Prevention Focus Research Articles

Applicable methodologies for business continuity management in IT services: A systematic literature review

Introduction: Currently, information technologies have one characteristic in common: their volatility. This is why it is important that companies have methodologies that allow adequate management of the continuity of the services offered through them.Objective: In this sense, the purpose of this systematic literature review is to identify the most appropriate methodologies that can be implemented in companies to deal with these unforeseen interruptions.Method: With a study based on a PICO question, the search for relevant literature in a scientific database was proposed using a search equation based on keywords.Results: The studies offer qualitative results that mainly allow reducing response times before incidents of unforeseen interruptions, among the most notable is that the proposed systems help increase the success rate of recovery procedures by 80%, allow identifying and apply integration technologies that allow improving business continuity systems, among others. However, there is a knowledge gap for which the implementation of these methods is suggested for future proposals in order to achieve quantitative results that can be presented through metrics.Conclusions: In conclusion, the present systematic literature review carried out the analysis and a comparison of the methodologies proposed by the authors and analyzes the results achieved in each of them, suggesting that 69% of the articles mention an origin of the associated interruptions to logical failures, 75% of the studies indicate that business continuity plans mostly have a preventive focus and 44% suggest continuous testing of plans to ensure their effectiveness.

Microbiome in a ground-based analog cabin of China Space Station during a 50-day human occupation.

Dead-corner areas in space station that untouched by the clean-up campaign often experience microorganisms outbreaks, but the microbiome of these areas has never been studied. In this study, the microbiome in a ground-based analog ``Tianhe'' core module of China Space Station was first investigated during a 50-day three-crew occupation. Dead-corner areas were receiving attention by adopting a new sampling method. Results indicate that the astronauts occupation did not affect the dominant bacteria community, but affected a small proportion. Due to the frequent activity of astronauts in the work and sleep areas, the biomarkers in these two areas are common human skin surface and gut microorganisms, respectively. For areas that astronaut rarely visits, the biomarkers in which are common environmental microbial groups. Fluorescence counting showed that 70.12-84.78% of bacteria were alive, with a quantity of 104-105 cells/100cm2. With the occupation time extension, the number of microorganisms increased. At the same sampling time, there was no significant bioburden difference in various locations. The cultivable bioburden ranged from 101 to 104 colony forming unit (CFU)/100cm2, which are the following eight genera Penicillium, Microsphaeropsis, Stachybotrys, Humicola, Cladosporium, Bacillus, Planomicrobium, and Acinetobacter. Chryseomicrobium genus may be a key focus for future microbial prevention and control work.

Effect of the fit between situational regulatory focus and feedback focus on customers' co-design behavior

PurposeCustomers' co-design behavior is an important source of knowledge for product innovation. Firms can regulate the focus of information interaction with customers to set goals and motivate their co-design behavior. Drawing on regulatory fit theory and construal level theory, the authors build a research model to study whether the fit between the regulatory focus of firms' task invitations (promotion focus vs prevention focus) and their feedback focus (self-focused vs other-focused) can enhance co-design behavior by improving customers' experiences (perceived meaning, active discovery and perceived empowerment).Design/methodology/approachThe authors conducted two online between-subjects experiments to validate the proposed research model.FindingsThe two online experiments reveal that customers' experiences are enhanced when the feedback focus is congruent with the regulatory focus of the firm's task invitations. Specifically, self-focused feedback has a stronger positive effect on customers' experiences in the prevention focus context. Other-focused feedback has a stronger positive effect on customers' experiences in the promotion focus context. Moreover, customers' experience significantly and positively affects co-design behavior (i.e. co-design effort and knowledge contribution).Originality/valueThis work provides theoretical and practical implications for firms to improve the effectiveness of information interaction with their customers and eventually ensure the sustainability of co-design.

The framing of information nudge and students effort: A behavioral economics approach

One of the important fields for achieving the goals of the higher education system is to use new methods to influence students' motivation. Therefore, the main goal of this study is to investigate the impact of the framing of information nudge on students' efforts using the behavioral economics approach, taking into account the theories of social psychology. To investigate this goal, a 2*2*2 factorial model including; two levels of framing effect (positive or negative), two levels of regulatory focus (promotion or prevention) and two levels of test difficulty (difficult or easy) were considered. The independent variables of this study are the negative frame, the promotion focus and the difficulty of the test and the dependent variable is the anticipated effort in a hypothetical exam. The random sampling of this research included 400 students of Ilam and Allameh Tabatabai University. The results of the estimation of the ordinary least squares model showed that the promotion focus frame increases students' effort compared to the prevention focus frame. The negative frame increases student effort relative to the positive frame, but without controlling for regulatory focus, it has no independent effect on student effort. The results of the estimation of interaction variables also showed that the variable of negative frame * promotion focus has a negative and significant coefficient. This result shows that the joint condition of negative frame and promotion focus increases students' effort less than negative frame and prevention focus. In other words, the negative frame increases students' effort both in the promotion focus and in the prevention focus, but the effect of the negative frame is greater in the prevention focus. It also confirms that students experience regulatory fit under the common conditions of prevention focus and negative frame, but regulatory fit is not confirmed under the common conditions of promotion focus and positive frame. In order to strengthen students' motivation and performance, policy makers and planners in higher education can use behavioral economics tools such as framing of information nudge appropriate to subjects such as exam preparation, education plan, choosing a field at higher levels of education, etc.

