Primary Control Research Articles

Bending/force switching control of pneumatic soft actuator based on multi-sensor fusion

Abstract The soft actuator has unlimited freedom, and can realize the grasping of irregular or fragile objects. A pneumatic soft actuator is designed in this paper, which consists of a series of symmetrically distributed pneumatic chambers. The soft actuator consists of a top expansion layer composed of 20 chambers and a bottom restraint layer. The Yeoh model and the finite element method (FEM) were employed to analyze the bending of the soft actuator. To improve the tracking performance, a PID strategy of the endocrine system (ES-PID) based on the neuroendocrine thyroid hormone regulation mechanism was constructed to tune the bending deformation. To achieve steady and precise force control, a bending/force switching control algorithm based on multi-sensor fusion is designed to realize high control accuracy. The bending/force switching control strategy mainly consists of two feedback loops for bending control, a force control, and a switching control. In the experimental process, the bending control is the primary control, and the force control is the primary control when the switching condition is satisfied. In order to prevent the occurrence of a false switching action, a switching factor is constructed using the method of successive comparison of neighboring values. Finally, several experiments are carried out to verify the effectiveness and feasibility of the control algorithm.

Ground beetle trophic interactions alter available nitrogen in forest soil

It is generally held that microbes exert primary control over nitrogen availability in temperate forests. Yet the role of soil and litter‐dwelling invertebrates to provide additional control via the breakdown of organic matter is an area of current exploration. Through trophic interactions within soil food webs, predators may indirectly affect prey with cascading effects on litter breakdown and nitrogen availability. The importance of these interactions, however, may be context‐dependent, varying with the stage of forest development and associated decomposer species composition given that young and old forests have vast differences in nitrogen availability, vegetation litter, soil properties and invertebrate functional groups. We examined ground beetle control over soil nitrogen and soil properties using a 68‐day mesocosm experiment that manipulated trophic structure (omnivore + predator beetles, predator beetles, and no beetles) in a young and old forest stand in the northeastern United States. In the young forest, net nitrogen mineralization decreased under predator + omnivore and the bulk soil C:N ratio in the old forest. However, we found no response in either forest context to the predator only treatment. Our study demonstrates the potential for ground beetles to strongly impact nitrogen availability and soil properties in forest ecosystems. Therefore, animal trophic interactions and their contexts must be included in our paradigm of nutrient cycles in temperate forests.

An observational analysis of the impact of deltamethrin + piperonyl butoxide insecticide-treated nets on malaria case incidence and entomological indicators in Ebonyi State, Nigeria, 2017–2021

BackgroundIntense pyrethroid resistance threatens the effectiveness of the primary vector control intervention, insecticide-treated nets (ITNs), in Nigeria, the country with the largest malaria burden globally. In this study, the epidemiological and entomological impact of a new type of ITN (piperonyl-butoxide [PBO] ITNs) distributed in Ebonyi State were evaluated. The epidemiological impact was also compared to the impact of standard pyrethroid-only ITNs in Cross River State.MethodsA controlled interrupted time series analysis was conducted on monthly malaria incidence data collected at the health facility level, using a multilevel mixed-effects negative binomial model. Data were analysed two years before and after the PBO ITN campaign in Ebonyi State (December 2017 to November 2021). A pre-post analysis, with no comparison group, was used to assess the impact of PBO ITNs on human biting rates and indoor resting density in Ebonyi during the high transmission season immediately before and after the PBO ITN campaign.ResultsIn Ebonyi, PBO ITNs were associated with a 46.7% decrease (95%CI: -51.5, -40.8%; p < 0.001) in malaria case incidence in the 2 years after the PBO ITN distribution compared to a modelled scenario of no ITNs distributed, with a significant decrease from 269.6 predicted cases per 1000 population to 143.6. In Cross River, there was a significant 28.6% increase (95%CI: -10.4, 49.1%; p < 0.001) in malaria case incidence following the standard ITN distribution, with an increase from 71.2 predicted cases per 1000 population to 91.6. In Ebonyi, the human biting rate was 72% lower (IRR: 0.28; 95%CI 0.21, 0.39; p < 0.001) and indoor resting density was 73% lower (IRR: 0.27; 95%CI 0.21, 0.35; p < 0.001) after the PBO ITNs were distributed.ConclusionsThe epidemiological and entomological impact of the PBO ITNs underscore the impact of these ITNs in areas with confirmed pyrethroid resistance. These findings contribute to ongoing research on the impact of new types of ITNs in Nigeria, providing critical evidence for the Nigeria National Malaria Elimination Programme and other countries for future ITN procurement decisions as part of mass ITN campaign planning and malaria programming.

