Primary Measurement Research Articles

Estimation of Hydration and Density of Fat-Free Mass in Indian Children Using a 4-Compartment Model: Implications for the Estimation of Body Composition Using 2-Compartment Models

BackgroundAccurate methods are needed to measure body fat mass (FM), particularly in South Asian children who are thought to have greater adiposity for a given body size. The accuracy of simple 2-compartment (2C) models of measuring FM depends on the primary measurement of the fat free mass (FFM) and the validity of assumed constants for FFM hydration and density. These have not been measured in this particular ethnic group. ObjectivesTo measure FFM hydration and density in South Indian children using a 4-compartment (4C) model and to compare FM estimates from this 4C-model with 2C-model-based estimates from hydrometry and densitometry, using literature-reported FFM hydration and density in children. MethodsThis study included 299 children (45% boys), aged 6–16 y from Bengaluru, India. Total body water (TBW), bone mineral content (BMC), and body volume were measured using deuterium dilution, dual-energy X-ray absorptiometry, and air displacement plethysmography, respectively, to calculate the FFM hydration and density, and the FM using 4C and 2C models. The agreement between FM estimates from 2C and 4C models was also evaluated. ResultsMean FFM hydration and density were 74.2% ± 2.1% and 71.4% ± 2.0% and 1.095 ± 0.008 kg/L and 1.105 ± 0.008 kg/L in boys and girls respectively, which were significantly different from published values. Using the presently estimated constants, the mean hydrometry-based FM (as % body weight) estimates decreased by 3.5% but increased by 5.2% for densitometry-based 2C methods. When 2C-FM (using previously reported FFM hydration and density) were compared with 4C-FM estimates, the mean difference was −1.1 ± 0.9 kg for hydrometry and 1.6 ± 1.1 kg for densitometry. ConclusionsPreviously published constants of hydration and density of FFM may induce errors of −12% to +17% in FM (kg) when using different 2C models in comparison to the 4C models in Indian children.

Protocol for a process evaluation of SCALA study – Intervention targeting scaling up of primary health care-based prevention and management of heavy drinking and comorbid depression in Latin America

This paper describes the plan for a process evaluation of a quasi-experimental study testing the municipal level scale-up of primary health care-based measurement and brief advice programmes to reduce heavy drinking and comorbid depression in Colombia, Mexico, and Peru. The main aims of the evaluation are to assess the implementation of intervention components; mechanisms of impact that influenced the outcomes; and characteristics of the context that influenced implementation and outcomes. Based on this information, common drivers of successful outcomes will be identified. A range of data collection methods will be used: questionnaires; interviews; observations; logbooks; and document analysis. All participating providers will complete a pen-and-paper questionnaire at recruitment and two time points during the implementation period. Providers attending training will complete post-training questionnaires. Additionally, 1080 patients will be invited to self-complete a patient questionnaire. One-in-ten participating providers and fifteen other key stakeholders will participate in semi-structured interviews. Training sessions and community advisory board meetings will be observed by a neutral observer. Logbooks will be kept by local research teams to document events affecting the implementation. Project related documentation and other relevant reports describing the context will be examined.

Primary calibration of photodiodes with monochromatic X‐ray beams using an electrical‐substitution radiometer

AbstractThe electrical‐substitution cryogenic detector BOLometer for Use in the range of X‐rays (BOLUX), which was developed some years ago at CEA/DAM, has been set up and restarted now at LNHB. It has been used for the primary measurement of the intensity (total energy per unit time) of monochromatic synchrotron beams in the energy range from 3 to 30 keV. These well‐determined photon beams have been employed for the efficiency calibration of two photodiodes in terms of current induced per unit optical power at different photon energies. In a final step, we explored the possibility to use these primary‐calibrated photodiodes to determine the efficiency curve of an energy‐dispersive spectrometer based on a semiconductor detector (Silicon Drift Detector) using less intense monochromatic photon fluxes. The characteristics of the radiometer BOLUX and its principle of operation are described, and the measurements carried out at the synchrotron beamline are presented, including the determination of the beams' intensities, the direct calibration of photodiodes with respect to BOLUX and the use of one of those photodiodes as a standard transfer for the calibration of the SDD.

