Previous Assessments Research Articles

Contrasting biogeographical patterns of threatened vertebrates on islands emerge from disparities between expert‐derived maps and Global Biodiversity Information Facility data

AbstractAimThe most popular sources of information on species distributions are the expert‐derived maps and georeferenced occurrences, mainly those compiled by the Global Biodiversity Information Facility (GBIF). These sources have been constantly used with biogeographical and conservation goals. However, their degree of accuracy in representing geographical biodiversity patterns remains poorly understood. Here, we compared both sources of information on species distributions to estimate global patterns of richness and species composition of threatened vertebrates on marine islands.LocationGlobal.TaxonTerrestrial vertebrates.MethodsWe gathered distributional data of all threatened terrestrial vertebrate species inhabiting 22,471 marine islands worldwide from GBIF and expert derived maps. Then, to assess strengths and biases from each source, using geographical information systems, we calculated and compared: (a) species richness per island, (b) general patterns of richness and (c) the number of shared species from both sources per island.ResultsThere were dramatic differences between the information derived from both data sources. The species richness estimated with expert‐derived maps resulted in 10 more species per island, on average, than the estimations obtained from GBIF data. The mean proportion of shared species per island (between both data sources) was very low (3.1% of the species), and the general patterns of richness were markedly different. The most significant differences occurred in tropical areas and Europe.ConclusionDifferences between the two sources emerged from intrinsic biases: expert‐derived maps tend to overestimate species' counts, whereas GBIF occurrences tend to do the opposite, except for some well‐sampled regions where both data types converge. Our findings suggest that previous global assessments performed with these information sources on species distributions, especially those focusing on protected areas, should be carefully considered.

As the Goose Flies: Migration Routes and Timing Influence Patterns of Genetic Diversity in a Circumpolar Migratory Herbivore

Migration schedules and the timing of other annual events (e.g., pair formation and molt) can affect the distribution of genetic diversity as much as where these events occur. The greater white-fronted goose (Anser albifrons) is a circumpolar goose species, exhibiting temporal and spatial variation of events among populations during the annual cycle. Previous range-wide genetic assessments of the nuclear genome based on eight microsatellite loci suggest a single, largely panmictic population despite up to five subspecies currently recognized based on phenotypic differences. We used double digest restriction-site associated DNA (ddRAD-seq) and mitochondrial DNA (mtDNA) sequence data to re-evaluate estimates of spatial genomic structure and to characterize how past and present processes have shaped the patterns of genetic diversity and connectivity across the Arctic and subarctic. We uncovered previously undetected inter-population differentiation with genetic clusters corresponding to sampling locales associated with current management groups. We further observed subtle genetic clustering within each management unit that can be at least partially explained by the timing and directionality of migration events along with other behaviors during the annual cycle. The Tule Goose (A. a. elgasi) and Greenland subspecies (A. a. flavirostris) showed the highest level of divergence among all sampling locales investigated. The recovery of previously undetected broad and fine-scale spatial structure suggests that the strong cultural transmission of migratory behavior restricts gene flow across portions of the species’ range. Our data further highlight the importance of re-evaluating previous assessments conducted based on a small number of highly variable genetic markers in phenotypically diverse species.

Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL®) for chickens for fattening and turkeys (Huvepharma N.V.).

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety for the target species of the coccidiostat halofuginone hydrobromide from STENOROL® when used as a feed additive for chickens for fattening and turkeys. In its previous assessment, the FEEDAP Panelcould not conclude on the safety of STENOROL® for the target species at the highest proposed use level of 3mg halofuginone hydrobromide/kg complete feed. On the basis of the new data provided, the FEEDAP Panelupdates its previous conclusions on the safety for the target species as follows: halofuginone hydrobromide from STENOROL® is safe for chickens for fattening and for turkeys up to a maximum of 12 weeks of age at the highest proposed concentration of 3mg/kg complete feed. For chickens for fattening, a margin of safety of about 1.3 can be established while for turkeys for fattening a margin of safety cannot be established.

Race and Ethnicity, Stage-Specific Mortality, and Cancer Treatment in Esophageal and Gastric Cancers: Surveillance, Epidemiology, and End Results (2000–2018)

Race and Ethnicity, Stage-Specific Mortality, and Cancer Treatment in Esophageal and Gastric Cancers: Surveillance, Epidemiology, and End Results (2000–2018)

Assessment and Treatment of Eating Disorders.

