Background: Surgical site infection (SSI) following Cesarean section (C-section) is a common cause of morbidity and imposes a significant load on the healthcare system. Therefore, the prevalence of factors that make individuals more susceptible to SSI after a C-section should be accurately assessed. Objectives: This study aimed to determine the frequency and risk factors for infection following C-section in women referred to the maternity ward of Ali ibn Abi Talib Hospital in Zahedan, Iran, from 2020 to 2022. Methods: This descriptive cross-sectional study was performed on all women admitted to the maternity ward of Ali ibn Abi Talib Hospital in Zahedan, whether undergoing elective or emergency C-sections. The patients were entered into the study with informed consent and were followed up to one month after surgery. Results: This study showed that approximately 5300 cases of C-sections were performed in Ali ibn Abi Talib Hospital during the mentioned period, of which 120 patients were referred to this hospital again because of surgical site infections. The occurrence of SSI in the present study was 2.26%, and obesity and anemia were identified as the predominant risk factors. The findings showed that the incidence of patients with SSI following a C-section with obesity, anemia, skin scar of previous C-section, rupture of membranes before C-section (> 6 hours), and diabetes mellitus were 80, 76.8, 36.7, 33.3, and 24.2 %, respectively. Conclusions: The recorded incidence of SSI following C-section was comparatively lower than findings from prior studies conducted in developing countries. Although the frequency of these complications is desirable, there are the same number of irreparable complications to mothers and infants and high costs for families and society.