Prevention Of Diabetes Mellitus Research Articles

The Primary Mechanisms of Drug-Food Homologous Traditional Chinese Medicine Polysaccharides in the Prevention and Treatment of Diabetes.

Diabetes mellitus is a metabolic disease associated with hyperglycemia caused by insufficient insulin secretion or insulin resistance. Early symptoms are related to an abnormal increase in water intake, food intake, and urination. In Chinese medicine, diabetes mellitus is categorized as a "thirst-quenching" condition. Currently, the clinical treatment of diabetes mellitus relies mainly on Western medications, which often target the symptoms rather than alter the cause of the disease, and can cause certain side effects and drug resistance. In comparison, the polysaccharides of Chinese medicines from the same source of food and medicine have become an emerging choice for the prevention and treatment of diabetes due to their wide sources, high safety, and low side effects. To reveal the mechanisms of the polysaccharides of traditional Chinese medicine (TCM) in the prevention and treatment of diabetes mellitus, the CiteSpace visualization software was used to conduct extensive literature searches through Chinese and international databases, such as PubMed, Medline, and China National Knowledge Infrastructure. Through literature volume analysis, keyword co-occurrence, cluster analysis, and trend highlighting, we found that the main mechanisms of TCM polysaccharides in the prevention and treatment of diabetes include regulating intestinal flora, improving insulin resistance, alleviating oxidative stress, adjusting lipid metabolism imbalance, and inhibiting inflammatory responses. Furthermore, this study systematically summarizes the mechanism of "using sugar to reduce sugar" to provide innovative ideas for the development of health products for the treatment of diabetes using the polysaccharides of Chinese medicinal herbs.

Fermented Ananas comosus and Carica papaya harbour putative probiotic Limosilactobacillus fermentum and Lacticaseibacillus paracasei strains with inhibitory activity against α-glucosidase and α-amylase

Diabetes mellitus (DM) is the condition represented by persistent hyperglycaemia, owing to the altered glucose metabolism. The current research aims to assess the capabilities of strains of lactic acid bacteria (LAB) that were obtained from fermented Ananas comosus (A. comosus) and Carica papaya (C. papaya) (non-dairy sources) as probiotics for the prevention of DM. The capacity of the strains to endure or survive extreme conditions was evaluated using bile tolerance using oxgall at varying concentrations, hydrophobicity, coaggregation ability, adhesion ability, and hemolytic activity, and their survival rate in gastric and intestinal juices. The LAB strains demonstrated the following results: phenol (>7 Log CFU/mL), acid-bile conditions (6.53–7.11 Log CFU/mL), gastric and intestinal juice tolerance (6.18–7.33 Log CFU/mL), thereby fulfilling the requirements to be a prospective probiotic agent. The LAB strains showed characteristics of cell surface hydrophobicity (≥ 40 %), autoaggregation (≥ 70 %), and coaggregation (≤ 48 %). Furthermore, they demonstrated antioxidant activity (≥ 59 %) as well as the ability to lower blood sugar levels by inhibiting α-glucosidase (≤ 57 %) and α-amylase (≤ 64 %). The development of antidiabetic probiotics from fermented papaya and pineapple has several potential uses. These probiotics may be used as functional foods or supplements to improve glycemic control in individuals with DM. They may also be used as adjunct therapies to conventional diabetes treatments to enhance their efficacy. The results of this research may pave way for creating probiotic products that function as food additives or supplements, with the aim of enhancing health and preventing long-term illnesses like diabetes. Additionally, probiotics have been proven to boost intestinal health, regulate the immune system, and decrease inflammation.

Regular Physical Activity in the Prevention of Post-Transplant Diabetes Mellitus in Patients after Kidney Transplantation.