Regulatory Focus, Ambidextrous Learning, and Opportunity Recognition in New Product Development

This study focuses on individual managers’ ambidextrous learning and examines its psychological antecedents and consequences in the new product development (NPD) context. Specifically, drawing on the paradox theory and the regulatory focus theory, this study examines the relationship between regulatory focus (i.e., promotion focus and prevention focus), ambidextrous learning, and NPD opportunity recognition, from the individual ambidexterity perspective. Based on the survey data of 225 NPD managers in high-tech small and medium-sized enterprises in China, we find that NPD managers’ promotion focus and prevention focus, acting as an enabler and a deterrent respectively, affect their ambidextrous learning, which in turn facilitates opportunity recognition in the NPD process. Further analyses reveal that ambidextrous learning mediates the effects of promotion focus and prevention focus on opportunity recognition in the NPD. Our findings offer new insights on the individual ambidexterity research regarding the unique role of ambidextrous learning, manifested as actionable managerial capability. The findings offer novel insights on the role of NPD managers’ ambidextrous learning in the NPD process, and practical implications for NPD managers to self-regulate their behavior for the benefit of opportunity recognition.

The relationship between regulatory focus and innovative performance of SMEs in Ghana: The role of entrepreneurial resilience, orientation and learning

Most small and medium scale enterprises in Ghana neglect very critical performance indicators in their bossiness. As a result most SMEs do not survive till their fifth anniversary. The purpose of this study is to examine the relationship between prevention focus, promotion focus, resilience, and SME performance in Ghana. Furthermore, we investigated the moderation effect of entrepreneurial learning and Entrepreneurial orientation on the relationship between entrepreneurial resilience and SME performance in Ghana. Our results show that both promotion- and prevention-focused increase entrepreneurial resilience and SME performance significantly. This is an indication that there is a strong positive correlation between entrepreneurial resilience and success in both the individual and firm levels. This inference can therefore assist policy makers, politicians and various industry players in designing training programs on how to improve the resilience of SME owners in Ghana. Statistically our analysis shows that prevention focus (PreV) has a positive effect on entrepreneurial resilience (EntR) (β = 0.250; p<0.001), and promotion focus (PreM) has a positive effect on entrepreneurial resilience (EntR) (β = 0.268; p<0.001). Additionally, entrepreneurial resilience (EntR) has a positive effect on innovative performance (IP) (β = 0.547; p<0.001). Furthermore, the mediation results has shown that entrepreneurial resilience (EntR) mediates the relationship between prevention focus (PreV) and innovative performance (IP) (β = 0.136; p<0.001); as well as that of promotion focus (PreM) and firm performance (IP) (β = 0.146; p<0.001). Finally, the results with regards to moderation effects has shown that entrepreneurial orientation (EntO) partially moderates the relationship between entrepreneurial resilience (EntR) and innovative performance (IP) (β = 0.109; p<0.05), however, the result established that entrepreneurial learning (EntL) does not moderate the relationship between entrepreneurial resilience (EntR) and firm performance (IP) (β = -0.031; p<0.05). Using the Resource Based View theory, we concluded that, SME’s needs to adopted prevention (vigilant/avoidant strategies) by minimizing losses, and taking calculated risks with motivation from mentors to avoid loss as this would achieve resilience as well as promotion of strategies (eager/approach strategies) to achieve gains for their SMEs during economic disruption and economic downturn such as COVID-19. We concluded that SME’s could also achieve resilience when managers or owners of SMEs inspire the employees to work harder, and think outside the box to identify latent ideas and opportunities within their SME business environment.

Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study.

