Prevention Methods Research Articles

Review of methods for prevention of post-mastectomic lymphorhea

Purpose of the study: to analyze the methods available in the literature for the prevention of postmastectomy lymphorrhea, systematize the data obtained, and substantiate the relevance of the search for new methods for the prevention of lymphorrhea.A search was conducted for published scientific studies in the Pubmed and Elibrary databases using the keywords: «лимфаденэктомия», «лимфорея», «рак молочной железы», “lymphadenectomy”, “lymphorrhea”, “breast cancer”. Using the given keywords, more than 500 scientific papers were found.Most of the currently existing methods for preventing postmastectomy lymphorrhea are systematized into groups. The disadvantages of known methods have been studied, which boil down mainly to unjustified anatomical destruction, economic unprofitability or ineffectiveness of these methods.Thus, the search for a new method of preventing lymphorrhea is still relevant.

Preventive Maintenance Decision-Making Optimization Method for Airport Runway Composite Pavements

Long-term preventive maintenance planning using finite annual budgets is vital for maintaining the service performance of airport runway composite pavements. Using the pavement condition index (PCI) to quantify composite pavement performance, this study investigated the PCI deterioration tendencies of middle runways, terminal runways, and taxiways and developed prediction models related to structural thickness and air traffic. Performance jump (PJ) and deterioration rate reduction (DRR) were used to measure maintenance benefits. Based on 112 composite pavement sections in the Long-term Pavement Performance Program, this study analyzed the influences of five typical preventive maintenance technologies on PJ, DRR, and PCI deterioration rates. The logarithmic regression relationship between PJ and PCI was obtained. For sections treated with crack sealing and crack filling, the DRR was nearly 0. For sections treated with fog seal, thin HMA overlay, and hot-mix recycled AC, the DRR was 0.2, 0.7, and 0.8, respectively. To solve the multi-objective maintenance problem, this study proposed a decision-making optimization method based on dynamic programming, and the solution algorithm was optimized, which was applied in a five-year maintenance plan. Considering different PCI deterioration tendencies of airport regions, as well as PJ, DRR, and costs of maintenance technologies, the preventive maintenance decision-making optimization method meets performance and financial requirements sufficiently.

Adverse events associated with immune checkpoint inhibitors in non-small cell lung cancer: a safety analysis of clinical trials and FDA pharmacovigilance system.

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC). However, the application of ICIs can also cause treatment-related adverse events (trAEs) and immune-related adverse events (irAEs). This study was to evaluate both the irAEs and trAEs of different ICI strategies for NSCLC based on randomized clinical trials (RCTs). The study also examined real-world pharmacovigilance data from the Food and Drug Administration Adverse Event Reporting System (FAERS) regarding claimed ICI-associated AEs in clinical practice. Based on Pubmed, Embase, Medline, and the Cochrane CENTRAL, we retrieved RCTs comparing ICIs with chemotherapy drugs or with different ICI regimens for the treatment of NSCLC up to October 20, 2023. Bayesian network meta-analysis (NMA) was performed using odds ratios (ORs) with 95% credible intervals (95%CrI). Separately, a retrospective pharmacovigilance study was performed based on FAERS database, extracting ICI-associated AEs in NSCLC patients between the first quarter (Q1) of 2004 and Q4 of 2023. The proportional reports reporting odds ratio was calculated to analyze the disproportionality. The NMA included 51 RCTs that involved a total of 26,958 patients with NSCLC. Based on the lowest risk of any trAEs, cemiplimab, tislelizumab, and durvalumab were ranked as the best. Among the agents associated with the lowest risk of grades 3-5 trAEs, tislelizumab, avelumab, and nivolumab were most likely to rank highest. As far as any or grades 3-5 irAEs are concerned, atezolizumab plus bevacizumab plus chemotherapy is considered the most safety option. However, it is associated with a high risk of grades 3-5 trAEs. As a result of FAERS pharmacovigilance data analysis, 9,420 AEs cases have been identified in 7,339 NSCLC patients treated with ICIs, and ICIs were related to statistically significant positive signal with 311 preferred terms (PTs), and comprehensively investigated and identified those AEs highly associated with ICIs. In total, 152 significant signals were associated with Nivolumab, with malignant neoplasm progression, death, and hypothyroidism being the most frequent PTs. These findings revealed that ICIs differed in their safety profile. ICI treatment strategies can be improved and preventive methods can be developed for NSCLC patients based on our results.

