Many adolescents with high-risk sexual behaviors only receive health care episodically in the emergency department (ED). ED visits offer an opportunity to deliver brief interventions to improve health, but no proven ED-based brief intervention to reduce sexual risk behaviors exists. The study objectives were to 1) assess feasibility of a novel intervention using National Research Council criteria (effectiveness, efficiency, and satisfaction), and 2) examine impact on attitudes and behaviors. In this cross-sectional pilot study, sexually active patients aged 14-19 years presenting to a Midwestern ED were recruited to receive an intervention to reduce sexual risk behaviors. The intervention, based on motivational interviewing (MI), included agenda setting, exploration of behaviors, decisional balance exercise, tailored feedback, and referral to the hospital-affiliated Adolescent Clinic. Individually-tailored sessions offered provision of condoms, prescriptions for emergency contraception, and/or testing for sexually transmitted infections (STI). Participants completed a survey and intervention at baseline, an immediate post-intervention survey at Time 1, and a three-month phone follow-up survey at Time 2. Surveys assessed sexual behaviors, attitudes and self-efficacy regarding condoms and birth control. Additional questions included: demographics (baseline), satisfaction, and fidelity measures (Time 1). Feasibility criteria were: 1) Subject rated interventionist fidelity to MI principles (Likert scale 1 = strongly agree to 4 = strongly disagree), 2) Session duration (minutes), and 3) Subject satisfaction (Likert scale 1 = not at all to 5 = very). Sixty-six subjects (96% of approached) completed the screening with 24 (37%) qualifying for enrollment by reporting previous sexual activity. Of those, 20 (83%) participated (mean age 16.2 years; 60% female). Subjects somewhat or strongly agreed that the interventionist: 1) “was easy to talk to” (90%), 2) “was concerned about me” (78%), 3) “understood me” (89%), 4) “treated me like an equal” (89%), and 5) “did not push me into something I wasn't ready for” (80%). The mean duration was 15.7 minutes. All subjects were fairly (20%) or very (80%) satisfied. One subject tested positive for Chlamydia trachomatis and received treatment at Adolescent Clinic. When offered, most (59%) accepted condoms and 71% accepted a prescription for emergency contraception. Five subjects kept appointments at Adolescent Clinic where additional services were provided: STI testing (n = 2), birth control prescribed/administered (n = 2), provision of condoms (n=1), and influenza vaccination (n = 1). Fifteen subjects (75%) were reached for 3-month follow-up. Among those reporting sex since enrollment (n = 6), 67% reported continued condom use at most recent sex. There were positive trends in attitudes towards condoms and birth control self-efficacy. This ED-based intervention was delivered with high fidelity and relative rapidity, and resulted in high satisfaction among these sexually active adolescents. A considerable proportion received health services essential for optimal sexual health. Studies to assess efficacy appear warranted.