Experimental investigation on wind loads and wind-induced responses of large-span flexible photovoltaic support structure

Flexible photovoltaic (PV) support structure offers benefits such as low construction costs, large span length, high clearance, and high adaptability to complex terrains. However, due to the high flexibility and low damping of the cable system, wind load becomes the primary control factor for structural safety and the key consideration in the design. In this study, a 45 m span flexible PV support structure with 3 spans and 12 rows was designed. The wind loads on PV panels were obtained by wind tunnel tests on a rigid model and the wind-induced responses were investigated by wind tunnel tests on an aeroelastic model. The shielding effects and tilt angle of PV modules on the wind load and wind-induced vibration of the flexible PV support were studied. The experimental results show that in the rigid model wind tunnel test, the wind pressure on the surface of PV modules exhibits a gradient distribution along the direction of wind flow, with symmetric distribution along the mid span. With the increase in the tilt angle of the PV module, the shielding effect becomes significant and the most pronounced shielding effect on the mean wind pressure coefficient occurs in the second row of the windward zone. In aeroelastic model wind tunnel tests, the mean vertical displacement of the flexible PV support structure increases with the increase of wind speed and tilt angle of PV modules. Due to the wind-resistant anchor cables set in both the windward and leeward zones, the vibration amplitude near the edge rows is significantly smaller than that of the middle rows when the structure is subjected to wind suction. When the flexible PV support structure is subjected to wind pressure, the maximum mean vertical displacement occurs in the first rows at high wind speeds. The shielding effect has a noticeable impact on the wind-induced response of the leeward zone at α = 20° under wind pressure, resulting in the decrease of amplitude vibration by approximately 53 %. The wind vibration coefficients in different zones under the wind pressure or wind suction are mostly between 2.0 and 2.15. Compared with the experimental results, the current Chinese national standards are relatively conservative in the equivalent static wind loads of flexible PV support structure.

Rapid phase current sampling in a permanent magnet synchronous motor servo system utilizing flexible memory controller bus

Background The permanent magnet synchronous motor (PMSM) servo system, integral to robots and other high-precision motion control applications, has its performance directly influenced by the current loop in the PMSM servo system. Though the theoretical adjustment time of the current loop can approach the electrical time constant of PMSM in order of magnitude, constraints such as control frequency make the adjustment time significantly larger than this theoretical limit. Methods This paper introduces a PMSM servo system using a flexible memory controller (FMC) bus for rapid phase current sampling. It leverages an independent current sampling module, equipped with an external analog-to-digital (AD) conversion chip for precise sampling of the output phase current of the PMSM. The sampling precision is 16-bit with a range of 0-3V. The sampled signal is preprocessed by a field-programmable gate array (FPGA), with the phase current data finally transmitted to the primary control chip through the FMC bus. Results By implementing this rapid current sampling architecture, we have successfully reduced the current sampling time by 95.4% while maintaining sampling accuracy. This scheme also substantially shortens the microcontroller unit’s (MCU) interrupt response time, potentially enhancing the current loop's control frequency, ultimately increasing the current loop bandwidth to 20kHz. Conclusions In conclusion, the proposed PMSM servo system with rapid current sampling significantly enhances the performance of the current loop. This advancement in sampling efficiency and control frequency offers substantial improvements for high-precision motion control applications, making it a valuable contribution to the field.

Revealing Goal-Directed Neural Control of the Pharyngeal Phase of Swallowing.