Background and Objectives: Post-transplant diabetes mellitus (PTDM) is a significant risk factor for the survival of graft recipients and occurs in 10-30% of patients after kidney transplant (KT). PTDM is associated with premature cardiovascular morbidity and mortality. Weight gain, obesity, and dyslipidemia are strong predictors of PTDM, and by modifying them with an active lifestyle it is possible to reduce the incidence of PTDM and affect the long-term survival of patients and grafts. The aim of our study was to determine the effect of regular physical activity on the development of PTDM and its risk factors in patients after KT. Materials and Methods: Participants in the study had to achieve at least 150 min of moderate-intensity physical exertion per week. The study group (n = 22) performed aerobic or combined (aerobic + strength) types of sports activities. Monitoring was provided by the sports tracker (Xiaomi Mi Band 4 compatible with the Mi Fit mobile application). The control group consisted of 22 stable patients after KT. Each patient underwent an oral glucose tolerance test (oGTT) at the end of the follow-up. The patients in both groups have the same immunosuppressive protocol. The total duration of the study was 6 months. Results: The patients in the study group had significantly more normal oGTT results at 6 months compared to the control group (p < 0.0001). In the control group, there were significantly more patients diagnosed with PTDM (p = 0.0212) and with pre-diabetic conditions (impaired plasma glucose and impaired glucose tolerance) at 6 months (p = 0.0078). Conclusions: Regular physical activity after KT provides significant prevention against the development of pre-diabetic conditions and PTDM.

Use of myo-inositol and other nutritional supplements for the primary prevention of gestational diabetes mellitus

Use of myo-inositol and other nutritional supplements for the primary prevention of gestational diabetes mellitus

Inositols and female reproduction disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-Women's Endocrinology.

To provide the latest scientific knowledge on the efficacy of inositols for improving reproductive disorders in women with and without polycystic ovary syndrome (PCOS) and to reach a consensus on their potential use through a Delphi-like process. A panel of 17 endocrinologists and 1 gynecologist discussed 4 key domains: menses irregularity and anovulation, fertility, pregnancy outcomes, and neonatal outcomes. A total of eight consensus statements were drafted. Myo-inositol (Myo) supplementation can be used to improve menses irregularities and anovulation in PCOS. Myo supplementation can be used in subfertile women with or without PCOS to reduce the dose of r-FSH for ovarian stimulation during IVF, but it should not be used to increase the clinical pregnancy rate or live birth rate. Myo supplementation can be used in the primary prevention of gestational diabetes mellitus (GDM), but should not be used to improve pregnancy outcomes in women with GDM. Myo can be preconceptionally added to folic acid in women with a previous neural tube defects (NTD)-complicated pregnancy to reduce the risk of NTDs in newborns. Myo can be used during pregnancy to reduce the risk of macrosomia and neonatal hypoglycemia in mothers at risk of GDM. This consensus statement provides recommendations aimed at guiding healthcare practitioners in the use of inositols for the treatment or prevention of female reproductive disorders. More evidence-based data are needed to definitively establish the usefulness of Myo, the appropriate dosage, and to support the use of D-chiro-inositol (DCI) or a definitive Myo/DCI ratio.

Improving support vector machine and backpropagation performance for diabetes mellitus classification

Diabetes mellitus is a glucose disorder disease in the human body that contributes significantly to the high mortality rate. Various studies on early detection and classification have been conducted as a diabetes mellitus prevention effort by applying a machine learning model. The problems that may occur are weak model performance and misclassification caused by imbalanced data. The existence of dominating (majority) data causes poor model performance in identifying minority data. This paper proposed handling the problem of imbalanced data by performing the synthetic minority oversampling technique (SMOTE) and observing its effect on the classification performance of the support vector machine (SVM) and Backpropagation artificial neural network (ANN) methods. The experiment showed that the SVM method and imbalanced data achieved 94.31% accuracy, and the Backpropagation ANN achieved 91.56% accuracy. At the same time, the SVM method and balanced data produced an accuracy of 98.85%, while the Backpropagation ANN method and balanced data produced an accuracy of 94.90%. The results show that oversampling techniques can improve the performance of the classification model for each data class.

