Primary Beam Research Articles

Review of Recent Advances in Gas-Assisted Focused Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry (FIB-TOF-SIMS).

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a powerful chemical characterization technique allowing for the distribution of all material components (including light and heavy elements and molecules) to be analyzed in 3D with nanoscale resolution. Furthermore, the sample's surface can be probed over a wide analytical area range (usually between 1 µm2 and 104 µm2) providing insights into local variations in sample composition, as well as giving a general overview of the sample's structure. Finally, as long as the sample's surface is flat and conductive, no additional sample preparation is needed prior to TOF-SIMS measurements. Despite many advantages, TOF-SIMS analysis can be challenging, especially in the case of weakly ionizing elements. Furthermore, mass interference, different component polarity of complex samples, and matrix effect are the main drawbacks of this technique. This implies a strong need for developing new methods, which could help improve TOF-SIMS signal quality and facilitate data interpretation. In this review, we primarily focus on gas-assisted TOF-SIMS, which has proven to have potential for overcoming most of the aforementioned difficulties. In particular, the recently proposed use of XeF2 during sample bombardment with a Ga+ primary ion beam exhibits outstanding properties, which can lead to significant positive secondary ion yield enhancement, separation of mass interference, and inversion of secondary ion charge polarity from negative to positive. The implementation of the presented experimental protocols can be easily achieved by upgrading commonly used focused ion beam/scanning electron microscopes (FIB/SEM) with a high vacuum (HV)-compatible TOF-SIMS detector and a commercial gas injection system (GIS), making it an attractive solution for both academic centers and the industrial sectors.

The role of low-energy electrons in the charging process of LISA test masses

The estimate of the total electron yield is fundamental for our understanding of the test-mass charging associated with cosmic rays in the Laser Interferometer Space Antenna (LISA) Pathfinder mission and in the forthcoming gravitational wave observatory LISA. To unveil the role of low energy electrons in this process owing to galactic and solar energetic particle events, in this work we study the interaction of keV and sub-keV electrons with a gold slab using a mixed Monte Carlo (MC) and ab-initio framework. We determine the energy spectrum of the electrons emerging from such a gold slab hit by a primary electron beam by considering the relevant energy loss mechanisms as well as the elastic scattering events. We also show that our results are consistent with experimental data and MC simulations carried out with the GEANT4-DNA toolkit.

Stability of MeV primary ion induced secondary ions

We report on the analysis of the onset and the intensity of metastable secondary ions, which are desorbed from the target material as a result of bombarding organic samples with MeV primary ions. The bimodal time-of-flight mass spectrometer, which can analyze secondary ion in linear and reflectron modes, was used for detection and characterization of such ions. The use of the bimodal mass spectrometer for this specific purpose is demonstrated on amino acid arginine, where three main fragments were detected. We have also analyzed the influence of the primary ion beam on the intensity of metastable ion signal. Results from chlorine ion beams with energies between 3 and 10 MeV have exhibited the importance of electronic sputtering on the product/precursor ion peak intensity ratio, which is significantly decreased when using primary ions with higher energy.

Long-term rates of biochemical recurrence after primary external beam radiation therapy (EBRT) for prostate cancer.

393 Background: Radiation therapy is a common form of treatment for men with prostate cancer. Biochemical recurrence (BCR) is most commonly defined using the Phoenix definition of PSA nadir + 2. We sought to characterize long term rates of biochemical recurrence in a large, well-characterized and well-followed cohort of men treated with primary EBRT. Methods: Patients enrolled in CaPSURE, a national registry of men diagnosed with prostate cancer, from 1995 - 2017 with clinically localized prostate cancer (cN0M0/X, PSA<=50) treated with primary EBRT were included. Cancer risk was defined by NCCN criteria. Cox proportional hazards regressions were used to assess associations between patient characteristics and BCR as defined by PSA nadir + 2. Results: 1193 patients were included. Mean age at diagnosis was 70 (SD 6.82), median PSA at diagnosis was 7.6 and mean number of follow up PSA tests was 5. Overall rates of BCR were 17.4% at 5 years and 39.4% at 10 years. Rates of BCR were significantly associated with NCCN risk with high-risk patients having the highest rates of recurrence, followed by intermediate- and low-risk groups (61.5%, 36.4% and 28.5% respectively at 10 years). NCCN high vs low clinical risk was significantly associated with likelihood of BCR (HR 4.8, CI 2.5 – 9.2). Rates of salvage treatment, usually ADT, were 16% at 5 years and 19% at 10 years and these were also significantly associated with NCCN high vs low clinical risk (HR 3.7, CI 2.3 – 6) and concurrent ADT (HR 1.83, CI 1.2 – 2.7). Overall rates of bone metastases were 2.6% at 5 years and 4% at 10 years. Overall prostate cancer specific mortality was 3% at 5 years and 7% at 10 years. Conclusions: In this analysis, rates of BCR were fairly high and consistent with published RTOG studies, but rates of salvage treatment were relatively low in comparison, indicating that not all patients who recur need, are offered or want treatment. The limitations of this analysis include incomplete information on radiation dose and field size. The strengths of this analysis include the size of the cohort and the length of follow-up. Furthermore, as this cohort largely represents treatment in community settings, the results may be broadly applicable.