Swallowing is considered a three-phase mechanism involving the oral, pharyngeal, and esophageal phases. The pharyngeal phase relies on highly coordinated movements in the pharynx and larynx to move food through the aerodigestive crossing. While the brainstem has been identified as the primary control center for the pharyngeal phase of swallowing, existing evidence suggests that the higher brain regions can contribute to controlling the pharyngeal phase of swallowing to match the motor response to the current context and task at hand. This suggests that the pharyngeal phase of swallowing cannot be exclusively reflexive or voluntary but can be regulated by the two neural controlling systems, goal-directed and non-goal-directed. This capability allows the pharyngeal phase of swallowing to adjust appropriately based on cognitive input, learned knowledge, and predictions. This paper reviews existing evidence and accordingly develops a novel perspective to explain these capabilities of the pharyngeal phase of swallowing. This paper aims (1) to integrate and comprehend the neurophysiological mechanisms involved in the pharyngeal phase of swallowing, (2) to explore the reflexive (non-goal-directed) and voluntary (goal-directed) neural systems of controlling the pharyngeal phase of swallowing, (3) to provide a clinical translation regarding the pathologies of these two systems, and (4) to highlight the existing gaps in this area that require attention in future research. This paper, in particular, aims to explore the complex neurophysiology of the pharyngeal phase of swallowing, as its breakdown can lead to serious consequences such as aspiration pneumonia or death.

Efficient power management strategies for AC/DC microgrids with multiple voltage buses for sustainable renewable energy integration

This study proposes a distinct coordination control and power management approach for hybrid residential microgrids (MGs). The method enhances the feasibility of hybrid MGs by reducing power loss on ILBCs. The MG has been modeled with solar and wind generators. The MG comprises multiple direct current (DC) and alternating current (AC) sub-microgrids (SMGs) with varying voltage levels. The coordination control and power management strategies for autonomous hybrid MGs with primary and secondary control levels. A novel technique is proposed to ensure seamless and precise power transfer among SMGs while minimizing the constant operation of ILBCs in islanded mode, with a focus on the secondary control level. The study uses MATLAB/Simulink to analyze on-grid, off-grid, and transient mode power transfer among MG. The MG has been operative during transient/faulty conditions. The results indicate that the proposed method demonstrates excellent adaptability in managing power flow.

Decentralized Goal-Function-Based Microgrid Primary Control with Voltage Harmonics Compensation

Decentralized Goal-Function-Based Microgrid Primary Control with Voltage Harmonics Compensation

Analysis of short- and long-term controls on the variability of event-based runoff coefficient

Study regionThis study focuses on the Ohio Region, which spans 11 states in the eastern United States. Study focusRunoff coefficients are crucial in hydrology, indicating the relationship between rainfall and runoff. Understanding their controls and variability is essential for water resource assessment, management strategies, and land use planning. This research examines factors influencing runoff coefficients and their trends in the Ohio region using data from the North American Land Data Assimilation System phase-2 (NLDAS-2) Mosaic Land Surface Model, covering 2000–2020. The analysis considers short-term controls, such as climatic features (rainfall intensity, amount, and duration), hydrological factors (antecedent soil moisture, drainage density, and curve number), topographic factors (drainage area, land use, slope, elevation), and watershed shape. Additionally, the study investigates trends in runoff coefficients and their long-term controls, including climatic factors and land use changes. New hydrological insights for the regionThe findings indicate that runoff coefficients increase with antecedent soil moisture and rainfall intensity. Higher elevations show lower runoff coefficients due to forested land use. Larger watersheds have lower runoff coefficients at low rainfall intensity but higher ones when intensity is high. Long-term trends reveal soil moisture as the primary control, with land cover changes as a secondary factor. This research deepens understanding of runoff coefficient dynamics and controls in the Ohio region. Future studies could explore the impacts of urbanization, reservoirs, evapotranspiration, and snowmelt on runoff coefficients.

A comparative study on the efficacy of different treatment methods for preventing vocal cord adhesion after laser treatment for glottic cancer

