Primary Lung Abscess Research Articles

Treatment of acute nonspecific primary lung abscess. Use of orally administered penicillin G

Treatment of acute nonspecific primary lung abscess. Use of orally administered penicillin G

Treatment of Acute Nonspecific Primary Lung Abscess

ALTHOUGH the infectious etiology of acute nonspecific primary lung abscess has not been established, it has been the general experience that most of the cases respond to penicillin G. The treatment in wide usage requires frequent injections for many weeks. The optimal regimen with regard to dosage, route of administration, and duration of therapy has not been determined. Since the parenteral method is inconvenient to nursing personnel and annoying to patients, orally administered penicillin is worth consideration. The present study was undertaken to investigate the efficacy of treating acute nonspecific primary pulmonary suppuration with large doses of penicillin G by mouth. In the past, the authors have treated acute lung abscess successfully with aqueous penicillin G in a dosage of 300,000 units intramuscularly every six hours. On the basis of pharmacologic studies1 an oral dosage of four times the intramuscular amount was considered likely to be effective. The regimen used

Primary lung abscess. Analysis of therapy and results in 55 cases.

Introduction The last 15 years have witnessed great advances in the medical and surgical management of lung abscess. Reduction in morbidity and mortality from this disease has been brought about by the introduction of antibiotics, improved thoracic surgical techniques, and improvements in anesthesiology. The purpose of this paper is to review the experience in all patients with primary lung abscess at four large teaching hospitals in a metropolitan area. * Primary lung abscess is defined as a putrid cavity formation where no local predisposing factor can be demonstrated at the site of the abscess. Thus, abscesses which are secondary to bronchial obstruction by neoplasm, those resulting from necrosis in an area of tumor or pulmonary infarction, infected lung cysts, and those due to specific infections such as tuberculosis and fungus diseases, are excluded. The exclusion of secondary lung abscesses is necessary if valid conclusions are to be drawn concerning the course