Sexual function after primary external beam radiation therapy (EBRT) for prostate cancer in a large cohort of men with long-term follow-up.

346 Background: Clinically localized prostate cancer can be treated with prostatectomy, radiation or focal therapy, with known impacts on sexual function. We sought to characterize long term sexual function in a large cohort of men treated with primary EBRT and to differentiate between those who have high vs low sexual function scores at baseline. Methods: Patients enrolled in CaPSURE, a national registry of men diagnosed with prostate cancer, from 1995 - 2017 with clinically localized prostate cancer (cN0M0/X, PSA < = 50) and treated with primary EBRT were included. Sexual function (SF) was self-reported using the UCLA Prostate Cancer Index (PCI). We performed repeated measures mixed models to evaluate SF after EBRT, stratified by baseline SF and adjusted for age, BMI, comorbidities, smoking, clinical risk, receipt of brachytherapy and/or hormonal therapy, and type of clinical site. Results: 1193 patients were included for analysis. Mean age was 70, mean number of comorbidities was 2, and median PSA was 7.5 at diagnosis. Baseline PCI scores were available for 43% of the cohort (data not collected before 1998). The mean PCI score was 38 out of 100 at baseline and after EBRT, declined gradually to 16 by 10 years. When only those men with good SF at baseline were assessed (scores 80 – 100), the initial rate of decline was more severe, but the nadir in this group was higher than those with lower baseline scores. Unadjusted mean PCI scores showed a similar decline amongst both groups, although those with good baseline SF consistently had better scores. 63% of patients were treated for erectile dysfunction (PDE5 inhibitors, intracavernosal injections or both), 13% of whom started therapy before EBRT. In the repeated measures mixed models analysis, we found that SF changed significantly over time and scores differed significantly by age, comorbidities, baseline SF, receipt of brachytherapy boost and concurrent ADT. Conclusions: SF after EBRT declines and persists. The most affected are those who had better PCI scores at baseline, although their overall PCI scores are consistently higher compared to those with baseline scores less than 80. Among both groups however, there was a similar decline that was statistically significant.

Auto-commissioning of a Monte Carlo electron beam model with application to photon MLC shaped electron fields

Objective. Presently electron beam treatments are delivered using dedicated applicators. An alternative is the usage of the already installed photon multileaf collimator (pMLC) enabling efficient electron treatments. Currently, the commissioning of beam models is a manual and time-consuming process. In this work an auto-commissioning procedure for the Monte Carlo (MC) beam model part representing the beam above the pMLC is developed for TrueBeam systems with electron energies from 6 to 22 MeV. Approach. The analytical part of the electron beam model includes a main source representing the primary beam and a jaw source representing the head scatter contribution each consisting of an electron and a photon component, while MC radiation transport is performed for the pMLC. The auto-commissioning of this analytical part relies on information pre-determined from MC simulations, in-air dose profiles and absolute dose measurements in water for different field sizes and source to surface distances (SSDs). For validation calculated and measured dose distributions in water were compared for different field sizes, SSDs and beam energies for eight TrueBeam systems. Furthermore, a sternum case in an anthropomorphic phantom was considered and calculated and measured dose distributions were compared at different SSDs. Main results. Instead of the manual commissioning taking up to several days of calculation time and several hours of user time, the auto-commissioning is carried out in a few minutes. Measured and calculated dose distributions agree generally within 3% of maximum dose or 2 mm. The gamma passing rates for the sternum case ranged from 96% to 99% (3% (global)/2 mm criteria, 10% threshold). Significance. The auto-commissioning procedure was successfully implemented and applied to eight TrueBeam systems. The newly developed user-friendly auto-commissioning procedure allows an efficient commissioning of an MC electron beam model and eases the usage of advanced electron radiotherapy utilizing the pMLC for beam shaping.