Objective:Comparing the primary tumor control, vocal function recovery, postoperative adhesion rate and degree of adhesion in early glottic cancer involving the anterior commissure treated with CO₂ laser staged and lateral surgery, one-stage surgery combined with laryngeal stent placement, and simple CO₂ laser excision. Methods:This study focuses on 83 patients with T1-2N0M0 stage glottic squamous cell carcinoma involving the anterior commissure who underwent CO₂ laser treatment. The study was divided into three groups: Group A with 15 cases, treated with staged resection surgery; Group B with 18 cases, treated with one-stage surgery combined with the placement of a silicone laryngeal stent; and Group C with 50 cases, treated with simple CO₂ laser excision. The Voice Handicap Index-10（VHI-10）, the GRBAS auditory-perceptual assessment, and the maximum phonation time（MPT） were used to evaluate the vocal function of the patients before and six months after surgery. The degree of vocal cord adhesion was assessed using the Cohen classification of vocal cord adhesion. Statistical analysis was performed to determine the differences in each indicator before and after surgery, and the primary tumor control rates among the three groups. Results:Local recurrence occurred in 1 case each in Groups A and B, and in 4 cases in Group C, with no distant metastasis observed. Postoperative vocal cord adhesion of varying degrees occurred in a total of 77 cases, with an adhesion rate of 73.3%（11/15） in Group A, 88.9%（16/18） in Group B, and 100%（50/50） in Group C. The postoperative vocal cord adhesion rate and degree in Group C were significantly higher than in Groups A and B. The postoperative VHI-10 scores in all three groups were significantly increased compared to preoperative scores（P<0.05）, and when compared between groups postoperatively, Group C was significantly worse than Groups A and B （P<0.05）. The postoperative maximum phonation time（MPT） in Group C was significantly reduced compared to preoperative and was markedly shorter than that of Groups A and B postoperatively（P<0.05）. The postoperative grades of G（Grade） and R（roughness） in Group C were significantly higher than preoperatively, indicating a noticeable deterioration in voice quality, and were also significantly worse than those postoperatively in Groups A and B, with all differences（P<0.05）. Conclusion:For early glottic cancer involving the anterior commissure, choosing staged surgery or one-stage surgery combined with the placement of a silicone anterior commissure laryngeal stent were better than simple laser tumor excision in terms of secondary vocal cord adhesion and voice function preservation.

In-tunnel pollutant concentration measurement and ventilation control indexes for highway tunnels in mountainous area: A case study of no.1 Qinling tunnel, China

The pollutant concentration and hygiene standards in mountain tunnels are key factors determining the ventilation effectiveness of tunnel operation. Previous studies have mainly focused on the spatiotemporal distribution patterns of in-tunnel pollutants, while research on ventilation control indexes for pollutants in long mountain tunnels are relatively limited. Therefore, this paper aims to discussing the hygiene control indexes for operational ventilation of mountain tunnels. Field tests were conducted in the No.1 Qinling Tunnel of Xi'an to Han zhong Highway in China, and the distribution laws of traffic flow, wind speed, and concentrations of particulate matter (PM), carbon monoxide (CO), and nitrogen oxide (NOX) were on-site measured. The spatiotemporal distribution characteristics of pollutants in the long mountain tunnel were revealed, and the ventilation hygiene control indexes for harmful gases were calculated and compared to those of urban highway tunnels. The results show that the traffic volume of operational highway tunnels in mountainous areas of China is increasing rapidly, and the particulate matter emitted from diesel vehicle exhaust will pose a threat to the normal environmental quality in the tunnel. The average value of CO base emission factor in 2000 for the upline of No.1 Qinling tunnel was 0.0019 m3/(veh·km) by back-calculation, and the annual decline rate of CO in the ventilation design for mountain highway tunnels should be 6 %–8 % and revised every 8 years. It is recommended to consider the geographical location and traffic conditions of mountain tunnels when calculating the air demand required for diluting NO2. NOx has basically replaced CO as the primary pollutant with the most significant impact on human health in mountain tunnels. It is recommended that NOX be considered as the primary hygiene control indicator in the ventilation design of mountain tunnels in China. The pollutant distribution and ventilation control indexes of mountain and urban highway tunnels are quite different, which should be treated differently in engineering applications. The research results can provide a significant reference for ventilation design and environmental evaluation of highway tunnels in mountainous areas.

The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain.

