Primary Mediastinal Liposarcoma Research Articles

Case Report: Resection of Giant Mediastinal Liposarcoma Using the Partial Sternotomy Incision

Primary mediastinal liposarcomas are rare. There are four types of liposarcoma: well differentiated/atypical lipomatous tumor, dedifferentiated, myxoid, pleomorphic. In this study we report a rare case of a mediastinal well-differentiated liposarcoma that was successfully surgically removed. Because of the noninvasive growth pattern of most liposarcomas, patients often present with few symptoms, which was the case in our patient presenting only with dry cough. Normally these tumors are diagnosed by radiologic imaging. Common symptoms include cough, dyspnea, wheezing, chest pain, and weight loss. There are different histologic variants of liposarcoma, the most frequent one is well-differentiated liposarcoma. In our case we couldn’t confirm the histology with fine needle aspiration but with the frozen section we confirmed the diagnosis of well-differentiated liposarcoma. An optimal approach is very important to remove mediastinal liposarcoma because of the diversity of size and location of lesions.

Recurrent primary mediastinal liposarcoma: A case report.

Primary mediastinal liposarcomas are extremely rare. The current study reports the case of a 63-year-old man presenting with a primary liposarcoma arising from the posterior mediastinum. The patient reported a 6-month history of chest pain with increasing dyspnea for 2 months. Enhanced computed tomography revealed a 10×16-cm mass in the posterior mediastinum. Other physical examinations were normal. Radical resection was performed under the agreement of patient. Subsequent pathological analysis indicated a liposarcoma. The patient recovered and was successfully discharged. However, at a follow-up examination 12 months after surgery, recurrence was identified in the anterior mediastinum. Therefore, the patient underwent surgery. The postoperative course was uneventful, however, there was evidence of disease recurrence 2 years after the second surgery. The patient refused any treatment and succumbed after 3 months.

Mediastinal Myxoid Liposarcoma with Intrapericardial Involvement and Large Pericardial Effusion

Liposarcoma is the name given to a group of soft tissue sarcomas (STSs) with adipocytic differentiation. As a group, liposarcomas are the second most common STSs in adults. In 1951 Kozonis et al published that in the English language only four cases of liposarcomas originating in the mediastinum had been described. Primary mediastinal liposarcoma is an uncommon neoplasm of intrathoracic origin. We present the case of a 47-year-old woman diagnosed with a large mediastinal mass with intrapericardial invasion and massive pericardial effusion; biopsies showed a mediastinal liposarcoma.

Primary Mediastinal Liposarcoma of the Superior, Middle, and Anterior Mediastinum

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Primary Mediastinal and Thoracic Liposarcomas: Clinical Analysis of 25 Cases

Primary Mediastinal and Thoracic Liposarcomas: Clinical Analysis of 25 Cases

Primary mediastinal pleomorphic liposarcoma involving the superior vena cava.

Primary mediastinal liposarcomas are extremely rare. They are primarily diseases of adults; however, they may be encountered in children. They are characterized by their large size and variable histologic subtypes, which correlate with clinical behavior and prognosis. Although the overall prognosis is poor, it is dependent upon the histologic subtype and completeness of surgical excision. Herein we present a case of a primary mediastinal pleomorphic liposarcoma in a 49-year-old male who received an en-bloc resection and superior vena cava replacement with Gortex graft. The patient has been disease-free after surgery for over 14 months.

Progressive dyspnea in patient with large mediastinal mass

Liposarcoma occurs very rarely in the mediastinum. Patients often remain asymptomatic until it grows large enough to cause direct invasion or compression of adjacent organs. We report a case of a 77-year-old male presented with dyspnea of exertion and was found to have a large mediastinal mass which was eventually diagnosed as primary mediastinal well-differentiated liposarcoma. The limited respiratory function at the initial presentation prompted phrenic nerve preserving incomplete resection rather than radical removal of the adjacent mediastinal structures. After surgical removal, the recurrence for well-differentiated mediastinal liposarcomas in the mediastinum is unknown; therefore, close follow-up is crucial.

Surgical Resection of a Massive Primary Mediastinal Liposarcoma Using Clamshell Incision Combined with Lower Median Sternotomy: Report of a Case

We experienced a case of massive mediastinal liposarcoma expanding to the bilateral pleural cavities. Preoperative positron emission tomography-computed tomography scan showed that the uptake of (18)F-fluorodeoxyglucose (FDG) into the tumor was slight for its size. Clamshell incision together with lower median sternotomy provided the excellent visualization and the complete resection of the tumor. The surgical resection should be performed even for a massive liposarcoma, especially if the uptake of F-FDG into the tumor is low, as complete surgical resection is the only definitive treatment for liposarcoma.