Is the reconstruction of medial support important for revision following failed treatment of femoral trochanteric fractures? a retrospective comparative study

BackgroundHip-preserving revision in patients with failed treatment of femoral trochanteric fracture is still a major challenge. Whether the medial support reconstruction could benefit the patients and improve the success rate of hip-preserving revision is still controversial. Hence, the purpose of this study was to evaluate the clinical significance and prognosis of medial support reconstruction during the hip-preserving revision of failed femoral trochanteric fracture treatment.MethodsPatients with failed femoral trochanteric fractures treatments addressed by hip-preserving revision at our hospital from January 2014 to December 2020 were analyzed retrospectively. 31 patients were included and divided into a medial support group (n = 16) and a non-medial support group (n = 15). The fracture healing rate was the primary measurement. In addition, the differences in Oxford Hip Score (OHS), quality of life, surgical trauma, and complications were also evaluated.ResultsThe fracture healing rate (100%, 16/16 vs. 66.67%, 10/15), the OHS (42.06 ± 4.12 vs. 30.93 ± 11.56, M ± SD), and the mental component score of the 12-item Short-Form Survey (SF-12) (54.48 ± 5.38 vs. 47.90 ± 3.47, M ± SD), were significantly better and the incidence of complications [0(0/16) vs. 40%(6/15)] was significantly lower in the medial support group than the non-medial support group (p < 0.05). No significant differences in the physical component score of the SF-12, surgical trauma and reduction in collodiaphyseal angle of affected femur were observed between groups.ConclusionsThe reconstruction of medial support seems important for revision following failed treatment of femoral trochanteric fractures. Due to the medial augmentation and improvement of the mechanical stability for proximal femur, the patients might benefit from fracture healing prognosis and functional.

Measuring water vapour permeability using remote-reading humidity sensors

The water vapour permeability is a material property used in calculations of the hygrothermal performance of buildings. The standard test method (the ‘cup test’), little changed for decades and based on measuring weight changes, has been shown repeatedly in round-robin comparisons to have poor accuracy and little consistency between laboratories. Here we describe a new approach in which the primary measurement is of the humidity difference across the test sample, which is monitored continuously using sensors that are remotely readable. The box-in-box (BiB) apparatus described is smaller and simpler than that of the standard cup test. The BiB test is of shorter duration and is carried out without disturbance to the sample. New results on calcium silicate sheet, brick ceramic and autoclaved aerated concrete are compared with published vapour permeability values obtained by the standard test (considered to be of lower accuracy).

The Application of 3D Imaging as an Appropriate Method of Wildlife Craniometry: Evaluation of Accuracy and Measurement Efficiency.

The suitability of CT and 3D scanners for craniometric proposes was tested using digital calipers when determining linear measurements, and a measuring cylinder was used for the accuracy of 3D printing of deer antlers obtained by the CT and 3D scanners. The resolution of digitized objects from a 3D scanner ranged from 0.008 mm to 0.122 mm. For mandibular dimensions, a positive deviation (p < 0.01) from the primary control measurement was recorded. The average antler volume measured with the cylinder was 60.47 cm3 at the first measurement, in the case of the CT scanner 61.62 cm3 and for the 3D scanner 64.76 cm3—both technologies exhibit a positive deviation from the primary measurement. Precise sensing and measurements can be used to evaluate the quality and evolution of wildlife populations, create digital museum collections, or to examine in detail certain traits such as antler and horn development or dentition.

Characteristics, Antithrombotic Patterns, and Prognostic Outcomes in Claudication and Critical Limb-Threatening Ischemia Undergoing Endovascular Therapy