Loading the tumor with 31P, 63Cu and 89Y provides an in vivo prompt gamma-based range verification for therapeutic protons

Introduction: The main rationale for using protons in cancer treatment is based on the highly conformal dose distribution and normal tissue spearing compared to conventional radiotherapy. The main limit of proton therapy is the particle range uncertainty due to patient setup, dose calculation and imaging. To account for this, a safety margin is added to the tumor to ensure the prescribed dose to the target. Reducing range uncertainties would result in the reduction of irradiation volume and would allow full exploitation of the proton therapy benefits. In this work, we presented a feasibility study for a strategy to achieve in vivo proton range verification based on prompt gammas (PG). This approach relies on the detection of signature prompt gammas, generated by the interaction of primary protons with a non-radioactive element, that is selectively loaded into a tumor with a drug carrier. The number of characteristic gammas is directly related to the proton range, and its measurement provides an estimate of the position at which the primary beam stops with respect to the tumor location.Method: We identified the criteria for selecting potential candidate materials and combined them with TALYS predictions to make the selection. We carried out an experimental campaign to characterize the PG spectra generated by the chosen materials when irradiated with therapeutic protons and compared them with TOPAS Monte Carlo toolkit predictions.Results: We identified 31-Phosphorous, 63-Copper and 89-Yttrium as potential candidates for this application based on TALYS calculations. The experimental data confirmed that all candidates emit signature prompt gammas different from water (here used as a proxy for normal tissue), and that the gamma yield is directly proportional to the element concentration in the solution. Four specific gamma lines were detected for both 31P (1.14, 1.26, 1.78, and 2.23 MeV) and 63Cu (0.96, 1.17, 1.24, 1.326 MeV), while only one for 89Y (1.06 MeV). The simulations indicate that the count of characteristic gammas is directly proportional to the proton range, reaching in some cases a saturation value around the tumor’s far edge. The results also indicate that to achieve a range accuracy below the current value of 2–3 mm, the uncertainty on the prompt gammas count has to be below 5% for 31-Phosphorous and 63-Copper, or 10% for 89-Yttrium.Discussion: We demonstrated that loading the tumor with a label element prior to proton treatment generates signature gammas that can be used to verify the beam range in vivo, reaching a potential range accuracy below the current limitations. This approach can be either used stand-alone or combined with other existing methodologies to further improve range resolution.

Self-focusing and self-splitting properties of partially coherent temporal pulses propagating in dispersive media.

Based on the coherence theory for non-stationary optical fields, we introduce a new class of partially coherent pulse sources with multi-cosine-Gaussian correlated Schell-model (MCGCSM) and derive the analytic expression for the temporally mutual coherence function (TMCF) of an MCGCSM pulse beam when it propagates through dispersive media. The temporally average intensity (TAI) and the temporal degree of coherence (TDOC) of the MCGCSM pulse beams spreading in dispersive media are investigated numerically, respectively. Our results show that over propagation distance, the evolution of pulse beams is from the primary single beam into multiple subpulses or form flat-topped TAI distributions by controlling source parameters. Moreover, when the chirp coefficient s < 0, the MCGCSM pulse beams through dispersive media will show the characteristics of two self-focusing processes. The reason why there are two self-focusing processes is explained from the perspective of physical meaning. The results in this paper can open the applications of pulse beams in multiple pulse shaping and laser micromachining and material processing.

