Primary Adenocarcinoma Of Fallopian Tube Research Articles

CYSTIC CHANGES IN MEDIASTINAL LYMPH NODES WITH METASTATIC SEROUS FALLOPIAN TUBE CARCINOMA

TOPIC: Disorders of the Mediastinum TYPE: Medical Student/Resident Case Reports INTRODUCTION: Fallopian tube carcinoma is associated with a high rate of distant metastasis, likely due to the lack of florid symptoms. We describe a case of fallopian tube carcinoma, metastatic to mediastinal lymph nodes with cystic changes developing in the lymph nodes. CASE PRESENTATION: Our patient is a 65-year-old female with stage IIIA2 high-grade serous carcinoma of the fallopian tube diagnosed in 2019. She initially presented with lower extremity weakness, thought to be Guillain-Barré syndrome. She underwent MR spine, which was notable for a pelvic mass. PET-CT revealed hypermetabolic appearance of abdominal and mediastinal lymph nodes and a right lung nodule. She underwent surgical debulking of the pelvic mass, wedge resection of the right lung, and extensive lymph node dissection. This was followed by chemotherapy with carboplatin and paclitaxel. Final pathology reported a high-grade serous carcinoma of the fallopian tube. The right lung nodule was noted to be a histoplasma granuloma. She had a good response to the initial management. Approximately two years after initial diagnosis, the patient had rising CA-125 and subsequent imaging revealed new pulmonary nodules with enlarged necrotic appearing mediastinal and retroperitoneal lymph nodes. She was hesitant to start chemotherapy without confirmation of recurrence. She underwent endobronchial ultrasound (EBUS) with bronchoscopy, which confirmed enlarged mediastinal lymph nodes and biopsies were performed. The lymph node at the 4R station was 24mm in size with distinct cystic changes. Fine needle aspiration was performed, and it yielded 3ml of yellow-colored fluid. The final pathology showed high-grade adenocarcinoma of gynecologic origin with cells positive for PAX8, CK-7 and p53. The patient returned to the care of her oncologist to undergo further chemotherapy. DISCUSSION: Fallopian tube carcinoma is an uncommon gynecological malignancy, with very few reported cases of metastasis to the mediastinum. There is a limited understanding of the manifestations of the disease, especially regarding the characteristics of distant metastasis. Our patient had delayed recurrence of this cancer and imaging demonstrated distant metastasis to the mediastinal lymph nodes. We are presenting ultrasound characteristics of mediastinal lymph nodes in metastatic serous fallopian tube cancer with cystic changes and EBUS guided aspiration of fluid. After an extensive literature search, a case with similar findings was not found. CONCLUSIONS: Cystic changes in malignant lymph nodes are uncommon. This case demonstrates the importance of bronchoscopy and EBUS in the investigation of gynecological malignancies which are metastatic to the mediastinum. REFERENCE #1: Zhang B, Liu R, Li T, et al. Anterior mediastinal metastasis of primary fallopian tube adenocarcinoma: a case report. J Cardiothorac Surg. 2020;15(1):77. Published 2020 May 11. doi:10.1186/s13019-020-01111-4 DISCLOSURES: No relevant relationships by Zaid Ansari, source=Web Response No relevant relationships by Sharjeel Israr, source=Web Response No relevant relationships by Ashish Sadolikar, source=Web Response No relevant relationships by Ali Saeed, source=Web Response No relevant relationships by Hursh Sarma, source=Web Response No relevant relationships by Cindrel Tharumia Jagadeesan, source=Web Response

Study of spectrum of neoplastic and non-neoplastic lesions in fallopian tube in a tertiary care hospital

Background: Fallopian tubes are affected by a wide spectrum of diseases varying from salpingitis to carcinoma. Most pathological processes involving the fallopian tube are inflammatory and are of clinical significance because they interfere with the function of the fallopian tube and result in infertility. Although fallopian tube is affected by a wide spectrum of diseases, a literature search reveals that there are only occasional studies, documenting histologic changes in the fallopian tube removed for all reasons. This prompts the present study. The aim is to study the gross and microscopic features of the excised fallopian tubes and to study the common and unusual lesions in them and to study the frequency of histological findings and relative frequencies of different findings. Materials and methods: Four hundred and forty-five cases of fallopian tubes that were removed were studied retrospectively, and their histopathological findings documented. Results: The majority of the fallopian tubes had inflammatory changes comprised of acute and chronic salpingitis, salpingitis isthmica nodosa, tuberculous salpingitis, xanthogranulomatous salpingitis, hematosalpinx, and hydrosalpinx. Sixteen cases comprised of ectopic pregnancy. One case of primary fallopian tube adenocarcinoma and two cases of metastatic adenocarcinoma. Conclusion: The majority of the fallopian tubes remain unremarkable in a majority of the surgical pathology specimens, yet the fallopian tube must be subjected to a thorough histopathological examination to evaluate the various pathological lesions.