Purpose: The underlying difference between intermittent claudication (IC) and critical limb-threatening ischemia (CLTI) still remains unclear. This prospective multicenter observational study aimed to clarify differences in clinical features and prognostic outcomes between IC and CLTI, and prognostic factors in patients undergoing endovascular therapy (EVT). Materials and Methods: A total of 692 patients with 808 limbs were enrolled from 20 institutions in Japan. The primary measurements were the 3-year rates of major adverse cardiovascular event (MACE) and reintervention. Results: Among patients, 79.0% had IC and 21.0% had CLTI. Patients with CLTI were more frequently women and more likely to have impaired functional status, undernutrition, comorbidities, hypercoagulation, hyperinflammation, distal artery disease, short single antiplatelet and long anticoagulation therapies, and late cilostazol than patients with IC. Aortoiliac and femoropopliteal diseases were dominant in patients with IC and infrapopliteal disease was dominant in patients with CLTI. Patients with CLTI underwent less frequently aortoiliac intervention and more frequently infrapopliteal intervention than patients with IC. Longitudinal change of ankle-brachial index (ABI) exhibited different patterns between IC and CLTI (pinteraction=0.002), but ABI improved after EVT both in IC and in CLTI (p<0.001), which was sustained over time. Dorsal and plantar skin perfusion pressure in CLTI showed a similar improvement pattern (pinteraction=0.181). Distribution of Rutherford category improved both in IC and in CLTI (each p<0.001). Three-year MACE rates were 20.4% and 42.3% and 3-year reintervention rates were 22.1% and 46.8% for patients with IC and CLTI, respectively (log-rank p<0.001). Elevated D-dimer (p=0.001), age (p=0.043), impaired functional status (p=0.018), and end-stage renal disease (p=0.019) were independently associated with MACE. After considering competing risks of death and major amputation for reintervention, elevated erythrocyte sedimentation rate (p=0.003) and infrainguinal intervention (p=0.002) were independently associated with reintervention. Patients with CLTI merely showed borderline significance for MACE (adjusted hazard ratio 1.700, 95% confidence interval 0.950–3.042, p=0.074) and reintervention (adjusted hazard ratio 1.976, 95% confidence interval 0.999–3.909, p=0.05). Conclusions: The CLTI is characterized not only by more systemic comorbidities and distal disease but also by more inflammatory coagulation disorder compared with IC. Also, CLTI has approximately twice MACE and reintervention rates than IC, and the underlying inflammatory coagulation disorder per se is associated with these outcomes. Clinical Impact The underlying difference between intermittent claudication (IC) and critical limb-threatening ischemia (CLTI) still remains unclear. This prospective multicenter observational study, JPASSION study found that CLTI was characterized not only by more systemic comorbidities and distal disease but also by more inflammatory coagulation disorder compared to IC. Also, CLTI had approximately twice major adverse cardiovascular event (MACE) and reintervention rates than IC. Intriguingly, the underlying inflammatory coagulation disorder per se was independently associated with MACE and reintervention. Further studies to clarify the role of anticoagulation and anti-inflammatory therapies will contribute to the development of post-interventional therapeutics in the context of peripheral artery disease.

Development of Measurement Procedures for the Characterization of Reference Materials for Carbohydrate Composition of Dairy Products

This article studies the development of measurement procedures based on various methods for a comprehensive analysis of the carbohydrate composition of food systems. The basis of the primary reference measurement procedure (PRMP) is the method of iodometric titration based on the ability of iodine to oxidize aldosaccharides to the corresponding uronic acids in an alkaline medium. The accuracy of the PRMP was improved by optimizing the measurement parameters, including the method of high-performance liquid chromatography with refractometric detection (HPLC/RD), and by establishing their possible variation limit based on a multifactorial experiment. The application of the PRMP made it possible to measure the mass fraction of carbohydrates (total sugar) as the sum of the mass fractions of reducing and non-reducing sugars in milk and dairy products, grain and milk products, low-lactose and lactose-free products, including those used for preparing baby food. In order to further detail the carbohydrate composition, highly selective methods were developed for measuring the mass fractions of lactose and galactose by the spectrophotometric (enzymatic) method, and the mass fractions of mono- and disaccharides by the HPLC/RD method in milk and dairy products. It was found that the measurement results of both the total content of carbohydrates and individual mono- and disaccharides in the samples of milk and dairy products obtained by various methods (iodometric titration, HPLC/RD, enzymatic method, refractometry, IR spectroscopy, calculation method) are consistent with each other subject to the stated uncertainties. Thus, the applicability of the developed PRMP in combination with other methods for conducting an in-depth analysis of the carbohydrate composition of milk and dairy products was confirmed. The developed procedures were used to characterize reference materials for the composition of dairy products (3 types), mono- and disaccharides (9 types).