Improving support vector machine and backpropagation performance for diabetes mellitus classification

Diabetes mellitus (DM) is a glucose disorder disease in the human body that contributes significantly to the high mortality rate. Various studies on early detection and classification have been conducted as a DM prevention effort by applying a machine learning model. The problems that may occur are weak model performance and misclassification caused by imbalanced data. The existence of dominating (majority) data causes poor model performance in identifying minority data. This paper proposed handling the problem of imbalanced data by performing the synthetic minority oversampling technique (SMOTE) and observing its effect on the classification performance of the support vector machine (SVM) and Backpropagation artificial neural network (ANN) methods. The experiment showed that the SVM method and imbalanced data achieved 94.31% accuracy, and the Backpropagation ANN achieved 91.56% accuracy. At the same time, the SVM method and balanced data produced an accuracy of 98.85%, while the Backpropagation ANN method and balanced data produced an accuracy of 94.90%. The results show that oversampling techniques can improve the performance of the classification model for each data class.

Education and Early Detection of Diabetes Mellitus Risk in North Jakarta Office Environment

A low level of knowledge related to the causative factors, signs and symptoms, dangers, prevention, and treatment of diabetes mellitus (DM) causes an increasing number of DM sufferers worldwide, including in Indonesia. This community service activity aims to increase public knowledge, especially in the office environment, about DM disease and conduct early detection of DM. Participants in the community service activities consisted of 90 employees of an Accountant's office in North Jakarta. The community service activities included education about DM disease, tests of blood sugar, and question-and-answer discussions about DM. The results showed an increase in knowledge by 20.3% based on the score obtained from the pretest compared to the posttest. Based on the blood sugar test results, 98.9% of participants had blood sugar levels within normal limits, 1.1% were below average (hypoglycemia), and 1.1% were at risk of DM. This activity concludes that educational activities can increase participants' knowledge about DM disease, so it is hoped that the community can implement a healthy lifestyle to prevent DM disease and reduce the number of DM sufferers.

NIR-Based Electronic Platform for Glucose Monitoring for the Prevention and Control of Diabetes Mellitus.

The glucose level in the blood is measured through invasive methods, causing discomfort in the patient, loss of sensitivity in the area where the sample is obtained, and healing problems. This article deals with the design, implementation, and evaluation of a device with an ESP-WROOM-32D microcontroller with the application of near-infrared photospectroscopy technology that uses a diode array that transmits between 830 nm and 940 nm to measure glucose levels in the blood. In addition, the system provides a webpage for the monitoring and control of diabetes mellitus for each patient; the webpage is hosted on a local Linux server with a MySQL database. The tests are conducted on 120 people with an age range of 35 to 85 years; each person undergoes two sample collections with the traditional method and two with the non-invasive method. The developed device complies with the ranges established by the American Diabetes Association: presenting a measurement error margin of close to 3% in relation to traditional blood glucose measurement devices. The purpose of the study is to design and evaluate a device that uses non-invasive technology to measure blood glucose levels. This involves constructing a non-invasive glucometer prototype that is then evaluated in a group of participants with diabetes.

Digital therapeutics-based lifestyle intervention for gestational diabetes mellitus prevention of high-risk pregnant women: a study protocol for a non-randomised controlled trial

IntroductionDigital therapeutics have been approved as a treatment aid for various medical conditions and are increasingly prevalent. Despite numerous studies on the potential of digital therapeutic interventions in preventing gestational...

Hubungan Peran Keluarga, Pola Makan, Dan Status Gizi Terhadap Pencegahan Diabetes Mellitus Gestasional Di BPM Wilayah Kerja Kecamatan Payung

Introduction: Prevention of Gestational Diabetes Mellitus is an effort that individuals deliberately make to avoid or control blood sugar levels so as not to interfere with pregnancy and the health of mothers and babies. This study aimed to determine the direct and indirect effects and the magnitude of the influence of information sources, family roles, diet, physical activity, and nutritional status on the prevention of Diabetes Mellitus in pregnant women in Payung Health Center in 2023. Methods: This research was taken from primary data using a questionnaire. The sample used was 60 respondents with a cross-sectional design. The research was conducted in December 2022-January 2023. The cross-sectional analysis method was used. Results: The results showed that there was a relationship between the role of kelaura (p-value 0,030); diet (p-value 0,.003); and nutritional status (p-value 0,053) on the behavior of preventing gestational diabetes mellitus in pregnant women. Discussion: This study concludes that there is a relationship between family roles, diet, and nutritional status on the behavior of preventing gestational diabetes mellitus in pregnant women in the working area of Payung District in 2023. Suggestions for mothers to always maintain their health during pregnancy to avoid complications during pregnancy.