The primary cilium, a single microtubule-based organelle protruding from the cell surface and critical for neural development, also functions in adult neurons. While some dorsal root ganglion neurons elaborate a primary cilium, whether it is expressed by and functional in nociceptors is unknown. Recent studies have shown a role of Hedgehog, whose canonical signaling is primary cilium dependent, in nociceptor sensitization. We establish the presence of primary cilia in soma of rat nociceptors, where they contribute to mechanical threshold, prostaglandin E2 (PGE2)-induced hyperalgesia, and chemotherapy-induced neuropathic pain (CIPN). Intrathecal administration of siRNA targeting Ift88, a primary cilium-specific intra-flagellar transport (IFT) protein required for ciliary integrity, resulted in attenuation of Ift88 mRNA and nociceptor primary cilia. Attenuation of primary cilia was associated with an increase in mechanical nociceptive threshold in vivo, and decrease in nociceptor excitability in vitro, abrogation of hyperalgesia, and nociceptor sensitization induced by both a prototypical pronociceptive inflammatory mediator PGE2 and paclitaxel CIPN, in a sex-specific fashion. siRNA targeting Ift52, another IFT protein, and knockdown of NompB, the Drosophila Ift88 ortholog, also abrogated CIPN and reduced baseline mechanosensitivity, respectively, providing independent confirmation for primary cilia control of nociceptor function. Hedgehog-induced hyperalgesia is attenuated by Ift88 siRNA, supporting a role for primary cilia in Hedgehog-induced hyperalgesia. Attenuation of CIPN by cyclopamine (intradermal and intra-ganglion), which inhibits Hedgehog signaling, supports a role of Hedgehog in CIPN. Our findings support a role of the nociceptor primary cilium in control of mechanical nociceptive threshold and inflammatory and neuropathic pain, the latter Hedgehog-dependent.Significance statement Many neurons have a tiny antenna-like structure, the primary cilium, protruding from their cell body, which processes information about the extracellular environment as well as regulates intracellular signaling. We report experiments aimed at understanding the role of the primary cilium in pain sensory neurons (nociceptors), including in the setting of inflammatory and neuropathic pain. We establish that nociceptors bear a primary cilium and show that this organelle regulates detection of noxious stimuli and contributes to nociceptor sensitization, using both the rat and the fruit fly as model organisms to manipulate primary cilia in pain states. We also identify primary cilium dependence of the contribution of Hedgehog to pain states.

Effects of cohesion and viscosity on lava dome growth following repose

Lava domes result from effusive eruption of high viscosity lava. These viscous lava extrusions range in shape from flat-topped domes with small height-to-width aspect ratios, to spine-like columns exhibiting large height-to-width aspect ratios. A primary control on morphology during early dome growth is thought to be the variation in rheological characteristics of extruded material. In this work, we present new scaled analogue models of lava dome growth that consider extrusion of a frictional plastic upper-conduit plug followed by viscous magma. We simulate the brittle plug using a sand-plaster mixture, the cohesion of which is varied by plaster content. We model the magma using sugar syrup, the viscosity of which is controlled by the weight percent of added crystalline sugar. The models both qualitatively and quantitatively reproduce part of the spectrum of natural dome morphology not previously obtained in most past analogue modelling studies. Model aspect ratios of 0.02 to 0.9 capture approximately 90 % of the reported aspect ratio variation in nature. Increasing plug cohesion results in extrusions with higher aspect ratios and spinier morphologies. Low viscosity fluid typically erupts through the brittle dome, whilst high viscosity fluid tends to promote endogenous growth or emerge as exogenous lobes. Particle Image Velocimetry shows that fracture localisation at the dome surface is cohesion-dependent, and eruption of fluid follows shear fractures within the dome. Where fluid remains contained within the dome, we see lateral spread leading to a wider and flatter dome morphology. Evolution of lava dome morphology, deformation, and associated hazards is guided by the complex rheological properties of the extruded material; we suggest that during episodic dome growth, these properties are largely defined in the conduit prior to their eruption.

Enrichment Mechanism of Polymetallic Elements at the Base of the Niutitang Formation in Southeast Chongqing

Polymetallic enrichment layers are commonly found at the base of the Lower Cambrian and extensively distributed across the Upper Yangtze Platform, yet their genetic models remain controversial. This study systematically collected samples from a typical section in the southeastern Chongqing region for mineral, organic, and inorganic analyses. It investigates the relationship between the abundance of various trace metal elements and organic matter at the base of the Niutitang Formation, as well as the vertical distribution characteristics of organic carbon isotopes and organic matter features. The results indicate that the Niutitang Formation shale exhibits a distinct three-part structure from bottom to top. Various metal elements are enriched in the lower interval, showing a close correlation between the abundance of polymetallic elements and the carbon isotopes of shale organic matter. The middle interval contains the highest TOC value and the lowest Ti/Al ratio, while the upper interval shows a significant decrease in organic matter abundance, with a clear positive correlation between the excess silicon content and Ti/Al ratio. Additionally, the mixing effect of deep-sea upwelling is the primary control on the formation of polymetallic enrichment layers in the lower interval, followed by the adsorption of organic matter under anoxic conditions. The sedimentary environment of the upper interval of the Niutitang Formation trends toward oxidation, with paleoclimate shifting toward colder and drier conditions, exhibiting aeolian sedimentary features that are unfavorable for the enrichment of trace metal elements. Consequently, upwelling is a key factor in the enrichment and mineralization of trace metal elements at the base of the Lower Cambrian in the Upper Yangtze region.

