Epilepsy is one of the oldest recorded medical ailments. Ethnomedicinal survey was carried out to identify and take a detailed list of the medicinal plant species used to treat epilepsy and assess how they are used in Etche Local Government Area (LGA) of Rivers State, Nigeria. Semi-structured questionnaires were used during the survey to conduct interviews with traditional healers and other knowledgeable individuals on the use of medicinal plants in the treatment of epilepsy. Twelve communities were randomly selected while a total of 54 respondents were purposively selected. The respondents consist of 82.5% males and 12.3% females, 43.9% were above 60 years while 28.1% were between 51-60 years. Traditional medicine practitioners (TMP) formed 75.4% of the respondents, primary occupation of other knowledgeable respondents on plants used for epilepsy were civil servants (8.8%), farming and trading (3.5%). A total of 25 medicinal plant species were recorded during the survey. Phytochemical screening was carried out on five medicinal plants based on frequency of mention, the screening showed presence of alkaloids, triterpenoids, steroids, saponins, tannins, flavonoids, anthraquinones, cardenolides and carbohydrates. Plant resources employed in the local treatment of epilepsy in Etche were documented. Further research on isolation of active compounds on frequently used plants for epilepsy is encouraged to harness their potentials.