Nuclear magnetic moment of the neutron-rich nucleus O21

The ground-state magnetic dipole moment of the neutron-rich $^{21}\mathrm{O}$ isotope has been measured via $\ensuremath{\beta}$-ray-detected nuclear magnetic resonance ($\ensuremath{\beta}\text{\ensuremath{-}}\mathrm{NMR}$) spectroscopy by using a spin-polarized secondary beam of $^{21}\mathrm{O}$ produced from the $^{22}\mathrm{Ne}$ primary beam. From the present measurement, the $g$ factor $|{g}_{\mathrm{exp}}(^{21}\mathrm{O}_{\mathrm{g}.\mathrm{s}.})|=0.6036(14)$ has been determined. Based on the comparison of this value with Schmidt values, we unambiguously confirm the $\ensuremath{\nu}{d}_{5/2}$ configuration with spin and parity assignments ${I}^{\ensuremath{\pi}}=5/{2}^{+}$ for the $^{21}\mathrm{O}$ ground state, suggested by previously reported studies. Consequently, the magnetic moment has been determined as ${\ensuremath{\mu}}_{\mathrm{exp}}(^{21}\mathrm{O}_{\mathrm{g}.\mathrm{s}.})=(\ensuremath{-})1.5090(35){\ensuremath{\mu}}_{N}$. The obtained experimental magnetic moment is in good agreement with the predictions of the shell-model calculations using the USD, YSOX, and SDPF-M interactions as well as random phase approximation (RPA) calculations. This observation indicates that the $^{21}\mathrm{O}$ nucleus in its ground state does not manifest any anomalous structure and is not influenced by the proximity of the drip line.

Compton scattering geometry: a tool to study radiation interaction characteristics of rare earth compounds doped in low-Z organic compound

Abstract The present measurements comprise of Compton scattering technique at six energies from 0.242 MeV to 0.402 MeV (not available from conventional radioisotopes) by scattering of primary gamma photon beam of 0.662 MeV energy from cylindrical aluminium target at different scattering angles. Two inorganic (rare-earth) compounds, Lanthanum (3+) nitrate hexahydrate and Samarium (3+) nitrate hexahydrate in a Low-Z organic solvent (acetone), have shown certain radiation interaction characteristics are the subject of study. The collimated beam of scattered gamma rays impinges on the plastic container having solution of rare earth compounds in the acetone of different concentrations. The transmitted gamma ray beam is detected by a well-collimated 2″ × 2″ NaI(Tl) scintillation detector and is analysed by a PC-based ORTEC Mastero-32 MCA. Attenuation coefficients along with some shielding parameters i.e. molar extinction coefficients, half value layer, tenth value layer and mean free path are evaluated. Besides this, Computed Tomography numbers and photon interaction cross-sections (photoelectric, coherent and incoherent) are also determined. The measured values of these parameters are compared with WinXCom software package’s values and are found to be in good agreement. The available data on rare earth salts’ solutions, in the current measurements, is scientifically important in nuclear and radiation physics, bridging the gap in which radiation workers do not have access to such data.

The Safety and Efficacy of Salvage Stereotactic Radiation Therapy in Patients with Intraprostatic Tumor Recurrence After Previous External Radiation Therapy: Phase 1 Results from the GETUG-AFU 31 Study

BackgroundThere is no consensus on the best local salvage treatment for prostate cancer recurrence after primary external beam radiotherapy. Prospective data on stereotactic body radiation therapy (SBRT) are very scarce. ObjectiveTo determine the optimal dose regimen for salvage SBRT. Design, setting, and participantsThe present report concerns the phase 1 part of the GETUG-AFU 31 multicenter open-label study. The main inclusion criteria were histologically proven biochemical recurrence, clinical stage T1-T2 upon relapse, multiparametric magnetic resonance imaging data, prostate-specific antigen (PSA) level ≤10 ng/ml prior to salvage SBRT, PSA doubling time >10 mo, and an International Prostate Symptom Score of ≤12. InterventionFive or six fractions of 6 Gy were delivered using focal SBRT. Outcome measurements and statistical analysisDose-limiting toxicity (DLT) was defined as grade ≥3 gastrointestinal or genitourinary tract toxicity, or any grade 4 toxicity (according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03) occurring in the first 18 wk following treatment initiation. A time-to-event continual reassessment method was used to select the dose regimen. Results and limitationsTwenty-one patients were treated (median [interquartile range] age: 76.8 yr [72.2–80.8]), including 12 at 6 × 6 dose level. No DLT was observed. The acute grade 2 genitourinary tract toxicity rate was 19%. With a median follow-up of 12.3 mo, the estimated cumulative incidence of late grade 2 genitourinary toxicity was 41.2% (95% confidence interval: 18.1–63.1%). No grade >2 genitourinary toxicity and no grade ≥2 gastrointestinal toxicity were reported. All treated patients were alive and relapse free at the last follow-up. ConclusionsA 6 × 6 Gy dose regimen was selected for our phase 2 study of salvage SBRT. With a short follow-up period, the level of toxicity appears to be acceptable. Patient summaryThere is no consensus on the best local treatment for patients with local relapse after radiotherapy for prostate cancer. Prospective data are very scarce. Our early phase trial allowed us to recommend six fractions of 6 Gy using high-precision radiotherapy for further studies.