Real-Time Co-Simulation Implementation for Voltage and Frequency Regulation in Standalone AC Microgrid with Communication Network Performance Analysis across Traffic Variations

Effective communication networks are crucial for ensuring reliable and stable operation and control in smart microgrids (MGs). This paper proposes a comprehensive analysis of the interdependence between power and communication networks in the real-time control of a standalone AC microgrid to address this vital need. Thus, the role of communication network design is emphasized in facilitating an effective centralized secondary control to regulate the voltage and frequency of an MG. Consequently, voltage and frequency deviations from the droop-based primary control should be eliminated. This study employs a real-time co-simulation testbed setup that integrates OPAL-RT and network simulator (ns-3), supporting a rigorous evaluation of the interplay between the communication networks and control within the MG. Experiments have been conducted to demonstrate the effectiveness of the designed communication infrastructure in seamlessly enabling real-time data exchange among the primary and secondary control layers. Testing scenarios have been implemented, encompassing low-traffic patterns with minimal load variations and high traffic characterized by more frequent and severe load changes. The experimental results highlight the significant impact of traffic variations on communication network performance. Despite the increase in traffic, the effectiveness and reliability of the designed communication network have been validated, underscoring the vital role of communication in ensuring the resilient and stable operation of cyber–physical standalone AC microgrids.

Research on the aerodynamic characteristics of electrically controlled rotor under Parallel Blade Vortex Interaction using Lattice Boltzmann Method

An electrically controlled rotor (ECR), also known as a swashplateless rotor, employs a trailing edge flap (TEF) system for primary rotor control instead of a swashplate, demonstrating the significant potential in rotor vibration and noise reduction. To investigate the aerodynamic characteristics of the blade flap segment of the ECR under parallel blade vortex interaction, an aerodynamic analysis model based on the lattice Boltzmann method (LBM) is established using the D3Q27 lattice model. The model is validated against experimental data of both the airfoil with trailing edge flap and conventional airfoil under vortex interaction, showing that the LBM can effectively predict variations in aerodynamic loads under both conditions. Based on this model, the effects of different flap deflection angles and miss distances on the aerodynamic characteristics of the ECR under parallel BVI are analyzed. The results indicate that under strong vortex interaction, a region of flow separation forms due to the entrainment effect of the vortex and adverse pressure gradient. The small-scale vortex structure upstream of the flap can also be observed and is believed to contribute to the unsteady flow phenomena such as vortex structure splitting, development, and separation on the upper surface of the flap. The different flap deflection angles mainly affect the scale and type of vortex structures developed on the flap upper surface. As the miss distance increases, the interaction effect is significantly weakened compared to strong vortex interaction. However, as the vortex moves downstream along the airfoil lower surface, it entrains vorticity from the lower surface, ultimately forming a negative pressure region on the lower surface of the flap. The different flap deflection angles will influence the structural characteristics during the downstream motion of the vortex, which changes the size of the negative pressure region, causing differences in the magnitude of the variations in aerodynamic parameters.

Long-term oxygen therapy in precapillary pulmonary hypertension – SOPHA study

Current guidelines recommend oxygen (O2) supplementation in patients with pulmonary hypertension (PH), despite scarce data on long-term O2 therapy (LTOT). The aim of this prospective, randomized, controlled trial was to investigate the effect of LTOT in patients with precapillary PH on exercise capacity, clinical parameters and hemodynamics. Patients with precapillary PH under stable therapy and O2 desaturations at rest and/or during exercise were randomized to receive LTOT (≥ 16 h/day) or no O2 (control group) for 12 weeks. The control group was offered LTOT after 12 weeks. The primary endpoint changes of 6-minute walking distance (6MWD) from baseline to 12 weeks was hierarchically tested: (1) pre-post primary and secondary intervention (2) intervention vs. control group. Secondary endpoints included changes in clinical parameters. Twenty patients were randomized (women n = 14, age 67 ± 11.4 years, mean pulmonary arterial pressure 39.7 ± 12.5 mmHg, 70% functional class III). 6MWD significantly improved by 42.2 ± 34.20 m (p = 0.003) within 12 weeks LTOT. The intervention group significantly improved in 6MWD (38.9 ± 33.87 m) compared to the control group (− 12.3 ± 21.83 m, p = 0.015). No consistent between-group differences in other parameters were found. LTOT was well tolerated and led to significant improvement of 6MWD. The effect of LTOT should be investigated in larger controlled-trials.