Improving breastfeeding care & support in a large, urban, pediatric primary care practice

Background and specific aimsHuman milk/breastfeeding is the gold standard for infant nutrition. Interventions in pediatric primary care could improve breastfeeding exclusivity and duration. Our specific aims were two-fold: 1) Accurately measure breastfeeding indicators and 2) Implement AAP Breastfeeding-Friendly Pediatric Office Practice Recommendations. Materials and methodsIn 2018, a single, urban, large primary care pediatric practice initiated a Quality Improvement project to improve breastfeeding outcomes. Stakeholders met to discuss metrics of interest, develop documentation templates, review data capture, and plan interventions to support breastfeeding. Practice based interventions to improve measurement included: piloting documentation templates, incorporation of default templates office-wide, and developing tracking tools for both use of templates and breastfeeding outcomes. Interventions to support breastfeeding occurred simultaneously and included workflow redesign to increase nurse-provided breastfeeding education, partnering with community-based lactation consultants for outpatient support, staff education, and National Breastfeeding Month activities. ResultsSince initiation of the data analytic tool, breastfeeding data has been analyzed from over 30,000 visits (86% Medicaid-insured, 82% Black race). Currently, 80% of providers use default templates that allow standardized data capture. At first newborn visit, 74% of infants were breastfed. At six months, 36% of infants were breastfed; 23% exclusively. Standardized documentation of infant feeding status improved and has remained consistent. Breastfeeding duration did not significantly improve despite practice interventions. ConclusionsPediatric primary care measurement tools are feasible and critical to understand breastfeeding continuation. Increased resources and interventions to support breastfeeding in Primary Care are necessary to improve outcomes.

In-situ Primary Stress Detection Based on Seismic Tomography Measurements and Numerical Back-analysis for an Underground Radwaste Repository

In order to understand how the in-situ primary stress state has evolved with subsidence and uplift in a granitic rock mass for anticipated of a radioactive waste repository in Hungary, the authors investigated the applicability of seismic tomography as an interpretive tool. Very high P wave velocity (Vp) values were obtained during the tomographic scanning of the study area of the repository, and these were compared with existing findings of in-situ and laboratory seismic measurements.Apart from seismic tomographic survey, dynamic FEM numerical modelling, empirical calculations of residual stresses, laboratory measurements of compression wave (ultrasonic) velocities on intact rock cores, in-situ primary stress measurements as well as site geological model were integrated to evaluate the use of seismic tomography for identifying possible in-situ stress increases around the excavation.A detailed calibration modelling was carried out based on the site seismic tomography measurements and during the large-scale modelling. It was observed that the increasing Vp is directly related to simulated increasing directional loadings on the rock mass. Using a measured wave raypath it was possible to check the different in-situ stress parametrizations which resulted in the best approximation to the measured Vp values.It was concluded that the rock mass under investigation to extend the repository must have higher in-situ stress values than the area of the constructed deposition chambers nearby. The results of this research indicated that seismic tomography is a useful tool for determining relative stress around and within the vicinity of underground excavation.

Preclinical Studies and Phase II Trial of Venetoclax in Combination with Chidamide and Azacitidine in Relapsed/Refractory Acute Myeloid Leukemia