All-sky modelling requirements for Bayesian 21 cm power spectrum estimation with bayeseor

ABSTRACT We present a comprehensive simulation-based study of the bayeseor code for 21 cm power spectrum recovery when analytically marginalizing over foreground parameters. To account for covariance between the 21 cm signal and contaminating foreground emission, bayeseor jointly constructs models for both signals within a Bayesian framework. Due to computational constraints, the forward model is constructed using a restricted field of view (FoV) in the image domain. When the only Epoch of Reionization contaminants are noise and foregrounds, we demonstrate that bayeseor can accurately recover the 21 cm power spectrum when the component of sky emission outside this forward-modelled region is downweighted by the beam at the level of the dynamic range between the foreground and 21 cm signals. However, when all-sky foreground emission is included along with a realistic instrument primary beam with sidelobes above this threshold extending to the horizon, the recovered power spectrum is contaminated by unmodelled sky emission outside the restricted FoV model. Expanding the combined cosmological and foreground model to cover the whole sky is computationally prohibitive. To address this, we present a modified version of bayeseor that allows for an all-sky foreground model, while the modelled 21 cm signal remains only within the primary FoV of the telescope. With this modification, it will be feasible to run an all-sky bayeseor analysis on a sizeable compute cluster. We also discuss several future directions for further reducing the need to model all-sky foregrounds, including wide-field foreground subtraction, an image-domain likelihood utilizing a tapering function, and instrument primary beam design.

MeerKAT Holography Measurements in the UHF, L, and S Bands

Radio holographic measurements using the MeerKAT telescope are presented for each of its supported observing bands, namely UHF (544–1087 MHz), L (856–1711 MHz), and S (1750–3499 MHz). Because the UHF-band receiver design is a scaled version of that of the L band, the electromagnetic performance in these two bands are expectedly similar to one another. Despite also being linearly polarized, S-band receivers have an entirely different design and distinct performance characteristics from the lower two bands. As introduced in previous work for the L band, evidence of higher order waveguide mode activation also appears in S-band measurements but there are differences in its manifestation. Frequency-dependent pointing (beam squint), beamwidth, beam ellipticity, error beam, instrumental polarization, and cross-polarization power measurements are illustrated for each of MeerKAT’s observational bands in a side-by-side style to facilitate the comparison of features. The derivation of collimation errors and main reflector surface errors from measurements made at these relatively low observation frequencies is also discussed. Results include elevation and ambient temperature effects on collimation, as well as the signatures of collimation degrading over time. The accompanying data release includes a snapshot of full Jones matrix primary beam patterns for all bands and antennas with corresponding derived metrics.

KOTO II at J-PARC : toward measurement of the branching ratio of

The KOTO II experiment at J-PARC is a next-generation experiment that is under design aiming at the measurement of the branching ratio of the decay. The KOTO II experiment is planned in the extended Hadron Experimental Facility at J-PARC using the second production target. With the second production target, the KL extraction angle of 5 degrees is chosen instead of 16 degrees in order to obtain a larger KL flux and harder KL momentum spectrum while keeping the same ratio of neutron and KL fluxes. To realize the extraction angle, the KOTO II detector is behind the primary beam dump. The KOTO II detector has a longer decay volume and a larger calorimeter to achieve a larger decay probability and higher acceptance of the KL decay. With the designed beam line and the detector, 40 signal events are expected for the branching ratio of 3×10−11 with 60 background events in the running period of 3 × 107 s, which corresponds to approximately 5-σ discovery of the decay.

Measurement of 2D density profiles using a second-harmonic, dispersion interferometer.