Performance Study of Asphalt Mixtures Reinforced with Gradated Basalt Fibers of Mixed Lengths

The length of basalt fibers affects the performance of asphalt mixtures. To explore the influence of different lengths of basalt fibers on the performance of asphalt mixtures, this study selected basalt fibers with lengths of 6 mm, 9 mm, and 12 mm to design gradations that were incorporated into asphalt mixtures to prepare specimens. High-temperature rutting tests, immersion Marshall tests, freeze-thaw splitting tests, and low-temperature splitting tests were conducted, resulting in 11 test mix designs and 12 test indicators. Then, a multi-objective grey target decision method was used to optimize the optimal combination ratio of basalt fiber lengths. The results indicate that compared to asphalt mixtures with single-length basalt fibers, incorporating well-combined basalt fibers significantly enhances the high-temperature, low-temperature, and water stability performance of asphalt mixtures. According to the grey target decision method, this study determined that a basalt fiber combination ratio of 3:4:3 for lengths of 6 mm, 9 mm, and 12 mm provides the best overall performance of asphalt mixtures. Additionally, when designing asphalt mixtures with graded basalt fibers, the inclusion of 9 mm fibers should be the primary control point. These research findings provide important guidance for the enhanced application of basalt fibers in road engineering.

Deterrent Effects of Clary Sage Oil and Two Major Constituents against Drosophila suzukii (Diptera: Drosophilidae).

Drosophila suzukii (Diptera: Drosophilidae), spotted-wing drosophila, poses a significant threat to soft-skinned fruit crops in the Americas, Europe, Africa, and Oceania, as well as in Asia. The application of chemical insecticides is the primary control strategy for D. suzukii; however, resistance has developed with the indiscriminate use of chemical insecticides. Essential oils, considered potential alternatives to pesticidal strategies, exhibit potent toxic and sublethal behavioral effects against numerous pests, including D. suzukii. Clary sage oil repels a variety of agricultural and household pests; however, whether it has a repellent effect against D. suzukii remains unknown. Here, we found that clary sage oil exhibited dose-dependent repellency against D. suzukii adults in a T-maze assay, a two-choice assay and a two-choice attraction assay. Also, clary sage oil showed a significant repellent effect against D. suzukii larvae. Next, we explored the chemical constituents of clary sage oil by GC-MS and identified two major constituents, linalyl acetate (40.03%) and linalool (23.02%). Furthermore, the behavioral assays of linalyl acetate and linalool showed that both compounds conferred comparable repellency against D. suzukii adults and larvae. Finally, we found clary sage oil, linalyl acetate, and linalool elicited EAG responses in D. suzukii, especially clary sage oil, suggesting the repellency was mediated by the olfactory system. These findings indicate that D. suzukii shows olfactory-based behavioral avoidance of clary sage oil, linalyl acetate, and linalool. Clary sage oil and its major constituents may be possible alternatives in the management of D. suzukii.

Modeling Climate and Tectonic Controls on Bias in Measured River Incision Rates

AbstractRates of land surface processes provide insights into climatic and tectonic influences on topography. Bedrock incision rates are estimated by dating perched landforms such as strath terraces, assuming a constant bedrock incision rate from terrace abandonment to the next terrace level or present river level. These estimates express biases from the stochastic nature of sediment and water discharge in controlling river incision as well as from using a mobile channel elevation as a reference frame, leading to different incision rates when calculated over different timeframes. We introduce a 1‐D model incorporating fluvial mechanics, tectonics, sediment, and climate variability to predict these biases and assess their sensitivity to climate and tectonics. Findings suggest biases intensify under highly variable climates and slow rock uplift, with climate periodicity being a primary control for our modeled scenarios. Our model provides a mechanism to improve river incision measurement uncertainty, impacting paleoclimate and tectonic geomorphology reconstructions.