Background: The treatment for relapsed and refractory acute myeloid leukemia (R/R AML) remains challenging and leukemia stem cells (LSCs) play a causal role in R/R AML. Recent progress in genomics and molecular biology has uncovered a spectrum of mutations in AML suggesting that translational research combined with targeted therapy for LSCs has greater guiding significance to improve outcome in R/R AML. Therefore, we used a high-throughput screening platform to identify a novel and effective therapeutic combination, which is venetoclax, chidamide, and azacitidine (VCA). Next, to assess the efficacy of VCA, we performed preclinical studies on LSCs-like cell lines and patient-derived xenograft (PDX) mouse model. In addition, a subsequent phase II study was conducted to test the safety and preliminary efficacy of this combination. Methods:Preclinical: We performed an automated drug screen to evaluate the drug sensitivity in CD34+CD38- KG-1α and Kasumi-1 cells simultaneously. Ultimately select the optimal combination therapy of venetoclax, chidamide, and azacitidine (VCA) by using a high-throughput platform. To validate the efficacy of the combination in vivo, we used primary CD34+ AML PDX model. Mice were treated with single, dual, or triple of venetoclax (VEN, 30 mg/kg, oral gavage), chidamide (CS055, 7.5 mg/kg, oral gavage), and azacitidine (5-AZA, 2 mg/kg, intraperitoneal injection) every 3 days for 12 days consecutively. Phase II: In a multi-center, single-arm, open-labeled phase II study, patients aged ≥18 years with R/R AML were treated with VEN at 200 mg orally daily for 14 days, CS055 at 30 mg orally twice per week for 14 days, and 5-AZA at 100 mg by continuous hypodermic injection (IH) daily for 7 days for up to two 28-day cycles. The primary objective was to assess the safety and efficacy of VCA. The primary efficacy measurement was overall response rate (ORR), which was the combined complete remission (CR), CR with incomplete hematologic recovery (CRi) and partial remission (PR). ResultsPreclinical: VCA exhibited synergistic effects on attenuating cell viability and inducing apoptosis in CD34+CD38- KG-1α and Kasumi-1 cells. Importantly, triple therapy intensively reduced leukemia burden and improved prognosis in a primary CD34+ AML derived PDX model without significant adverse effects versus single or double combination. Mechanistically, co-exposure to three agents led to the inhibition of anti-apoptotic BCL-2 family proteins (including BCL2, BCL-XL and MCL-1), associating with enhanced ubiquitination. Moreover, CS055-mediated HDAC inhibition increased F-box and WD repeat domain-containing protein 7 (FBW7) acetylation, thus resulting in FBW7 stabilization, which further enhanced the MCL-1 protein degradation. Phase II: As of July 30th, 2022, 29 patients were enrolled in the study. Patients had a median age of 51 years (range: 35-64). The median time on study was 31 (range: 4-not reached [NR]) days. 25 patients (86.2%) had confirmed responses. The ORR was 75% (12/16: 2 CR, 7 CRi and 3PR) with one complete and 88.9% (8/9: 5 CR, 2 CRi and 1 PR) with two completes. The most common non-hematologic adverse events (AE) were nausea (75%) and vomiting (25%), and no grade III or IV non-hematologic AE was observed. There was no tumor lysis syndrome (TLS) or treatment-discontinuation due to therapy. Conclusions: This novel combination strategy of VEN, CS055 and 5-AZA has shown synergy in AML LSCs-like cells and PDX model. The phase II data suggests that VCA as a chemo-free therapy exhibits promising efficacy and is safe and well-tolerated in patients with R/R AML.

Primary Measurement of Gaseous Elemental Mercury Concentration with a Dynamic Range of Six Decades.

We present a primary method for absolute reference material-free measurement of gaseous elemental mercury mass concentration based on laser absorption spectroscopy at wavelengths near 254 nm and anchored to the international system of units. A 76 m-long multipass cell provides a detection limit of 1 ng m-3 for an averaging time of 8 min. A dual-cell arrangement, comprising a single-pass and a multipass cell, provides a dynamic range of six decades and spans from ambient to emission levels of gaseous elemental mercury (1 ng m-3 to 1000 μg m-3). The relative standard uncertainty of the measurement is 0.5% in the 0.25 to 1000 μg m-3 range.

Self-reporting of Conflicts of Interest by Ophthalmology Researchers Compared with the Open Payments Database Industry Reports