FSNet: Enhancing Forest-Fire and Smoke Detection with an Advanced UAV-Based Network

Forest fires represent a significant menace to both the ecological equilibrium of forests and the safety of human life and property. Upon ignition, fires frequently generate billowing smoke. The prompt identification and management of fire sources and smoke can efficiently avert the occurrence of extensive forest fires, thereby safeguarding both forest resources and human well-being. Although drone patrols have emerged as a primary method for forest-fire prevention, the unique characteristics of forest-fire images captured from high altitudes present challenges. These include remote distances, small fire points, smoke targets with light hues, and complex, ever-changing background environments. Consequently, traditional target-detection networks frequently exhibit diminished accuracy when handling such images. In this study, we introduce a cutting-edge drone-based network designed for the detection of forest fires and smoke, named FSNet. To begin, FSNet employs the YOCO data-augmentation method to enhance image processing, thereby augmenting both local and overall diversity within forest-fire images. Next, building upon the transformer framework, we introduce the EBblock attention module. Within this module, we introduce the notion of “groups”, maximizing the utilization of the interplay between patch tokens and groups to compute the attention map. This approach facilitates the extraction of correlations among patch tokens, between patch tokens and groups, and among groups. This approach enables the comprehensive feature extraction of fire points and smoke within the image, minimizing background interference. Across the four stages of the EBblock, we leverage a feature pyramid to integrate the outputs from each stage, thereby mitigating the loss of small target features. Simultaneously, we introduce a tailored loss function, denoted as Lforest, specifically designed for FSNet. This ensures the model’s ability to learn effectively and produce high-quality prediction boxes. We assess the performance of the FSNet model across three publicly available forest-fire datasets, utilizing mAP, Recall, and FPS as evaluation metrics. The outcomes reveal that FSNet achieves remarkable results: on the Flame, Corsican, and D-Fire datasets, it attains mAP scores of 97.2%, 87.5%, and 94.3%, respectively, with Recall rates of 93.9%, 87.3%, and 90.8%, respectively, and FPS values of 91.2, 90.7, and 92.6, respectively. Furthermore, extensive comparative and ablation experiments validate the superior performance of the FSNet model.

The advantages of sponge cities in urban flood prevention and control

Frequent occurrence of extreme precipitation is highly susceptible to flooding. The urbanization process has exacerbated the current situation of urban flooding. Sponge city technology has an important role in solving the problem of urban flooding. Since 2012, sponge city construction has been gradually launched in China. However, there are problems and challenges in China's sponge city construction. In this context, this paper explains the concept and advantages of sponge city. It attributes the main factors causing urban flooding to natural and social factors and discusses them separately. This paper uses the sponge city concept to construct the method of urban flood prevention and control system, and gives how to solve the problem of good articulation within the system. It also categorizes the existing sponge cities in China and puts forward the misunderstandings and deficiencies of the current state of construction of sponge cities. This study finds that sponge city construction is an important method to address the issue of urban flooding. It is also a necessary project to comply with the situation of urban development and plays a guiding role in the future urban construction project.

