The aim of this study was to find out the predictors for aesthetic tourism patients´ satisfaction of the American travelers to Tijuana. The information was obtained by applying a survey to a sample of 385 visitors - patients from clinics in the city. Four dimensions were included in the multiple regression analysis. The results obtained show that the two key factors influence satisfaction level: Medical facilities, services and price dimension, and Geographical and cultural proximity dimensions. Theoretical value of this article is in its contribution to the few body of knowledge on factors that influence the aesthetic tourism satisfaction, as well as, the identification of its main characteristics that allow for the understanding of tourist’s behavior in a binational environment. In the same sense, the results allow the owners and managers of clinics in this binational region to develop strategies to attract this market segment.