Primary Fallopian Tube Adenocarcinoma Discovered with the Vaginal Cytology: A Case Report with Pathological and Immunohistochemical Investigation

Background: Primary fallopian tube cancer is an extremely rare gynecological malignancy. Aim: To discuss, through a case report, the diagnostic process by means of cytology immunohistochemistry. Case Presentation: A 47-year-old Japanese woman, who also had lung cancer, presented with enlarged para-aortic lymph node without any symptoms. Based on the vaginal cytology report suggestive of gynecologic malignant tumor (possibly fallopian tube adenocarcinoma), primary surgery comprised of total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histopathology and immunohistochemistry examinations revealed primary fallopian tube carcinoma with metastasis of para-aortic lymph node. She is free from recurrence and metastases 9 months after the surgery and chemotherapy. Conclusion: Although primary fallopian tube cancer is a rare gynecologic malignancy, vaginal cytology may be useful for detecting fallopian tube carcinoma.

Primary Adenocarcinoma of the Fallopian Tube: Report of Two Cases

Primary fallopian tube cancer is the rarest cancer of female genital tract. In fact, it represents less than 1% of all the gynaecological and breast cancers. Adenocarcinoma is the most common histological type. This paper revels two cases of primary fallopian tube adenocarcinoma. They are diagnosed in pathology department. There are two patients to 53 years and 62 years respectively, with no significant personal or family history. They are consulted for chronic pelvic pain with pelvic mass. The clinical assessment revealed an abdomino-pelvic mass of hard consistency. We review the epidemiological, clinical, anatomo-pathological, therapeutic and prognosis specificities of this tumor. This cancer occurs in patients in their sixties, in a context of infertility, pauci-parity, chronic tubal infection or a genetic predisposition. The pelvic pain and the perception of a pelvic mass are the most frequent clinical manifestations. Paraclinical examinations (pelvic ultrasound, CT, MRI and serum markers) are not specific and diagnosis is often made peroperatively or postoperatively by anatomo-pathological examination. In fact, the tubal carcinoma is often confused with his ovarian counterpart which have several similarities. The prognosis is relatively dark, but still better than ovarian carcinoma. It mainly depends on the stage of disease and quality of surgical resection.

Spinal Metastases from a Primary Fallopian Tube Serous Adenocarcinoma: A Case Report

Study Design Case report. Objective This case exemplifies the importance of a high index of suspicion when dealing with intractable pain and neurologic symptoms in patients with a history of cancer. Fallopian tube cancer is relatively uncommon, accounting for less than 0.2% of all female malignancies. Because of a low index of suspicion, it is often detected at an advanced stage. From an orthopedic perspective, osseous metastasis from primary fallopian tube malignancies is rare with only a few documented cases in the medical literature. Methods This case report documents a 68-year-old woman who developed back pain and leg weakness after undergoing surgical resection with adjuvant therapy of a primary fallopian tube adenocarcinoma. Her hospital course and follow-up are documented. Results Imaging revealed a compression fracture in the L1 vertebral body that when a biopsy confirmed a soft tissue diagnosis of a high-grade serous papillary adenocarcinoma of fallopian tube origin. The patient underwent a surgical decompression, posterior stabilization, and tumor debulking with postoperative resolution of her symptoms. Conclusions This is the first reported case of a spine metastasis from a fallopian tube serous carcinoma in a living patient. This case documents the diagnosis of a pathologic vertebral fracture due to metastasis of an atypical cancer.

A rare primary malignant tumor of fallopian tube

Primary adenocarcinoma of fallopian tube is one of the rarest and accounts for about 1% of all gynecological malignancies. We are presenting this rare case of the primary fallopian tubal carcinoma. A 60-year-old female patient with para 2 visited the Gynecologic and Obstetric Department with the complaints of white discharge and abdominal pain since 4 months duration. Radiological study suggested hydrometra with polypoidal growth in the left adnexa suggestive of malignant lesion. The patient und

A Case Report Of Fallopian Tubal Carcinoma

Primary adenocarcinoma of fallopian tube is one of the rarest gynaecological malignancies. Its incidence is under estimated because advanced tumors usually spread to ovaries are often wrongly diagnosed as ovarian tumor. We are presenting this rare case of Primary Fallopian Tubal Carcinoma(PFTC).