Conducting a diabetes mellitus prevention trial in women with GDM in Pakistan: a feasibility study

BackgroundWomen with gestational diabetes mellitus (GDM) are at a greater risk of developing type 2 diabetes mellitus (T2DM) than women without GDM. Despite this elevated risk, few trials on the prevention of T2DM among South Asian women with GDM have been reported. Therefore, this study aimed to assess the feasibility of conducting a diabetes prevention program on women with a history of GDM to inform the development of a contextually relevant definitive trial.MethodsUsing a randomized controlled trial, women with GDM (n = 180) who delivered at the study hospitals (one public and one private teaching hospital, Karachi) with fasting blood glucose levels < 120 mg/dl at 6 weeks postpartum were randomized to the intervention (n = 88) or control arms (n = 92). Women in the intervention group received individualized home-based educational sessions from trained community health workers at 0, 1, 3, 6, and 9 months. In addition, they received short text messages, prerecorded messages, and printed educational material (calendars and pamphlets) for reinforcement. The intervention was centered on equipping women with knowledge, skills, and confidence to eat a healthy diet rich in fruits, vegetables, and low-fat dairy products and perform regular physical activity based on walking and household chores to reduce weight (up to 5% of their initial body weight). Women in the control arm received standard care. The feasibility outcomes of the study included screening, recruitment, and retention rates and in-depth interviews at 6 months post-intervention to explore women’s experiences with the intervention. Descriptive analysis and thematic analysis were performed.ResultsOf the 324 women screened during the antenatal care visits and after delivery, 255 (78.7%) were contactable 6 weeks postpartum, and 180 (70.6%) were eligible and randomized to intervention (n = 88) and control (n = 92) groups. Loss to follow-up in the intervention and control arms was 22.7% (n = 20/88) and 18.5% (n = 17/92), respectively. Women expressed satisfaction with home-based counseling and follow-up visits, text message reminders, and printed material in the form of a calendar through our qualitative interviews.ConclusionsHome-based lifestyle modification intervention augmented with text messages and printed material is feasible. However, to evaluate the intervention’s effectiveness, a larger trial is warranted to assess its long-term impact on diabetes prevention.Trial registrationISRCTN, ISRCTN11387113. Registered 5 December 2017—retrospectively registered.

Improvement of Theaflavins on Glucose and Lipid Metabolism in Diabetes Mellitus.

In diabetes mellitus, disordered glucose and lipid metabolisms precipitate diverse complications, including nonalcoholic fatty liver disease, contributing to a rising global mortality rate. Theaflavins (TFs) can improve disorders of glycolipid metabolism in diabetic patients and reduce various types of damage, including glucotoxicity, lipotoxicity, and other associated secondary adverse effects. TFs exert effects to lower blood glucose and lipids levels, partly by regulating digestive enzyme activities, activation of OATP-MCT pathway and increasing secretion of incretins such as GIP. By the Ca2+-CaMKK ꞵ-AMPK and PI3K-AKT pathway, TFs promote glucose utilization and inhibit endogenous glucose production. Along with the regulation of energy metabolism by AMPK-SIRT1 pathway, TFs enhance fatty acids oxidation and reduce de novo lipogenesis. As such, the administration of TFs holds significant promise for both the prevention and amelioration of diabetes mellitus.

