Cryptococcus neoformans (anamorph) or Filobasidiella neoformans (teleomorph) is an environmentally, worldwide distributed encapsulated yeast (Kwon-Chung KJ, Mycologia 1975; 67: 1197–200, Neuville S et al., Clin Infect Dis 2003; 36: 337–47, Findley K et al., Eucaryot Cell 2009; 8: 353–61). Usually, it is recovered from soil contaminated with avian excreta, especially pigeon droppings, and decaying wood, fruits, vegetables and dust (Neuville S et al., Clin Infect Dis 2003; 36: 337–47). The main portal of entry is the respiratory tract. Lungs constitute the primary site of infection, whereas, disseminated meningoencephalitis represents the most common clinical manifestation in patients with AIDS. Cutaneous cryptococcosis is distinguished into skin lesion confined to a limited body region associated with a skin portal of entry, without signs of simultaneous dissemination (primary cutaneous cryptococcosis, PCC), and into skin manifestation due to haematogenous dissemination (secondary cutaneous cryptococcosis, SCC) commonly seen in patients with underlying diseases (Neuville S et al., Clin Infect Dis 2003; 36: 337–47; Xiujiao X and Ai e X, Mycoses 2005; 48: 238– 41). The clinical, mycological and therapeutic characteristics of two cases of PCC are presented.