In keeping with our emphasis on positive mental health in the journal for 2012, my topic for this month’s editorial is prevention of depression in children and adolescents. I am prompted to write because of the recent release of a thorough literature review and synthesis by the Cochrane Collaboration (Merry, et al., 2011). The good news, in short, is that depression prevention programs work. Given the widespread prevalence of depression in young people, sometimes culminating in suicide, it is incumbent on all psychiatric professionals to read this Cochrane review. What literature was reviewed for the analysis? Merry and colleagues examined 53 studies which had involved over 14,000 participants. To fulfill selection criteria, these studies had to target young people ages 5 to 19 years, and the researchers must have conducted randomized controlled trials of psychological or educational depression prevention programs. In some cases, the programs were compared to a placebo intervention; in others, the comparison group received no intervention. The Cochrane review team assessed the quality of the studies before including them in the analysis. As you might suspect, when the prevention programs were compared to no intervention, there was a reduced likelihood of depression at follow-up (follow-up in 15 studies was conducted immediately after the intervention was provided, in 14 other studies conducted at 3–9 months, and at 12 months in 10 studies). Beyond one year, findings were not as positive, but this should not be surprising when you consider the rapid growth trajectory of children and adolescents and the myriad influences that could contribute to their development of depression (e.g., family upheaval, learning problems in school, bullying by peers, losses of significant others). As usual, some flaws in the research were identified, and further research was recommended (Merry et al., 2011). Psychiatric nurses should conduct some of this intervention research and submit reports of their findings to Issues in Mental Health Nursing. I also invite clinicians to write of their experience in delivering depression prevention programs in the schools and other community venues. I look forward to your submissions.