Primary Ovarian Lymphoma Research Articles

24-year-old female with amenorhea: bilateral primary ovarian Burkitt lymphoma

Background Burkitt's lymphoma (BL) occurs mostly in children. Isolated bilateral ovarian involvement presenting with amenorrhea is extremely rare in young adults. Case A 24-year-old female presented with secondary amenorrhea. Bilateral adnexal masses were identified on physical examination and abdominal computed tomography (CT). She underwent total abdominal histerectomy and bilateral salpingoophorectomy. Histopathologic evaluation yielded a diagnosis of BL of ovaries. Combined chemotherapy was administered. After complete remission an autologous bone marrow transplantation (ABMT) was performed. She died 35 days after ABMT. Conclusion Although rare, BL should be kept in mind when isolated ovarian tumors are detected in young patients.

A case of malignant lymphoma of the ovary manifesting like an advanced ovarian cancer

Background In recent years, true primary ovarian lymphoma has been considered to carry a favorable prognosis, although most studies of supposedly primary ovarian lymphoma have reported a poor outcome. Case A 47-year-old woman presented with signs and symptoms suggestive of an advanced ovarian cancer. Ultrasonography and magnetic resonance imaging revealed bilateral abdominal tumors, each measuring 10 cm in diameter, thickened omentum, and a large amount of ascitic fluid, but no enlarged lymph nodes. The diagnosis of malignant lymphoma was established from the biopsy specimen after exploratory laparotomy. Six years following chemotherapy, the patient is alive and disease free without additional surgery. Conclusion The prognosis of ovarian lymphoma was evaluated according to clinical stage, modality of onset, histologic type, and phenotype. It remains controversial whether this case can be considered truly primary ovarian lymphoma and not merely a localized initial manifestation of a generalized disease. But if this case of advanced ovarian lymphoma were not primary, it could still be managed successfully with chemotherapy appropriate for the specific histology.

Primary Ovarian Lymphoma: Report of Cases and Review of Literature

Primary female reproductive system lymphomas are distinctly uncommon. We report two cases with primary ovarian non Hodgkin's lymphoma (NHL) having unilateral involvement in one case while the other had bilateral ovarian involvement. Both cases initially presented with ovarian enlargement. The median size of the tumour was 5.8 × 5 cm 2. Histologically, by using the WHO classification, one lesion was classified as diffuse small B cell phenotype of intermediate grade and the other as diffuse high grade, B cell phenotype. On the basis of staging studies and clinical follow up, we conclude that both of the neoplasms in the report arose in the ovary. Both of the patients are disease free at 24 months and 6 months of follow up respectively, following excision and chemotherapy. We conclude that that the complete remission and failure free survival of patients with ovarian NHL treated with appropriate treatment appear to be similar to that of patients with extranodal NHL.

Follicle center lymphoma involving the female genital tract: a morphologic and molecular genetic study of three cases.

Primary female reproductive system lymphomas are distinctly uncommon, and are defined as lymphomas that present primarily as gynecologic tumors. We describe 3 cases which presented in this location, 1 primary ovarian disease and 2 others presenting the initial manifestations of disseminated lymphoma. Clinical history, follow-up information, and paraffin embedded archival tissue were available for all 3 cases. A panel of immunoperoxidase studies and molecular genetic studies were performed for each case. The primary ovarian follicle center lymphoma was a grade III/III (large cell) while the cases representing secondary involvement were grade I/III (small cell). Immunohistochemistry demonstrated reactivity of the malignant cells in each case with CD20 and bcl-2. In the grade I/III cases the cells were immunoreactive for CD45RA and CD10. Molecular genetic analysis demonstrated the t(14;18) translocation in the case of primary ovarian follicle center lymphoma. Follicle center lymphoma uncommonly presents in the female genital system, and may rarely be primary to this site. Immunoperoxidase and molecular studies in concert with the morphology are invaluable in rendering a correct diagnosis and ensuring correct treatment of the patient.

Non-Hodgkin lymphomas of the ovaries: MR findings.

The goal of this work was to describe MR findings (morphology, structure, signal intensity) of ovarian non-Hodgkin lymphoma (NHL). We reviewed the MR images of five female patients aged 13-70 years (mean 46 years) with histologically proven NHL of the ovaries. We evaluated morphological and signal intensity findings of the lesions. MR features were correlated with pathologic parameters. All the patients were affected by B-cell NHL; one patient showed a primary involvement of the ovaries; in one patient, ovarian disease was diagnosed 30 months after surgical resection of a primary uterine lymphoma; the remaining three had a systemic lymphoma. In three cases, the ovarian involvement was bilateral. The mean size of the lesions was 7.9 cm. All the lesions showed homogeneous low signal intensity on T1-weighted images and intermediate to high intensity on T2-weighted images. The postgadolinium images showed mild to moderate heterogeneous enhancement. The peripheral enhancement was better demonstrated in fat-suppressed images. The diagnosis of primary ovarian lymphoma should be considered in the presence of large bilateral solid ovarian masses with homogeneous appearance (low signal on T1 and mildly high on T2) without infiltrative pattern of growth or regressive changes (necrosis, hemorrhage, calcifications) and with little contrast enhancement.

MR Findings of a Primary Ovarian Lymphoma

The imaging findings of primary ovarian lymphoma have not been reported, and, we therefore describe the MRI(magnetic resonance imaging) findings of a case of this disease, which manifested as bilateral lobulated solid masses with heterogenous sig-nal intensity and central feeding vessels.