Eating disorders are serious psychiatric conditions in terms of chronicity and have the highest mortality rate among psychiatric disorders. The assessment and treatment of eating disorders are also challenging, due to patients' denial of their illness and reluctance for change. Despite a large number of previous assessment and treatment studies, new strategies to overcome these difficulties are still needed. This study casts light on four aspects; involvement of the brain's reward system, stages of change in relationship with motivation, refeeding syndrome during renourishment, and gut microbiota changes relating to chronicity. Further studies relating to these aspects are encouraged.

An Improved Repository Structure to Identify, Select and Integrate Components in Component-based Development

An ultimate goal of software development is to build high quality products. The customers of software industry always demand for high-quality products quickly and cost effectively. The component-based development (CBD) is the most suitable methodology for the software companies to meet the demands of target market. To opt CBD, the software development teams have to customize generic components that are available in the market and it is very difficult for the development teams to choose the suitable components from the millions of third party and commercial off the shelf (COTS) components. On the other hand, the development of in-house repository is tedious and time consuming. In this paper, we propose an easy and understandable repository structure to provide helpful information about stored components like how to identify, select, retrieve and integrate components. The proposed repository will also provide previous assessments of developers and end-users about the selected component. The proposed repository will help the software companies by reducing the customization effort, improving the quality of developed software and preventing integrating unfamiliar components.

The primal garden: Tajikistan as a biodiversity hotspot of food crop wild relatives

Despite being located within a primary region of crop diversity, documentation of Tajik crop and crop wild relative (CWR) resources is far from comprehensive, particularly regarding CWR. Here, we compile the first inventory of food CWR of Tajikistan. A total of 549 food CWR taxa belonging to 36 families and 125 genera were documented as occurring in the country. Among them, 71 taxa were recognized as native close relatives of globally important crops (category 1A), 67 as native distant relatives of these crops (1B) and 411 as native taxa with an undetermined relationship to these crops (1C). This documented CWR diversity far exceeds previous scientific assessments for the country and, in doing so, distinguishes the Tajik region from surrounding countries. Within the country, the results indicate a clear gradient of food CWR taxonomic richness from the eastern part of the country (least diversity) to the western part (greatest diversity). This trend adds important new information to the body of literature published by N. I. Vavilov and others, who mainly stressed the importance of the Pamir region (Eastern Tajikistan) for crop and CWR diversity.

Prehospital Preparedness for Major Incidents in Sweden: A National Survey with Focus on Mass-Casualty Incidents.

Major incidents (MIs) put great demands on the medical response to effectively organize and redistribute resources and personnel, in prehospital care as well as hospital care, and coordinating functions. Studies indicate that regular training and well-established contingency plans are vital for the medical response to MIs. Previous assessments have concluded that Swedish disaster preparedness requires improved organization and coordination. There is currently no method to easily follow-up the preparedness work of the prehospital medical response organizations for MIs in Sweden. The aim of the study was to assess qualifications and training requirements for central individual roles, to examine frequency and focus of training and simulation, as well as to examine current regional routines for MIs in Sweden. The aim was also to identify, to evaluate, and to investigate areas for improvement in prehospital health care preparedness for MIs in Sweden. Descriptive comparative study of Sweden's prehospital organization, planning, education, and training for MIs through a web-based survey sent to all 21 regions in Sweden. The survey included 64 questions and was based on national legislation and guidelines for preparedness and previous investigations of real MIs. A total of 37 answers to the survey were collected representing 17/21 regions (80.9%) from which Regional Management Individuals (RMIs) were selected from 15 regions and used as representative primary responses. The initial routines regarding alarm and establishment of management functions were mainly in-line with national guidelines. Staffing and qualification requirements for certain leadership roles differed substantially between regions. The requirements for the health care staff's knowledge of the contingency plan were generally low and routines for follow-up were often lacking. The frequency of exercises in certain areas were deficient. The results of the study showed several potential areas for improvement within the prehospital emergency medical preparedness for MIs in Sweden. Methodology and adherence of national guidelines for medical response preparedness differ between regions in Sweden, which motivates recurring assessments. It is possible to use a well-prepared questionnaire study to follow-up and to examine parts of the regional prehospital preparedness work and organization for MIs.

