Dens Invaginatus (DI) is a developmental abnormality, usually affecting the maxillary incisor teeth, particularly lateral incisors. These cases usually present technical difficulties concerning their management owing to their aberrant canal morphology. Conventional root canal therapy, periapical surgery, and extraction have been reported as treatment modalities for such anomalies. The following case report depicts surgical endodontic management of an Oehler’s Type III DI involving a maxillary lateral incisor associated with periapical lesion aided by cone beam computed tomography (CBCT) and with the use of mineral trioxide aggregate (MTA), hydroxyapatite bone graft and platelet-rich fibrin (PRF) membrane. At 12 months post-treatment, the patient did not report any eventful episodes, and the size of the periapical lesion was markedly reduced.