To evaluate the completeness of conflict-of-interest self-reporting by ophthalmology researchers and to assess factors associated with self-reporting. Cross-sectional observational study. We evaluated articles published between January and June 2017 in Ophthalmology, JAMA Ophthalmology, the American Journal of Ophthalmology, and Investigative Ophthalmology and Visual Science. To assess more accurately the cases in which an author published multiple articles, we defined a unit of analysis, authorship, for which each author of each article is a unique data point. To enable comparison with the Open Payments Database (OPD), we only included United States physician authorships. For each authorship, we defined self-reported relationships as the companies listed in the article's conflict-of-interest disclosures. Based on journal policies, we defined OPD-reported relationships as the list of companies that reported payments to the author within 36 months before submission. For each authorship, we assessed the proportion of OPD-reported relationships that were self-reported. The primary measurement was the proportion of authorships reporting none of their OPD-reported relationships. Of the 660 total authorships (486 unique authors), 413 authorships (63%) reported none of their OPD-reported relationships, 112 (17%) reported some of them, 9 (1%) reported all of them, and 126 (19%) had 0 relationships. The proportion of authorships reporting none of their relationships did not differ significantly between journals that required reporting of all relationships compared with journals that required reporting only of relevant relationships (adjusted percentage, 61.4% vs. 64.3%; P= 0.46). Authorships with more dollars received during the reporting period showed higher rates of self-reporting (P < 0.001). Even among journals that required complete reporting, self-reporting was low compared with an industry-maintained database of financial relationships. Deficiencies in reporting may undermine confidence in self-reporting and may compromise the transparency that is needed to interpret research results fairly. Proprietary or commercial disclosure may be found after the references.

Redirecting Nonurgent Patients From the Pediatric Emergency Department to Their Pediatrician Office for a Same-Day Visit-A Quality Improvement Initiative.

Providing high-quality care in the appropriate setting to optimize value is a worthy goal of an efficient health system. Consequences of managing nonurgent complaints in the emergency department (ED) have been described including inefficiency, loss of the primary care-patient relationship, and delayed care for other ED patients. The purpose of this initiative was to redirect nonurgent patients arriving in the ED to their primary care office for a same-day visit, and the SMART AIM was to increase redirected patients from 0% of those eligible to 30% in a 12-month period. The setting was a pediatric ED (PED) and primary care office of a tertiary care pediatric medical system. The initiative utilized the electronic health record to identify and mediate the redirection of patients to the patient's primary care office after ED triage. The primary measurement was the percentage of eligible patients redirected. Additional measures included health benefits during the primary care visit (vaccines, well-visits) and a balancing measure of patients returned to the PED. The SMART AIM of >30% redirection was achieved and sustained with a final redirection rate of 46%. In total, 216 of 518 eligible patients were redirected, with zero untoward outcomes. The encounter time for redirected patients was similar for those who remained in the PED, and additional health benefits were appreciated for redirected patients. This initiative redirected nonurgent patients efficiently from a PED setting to their primary care office. The process is beneficial to patients and families and supports the patient-centered medical home. The balancing measure of no harm done to patients who accepted redirect reinforced the reliability of PED triage. The benefits achieved through the project highlight the value of the primary care-patient relationship and the continued need to improve access for patients and families.

Key Success in Fostering Human Development Index at the Local Level

Human Development Index (HDI) determines human prosperity in different countries using value assets. In general, the primary measurement includes the three basic indices, namely education, health, and a decent standard of living. HDI is a measure of development and governance success in terms of economic growth and human development. Generally, studies on HDI take place at the national and regional levels, and comparisons of its achievements between countries, while those at the municipal level are limited. Studies on the determinants of the success of increasing HDI tend to focus on local governments' fiscal capacity and political will and rarely touch the capacity of public administration in managing government, specifically in the development planning stage. This study examined the increased success of the Malang City's HDI by adopting a logical framework (log-frame) analysis with secondary data from the Malang bureau of statistics. The results showed an 80.89 increase in HDI from 2014 to 2018, including the education and health indexes, with a decent standard of living. The increased success is shown by the Regional Medium Term Development Plan (RPJMD), including basic education development program, regional public hospital service programs, and food security program for education, health, and purchasing power indices. Therefore, the local government needs to maintain and enhance the HDI in both medium- and long-term plans. The novelty of this study lies in the use of a logical framework in preparing regional development plans that support efforts to increase HDI consistently in the medium term. This reinforces the need to strengthen the perspective of how to achieve development goals compared to other studies that focus more on the perspective of the substance of development.