A second-harmonic, dispersion interferometer is used to image large-area (≃5cm2) plasma-jet and gas-jet density profiles. Achromatic telescopes magnify the diameters of the primary-laser beam (1064nm) and its second-harmonic (532nm) before probing the sample and de-magnify the beam diameters after the sample, where the primary beam transfers its phase change to a second, second-harmonic beam, allowing the sample's dispersive-phase change to be measured between two, orthogonally polarized second harmonic beams. The telescopes produce an azimuthally symmetric, dispersive-phase shift in the sample + background phase-change image and in the background phase-change image, which is removed by digital subtraction. The interferometer's performance was verified using standard-optical components as dispersive elements (BK7 lenses and wedge plates), resolving a minimum, phase-change sensitivity of Δϕmin ≳ 15 mrad and spatial resolution of Δxres ≃ 100μm. The phase change produced by unknown-density objects (a pulsed-plasma-jet and a pulsed-gas-jet) was measured, and their data were used to recover the original, 2D density profiles using an inverse Abel transform: peak-number density, Ngas ≃ 6 × 1020cm-3 and Ne ≃ 5 × 1016cm-3; line-integrated density, ∫Ngasdl ∼ 2 × 1019cm-2 and ∫Nedl ∼ 1 × 1016cm-2. The techniques and methods developed here are scalable to even larger probe-beam diameters and frame-capture rates, leading to a diagnostic capability that is well-suited for applications involving the real-time measurement of density.

Chemical Imaging of Organic Materials by MeV SIMS Using a Continuous Collimated Ion Beam

MeV SIMS is a type of secondary ion mass spectrometry (SIMS) technique where molecules are desorbed from the sample surface with ions of MeV energies. In this work, we present a novel system for molecular imaging of organic materials using a continuous analytical beam and a start trigger for timing based on the detection of secondary electrons. The sample is imaged by a collimated primary ion beam and scanning of the target with a lateral resolution of ∼20 μm. The mass of the analyzed molecules is determined with a reflectron-type time-of-flight (TOF) analyzer, where the START signal for the TOF measurement is generated by the secondary electrons emitted from a thin carbon foil (∼5 nm) placed over the beam collimator. With this new configuration of the MeV SIMS setup, a primary ion beam with the highest possible electronic stopping can be used (i.e., highest secondary molecular yield), and samples of any thickness can be analyzed. Since the electrons are collected from the thin foil rather than from the sample surface, the detection efficiency of secondary electrons is always the same for any type of analyzed material. Due to the ability to scan the samples by a piezo stage, samples of a few cm in surface size can be imaged. The imaging capabilities of MeV SIMS are demonstrated on crossing ink lines deposited on paper, a thin section of a mouse brain, and a fingerprint deposited on a thick Si wafer to show the potential application of the presented technique for analytical purposes in biology and forensic science.

Modeling scatter through sides of island blocks used for intensity-modulated bolus electron conformal therapy.

Passive Radiotherapy Intensity Modulators for Electrons (PRIME) devices are comprised of cylindrical tungsten island blocks imbedded in a machinable foam slab within the patient's cutout. Intensity-modulated bolus electron conformal therapy (IM-BECT) uses PRIME devices to reduce dose heterogeneity caused by the irregular bolus surface. Heretofore, IM-BECT dose calculations used the pencil beam redefinition algorithm (PBRA) assuming perfect collimation. This study investigates modeling electron scatter into and out the sides of island blocks. Dose distributions were measured in a water phantom at 7, 13, and 20 MeV for devices having nominal intensity reduction factors of 1.000 (foam only), 0.937, 0.812, and 0.688, corresponding to nominal island block diameters (dnom ) of 0.158, 0.273, and 0.352cm, respectively. Pencil beam theory derived an effective diameter (dIS ) to account for in-scattered electrons as a function of dnom and beam energy (Ep,0 ). However, for out-scattered electrons, an effective diameter (dmod ) was estimated by best fitting measured data. In the modulated region (under island blocks, depth<R90 ), modified PBRA-calculated dose distributions showed 2%/2mm passing rates for dnom =0.158, 0.273, and 0.352cm of (100%, 100%, 100%) at 7 MeV, (100%, 100%, 93.5%) at 13 MeV, and (99.8%, 85.4%, and 71.5%) at 20 MeV. The largest dose differences (≤6%) occurred at the highest energy (20 MeV), largest dnom , shallowest depths (≤2cm), and on central axis. An equation for modeling island block scatter, dmod (dnom , Ep,0 ), has been developed for use in the PBRA, insignificantly impacting calculation time. Although inaccuracy sometimes exceeded our 2%/2mm criteria, it could be clinically acceptable, as superficial dose differences often fall inside the bolus. Also, patient PRIME devices are expected to have fewer large diameter island blocks than did test devices. Inaccuracies are attributed to out-scattered electrons having energy spectra different than the primary beams.

