Primary Squamous Cell Carcinoma Of Ovary Research Articles

Primary ovarian squamous cell carcinoma arising from an epidermoid cyst of Ovary- A rare case report with review of literature

Primary ovarian squamous cell carcinoma is a rare entity that usually arises from the malignant transformation of a mature cystic teratoma, endometriosis or Brenner’s tumor. The denovo occurrence of primary squamous cell carcinoma of the ovary without prior lesion is a rare entity accounting for less than 1%. However, ovarian squamous cell carcinoma arising from an epidermoid cyst is an infrequent entity and only one case has been reported in literature. The prognosis of such cases is quite poor and there are no definite guidelines for treatment. Here we present a case of a 50-year-old female diagnosed with primary ovarian squamous cell carcinoma arising from an epidermoid cyst of the ovary who was treated with surgery followed by chemotherapy along with the review of literature.

Pure primary ovarian squamous cell carcinoma with homologous recombination deficiency: a case report

Pure primary ovarian squamous cell carcinoma with homologous recombination deficiency: a case report

Ovarian squamous cell carcinoma associated with teratoma: a report of six cases with genomic analysis

Ovarian squamous cell carcinoma (SCC), particularly the sarcomatoid variant, arising from teratoma is a rare malignant tumour with unfavourable clinical outcomes. Its molecular genetic alterations have not been well-documented to date. This study aims to characterise the molecular features and to provide potential therapeutic targets in this rare entity. We analysed the clinicopathological and immunohistochemical features of six primary ovarian SCC. These cases were subject to targeted next-generation sequencing to detect genomic features. We found that all six ovarian SCC (four conventional and two sarcomatoid SCC) were associated with mature cystic teratomas. Patient 3 (FIGO stage IIIa) and Patient 4 (stage IIb) died of disease at 10 and 11 months, respectively. The remaining patients (three with stage I and one with IIc) including the two with sarcomatoid SCC, were alive with no evidence of disease at 28-72 months. All patients showed PD-L1 expression (tumour proportion score: range 10-78%, median 41%; combined positive score: range 12-85, median 42) and a high tumour mutation burden (range 13.4-25.7 mutations/Mb, median 16.5). The most frequently recurrent mutations included PIK3CA (4/6), TP53 (4/6), TERT promoter (4/6), CDKN2A (3/6). Mutations in homologous recombination repair pathway genes (BLM, ATM, BRCA1, BRIP1 and ATM) were found in 5/6 patients. The sarcomatoid SCC shared a similar mutational profile with conventional SCC, and no recurrent genetic mutations exclusively in sarcomatoid SCC were identified. Our study suggests the potential benefits of immune checkpoint inhibitors and/or PARP inhibitors in patients with primary ovarian SCC on account of PD-L1 expression and genomic features. Ovarian sarcomatoid SCC may be clonally related to the conventional SCC. A multiple-institutional, clinical and molecular study will consolidate these findings in the future.

Primary ovarian squamous cell carcinoma: clinicopathological features and prognostic analysis of fifteen cases

Objective: To assess the clinical features and treatment outcomes in patients with primary ovarian squamous cell carcinoma (POSCC). Methods: Fifteen patients with primary ovarian squamous cell carcinoma diagnosed from January 2009 to December 2018 in Cancer Hospital of the University of Chinese Academy of Sciences were collected. The expression of p16, hMLH1, hMSH2, hMSH6 and PMS2 in POSCC was detected by immunohistochemistry, and the status of high-risk human papillomavirus (HPV) by RNAscope test. Results: Squamous cell carcinoma with different degrees of differentiation was found in 15 cases, including three cases with high differentiation and 12 cases with medium to low differentiation. There were four cases with in situ squamous cell carcinoma, four cases with teratoma, one case with endometrial carcinoma/atypical hyperplasia, and one case with endometriosis. p16 was expressed in five cases (5/15), indicating coexisting high-risk HPV infection. There was no high-risk HPV infection in the remaining 10 cases, and p16 staining was negative. There was no deficient mismatch repair protein in all cases. The overall survival time (P=0.038) and progression free survival (P=0.045) of patients with high-risk HPV infection were longer than those without HPV infection. Conclusions: POSCC is more commonly noted in postmenopausal women and often occurs unilaterally. Elevated serological indexes CA125 and SCC are the most common finding. Morphologically, the tumors show variable degrees of differentiation, but the current data suggest that the degree of differentiation cannot be used as an independent prognostic index. High-risk HPV infection may be associated with the occurrence of POSCC, and that the prognosis of POSCC patients with HPV infection is better than that of patients without infection.