Development of a Diffusion Mobility Database for Co-Based Superalloys

To facilitate the development of high-temperature Co-based γ-γ′ superalloys, a Co-Ni based diffusion mobility database is developed for the eight component FCC (Face Centered Cubic) system of Co-Al-W-Ni-Cr-Ti-Ta-Re. A CALPHAD approach is used to represent the temperature and composition dependency of the multicomponent system. The mobility descriptions were based on previous assessment work for the Ni-based superalloys, published experimental and computational data, and established diffusion correlations. The initial mobility descriptions were then refined using additional diffusion couple experimental data, particularly for the Co-Cr, Co-Ta, and Ni-Ta systems. After re-optimizing the descriptions with the new experimental data, the mobility descriptions were validated using a collection of published diffusion couple composition profiles, which were not included in the initial assessment process.

Semi-quantitative evaluation of levees risk within the context of hydrology uncertainty

Risk assessment is necessary to understand whether a levee is safe and able to prevent flood invasion. Most previous assessment methods attempted to quantitatively assess the risks posed by hydraulic structures using probabilistic analysis from a research perspective. The kind of method depends on the probability density function of factors but sometimes difficult to determine either a priori or posteriori in practice. On the other hand, current semi-quantitative methods despite the convenience are somewhat subjective in their implementation. This study sought to rectify the shortcomings of previous quantitative and semi-quantitative approaches to assessing the risk of levee failure wherein the uncertainty of risk factors is presented within a semi-quantitative framework, in accordance with ISO assessment procedures. The risk of levee failure discussed in this work is mainly related to overtopping and erosion of its foundation. This study proposed a semi-quantitative approach to maintain the exactness and objectivity of the risk assessment of levees and use Puzih river in Taiwan as a case study. In this study, we tried to add uncertainty facts and developed a risk assessment framework for levee management using a risk map according to our semi-quantitative methods. This study firstly defines the risk and associated factors within the context of government regulations, then implement a series of risk assessment tasks using the widely used hydraulic and sedimentation transport model, HEC-RAS, to simulate the risk of inundation, where hydrological events are used as a proxy for uncertainty. This study considers that consequence of levee failure and compute representative qualitative indices by which to evaluate hazards using a risk map and risk matrix in order to illustrate potential economic losses under given flood scenarios. After gaining the levee assessment results, the risk map is also built which can be applied on the practical engineering works. Our results reveal that the most secure levees along Puzih river should be able to withstand flood events with a 100-year return period; however, the levees in a several areas fail to provide suitable protection. Accordingly, this work developed a risk map and corresponding flood prevention strategies to decrease the risk in specific regions for the consideration of rive management administration.

Paracoccidioides restrepiensis has undergone a severe population bottleneck

Genus Paracoccidioides now encompasses five species, P. lutzii, P. brasiliensis sensu stricto, P. americana, P. venezuelensis, and P. restrepiensis. All the paracoccidioidomycosis (PCM) cases reported in Colombia have been classified as P. restrepiensis, which was named in honor of Angela Restrepo, a leading researcher in the field of the biology of the fungus. Previous assessments of genetic diversity have suggested that Paracoccidioides species have differences in their level of polymorphism. To infer changes in effective population size, we used the Pairwise sequentially Markovian coalescent (PSMC) by generating two pseudodiploids for P. restrepiensis and one for P. brasiliensis sensu stricto. We found that P. restrepiensis diverged from its sister species recently, the divergence time from P. venezuelensis being 125,000 (± 42,000) years. The analyses using PSMC show a systematic reduction in the effective population size of P. restrepiensis with a rapid decrease in genetic variability compared to P. brasiliensis sensu stricto, which indicates that P. restrepiensis has undergone a systematic population bottleneck. None of the other two species show the dramatic effective population size reduction observed in P. restrepiensis. These comparisons suggest that the trajectory of P. restrepiensis is somehow different from the other Paracoccidioides species and poses the question regarding the biogeographic events that have led to such a dramatic population pattern.

A methodological review with meta-epidemiological analysis of preclinical systematic reviews with meta-analyses

Systematic reviews and meta-analyses have been proposed as an approach to synthesize the literature and counteract the lack of power of small preclinical studies. We aimed to evaluate (1) the methodology of these reviews, (2) the methodological quality of the studies they included and (3) whether study methodological characteristics affect effect size. We searched MEDLINE to retrieve 212 systematic reviews with meta-analyses of preclinical studies published from January, 2018 to March, 2020. Less than 15% explored the grey literature. Selection, data extraction and risk of bias assessment were performed in duplicate in less than two thirds of reviews. Most of them assessed the methodological quality of included studies and reported the meta-analysis model. The risk of bias of included studies was mostly rated unclear. In meta-epidemiological analysis, none of the study methodological characteristics was associated with effect size. The methodological characteristics of systematic reviews with meta-analyses of recently published preclinical studies seem to have improved as compared with previous assessments, but the methodological quality of included studies remains poor, thus limiting the validity of their results. Our meta-epidemiological analysis did not show any evidence of a potential association between methodological characteristics of included studies and effect size.