Evaluation of glycemic response of ten local meals commonly consumed from Chad

Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyperglycaemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins, including defects in either insulin secretion or response. The function of pancreatic cells gradually declines before the onset of clinical hyperglycemia. Its prevalence is increasing everywhere, especially in the developing countries due to the consumption of unknown glycemic index (GI) foods. Thus, the present study aimed to determine the GI of some local meals from Chad. In this purpose, ten meals were investigated and 60 non-diabetic volunteers were recruited in the present study. The proximate composition and the GI of these meals were determined. Results showed that 5 main ingredients (Hibiscus esculentus, Ipomea batata, Hibiscus sabdariffa, Corchorus oletorius and seeds of Parkia biglobosa) differentiate the meals. Soluble sugars and total carbohydrates levels showed a significant (p < 0.05) difference between meals (staples and sauces). The highest value of total carbohydrate of staples was found in Peeled dried sorghum ((BD); 31.80 %) while Cooked rice ((RZ); 19.82 %) has the lowest amount. Then, total carbohydrate content of sauces was in the range of 3.95 % (Leaves of Corchorus oletorius (MLK)) and 8.76 % (Dried okra + Fresh meat (GSV)) while, Sorrel leaves + Smoked fish ((OSP); 2.51 %) and Dried okra + Smoked fish ((GSP); 1.31 %) recorded the highest and lower values of soluble sugars, respectively. Moreover, Peeled dried maize + Dried okra + Fresh meat (MD/GSV) meal showed the highest GI (115.76 %) while the lowest value was found with Cooked rice + Sorrel leaves + Smoked fish (RZ/OZP) meal (31.08 %). The GI of Peeled dried maize + Fresh okra + Fresh meat (MD/GFV) attained a peak of 140 at 40 min while the peak of 130 was obtained with Peeled dried maize + Fresh okra + Smoked fish (MD/GFP) meal at the same time compared to glucose (160 at 40 min). Five meals (OSP/RZ; MD/GFP; MD/GFV; BD/GFP and BD/MLK) were low GI foods and were the best meals for human-being in terms of preventing diabetes mellitus. The consumption of such meals can provide a substantial contribution to the improvement of the Chadian diets.

PENYULUHAN KESEHATAN DAN PEMERIKSAAN KADAR GULA DARAH SEBAGAI UPAYA PENCEGAHAN DIABETES MELITUS DI DESA CURAH COTTOK, SITUBONDO

Diabetes mellitus is a disease whose population is increasing and can occur at all ages. This disease generally appears in the elderly. Diabetes mellitus is characterized by increased glucose levels in the blood. In rural communities, knowledge about this disease is still minimal, so hyperglycemia is usually only discovered when the condition gets worse. Blood sugar levels can be determined through blood sugar checks. The people in Curah Cottok Village have a pattern of consuming quite a lot of sugar. Drinks tend to taste very sweet when consumed. Apart from that, this village also produces crackers where the basic ingredient for making crackers is flour which is another source of carbohydrates. This needs to be watched out for because it can be a factor in increasing blood sugar levels. Increasing community knowledge in rural areas is carried out through health education activities and health consultations. Early detection of diabetes mellitus is carried out through random blood sugar level checks. This community service activity was carried out in Curah Cottok Village, Situbondo. Participants in this activity were 26 people aged 50-80 years. The result of this community service activity is a change in the village community's knowledge from knowing to knowing about diabetes mellitus and the prevention that needs to be done. Another result is data reports on residents who are at risk of developing diabetes mellitus. This data can be used by village officials or village midwives to plan referrals to health facilities or programs to prevent diabetes mellitus complications

Extraction of Sericin from Cocoons of the Silkworm Bombyx Mori, Its Characteristics, and a Dietary Supplement on Its Basis to Prevent Diabetes Mellitus

Extraction of Sericin from Cocoons of the Silkworm Bombyx Mori, Its Characteristics, and a Dietary Supplement on Its Basis to Prevent Diabetes Mellitus

The Effect of an Educational Video on Physical Activity for Diabetes Prevention among Obese High School Students in Yogyakarta