Malignant Lymphoma of the Ovary: Report of a Case Successfully Managed with Surgery and Chemotherapy

Incidental finding of a primary malignant lymphoma of the ovary in a 20-year-old patient is presented. Two and a half years following ablative surgery and adjuvant chemotherapy, the patient is alive and disease free. Ovarian lymphoma is a disease of reportedly poor prognosis. However, many previously reported cases of ovarian lymphoma actually represented ovarian involvement by a more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis.

Primary ovarian non-Hodgkin's lymphoma: Outcome after treatment with combination chemotherapy: Dimopoulos M.A.; Daliani D.; Pugh W.; Gershenson D.; Cabanillas F.; Sarris A.H. USA Gynecol Oncol 1997 64/3 (446–450)

Primary ovarian non-Hodgkin's lymphoma: Outcome after treatment with combination chemotherapy: Dimopoulos M.A.; Daliani D.; Pugh W.; Gershenson D.; Cabanillas F.; Sarris A.H. USA Gynecol Oncol 1997 64/3 (446–450)

Primary Ovarian Non-Hodgkin's Lymphoma: Outcome after Treatment with Combination Chemotherapy

Because the outcome of patients with primary ovarian non-Hodgkin's lymphoma (NHL) is controversial, we retrospectively analyzed experience with adults seen at the University of Texas M.D. Anderson Cancer Center from 1974 to 1993. Patients were included if at least one ovary was pathologically involved, and if combination chemotherapy was used that must have included doxorubicin for intermediate grade histologies. We identified 15 patients who constituted 0.5% of all untreated NHL and 1.5% of untreated ovarian neoplasms that presented to our instutition during this time. One patient refused therapy, leaving 14 assessable for response. Nine patients had intermediate-grade, 5 had high-grade, and none had low-grade NHL. One ovary was involved in 4 patients, and both in 10, in 7 of whom additional sites were involved, including supradiaphragmatic nodes in 2. Four patients had AAS I and 10 had AAS IV. Favorable (0 or 1) and unfavorable (>1) IPI scores were seen in 5 and 9 patients, respectively. The complete remission rate for all patients was 64%, and 5-year survival and FFS for all assessable patients were 57 and 46%, respectively. We conclude that the complete remission rate and FFS of patients with ovarian NHL treated with appropriate chemotherapy appear to be similar to that of patients with other nodal NHLs. Further work is required to determine prognostic factors in ovarian NHL.

The Coexistence of a Primary Ovarian Lymphoma and a Serous Tumor of Low Malignant Potential in the Same Ovary

ABSTRACT The existence of primary ovarian lymphoma is controversial, and its incidence is rare. Serous tumors of low malignant potential (LMP) of the ovary are relatively common and account for nearly 15% of all serous tumors of the ovary. Primary ovarian lymphomas, however, are rare, with less than 1% of lymphomas occurring as an ovarian mass. We report the occurrence of a primary ovarian small noncleaved cell lymphoma adjacent to a serous tumor of LMP in the same ovary of a 32-year-old woman. We discuss the diagnostic criteria for primary lymphoma of the ovary and serous tumor of LMP of the ovary. (J GYNECOL SURG 10:189, 1994)

Lymphoma of ovary with stromal luteinization, presenting as secondary amenorrhea

A case of primary lymphoma of the ovary with extensive stromal luteinization is presented. Immunohistochemical markers that work satisfactorily in fixed tissues allowed a diagnosis of B cell lymphoma to be made on formalin-fixed tissue sections. Immunohistochemical analysis of frozen tissue and genotypic analysis confirmed the diagnosis of B cell lymphoma. By electron microscopy two populations of cells, including large atypical lymphoid cells and luteinized stromal cells, were identified. Presentation with amenorrhea and resumption of menstrual periods after removal of the tumor suggested the possibility of functional activity in the luteinized stromal cells. Stromal luteinization has not been previously described in primary ovarian lymphoma.

Primary Ovarian Lymphoma and Colloid Cyst of Anterior Third Ventricle Complicating Pregnancy

Primary Ovarian Lymphoma and Colloid Cyst of Anterior Third Ventricle Complicating Pregnancy

Primary Ovarian Lymphoma in Pregnancy: A Case Report

Primary Ovarian Lymphoma in Pregnancy: A Case Report

Cell Junctions in Lymphomas: Study of a Primary Ovarian T-Cell Lymphoma and Review of Fifty-Six Other Cases of Lymphoma

A case of primary ovarian lymphoma was studied by light microscopy, immunohistochemistry, and electron microscopy. The ultrastructural study revealed the presence of cell junctions of the paired subplasmalemmal densities and tight junctions between adjacent lymphoid cells. Fifty-six cases of non-Hodgkin's lymphoma randomly selected from the files of the Electron Microscopy Facility of the Faculty of Health Sciences, McMaster University, were reviewed. Paired subplasmalemmal densities and tight junctions were identified in five of the cases (9%). This study suggests that the absence of cell junctions should not be considered an essential criterion for the ultrastructural diagnosis of lymphomas.

Bilateral ovarian involvement as the only manifestation of malignant lymphoma

A 16-year-old girl presented with a large pelvic mass. At laparotomy, bilateral ovarian tumors were disclosed and bilateral salpingo-oophorectomy was performed. No evidence of extra-ovarian disease was found. Histopathological examination and histochemical immunoperoxidase studies demonstrated the tumors to be malignant lymphoma of the lymphoblastic type. The patient had radiotherapy and systemic chemotherapy and more than 10 years later she is alive with no evidence of recurrent disease. The rarity of ovarian involvement as the initial manifestation of malignant lymphoma is discussed. The question of whether this patient represents a case of a primary ovarian malignant lymphoma or merely represents a case of ovarian initial manifestation of an occult generalized disease cannot be answered.

Primary Ovarian Non-Hodgkin Lymphoma

Primary Ovarian Non-Hodgkin Lymphoma