Concept and strategy of SuperSUN: A new ultracold neutron converter

A new source of ultracold neutrons (UCNs), developed at the Institut Laue-Langevin (ILL) and named SuperSUN, is currently being commissioned. Its operational principle is the conversion of cold neutrons, delivered by ILL’s existing beam H523, to UCNs in a vessel filled with superfluid helium-4, wherein the neutron’s energy and momentum are transferred by inelastic scattering to phonons in the superfluid. The inverse Boltzmann-suppressed process is negligible at temperatures below 0.6 K, enabling long storage times and high in-situ UCN densities as demonstrated at the ILL for two prototype sources. These two prototypes are installed at secondary beams behind crystal monochromators, whereas a primary beam with a white cold spectrum illuminates the SuperSUN conversion volume. This provides not only higher intensity around the wavelength 0.89 nm where the dominant single-phonon process for UCN production takes place, but also a contribution to UCN production by multi-phonon processes. In the first phase of the project, material walls will trap the UCNs, while in the second phase an octupole magnet will generate a 2.1 T magnetic field at the edge of the conversion volume. For low-field-seeking UCNs, this field increases the trapping potential and reduces wall losses so that the accumulated UCNs are spin-polarized as a result. SuperSUN aims to deliver the highest possible UCN densities to external storage experiments, the first of which will be the PanEDM experiment measuring the neutron’s permanent electric dipole moment.

Extended bandwidth of 2DOF double impact triboelectric energy harvesting: Theoretical and experimental verification

Increasing the bandwidth of the vibrational energy harvesters is one of the research emphases to maximize the energy harvested from the ambient. Here we design a Two-Degree of Freedom (2DOF) Vibro-impact Triboelectric Energy Harvester with a double impact configuration, which combines multi-modality and piecewise linearity to improve the harvesting bandwidth of triboelectric energy harvesters. The harvester structure consists of a primary cantilever beam attached to a secondary cantilever beam through a tip mass opposite the primary beam. The tip of each beam was designed to act as a multi-layers triboelectric energy harvester. When the system is subjected to a base excitation, the beams will vibrate, resulting in an impact between the triboelectric layers, and an alternating electrical signal is generated. The two beams are designed to have close natural frequencies, and under the effect of the impact, the bandwidths of the resonators are combined to create a wide bandwidth, hence increasing the efficiency of the energy harvester. A theoretical 2DOF lumped parameter model was developed to extract the governing equations of the double impact system. A simulation analysis was conducted to examine the structure’s dynamic behavior at different excitation levels, separation distance, and surface charge density to extract an optimal parameter for combining beams’ bandwidths. A wide bandwidth of 23 Hz was achieved at an excitation frequency of 0.7 g. Finally, experimental results were extracted to validate the simulation results. The system demonstrates the capability of connecting multi-modality and piecewise linearity to significantly broaden the bandwidth of the triboelectric energy harvester for scavenging ambient vibrations over a wide range of excitation frequencies.

Optimization of Radiation Shielding Considerations for Designing Halcyon Vault.

To determine the radiation shielding considerations for optimization of Halcyon vault shielding requirements. The primary and leakage workloads were estimated using actual clinical treatment planning and treatment delivery data acquired from three busy operational clinical Halcyon facilities. The effective use factor was determined based on a newer approach proposed in this paper using the percentage of patients treated with different treatment techniques. The transmission factor of the primary beam block, maximum head leakage, and patient scatter fractions around the Halcyon machine were experimentally determined. The first tenth-value layer (TVL1) and equilibrium tenth-value layer (TVLe) for 6 MV - flattening-filter-free (FFF) primary X-ray beam for ordinary concrete were measured. The primary and leakage workloads are estimated as 1 × 105 cGy/wk and 3.1 × 105 cGy/wk at 1 m respectively. The effective use factor is found as 0.114. The primary beam-block transmission factor is determined as 1.7 × 10-4 at 1 m distance from isocenter along the central beam axis. The maximum head leakage is noted as 6.23 × 10-4. The patient scatter fractions are reported for various planar angles around the Halcyon machine at a radial distance of 1 m in a horizontal plane passing through isocenter. The TVL1 and TVLe of 6 MV-FFF X-ray beam energy for ordinary concrete are found to be 33 and 29 cm, respectively. Using experimentally determined shielding considerations, the optimized vault shielding requirements for the Halcyon facility are calculated and a typical layout drawing is proposed.