The association of obesity with type 2 diabetes mellitus (T2DM) in adolescents has increased globally over the past 2 decades. Thus, it must be prevented and overcome with particular management. The study aimed to analyze the impact of video education on physical activity for the prevention of T2DM among obese high school students in Mergangsan district, Yogyakarta. This was a quasi-experimental study with one group pre and post-test design. Educational videos about the introduction to physical activity education were made and given to students. A total of 47 obese adolescents were recruited and tested for physical activity using the Physical Activity Questionnaire for Adolescents questionnaire. (PAQ-A). The data was processed and analyzed using the Wilcoxon test with SPSS version 23.0. The results of the study were obtained before video education, physical activity in students with obesity was classified as mild (66%). After the video education was given, the physical activity of the majority was moderate (78.7%). There was an association between video education media and physical activity for the prevention of diabetes mellitus in students (p&lt;0.001). The school is expected to continue to provide health advice to students, especially on obesity students to prevent T2DM in adolescents, and the use of educational media with video will be more effective.

ANALISIS KADAR GULA TOTAL, FLAVONOID, DAN UJI AKTIVITAS ANTIOKSIDAN DARI FORMULASI BROTOWALI DENGAN APEL MANALAGI SEBAGAI MINUMAN FUNGSIONAL

Currently, the highest number of deaths in Indonesia is caused by non-communicable diseases. One of the non-communicable diseases is diabetes mellitus which is a metabolic disease. Efforts to prevent diabetes mellitus with non-pharmacological therapy can use plants that have the potential to have anti-diabetic effects. This study aims to make brotowali with manalagi apples as a functional drink which has potential as an antidiabetic and to determine total sugar content, flavonoids, and antioxidant activity with 3 ratios of brotowali : manalagi apple (F1 1:2, F2 1:1, and F3 2:1). This study used a completely randomized design (CRD) with 3 formulations and 3 repetitions. The statistical tests used were Analysis of Variance (ANOVA) and Duncan's Multiple Range Test (DMRT). The results showed that F1, F2, and F3 averaged total sugar content respectively 27.4%, 22.3% and 20.9%, the average of flavonoids was 41.7 mgQE/g, 48.8 mgQE/g, and 62.8 mgQE/g, and the average antioxidant activity with IC50 values were 145.5 µg/ml, 109.3 µg/ml, and 92.2 µg/ml. The best formulation of brotowali functional drink with manalagi apple is formula F3 with total sugar content of 20.9%, flavonoid content of 62.8 mgQE/g and antioxidant activity with IC50 value of 92.2 µg/ml.

Exploring the therapeutic potential of barley grain in type 2 diabetes management: a review

SummaryA healthy lifestyle with a high intake of whole grains is preferred for the effective type 2 diabetes mellitus (T2DM) prevention. Plenty of studies have shown the health benefits of barley on metabolic diseases, but there is a dearth of review articles specifically focused on antidiabetic effects. Hence, it is urgent to consolidate the up‐to‐date findings and provide guidance for future research endeavours in a timely review. This review aims to provide an overview on barley consumption for T2DM prevention and management, focusing on certain key aspects such as glycaemic control, insulin sensitivity and lipid profile. Extensive research has highlighted the potential benefits of barley grains in T2DM prevention, attributed to their high dietary fibre content, a diverse array of phytochemicals, and bioactive peptides. The dietary fibre (e.g., β‐glucan and arabinoxylan), characterised by their viscous and water‐soluble nature, is involved in modulating gastrointestinal physiology, thereby exerting regulatory effects on blood glucose and insulin levels. Phenolic compounds in barley have the potential to inhibit α‐amylase and α‐glucosidase enzymes, offering further support for glucose homeostasis. In addition, outer layers of barley are found to have high levels of fibres and bioactive compounds. The levels of these bioactive compounds can be improved through food processing techniques. Future investigation is necessary to establish the relationships between barley bioactive components and their specific antidiabetic capacity to improve study consistency and innovative strategies to incorporate barley into daily diet.

Preferred sources of information on diabetes prevention programmes: a population-based cross-sectional study in Poland

ObjectiveThis study aimed to analyse preferred sources of information on diabetes prevention programmes and to identify sociodemographic determinants influencing these preferences among adults in Poland.DesignA cross-sectional survey was carried out...