A Model of Accident Avoiding System for Trains

Abstract: Safety must be the top most priority in train running and it plays an important role in safe running of trains in our country. Already many systems are existed to avoid accidents, even though an attempt is made in this project work to study the subject of train accidents avoiding systems to enhance the technology further. The Train Collision Avoidance System (TCAS) is the major subject to detect unsafe situations arising due to over speed and train collisions in station area. The advanced accident prevention methods must be incorporated those measures under which the trains will be in constant communication with the protection systems through electronic communication systems. Although, Indian Railways have safe running devices, we have made an effort to cover few more important features like, 1 – to detect the track break in running rail track, 2 – object detection in between the tracks with auto control, and 3 – auto stop when train detects Red signal present over the track side signal post. These are the three important parameters incorporated in our project work and for live demo, a mini model train will be constructed over which all required sensors and their control circuits will be installed to prove the theme practically.

Investigation of Issues and Recommendations for a Better Management of Waqf Disputes in Sri Lanka

Waqf is a crucial instrument for providing socio-economic assistance in various sectors, including social finance, health, education, and socio-religious practices. It indicates that there are different levels of effectiveness in fulfilling socioeconomic needs, and this could be primarily associated to the effective and proper management of waqf. Post-amendment to the Waqf Act in Sri Lanka in 1982, there has been a significant increase in disputes and issues related to waqf in Sri Lanka, involving its managers, stakeholders, and various parties. As a result, over 5,000 waqf cases are currently unresolved at the Waqf Board of Sri Lanka, involving numerous accusations of corruption, mismanagement, misappropriation, and underuse of mosques and waqf properties. The challenges can be connected to the inadequate management of Sri Lanka's fundamental waqf administration and legal system. This study employs a qualitative approach for data collection and analysis to understand the issues. It gathers data from various sources, including books, theses, journal articles, and other relevant materials, especially legislation and legal reports. This study primarily focuses on providing brief descriptions of case studies and waqf conflicts in Sri Lanka. The findings include the most common categories of disputes, their primary causes, methods for dispute prevention, the waqf tribunal's resolution and settlement procedures, and the relevant laws. To further advance waqf in Sri Lanka, this study evaluates the operation of waqf tribunals in other jurisdictions. It is recommended that the Board may consider waqf disputes highlighted by amendments to the law and effective administrative procedures of the tribunal to minimize and prevent waqf conflicts, with the assistance of Shari'ah scholars. This study indicates that the recommendations might assist waqf administrators in Sri Lanka in attaining appropriate waqf management. Sri Lanka needs to develop a proficient waqf dispute resolution system. Keywords: Waqf Dispute, Recommendation, Management, Tribunal, Sri Lanka

Natural resources can help reducing cardiovascular risk: randomized controlled study

Cardiovascular diseases are the leading cause of death globally accounting for 32 % of all global deaths. Addressing modifiable risk factors, including hypertension and stress, remains paramount in the prevention of CVD. This study aimed to assess the impact of the balneotherapy on blood pressure, heart rate, electrocardiogram parameters, utilization of antihypertensive medications, and stress levels. Methodology. Multicenter randomized controlled single-blind parallel group trial was made in 6 Lithuania resort centers. 373 participants with the stress level > 3 (10, VAS) randomly divided into 6 groups in two clusters for receiving a 6- or 11-day complex treatment using natural resources – mineral waters, peloids, salt, nature therapy; follow-up period was 6 months. The BP, HR, ECG, stress level and other parameters were analyzed in 131 participants who passed a full course of investigation. Results. The significant reduction of systolic blood pressure after treatment (7.8 mmHg) and during 6 months (7.3 mmHg) together with diastolic 5.5 after 6 month and heart rate (4 b/min) was achieved in 11-day ambulatory balneotherapy group. Increase in the activity of the parasympathetic nervous system was observed, which is reflected by an increase in the duration of the ECG indicators. The stress level decreased by up to 43%, and stress management improved by up to 41% following inpatient treatment. Conclusion. Therapy using natural resources could stand for additional cardiovascular disease prevention and management method in integrative therapy.

The reduction of the m6A methyltransferase METTL3 in granulosa cells is related to the follicular cysts in pigs.

