Primary Ovarian Carcinoid Tumor Research Articles

Proliferative activity in primary ovarian carcinoid tumors

Proliferative activity in primary ovarian carcinoid tumors

Proliferative activity in primary ovarian carcinoid tumors

The proliferative potential of six primary ovarian carcinoids with different clinical outcome and histogenetic origin was examined immunohistochemically. The results showed that two cases with extremelyhigh level of proliferative activity were associated with metastatic spread. In the remaining tumors ,the examined factor was found to be at low level comparable with excellent prognosis of typical carcinoidsin other locations. The preliminary results showed a possibility of a prognosis prediction according to typing of the ovarian carcinoids into two categories ,i.e. ,tumors of low and intermediate malignancy.Topoisomerase II-α and Ki-67 are suitable markers giving valuable information about this phenomenon.

Tumor carcinoide de ovario

Primary ovarian carcinoid tumour is a rare entity, less than 0.1% of all ovarian cancer. These should be treated like ovarian tumours of low malignity. We present a case associated with benign cystic teratoma, in an asymptomatic 64 year old patient. El tumor carcinoide primario de ovario es una rara entidad, con menos del 0,1% de todos los cánceres de ovario. Deben ser tratados como tumores ováricos de baja malignidad. Presentamos un caso asociado a te-ratoma quístico benigno, en una paciente asintomáti-ca de 64 años de edad.

Primary ovarian mixed type carcinoid tumour

Primary ovarian mixed type carcinoid tumour

Primary Ovarian Carcinoid Tumors

Primary ovarian carcinoid tumors were reviewed from Mayo Clinic and Colorado Tumor Registry data. A total of 17 patients with this diagnosis were identified. Histologic analysis of these carcinoid tumors revealed 9 (53%) were insular, 5 (29%) were trabecular, and 4 (26%) were strumal carcinoid with or without a mature dermoid component. There were 11 patients with stage I and 6 patients with stage III or IV disease at diagnosis. Carcinoid syndrome was found in 29% of patients. Pressure or pain with defecation was noted in 41% of cases. Recurrence of tumor occurred in 1 of 11 patients with suspected stage I disease 13 years after initial diagnosis. Overall survival was excellent in the 11 patients whose disease was confined to one ovary (100% 5-year survival), but only 1 of 6 patients survived (33% 5-year survival) if advanced stage at diagnosis. Systemic chemotherapy for advanced disease achieved a complete response in 1 patient and stable disease in another. Although rare, primary ovarian carcinoid tumors treated with surgery alone and found to be confined to the ovary can be expected to have an excellent overall outcome.

Primary Mucinous Carcinoid Tumor of the Ovary

A case of primary ovarian mucinous carcinoid tumor in a 36-year-old woman is described. The tumor was present in the wall of a mature teratoma and microscopically showed tubules and glands containing goblet cells interspersed among columnar to cuboidal cells with uniform round nuclei and granular cytoplasm. The cytoplasm of the tumor cells contained argyrophil granules on Grimelius stains. Immunohistochemical stains utilizing antibodies against carcinoembryonic antigen, chromogranin, and pancreatic polypeptide were positive. Although primary mucinous carcinoid tumors are generally believed to exhibit more aggressive behavior than other categories of carcinoid tumors, the patient was treated conservatively with a right salpingo-oophorectomy and remains well 3 years later, suggesting that unilateral salpingo-oophorectomy and careful follow-up are adequate therapy in a young woman when the tumor is confined to the ovary.

Primary ovarian carcinoid tumor in combination with carcinoid heart disease; a case report

Primary ovarian carcinoid tumors (POCT) with secondary carcinoid heart disease are rare, only 13 cases have been reported in the literature to date. In most instances POCT can be completely removed surgically contrary to primary carcinoid tumor of the gastro-intestinal tract. Laparoscopy may be helpful in localizing the tumor. We present a case in which the carcinoid heart lesions progressed despite total eradication of the carcinoid.

Primary bronchial and ovarian carcinoid tumors in the same patient: A case report and histopathologic analysis

The first case report of a 58-year-old woman with two different primary carcinoid tumors is presented. The bronchial carcinoid exhibited a mosaic pattern, whereas the ovarian tumor showed both insular and trabecular patterns. No teratomatous component was observed in the ovary. Both tumors presented an argyrophil reaction and neuron-specific enolase (NSE) immunoreactivity. The ovarian carcinoid contained a cell population of argentaffin and serotonin immunoreactive cells, while the bronchial carcinoid was unreactive. Peptide hormone immunostaining disclosed the presence of glucagon and pancreatic polypeptide (PP) in the bronchial carcinoid, whereas the ovarian carcinoid showed no immunoreactivity with the antisera used. The patient was treated surgically (bilobectomy of the right lung, 1978, and total abdominal hysterectomy and bilateral salpingo-oophorectomy, 1984) and is now well with normal blood chemistry, normal urinary HIAA, and normal routine X rays of the lungs and the gastrointestinal tract, as well as normal ultrasonography of the abdomen and the liver.

A strumal carcinoid primary in the ovary

A primary ovarian carcinoid tumour of insular strumal type in a 78-yr-old patient is reported. Strumal carcinoid of the ovary is a rare tumor of germ cell origin characterized by an intimate mixture of thyroid tissue and carcinoid. Correct diagnosis depends on a pathologic examination with the use of special stains. Because of its benign character, the treatment is primarily a surgical one and consists of a simple oophorectomy or salpingo-oophorectomy.