Theoretical analysis on the measurement accuracy of embedded strain sensor in asphalt pavement dynamic response monitoring based on FEM

Embedded strain sensors are the primary measurement device for strain in the tensile layer of asphalt pavement. The favorable deformation compatibility between embedded strain sensor and asphalt layer is the key to ensure the precise measurement of mechanical response. However, the good deformation coordination may be difficult to maintain under different environments due to the viscoelasticity of asphalt mixture. In this study, 4-point bending beam tests were performed to investigate deformation compatibility between embedded strain sensor and asphalt mixture under different temperature. Then, a quasi-static finite element model (FEM) was employed to simulate static mechanical response of asphalt pavement, and the design requirements for embedded strain sensor were proposed considering deformation coordination. In addition, the rationality of the design requirements of the sensor was further validated in the dynamic response monitoring. The results indicate that the deformation compatibility between embedded strain sensor and pavement material changes at different temperatures. In order to ensure favorable deformation compatibility, the reinforcement of the protective housing should be eliminated and the equivalent modulus (EM) of the sensitive element shall be the same as that of the asphalt mixture. Considering the viscoelasticity of asphalt mixture, the strain sensor with lower EM is recommended in the dynamic response monitoring of pavement structure. This study provides a basis for optimizing the embedded strain sensor of asphalt pavement from the perspective of deformation compatibility.

The calculation of light element impurity ([formula omitted], n) yield curves in a PuO[formula omitted] matrix and associated specific yield coefficients: Influence of the reaction cross sections

Most of the Pu separated from irradiated commercial nuclear fuel is stored as PuO 2. The primary quantitative nondestructive measurement technique used to verify the amount of Pu in storage containers is passive neutron correlation counting. An important physical property of the oxide material is the ratio, α, of the rate of (α, n) neutrons produced inside the item to the rate of neutrons produced by spontaneous fission. This ratio influences the precision of the correlated counting method and affects the interpretation of the data because of how it changes both the primary total neutron production rate and the rate of induced fission events taking place inside the item. In addition to the main O(α, n) contribution, additional contributions come from α-particle interactions with light element impurities that are inevitably present. In this work, we calculate specific (α, n) yield coefficients, expressed in units of neutrons per second per gram of α-emitting nuclide per part per million by mass of the specified impurity element distributed in a pure PuO 2 matrix, for some key α-emitting actinides commonly present in reprocessed Pu (238–242Pu+241Am). These coefficients are directly applicable to nuclear safeguards verification work in which the α ratio is often calculated from the Pu-isotopic composition and chemical information obtained by other means. They also provide a convenient up-to-date reference set against which values generated by other methods can be compared. Results are presented for impurities with atomic number from 3 to 17 inclusive, plus K and Fe. In most cases, these coefficients are not expected to change by more than 5%–10% at any time in the future. However, as new data become available, changes as large as 20% may be needed for some targets (e.g., F). The present yield calculations are limited by the general shortage of quality experimental total (α, n) reaction cross section data, which, together with unexplained variation between determinations, means that an objective and coherent evaluation is not possible. The situation is even less satisfactory for the partial differential cross section needed to calculate neutron spectra.

Comparison of insulin requirements across gestation in women with hyperglycemia in pregnancy: A prospective cohort study.

The aim of this study is to explore the daily insulin dose and the percentage change in preprandial and basal insulin dosage of women with different types of hyperglycemia in pregnancy (HIP) during the whole gestation and postpartum period. A total of 121 subjects with HIP requiring insulin therapy were enrolled from a prospective cohort consisted of 436 pregnant women with hyperglycemia. The subjects were divided into three groups: Group 1 [type 1 diabetes mellitus (T1DM) and maturity onset diabetes of the young (MODY)], Group 2 [type 1 diabetes mellitus (T2DM)], and Group 3 [gestation diabetes mellitus (GDM)]. The primary study measurements included daily dose and percentage of different types of exogenous insulin requirements across gestation in different groups. Insulin total daily dosage of Group 1 was highest among the three groups and increased significantly from the first to the second/third trimester. Percentage of preprandial insulin increased from 53.8% (46.7, 60.0) and 54.5% (42.3, 62.9) in the first trimester to 63.6% (54.9, 75.0) and 67.2% (51.8, 73.7) in the second/third trimester in Group 1 and Group 2. All subjects with T1DM and 18.6% of subjects with T2DM still required insulin administration after delivery, with a 26.9% (19.0, 46.0) and 36.7% (26.9, 52.6) decrease in total insulin dose, respectively, whereas subjects with GDM and MODY weaned off insulin completely. The insulin requirements for pregnancy complicated with T1DM and MODY were higher than those for T2DM and GDM. In the subjects with PGDM, the insulin requirement and percentage of preprandial insulin increased gradually from early to mid- and late pregnancy.

Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells.

Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable nonselective cation channel whose dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 is present in different cell locations, including the primary cilium of renal epithelial cells. However, little is known as to whether PC2 contributes to the primary cilium structure. Here, we explored the effect(s) of external Ca2+, PC2 channel blockers, and PKD2 gene silencing on the length of primary cilia in wild-type LLC-PK1 renal epithelial cells. Confluent cell monolayers were fixed and immuno-labeled with an anti-acetylated α-tubulin antibody to identify primary cilia and measure their length. Although primary cilia length measurements did not follow a Normal distribution, the data were normalized by Box-Cox transformation rendering statistical differences under all experimental conditions. Cells exposed to high external Ca2+ (6.2 mM) decreased a 13.5% (p < 0.001) primary cilia length as compared to controls (1.2 mM Ca2+). In contrast, the PC2 inhibitors amiloride (200 μM) and LiCl (10 mM), both increased primary ciliary length by 33.2% (p < 0.001), and 17.4% (p < 0.001), respectively. PKD2 gene silencing by siRNA elicited a statistically significant, 10.3% (p < 0.001) increase in primary cilia length compared to their respective scrambled RNA transfected cells. The data indicate that conditions that regulate PC2 function or gene expression modify the length of primary cilia in renal epithelial cells. Blocking of PC2 mitigates the effects of elevated external Ca2+ concentration on primary cilia length. Proper regulation of PC2 function in the primary cilium may be essential in the onset of mechanisms that trigger cyst formation in ADPKD.

Research on the layout of primary control network and new measurement method for the HIAF survey and alignment

HIAF (High Intensity heavy ion Accelerator Facility) is one of the major national science and technology infrastructure projects in the “12th Five-Year Plan” undertaken by the Institute of Modern Physics, CAS. The primary control network, as the basic framework of the local coordinate system control of the particle accelerator, is the basis for calculating the coordinates in the process of accelerator construction and implementation, and plays a very important role in the survey and alignment during the construction period and the maintenance and monitoring during the operation period. Based on the multi-dissimilar design structure of HIAF and the unique geological conditions of the construction area, a new high-density layout method of the primary control network and a high-precision 3D(three-dimensional) measurement method were studied, and were successfully applied to the survey and alignment of HIAF. Inside and outside the accelerator tunnel, a high-density 3D primary control network that can form a full envelope for the accelerator beam is respectively laid out. All primary control networks are embedded in the bedrock layer with stainless steel reference inner cylinder and outer protective cylinder, and special waterproof filling layer is set up. All primary control network points in the accelerator tunnel are equipped with measuring intervisible holes and measurement platforms that can directly perform 3D measurements on the ground. By setting up the laser tracker on the horizontal attitude of the measurement platform, the 3D coordinates of the primary control network points inside and outside the accelerator tunnel can be measured directly and with high precision, and the simultaneous adjustment of the measurement data can be completed. The HIAF primary control network layout and measurement method proposed in this paper overcomes the problems of heavy pile foundation, poor crack resistance and poor water seepage resistance of the primary control network laid by the traditional method and solves the problem that the traditional primary control network must separate the plane network and the elevation network for independent measurement. The traditional method of tunnel point and forced centering measurement is avoided. By using a laser tracker to directly measure the 3D coordinates of the primary control network points inside and outside the tunnel, the measurement efficiency and measurement accuracy of the primary control network are improved, and the reliability of primary control network measurements is increased. The feasibility and correctness of the HIAF primary control network layout and measurement method are verified by comparing the actual multi-system measurement results in the field. This method has a certain reference value for the layout of the primary control network of the same type of accelerator.