Follicular cysts are a common reproductive disorder in domestic animals that cause considerable economic losses to the farming industry. Effective prevention and treatment methods are lacking because neither the pathogenesis nor formation mechanisms of follicular cysts are well-understood. In this study, we first investigated the granulosa cells (GCs) of cystic follicles isolated from pigs. We observed a significant reduction in the expression of methyltransferase-like 3 (METTL3). Subsequent experiments revealed that METTL3 downregulation in GCs caused a decrease in m6A modification of pri-miR-21. This reduction further inhibited DGCR8 recognition and binding to pri-miR-21, dampening the synthesis of mature miR-21-5p. Additionally, the decrease in miR-21-5p promotes IL-1β expression in GCs. Elevated IL-1β activates the NFκB pathway, in turn upregulating apoptotic genes TNFa and BAX/BCL2. The subsequent apoptosis of GCs and inhibition of autophagy causes downregulation of CYP19A1 expression. These processes lower oestrogen secretion and contribute to follicular cyst formation. In conclusion, our findings provide a foundation for understanding and further exploring the mechanisms of follicular-cyst development in farm animals. This work has important implications for treating ovarian disorders in livestock and could potentially be extended to humans.

Early Detection of Allergy Symptoms in Children and Adolescents, Characteristics of Possible Pathogens, Pre-Treatment Prevention Measures (in Poland)

Background: The purpose of this study was to investigate the main allergens and signs of the onset of allergic diseases and explore methods of prevention that do not include medicines. Methods: Non-parametric statistical methods were used. A retrospective study was conducted, which included 270 case histories. The average age of the patients was 19 (12.5; 40.1) years, 127 (47%) were men and 143 (53%) were women. Clinical diagnoses, early symptoms, allergen spectrum, and treatment recommendations provided by doctors were analyzed. It was established that the early signs of allergic rhinitis and rhinoconjunctivitis are nasal congestion, runny nose, and lacrimation, and the onset of atopic dermatitis is -characterized by dry and itchy skin. Results: Allergy to triggers from one group was present in 136 (50.4%) patients, irritants from two groups – in 95 (35.2%) patients, and irritants from three groups – in 39 (14.4%) patients. Polish doctors advised patients to limit their exposure to allergens but did not give recommendations for concrete actions. Conclusion: The results of the study can be used to help in the identification of the most common symptoms of allergic diseases and allergens, which is vital for the early diagnosis of this pathology by clinicians.

Understanding the Factors Promoting Mother to Child Transmission of HIV/AIDS in Nigeria

Mother-to-child transmission (MTCT) of HIV/AIDS remains a significant public health challenge in Nigeria. This review aimed to identify and understand key factors promoting MTCT and assess the effectiveness of current prevention interventions. A systematic literature search was conducted across multiple databases using relevant keywords and approximately 57 individual literatures was reviewed. Studies focusing on MTCT in Nigeria published after 2015 were included. Eligible studies were critically appraised for quality and relevance. Findings indicate significant knowledge gap (such as misconceptions about transmission routes, limited understanding of prevention methods, delay in seeking testing and care and inconsistent adherence to Antiretroviral therapy) among pregnant women regarding HIV transmission, persistent stigma and discrimination hindering access to PMTCT services, and challenges within the healthcare system such as geographical disparities and inadequate provider training. Cultural practices, including breastfeeding and postnatal rituals, further exacerbate MTCT risk. Male partner involvement emerges as a crucial yet often overlooked aspect of PMTCT. Existing interventions showed moderate effectiveness, highlighting the need for tailored approaches. Strengthening multi-level interventions addressing social, economic, and cultural determinants, alongside culturally sensitive approaches and increased male engagement, are crucial to address MTCT and improve maternal and child health outcomes in Nigeria. Future research should focus on developing and evaluating interventions tailored to specific contexts and populations.