Optimizing Color-Difference Formulas for 3D-Printed Objects.

Based on previous visual assessments of 440 color pairs of 3D-printed samples, we tested the performance of eight color-difference formulas (CIELAB, CIEDE2000, CAM02-LCD, CAM02-SCD, CAM02-UCS, CAM16-LCD, CAM16-SCD, and CAM16-UCS) using the standardized residual sum of squares (STRESS) index. For the whole set of 440 color pairs, the introduction of kL (lightness parametric factor), b (exponent in total color difference), and kL + b produced an average STRESS decrease of 2.6%, 26.9%, and 29.6%, respectively. In most cases, the CIELAB formula was significantly worse statistically than the remaining seven formulas, for which no statistically significant differences were found. Therefore, based on visual results using 3D-object colors with the specific shape, size, gloss, and magnitude of color differences considered here, we concluded that the CIEDE2000, CAM02-, and CAM16-based formulas were equivalent and thus cannot recommend only one of them. Disregarding CIELAB, the average STRESS decreases in the kL + b-optimized formulas from changes in each one of the four analyzed parametric factors were not statistically significant and had the following values: 6.2 units changing from color pairs with less to more than 5.0 CIELAB units; 2.9 units changing the shape of the samples (lowest STRESS values for cylinders); 0.7 units changing from nearly-matte to high-gloss samples; and 0.5 units changing from 4 cm to 2 cm samples.

Lateral Extent of Pyroclastic Surge Deposits at Ubehebe Crater (Death Valley, California) and Implications for Hazards in Monogenetic Volcanic Fields

AbstractHazard assessments in monogenetic volcanic fields require estimates of the runout of pyroclastic surges that result from phreatomagmatic explosive activity. Previous assessments used runout distances of 1–4 km, with large cases up to 6 km. Surge deposits at Ubehebe Crater (∼2100 y.b.p., Death Valley, California) have been traced ∼9 km from the crater center, and likely originally extended 1–3 km farther. There is no evidence that the Ubehebe Crater activity was unusually energetic; rather, its distal deposits are better preserved than those at most maar volcanoes because of its young age and the arid environment. Numerical simulations illustrate how low temperatures facilitate long runout of phreatomagmatic surges due to reduced expansion of entrained air compared to hot surges, allowing cool surges to retain higher densities than ambient air. We suggest that hazard assessments for volcanic fields with phreatomagmatic, maar‐forming eruptions should consider runout distances in the range of 10–15 km.

Detecting Imperfect Substitution between Comparably Skilled Immigrants and Natives: A Machine Learning Approach

Immigration economists often disagree about whether comparably skilled immigrants and natives are perfect substitutes in the United States and other developed countries, leading these scholars to different assessments of the labor market impacts of immigration and policy recommendations. This article attempts to provide theoretical bases for understanding the immigrant-native substitution and to introduce machine learning techniques to resolve the empirical debate. Using the male subsample from the US Census and American Community Survey, it shows that the difference in covariate selection explains substantial disagreements in estimating immigrant-native substitution. Given the difficulties in providing compelling theoretical justifications for covariates selected, this article proposes estimating via the Lasso-type (least absolute shrinkage and selection operator) estimators. My Lasso-based estimation rejects perfect substitution, but it also implies easier substitution than that preferred by Ottaviano and Peri, suggesting more direct immigrant-native competition. By extending the sample to women, I find similar immigrant-native substitution across gender. Therefore, this article casts doubt on previous immigration impact assessments. Indeed, my simulation suggests considerable precision gains concerning the immigration's wage impacts on immigrants themselves. Furthermore, this article identifies immigrant segregation as a critical source of the national-level imperfect substitution, which decreases within progressively smaller regions and almost disappears in the same city. By introducing the Lasso-type estimators into migration studies, this article makes solid progress toward evaluating and understanding imperfect immigrant-native substitution and its socioeconomic consequences.

