniature dachshund presented with a right femoral muscle mass and anorexia. Cytology of the mass revealed a number of small-sized lymphoid cells containing a pleomorphic-shaped dense nucleus and narrow pale cytoplasm. Histopathology indicated that neoplastic lymphoid cells proliferated in skeletal muscles and replaced the muscular architecture. Immunohistochemical and genetic examinations confirmed the diagnosis of primary skeletal muscle lymphoma classified as the pleomorphic small cell type and T-cell low-grade. Although the dog suffered at least three relapses by combination chemotherapy, the dog survived 713 days after the initial presentation.

Lymphoma‐Associated Polymyositis in Dogs

Lymphoma‐Associated Polymyositis in Dogs

Two cases of primary skeletal muscle lymphoma, and a review of the literature

Two cases of primary skeletal muscle lymphoma, and a review of the literature

Primary Anaplastic Large Cell Lymphoma of Skeletal Muscle Presenting with Compartment Syndrome

We describe a patient with primary anaplastic large cell lymphoma of the forearm presenting with compartment syndrome. Urgent decompression fasciotomy and combination chemotherapy resulted in durable remission status. This is followed by a review of primary skeletal muscle lymphoma in the English literature.

Primary non-Hodgkin's lymphoma presenting in the upper extremity: A case report

Adenopathy is the main presentation of lymphoma. Despite frequent nodal involvement, extranodal origins are not uncommon. Freeman et al. 1 reviewed 8767 non-Hodgkin's lymphomas and noted that 24% were considered to have extranodal origins. 2 Primary skeletal muscle lymphoma, however, is rare. 3–5 We recently treated a case of primary skeletal muscle non-Hodgkin's lymphoma of the upper extremity.