Comparative efficacy of prophylactic protocols in reducing perioperative nausea and vomiting during video-assisted thoracoscopic radical resection of lung cancer

Lung cancer, a global mortality leader, often necessitates Video-Assisted Thoracoscopic (VATS) surgery. However, post-operative nausea and vomiting (PONV) is common, highlighting a need for effective management and prevention strategies in this context. A retrospective case–control study at Fujian Medical University Union Hospital evaluated patients undergoing VATS radical resection of lung cancer between May and September 2022. Patients were categorized based on PONV prevention methods, and data encompassing demographics, surgical history, and postoperative adverse events s were analyzed to assess the association between prophylactic protocols and PONV incidence. The Netupitant and Palonosetron Hydrochloride (NEPA) group showed a significant reduction in PONV occurrences post-surgery compared to Ondansetron (ONDA) and Control groups, emphasizing NEPA’s efficacy in alleviating PONV symptoms (P < 0.05). Furthermore, following VATS radical resection of lung cancer, NEPA markedly reduced the intensity of PONV symptoms in patients. Both univariate and multivariate logistic analyses corroborated that NEPA independently reduces PONV risk, with its protective effect also apparent in susceptible populations like females and non-smokers. NEPA utilization markedly reduced both the incidence and severity of PONV in patients undergoing VATS radical resection of lung cancer, serving as an independent protective factor in mitigating PONV risk post-surgery.

Causal relationship between gut microbiota and diabetic nephropathy: A bidirectional mendelian randomization study.

In this study, we summarized the key findings and potential implications of association studies investigating the relationship between gut microbiota composition and risks for Diabetic nephropathy (DN). We used Mendelian randomization (MR) analysis to explore the relationship between gut microbiota and DN using two different publicly available DN databases. The results were also summarized using five mainstream MR analysis methods. We controlled for various possible biases in the results. The results showed that specific bacterial genera were associated with increased or decreased risk of DN. These associations can be attributed to a variety of factors, including metabolites produced by certain bacteria. Most of our findings are consistent with the existing research findings, but there are still some differences with the existing results. In addition, we also pointed out that some microbiota that may be associated with DN but remain unnoticed can bring new research directions. Our work made use of MR, a reliable technique for examining causal correlations using genetic data investigating potential processes, carrying out longitudinal studies, looking into intervention options, and using a multi-omics approach may be future research avenues. Further, our findings also point to a few unexplored possible study paths for DN in the future. These initiatives may improve our reconciliation of the internal relationships between the gut microbiota and DN and pave the way for more precise prevention and treatment methods. However, it is also critical to recognize any potential restrictions, such as those caused by sample size, population variety, and analytical techniques.

Awareness of Pregnant Patients about Congenital Cytomegalovirus Infection-A Semi-Systematic Review.

Background: Cytomegalovirus (CMV) infection represents a major issue worldwide, since it constitutes the most common viral congenital infection, with a prevalence of 0.58% and 1-5% in developed and developing countries, respectively. According to recent studies, prenatal treatment significantly decreases the risk of vertical CMV transmission, and early intervention may even prevent the termination of pregnancy. This study aimed to investigate the level of awareness of CMV among pregnant patients through a semi-systematic review. Methods: We included all of the original articles investigating knowledge and awareness about CMV infection among pregnant women. Our research included the PubMed database. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, the Covidence system automatically guided us to screen the titles and/or abstracts, and then full-texts, followed by data extraction from the eligible studies. Results: We screened 764 studies altogether, with 13 studies included in this analysis. Knowledge about the existence of CMV infection risk varied between the articles, ranging from 11.4% in a study performed in Ireland to 60% reported in a study on the French population. Studies analyzing the impact of educational interventions on patients' knowledge about preventive measures reported significant improvement compared to their level of awareness before the intervention. Conclusions: Patients' awareness and knowledge about CMV seemed to be generally low or very low during the last decade before the development of effective secondary prevention methods. Educational interventions seem to be effective, and therefore their wide use could be of potential benefit. In the era of available secondary prevention of vertical transmission, it is crucial to concentrate the efforts of different stakeholders to increase the awareness of cCMV among pregnant women.