INNV-21. FEASIBILITY OF A VIRTUAL REALITY (VR) INTERVENTION TARGETING DISTRESS AND ANXIETY IN PRIMARY BRAIN TUMOR (PBT) PATIENTS AT THE TIME OF NEUROIMAGING: INTERIM ANALYSIS OF A PHASE 2 CLINICAL TRIAL

Abstract BACKGROUND PBT patients experience high levels of distress and anxiety symptoms at the time of neuroimaging, yet few non-pharmacological interventions are available. This phase 2 clinical trial interim analysis explored feasibility of a VR relaxation intervention for a PBT population. METHODS PBT patients seen at NIH were recruited to participate in this single arm trial conducted via telehealth. English-speaking, adult patients with upcoming neuroimaging who can self-report symptoms and have reported distress on previous MD Anderson Symptom Inventory-Brain Tumor assessments were eligible. Exclusion criteria include recent surgery or seizures, anxiety disorders, nausea, or visual deficits. The primary intervention consisted of a brief VR session done within 2 weeks prior to neuroimaging with patient-reported outcomes (PROs) collected before and immediately post-intervention, as well as 1 week and 4 weeks later, with self-directed VR use over 1 month. A qualitative phone interview was also completed to assess patient satisfaction. RESULTS Fifty-five patients were screened and approached with 40 (73%) responding to initial reach-out and 20 ultimately enrolling (9 declines, 11 screen fails). Decline reasons included: no distress/anxiety (30%), treatment-related toxicities (11%), and unknown (59%). Seven (64%) failed screening due to exclusionary anxiety disorders (36% GAD, 18% PTSD, 9% claustrophobia). Of those enrolled, 65% were ≤ 50 years, 50% were male, 90% were White/non-Hispanic, 85% had good KPS ( > 80), 65% had high-grade tumors, and most were on active treatment. All enrolled patients completed the VR intervention and participation period, PROs questionnaires, weekly check-ins, and qualitative interview. Most patients (90%) reported frequent VR use with 7 mild adverse effects reported (headache, dizziness, nausea, neck pain). CONCLUSION These findings suggest that this intervention is feasible for this population with high enrollment and study completion, though incidence of anxiety disorders was higher than anticipated and a comprehensive evaluation of this cohort is planned.

Designing a surveillance program for early detection of alien plants and insects in Norway

Naturalized species of alien plants and animals comprise < 3% of biodiversity recorded in Norway but have had major impacts on natural ecosystems through displacement of native species. Encroachment of alien species has been especially problematic for coastal sites close to transport facilities and urban areas with high density housing. The goal of our field project was to design and test a surveillance program for early detection of alien species of vascular plants and terrestrial insects at the first phase of establishment in natural areas. In our 3-year project (2018–2020), we sampled 60 study plots in three counties in the Oslofjord region of southern Norway. Study plots (6.25 ha) were selected by two criteria: manual selection based on expert opinion (27 plots) or by random selection based on weights from a hotspot analysis of occurrence of alien species (33 plots). Vascular plants were surveyed by two experienced botanists who found a total of 239 alien species of vascular plants in 95 rounds of surveys. Insects and other invertebrates were captured with a single Malaise trap per site, with 3–4 rounds of repeated sampling. We used DNA-metabarcoding to identify invertebrates based on DNA extractions from crushed insects or from the preservative media. Over 3500 invertebrate taxa were detected in 255 rounds of sampling. We recorded 20 alien species of known risk, and 115 species that were new to Norway, including several ‘doorknocker’ species identified by previous risk assessments. We modeled the probabilities of occupancy (ψ) and detection (p) with occupancy models with repeated visits by multiple observers (vascular plants) or multiple rounds of sampling (insects). The two probabilities covaried with risk category for alien organisms and both were low for species categorized as no known or low risk (range = 0.052–0.326) but were higher for species categorized as severe risk (range = 0.318–0.651). Selecting sites at random or manually did not improve the probability of finding novel alien species, but occupancy had a weak positive relationship with housing density for some categories of alien plants and insects. We used our empirical estimates to test alternative sampling designs that would minimize the combined variance of occupancy and detection (A-optimality criterion). Sampling designs with 8–10 visits per site were best for surveillance of new alien species if the probabilities of occupancy and detection were both low, and provided low conditional probabilities of site occupancy (hat{psi }_{condl} ≤ 0.032) and a high probabilities of cumulative detection (hat{p}* ≥ 0.943). Our field results demonstrate that early detection is feasible as a key component of a national surveillance program based on early detection and rapid response.

Geographic accessibility to public and private health facilities in Kenya in 2021: An updated geocoded inventory and spatial analysis.