A Case Report of Primary Ovarian Squamous Cell Carcinoma: Pathways (And Pitfalls) To A Difficult Diagnosis

A Case Report of Primary Ovarian Squamous Cell Carcinoma: Pathways (And Pitfalls) To A Difficult Diagnosis

Pure Primary Ovarian Squamous Cell Carcinoma Perforating the Rectum

Rectal perforation is uncommon in ovarian cancer, even in advanced stages. Pure primary ovarian squamous cell carcinoma is a very rare subtype of ovarian cancer and has not been reported to cause rectal perforation. A 50-year-old woman presented with rectal bleeding. Rectosigmoidoscopy suggested perforation of a pelvic tumor into the rectum. Abdominopelvic magnetic resonance imaging revealed a 9 cm heterogeneous mass in the pouch of Douglas. We performed complete cytoreduction, including an en-bloc resection of the tumor and rectosigmoid colon. Histopathology showed squamous cell carcinoma of the left ovary penetrating the rectal wall. A common symptom of rectal bleeding was caused by a very rare entity of ovarian cancer penetrating the rectal wall, but thorough evaluation led to its accurate diagnosis and appropriate treatment.

Primary ovarian squamous cell carcinoma occurring in mature cystic teratoma

Mature cystic teratoma (MCT) is a common benign tumor of the ovary in females. Malignant transformation in a MCT of the ovary is a rare condition and accounts for only 1%–2% cases. The most common malignancy is squamous cell carcinoma (SCC), which comprises about 75% of malignant transformations. We report a case of a 52-year-old postmenopausal female who presented with complaint of pain and mass per abdomen for 4 months. She underwent bilateral salpingo-oophorectomy, and histopathological examination revealed primary ovarian SCC arising in a MCT. Later, she underwent chemotherapy, total hysterectomy, and omentectomy with iliac lymph node dissection.

Pure primary ovarian squamous cell carcinoma: A case report and review of the literature.

Pure primary ovarian squamous cell carcinoma (SCC) is a rare lesion that usually arises from the malignant transformation of an existing ovarian dermoid cyst. The de novo occurrence of an ovarian SCC in the absence of a prior ovarian dermoid cyst, Brenner tumor or endometriosis is extremely rare. At present, no effective therapy exists for treating pure primary ovarian SCC. The present case study describes a patient that presented with progressive coughing, who was diagnosed with an International Federation of Gynecology and Obstetrics stage IV pure primary ovarian SCC with lung metastases. The patient received postoperative chemotherapy, however, the patient succumbed to the disease. The current study also presents a review of the literature.

卵巣原発扁平上皮癌の 1 例

背景 : 卵巣原発の扁平上皮癌はまれで, その発生母地は奇形腫, ブレンナー腫瘍や子宮内膜症などが報告されているが, それらを伴わない純粋型も存在する. われわれは本疾患の 1 例を経験したので報告する.症例 : 51 歳, 女性, 2 経産. 腹部膨満と頻尿を主訴に紹介受診となり, 画像診断にて径約 18 cm の嚢胞部分と充実部分の混在する卵巣腫瘍を認めた. 充実性部分は術中迅速病理にて扁平上皮癌と診断され, 卵巣癌標準手術を施行した. 術後 paclitaxel+carboplatin 療法を施行し, 18 ヵ月間再発を認めていない. 捺印細胞診所見は紡錘形, 長楕円形でライトグリーンあるいはエオジン好性の細胞質を有し, クロマチン増量と軽度の核異型を示す異型扁平上皮細胞がシート状に出現していた. 病理組織学的には著明な角化を示す胞巣を形成する高分化型扁平上皮癌Ia 期 (pT1aN0M0) と診断された. 嚢胞壁の扁平上皮化生が著明であり, 病理組織学的には本腫瘍の組織発生として, 移行像は確認できないものの子宮内膜症が関与している可能性が示唆された. なお, CIN の合併はなく, 腫瘍組織に HPV-DNA は検出されなかった.結論 : 卵巣原発扁平上皮癌は進行癌が多く, 予後不良とされているが, 今回早期癌の症例を経験し, その捺印細胞診を報告した.

Pure primary ovarian squamous cell carcinoma

A 65-year-old woman with pure primary ovarian squamous cell carcinoma invading the fallopian tube and the terminal illeum is described. The tumor recurred shortly after surgery in spite of complete ressection. No response to chemotherapy was observed and the patient expired 6 months after diagnosis. In order to establish the diagnosis of pure primary ovarian squamous cell carcinoma extragenital and genital tumors containing squamous elements as well as endometriosis have to be excluded.