Clinical analysis of 19 cases of adult primary mediastinal liposarcoma.

To explore the pathoclinical features of adult primary mediastinal liposarcoma and their correlation with the prognosis. The clinical data of 19 patients with adult primary mediastinal liposarcoma who were treated in our hospital between 1970 and 2011 were retrospectively analyzed. Eighteen patients underwent open thoracic tumor excisions for at least one time, and the remaining one patient only received biopsy surgery. Histopathological results after surgery revealed that 6 well-differentiated type tumors, 6 myxoid type tumors, 3 pleomorphic type tumors, 2 mixed type tumors, and 2 un-classified tumors. Among 6 patients with well-differentiated type tumors, 1 died after having been survived for 10 years; 5 were still alive, with a mean duration of 126.2 months,the 5-year survival rate was 100%. Among 6 patients with myxoid type tumors, 5 patients had follow-up data, with a mean survival of 26.2 months. Among 3 patients with pleomorphic type tumors, only one patient had follow-up data: the patient finally died, with a survival of 34 months. Of 2 patients with mixed type tumors, only one patient had follow-up data: the patient survived 8 months and died. Of 2 patients with un-classified type tumors, one had follow-up data: the patient lived for 24 months and died. Mediastinal liposarcoma is a rare disease. Surgery is the primary therapeutic modality. Different pathological subtypes have different epidemiological features, biological behaviors, and malignant potentials. Pathological subtype is an important prognosis factor. Patients with well-differentiated tumors have much better prognosis than those with other subtypes.

Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case

Primary mediastinal liposarcomas are rare malignancies, comprising fewer than 1% of all mediastinal tumors. We herein report a radical resection of a massive liposarcoma arising from the anterior mediastinum. A 63-year-old male patient presented with a 4-week history of dyspnea that had worsened over the previous several days. The patient had also experienced hoarseness for 2 weeks. Chest X-ray and computed tomography revealed a huge tumor occupying the entire left thoracic cavity. Anesthesia was induced when the patient was in the left semilateral position. The patient was moved into the right lateral position after initially stabilizing anesthesia with separate lung ventilation. The fourth rib was initially resected for thoracotomy, but there was no clearance between the tumor and the adjacent mediastinal structures, and two more ribs were therefore removed. The tumor had not invaded the other structures such as the chest wall, lung, or mediastinum. To reduce the tumor blood flow, the left internal mammary artery was ligated before the tumor was resected en bloc. The tumor was diagnosed as a liposarcoma arising from the thymus. The patient remains alive with no evidence of disease recurrence at 22 months after the operation.

Huge Primary Pericardial Liposarcoma

Liposarcomas are the second most common soft tissue sarcoma in adults. They occur predominantly in the lower limbs and retroperitoneum, whereas primary mediastinal liposarcomas are extremely rare. Liposarcomas are often asymptomatic and may reach a considerable size before causing any symptoms related to direct invasion or compression of other thoracic organs. We report a case of a 69-year-old woman with a giant primary pericardial liposarcoma causing cardiac tamponade and discuss its clinical and imaging features and surgical treatment and review the literature.

A Case of Mediastinal Liposarcoma

Liposarcoma commonly occurs in the lower extremities and retroperitoneum, but rarely in the mediastinum. We report a rare case of primary mediastinal liposarcoma treated surgically. A 77-year-old man seen for an asymptomatic superior mediastinal mass found in magnetic resonance imaging had been exposed to radiation in the atomic bombing of Hiroshima. The large lobulated mass had surrounded and displaced major vessels and the trachea. The encapsulated mass was removed surgically, and the final pathological diagnosis was well-differentiated liposarcoma.

Liposarcome médiastinal primitif récidivant avec modification histologique

Primary mediastinal liposarcomas are rare tumours with various histological features. Local recurrence is frequent. We report the case of a 70-year-old patient, in whom a mediastinal mass was resected surgically and identified as a mediastinal, "lipoma-like" liposarcoma on histopathological examination. Nine years later, the patient complained of dyspnoea with cough. The chest X-ray showed anterior mediastinal enlargement and the chest CT scan revealed a heterogeneous mass containing both solid tissue and fat. The patient underwent a successful surgical resection of the mass and the histopathological examination confirmed the diagnosis of a recurrent, mixed-type liposarcoma of the mediastinum (well-differentiated and myxoid). This report discusses the epidemiological, clinical and therapeutic features of this tumour.