Primary adenocarcinoma of fallopian tube

Primary adenocarcinoma of fallopian tube

Primary fallopian tube adenocarcinoma with brain and lung metastasis

Primary fallopian tube adenocarcinoma with brain and lung metastasis

Fallopian tube carcinoma

Primary adenocarcinoma of Fallopian tube is a rare gynecological malignancy affecting women in the fifth and sixth decades of their lives. The rarity of this type of carcinoma has prompted reports of individual cases rather than publication of a large series. One such case is reported in a 50-year-old nulliparous post-menopausal female. The age, low fertility index and presentation of the disease are in accordance with previous reports in the literature. The present case also fulfills the diagnostic criteria's applied to this tumor.

Sister Mary Joseph’s nodule as the first presenting sign of primary fallopian tube adenocarcinoma

Umbilical metastasis (Sister Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of Sister Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, Sister Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of Sister Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.

Overexpression of p53 and HER-2/neu and c-myc in Primary Fallopian Tube Carcinoma

Primary fallopian tube carcinoma is a rare form of female cancer and the genetic basis of its carcinogenesis remains unclear. Eighteen cases of primary fallopian tube adenocarcinoma were studied. Immunohistochemical staining for p53, HER-2/neu and c-myc genes were performed. Overexpression of p53 was detected in 12 cases (67%), HER-2/neu in 16 cases (89%), and c-myc in 11 cases (61%). The potential relevance of overexpression of the three genes with clinicopathological features was examined, but no significant correlation was found. The high incidence of p53, HER-2/neu and c-myc overexpression in fallopian tube adenocarcinoma suggests these genes may play a role in its tumorigenesis.

Surgico-pathological stage I primary fallopian tube adenocarcinoma

Due to the rarity of primary fallopian tube Ž . adenocarcinoma PFTA , the optimal management has not been well defined, especially in the early-stage of the disease. Furthermore, the role of adjuvant therapy in the early-stage of the disw x ease has not shown a benefit in survival 1 . It may be contributed partly to underestimated staging, or ineffective adjuvant therapy. For evaluating the value of adjuvant therapy, we retrospectively studied the patients with proven surgicopathological stage I PFTA. Eleven patients from 1970 to 1995 were confirmed to have full surgical staging I after receiving a complete, thorough surgical staging surgery including washing cytology, abdominal total hysterectomy, bilateral salpingo-oophorectomy, partial omentectomy, retroperitoneal lymphadenectomy and excisional

P53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma

Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tumours with mutant and wild-type p53 was 25.74% (median) and 12.55% (median) respectively.

Primary Fallopian Tube Adenocarcinoma: Clinical Complete Response after Salvage Treatment with High-Dose Paclitaxel

This Case Report describes a patient with primary fallopian tube cancer who had a late recurrence of pelvic disease following adjuvant chemotherapy for early-stage disease. Secondary cytoreductive surgery was suboptimal. The bulky residual disease was refractory to platinum-based therapy. Extention of the disease to the retroperitoneum resulted in obstructed venous return, ureteral obstruction, and renal infection. The latter necessitated a third laparotomy and a nephrectomy. Upon recovery from surgery and failure of platinum reinduction, the patient was treated with high-dose paclitaxel. The large pelvic mass regressed rapidly and completely. Current chemotherapy for fallopian tube cancer is briefly reviewed.

Primary fallopian tube adenocarcinoma in situ associated with adjuvant tamoxifen therapy for breast carcinoma

We report the first case of primary fallopian tube adenocarcinoma in situ in a patient who had received antiestrogen tamoxifen as adjuvant therapy for breast carcinoma. Clinical and in vivo animal model studies, referable to the possible estrogen agonist effect of tamoxifen on the female genital tract, are also reviewed.

Primary Fallopian Tube Adenocarcinoma in Situ Associated with Adjuvant Tamoxifen Therapy for Breast Carcinoma

We report the first case of primary fallopian tube adenocarcinoma in situ in a patient who had received antiestrogen tamoxifen as adjuvant therapy for breast carcinoma. Clinical and in vivo animal model studies, referable to the possible estrogen agonist effect of tamoxifen on the female genital tract, are also reviewed.

Supraclavicular lymph node metastasis as the first presentation of primary fallopian tube adenocarcinoma

(1989). Supraclavicular lymph node metastasis as the first presentation of primary fallopian tube adenocarcinoma. Journal of Obstetrics and Gynaecology: Vol. 9, No. 3, pp. 258-259.