To achieve universal health coverage, adequate geographic access to quality healthcare services is vital and should be characterized periodically to support planning. However, in Kenya, previous assessments of geographic accessibility have relied on public health facility lists only, assembled several years ago. Here, for the first time we assemble a geocoded list of public and private health facilities in 2021 and make use of this updated list to interrogate geographical accessibility to all health providers. Existing health provider lists in Kenya were accessed, merged, cleaned, harmonized, and assigned a unique geospatial location. The resultant master list was combined with road network, land use, topography, travel barriers and healthcare-seeking behavior within a geospatial framework to estimate travel time to the nearest (i) private, (ii) public, and (iii) both (public and private-PP) health facilities through a travel scenario involving walking, bicycling and motorized transport. The proportion of the population within 1 h and outside 2-h was computed at 300 × 300 spatial resolution and aggregated at subnational units used for decision-making. Areas with a high disease prevalence for common infections that were outside 1-h catchment (dual burden) were also identified to guide prioritization. The combined database contained 13,579 health facilities, both in the public (55.5%) and private-for-profit sector (44.5%) in 2021. The private health facilities' distribution was skewed toward the urban counties. Nationally, average travel time to the nearest health facility was 130, 254, and 128 min while the population within 1-h was 89.4, 80.5, and 89.6% for the public, private and PP health facility, respectively. The population outside 2-h were 6% for public and PP and 11% for the private sector. Mean travel time across counties was heterogeneous, while the population within 1-h ranged between 38 and 100% in both the public sector and PP. Counties in northwest and southeast Kenya had a dual burden. Continuous updating and geocoding of health facilities will facilitate an improved understanding of healthcare gaps for planning. Heterogeneities in geographical access continue to persist, with some areas having a dual burden and should be prioritized toward reducing health inequities and attaining universal health coverage.

Assessment of genetically modified oilseed rape GT73 for placing on the market of isolated seed protein for food under Regulation (EC) No 1829/2003 (application EFSA-GMO-RX-026/2).

Genetically modified oilseed rape GT73 was developed to confer herbicide tolerance; this property was achieved by introducing the single insert containing one copy of goxv247 and the CP4 epsps expression cassettes. The scope of the application EFSA-GMO-RX-026/2 is for the modification of the terms of the authorisation regarding the placing on the market of isolated seed protein from oilseed rape GT73 for food. Considering previous opinions on this event of the GMO Panel, the molecular characterisation data do not identify issues requiring additional food safety assessment. Based on previous assessments, no biologically relevant differences were identified in the compositional, agronomic and phenotypic characteristics of oilseed rape GT73 compared with its conventional counterpart, except for the newly expressed proteins. No new agronomic, phenotypic and compositional data in support of the comparative analysis were considered necessary in the context of this application. The GMO Paneldid not identify indications of safety concern regarding toxicity, allergenicity or adjuvanticity related to the presence of the newly expressed proteins CP4 EPSPS and GOXv247 in oilseed rape GT73. Therefore, the GMO Panelconcludes that in the context of this application, the consumption of oilseed rape GT73 does not represent any nutritional concern and is as safe as the conventional counterpart. No post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable oilseed rape GT73 into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of oilseed rape GT73. The GMO Panelconcludes that oilseed rape GT73 is as safe as its conventional counterpart with respect to potential effects on human and animal health and the environment. These conclusions also apply to the placing on the food market of isolated seed protein produced from oilseed rape GT73.

Jewish Echoes of Anti-Talmudic Literature: Revisiting "The Talmud in the Additiones of Paul of Burgos"

This article revisits two Latin antitalmudic texts penned by the converted bishop of Burgos, Pablo de Santa María (c. 1352–1435). It argues, in contrast to previous assessments, that far from being a failed replica of Christian scholastic formulas, they echo the conversionist or "apostatic" argumentation that proselytes to Christianity were making in Jewish quarters, a polemic that was not shaped by a scholastic-inquisitorial perspective but rather was still very much rabbinic in style and methods. The article traces echoes of this intra-Jewish polemic, using the extraordinary corpus of Abner of Burgos (d. 1347). It focuses on three themes: the antirabbinic allusions to Zechariah's prophecy; the historical-hermeneutical brawl over the identity of Edom; and the notion of talmudic-demonic alliance. Evaluating the potential agency that Pablo's peculiar texts could have had among Christian readership, I propose that his critique of talmudic literature undermined important aspects of the Christian antitalmudic tradition, reframing the Talmud according to rabbinic conventions.