Performance of fly ash and CNI as corrosion prevention methods for steel reinforcement embedded in cracked HPC concrete exposed to a natural marine environment

In this study, the effectiveness of fly ash and a calcium nitrite-based corrosion inhibitor in cracked high-performance concrete was investigated. Concrete prisms were fabricated and the specimens featured artificially transverse cracks 0.25 and 0.5 mm width. These specimens were exposed to a natural marine environment for seven years and the corrosive activity was monitored annually using electrochemical techniques. At the end of the exposure period, chloride ion content at the steel-concrete interface, mass loss, pitting depth and tensile parameters on the steel reinforcement were estimated. It was found that cracking exacerbated corrosion and the prevention methods assessed or their interactions were ineffective. Ultimate strength and ductility losses of the steel reinforcement ranged between 7% and 11% and 44–60% for 0.25 mm crack, while between 11% and 14% and 48–66% for 0.50 mm crack. The results from this research are original because they contribute to elucidating the effect of the interactions between the investigated corrosion prevention methods.

Soil compaction due to agricultural machinery impact: A systematic review

AbstractSoil compaction is generally viewed as one of the most serious soil degradation problems and a determining factor in crop productivity worldwide. It is imperative to understand the processes involved in soil compaction to meet the future global challenges of food security. In this work, we used co‐occurring keyword analysis to summarize 3491 papers on soil compaction over the past 40 years, elaborating on the main research focuses such as the causes, influencing factors, and effects of soil compaction on crops, and the mitigation and prevention of soil compaction. This review provides a comprehensive discussion of the effects of soil compaction, including altering soil structure, increasing bulk density (BD) and penetration resistance (PR), and reducing porosity and soil hydraulic properties. Notably, based on the 387 data points of 11 papers about BD, our results demonstrated soil compaction on average, increased BD by 7.6%, 6.9%, and 3.2% in the medium‐, coarse‐, and fine‐textured soils, respectively. Based on the 264 data points of 18 papers, in the 0–30 cm soil layer, compaction increased penetration resistance (by 91% in the coarse‐textured, 84.2% in the medium‐textured, and 8.8% in the fine‐textured soils). Compacted soil limits the access of crop roots to water and nutrients, leading to poor root development and reduced crop productivity. There was a difference in soil compaction sensitivity between the different crops, but crop growth and yield showed an overall worsening trend with increasing degrees of compaction. This review collected data points on 142 crop yields and found that wheat, barley, corn, and soybean yields decreased by an average of 4.1%, 15.1%, 37.7%, and 22.7%, respectively, in the BD range of 1.1–1.8 Mg/cm3 after compaction. Additionally, the effectiveness of different compaction mitigation measures, including natural, tillage, and biological, is systematically discussed. Compared with soil compaction mitigation measures, prevention should be the top priority although there is still a lack of practical prevention methods. Soil conditions and agricultural machinery type are the main factors affecting the risk of soil compaction in the process of soil compaction. Therefore, it is particularly important to optimize the soil working conditions in the field and the type of farm machinery used to reduce the risk of soil compaction. This initiative is pivotal for ensuring sustainable systems for food production and recovering crop productivity from compacted soil.

Comment faire de l’après-cancer un projet de vie, plutôt qu’un projet de survie

The promise of a Post-cancer outcome synonymous with a new life project rather than survival involves a number of stages, some of which even precede treatment. The first step is to tailor cancer risk management to each individual's family history and risk factors, so as to adapt screening and prevention methods and thus enable early diagnosis, which limits the impact of treatment and can improve survival. Once a patient has been diagnosed with cancer, access to comprehensive, rapid diagnostic pathways that take into account the specific characteristics of each patient will enable them to have a better experience, which in turn will ensure a better recovery. The practitioner in a situation of "shared decision-making" with the patient must choose the most effective treatment but also limit the risks of after-effects. The Post-cancer period itself can be a lonely one, and with the help of new healthcare professionals, the practitioner must also support the patient during this stage of his or her recovery.