Successful resection of a large incidentally found primary mediastinal liposarcoma.

Primary liposarcoma of the mediastinum is an uncommon tumour. We report a case of a 45-year-old female who was found incidentally to have a large anterior mediastinal mass. Complete removal of the tumour was accomplished successfully. Appropriate immunohistochimical stains were performed, confirming the presence of a well-differentiated liposarcoma of the mediastinum. We describe an unusual case of a large asymptomatic primary liposarcoma of the mediastinum.

Primary Mediastinal Liposarcoma, with 6 Years of Follow-up to Autopsy, Revealed Histopathological Features of Primary and Metastatic Lesions

Primary mediastinal liposarcoma was observed in a 73-year-old man. Because of tight adhesions to adjacent tissues, neither complete resection nor surgical debulking of the tumor was possible. A T-tube was inserted into the patient's trachea for severe dyspnea, and he was treated with radiotherapy and an oral peroxisome proliferator-activated receptor-gamma agonist. The patient died 6 years after the initial diagnosis. Autopsy revealed liposarcoma composed of 3 subtypes in the primary tumor: well-differentiated, dedifferentiated, and round cell components. Round cell and dedifferentiated liposarcomas were predominantly observed in the metastatic nodules.

Primary mediastinal liposarcoma - computed tomography and pathological findings: a case report

Liposarcomas are the most common soft tissue sarcoma of adults, and primary mediastinal liposarcomas are rare. We present a case of a 50-year-old man with primary mediastinal liposarcoma without any invasion into the surrounding structures, such as the esophagus, trachea, or left atrium of the heart. Following surgical removal of the liposarcoma, the patient has had no recurrence after one year. Surgical removal is the treatment of choice for a mediastinal liposarcoma; however, careful long-term follow-up is necessary because the recurrence rate is very high.

Primary mediastinal liposarcoma: a case report

IntroductionLiposarcoma is the most commonly diagnosed soft tissue sarcoma in adults and occurs predominantly in the lower limbs and retroperitoneum. Primary mediastinal liposarcomas are rare.They are often asymptomatic and when growing to large size the presenting symptoms are related to direct invasion or compression of other thoracic organs such as the heart, great vessels and lung.Case presentationA case of a 68-year-old man with primary mediastinal liposarcoma involving the diaphragm and pericardium and successfully managed by complete surgical excision is presented. The patient's postoperative course was uneventful with no evidence of recurrence 9 months after the operation.ConclusionSurgical removal is the optimal treatment for a mediastinal liposarcoma. If the entire tumor can not be resected, surgical debulking often results in symptomatic relief. International literature has demonstrated that recurrent disease occurs and therefore a long-term careful follow up is required.

Posterior mediastinal liposarcoma simulating a lung mass: an unusual case report

Liposarcomas constitute approximately 15% of all sarcomas among the mesenchymal neoplasms. They usually arise in the lower extremities or in the retroperitoneum but have been reported in sites such as abdomen, vulva and buttocks. Primary mediastinal liposarcomas are rare with less than 100 cases reported worldwide so far. We present an interesting case of primary myxoid LPS of the posterior mediastinum with presenting complaints, imaging diagnosis and management with a review of the current literature.

PRIMARY MEDIASTINAL LIPOSARCOMA: CASE REPORT AND REVIEW OF THE LITERATURE

INTRODUCTION: Primary mediastinal liposarcoma is an uncommon neoplasm of intrathoracic origin. It is usually encountered in later stages when the tumor has become large and symptomatic due to mass effect. Liposarcoma originating in the mediastinum represents less than 1% of mediastinal tumors with less than 150 cases reported in the literature.

Surgical resection of recurrent bilateral mediastinal liposarcoma through the clamshell approach

Primary mediastinal liposarcoma is an unusual variant of mediastinal neoplasms. We describe a long-term survivor who underwent repeated operations. After resections through a posterolateral thoracotomy and median sternotomy, a third operation was performed for recurrent bilateral huge tumors through a clamshell incision, and both tumors were removed en bloc. Results of pathologic examination showed that both tumors were well-differentiated liposarcoma. The patient is currently well 16 years after the first operation. Aggressive surgical intervention whenever possible appears to improve the quality of life and prolong the survival of patients with mediastinal liposarcoma.