Development of a Bio-Hybrid Mosquito Stinger-Based Atomic Force Microscopy Probe.

Mosquitoes, notorious as the deadliest animals to humans due to their capacity to transmit diseases, pose a persistent challenge to public health. The primary prevention strategy currently in use involves chemical repellents, which often prove ineffective as mosquitoes rapidly develop resistance. Consequently, the invention of new preventive methods is crucial. Such development hinges on a thorough understanding of mosquito biting behaviors, necessitating an experimental setup that accurately replicates actual biting scenarios with controllable testing parameters and quantitative measurements. To bridge this gap, a bio-hybrid atomic force microscopy (AFM) probe was engineered, featuring a biological stinger - specifically, a mosquito labrum - as its tip. This bio-hybrid probe, compatible with standard AFM systems, enables a near-authentic simulation of mosquito penetration behaviors. This method marks a step forward in the quantitative study of biting mechanisms, potentially leading to the creation of effective barriers against vector-borne diseases (VBDs) and opening new avenues in the fight against mosquito-transmitted illnesses.

Європейські рекомендації 2023 року щодо лікування кардіоміопатій та впровадження їх у практику в Україні

In this article we analyzed the main positions of the recommendations of the European Society of Cardiology regarding the treatment of cardiomyopathies and presented the actual issues of implementing recommendations into clinical practice in Ukraine. The diagnostic flowchat of a patient with suspected cardiomyopathy is presented. Five phenotypes of cardiomyopathies are presented with current definition. New fenotype of non-dilated left ventricular cardiomyopathy is presented. The role of various imaging methods in diagnosis of cardiomyopathy phenotype is considered. The role of methods of genetic testing and magnetic resonance imaging of the heart with contrast is determined. The attention is focused on the need to differentiate the etiology of phenotypes and phenocopies of cardiomyopathies for pathogenetic treatment. Methods of assessing the risk of sudden cardiac death in cardiomyopathies and methods of secondary and primary prevention are discussed. Calculators for the risk of sudden death in cardiomyopathies and indications for implantation of a cardioverter-defibrillator are given. The management of patients with atrial fibrillation in various cardiomyopathies is determined. The issue of treatment of heart failure in patients with different phenotypes and ethiology of cardiomyopathies is discussed. Attention is focused on the role of «cardiomyopathy teams» in cardiological centers. An experience of echocardiographic diagnostics of cardiomyopathies, genetic testing, usage of magnetic resonance imaging in cardiomyopathies is presented.

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin has hepatoprotective activity, its low solubility and bioavailability limit its applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures and large inner cavities, which make them excellent carriers of poorly soluble drugs. In this study, we used CD-MOFs as carriers to improve the dissolution of luteolin and assessed their antioxidant activity, bioavailability, and hepatoprotective effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, and γ-CD, and characterized by powder X-ray diffractometry (PXRD) and thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF was the most stable. The main driving forces were hydrogen bonds and van der Waals forces, as determined by molecular simulation. The loading capacity of luteolin-β-CD-MOF was 14.67 wt%. Compared to raw luteolin, luteolin-β-CD-MOF exhibited a 4.50-fold increase in dissolution and increased antioxidant activity in vitro. Luteolin-β-CD-MOF increased the bioavailability of luteolin by approximately 4.04- and 11.07-fold in healthy rats and liver injured rats induced by acetaminophen in vivo, respectively. As determined by biochemical analysis, luteolin-β-CD-MOF exhibited a better hepatoprotective effect than raw luteolin in rats with acetaminophen-induced liver injury. This study provides a new approach for preventing acetaminophen-mediated liver damage.