Acute kidney injury (AKI) is a common clinical critical condition that has become a significant healthcare burden. In recent years, the relationship between AKI and mitochondria has attracted increasing attention. Protecting mitochondria or restoring their function has emerged as a novel therapeutic strategy for alleviating AKI. This study aims to analyze and summarize the current status, research trends, and hotspots in this field, providing references and directions for future research. AKI and mitochondria-related literature from the Web of Science core collection were retrieved and collected. Bibliometric and visualization analyses were conducted using Microsoft Excel 2021, bibliometric tools (VosViewer, Citespace 6.3.R1, and the bibliometrix R package), R 4.3.2, and SCImagoGraphica software. A total of 2433 publications were included in this study. The number of annual publications in this field has increased year by year. China and the United States are the two most productive countries. Central South University is the most influential research institution in terms of research output, and Parikh SM, Schnellmann RG, and Dong Z are the most influential authors in this field. KIDNEY INTERNATIONAL, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, and AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY are the most influential journals. Initially, the research focused on keywords such as oxidative stress, ischemia-reperfusion injury, apoptosis, inflammation, and autophagy. In recent years, new research hotspots have emerged, including ferroptosis, aging, mitochondrial quality control, messenger RNA, mitochondrial-targeted antioxidants, extracellular vesicles, and nanodrug delivery. Research on the relationship between mitochondria and AKI has broad developing prospects, and targeting mitochondrial regulation will become a focus of future AKI prevention and treatment research.

Towards Shared and Effective Self-Care: A User-Centric Framework for Enhancing HIV Prevention

Background: Despite a declining trend in Human immunodeficiency virus (HIV) prevalence across sub-Saharan Africa, specific vulnerable groups continue to be disproportionately impacted (29.9% for sex workers, 12.9% for gay men having sex with men (MSM) vs 5.9% for adults). In the face of this challenge, it is critical to tailor demand creation for prevention, in particular self-care, for maximum impact and cost-efficiency. This study seeks to provide a behavioral understanding towards HIV prevention that shape the efficacy of prevention strategies among priority populations (female sex workers, MSM and adolescent girls and young women) in southern and eastern Africa. Methods: This study involved a literature review of 110 articles, focusing on HIV prevention in priority populations, behavioral interventions, and policy priorities from governments and funders. Additionally, insights were gained from 11 in-depth interviews and a workshop with 10 experts at the AIDS Impact 2023 conference. Participants included behavioral researchers and program leaders from Global Fund, United States Agency for International Development (USAID), U.S. President's Emergency Plan for AIDS Relief (PEPFAR), Bill and Melinda Gates Foundation, FHI360, Population Services International and Genesis Analytics. A user-centric behavioral framework was devised to identify actionable drivers and barriers in HIV prevention during the consultation exercise. Results: The study highlights the importance of shared and effective self-care in enhancing HIV prevention, particularly in vulnerable groups. The behavioral framework integrates the decision-making contexts and the health ecosystem layers to inform research and demand strategy. Key findings include: (1) effective self-care is not the same as continuous use of Pre-exposure prophylaxis and therefore, programs and policies need to measure them differently; (2) users exercise choice through a combination of prevention products and focus on a few may be sub-optimal, and (3) perceived risk is transient and hence risk-based messaging lacks sustained relevance. Conclusion: Effective self-care strategies extend beyond overcoming access and availability issues. Examining the underlying factors causing the barriers is essential. The behavioral framework presented here suggests that: (a) Self-care is a shared responsibility between the user and healthcare system and (b) demand creation should be de-medicalised, away from products and towards meeting the needs and preferences of users.

Maintaining prevention focus: the impact of an interdisciplinary taskforce on CAUTI rates during an EMR transition.

We employed an interrupted time series analysis to assess the impact of changing electronic medical records, concurrent with a Catheter-Associated Urinary Tract Infection (CAUTI) Taskforce, on CAUTI rates. We found that rates increased in most ICUs before returning to baseline. These findings suggest that a multi-faceted approach may reduce CAUTI rates.

WISDOM-RELATED EMOTION REGULATION RESOURCES EXPLAIN MIDDLE-AGED AND OLDER ADULTS’ COVID-19-RELATED DISTRESS

Abstract As the pandemic wrought wide-reaching disruption across the world, younger adults appeared to be faring more poorly than other adults. We hypothesized that younger adults might possess fewer emotion regulation resources and skills, accounting for their relatively high levels of distress. In data gathered from a national sample of 1258 adults, we examined how baseline resources (in mid-April, during initial peak infections) predicted distress (depression, anxiety, PTSD symptoms) five weeks later, when states began initial re-openings. Younger adults (18-35 years; n = 317; mean age = 29.2 years) reported greater distress and less social support, mindfulness, and emotion regulation skills than did middle aged (36-60 years; n = 513; mean age =51.7 years) and older adults (61-88 years; n =428; mean age = 70.1 years). Controlling for stress exposure, younger adults’ distress was predicted by impulsivity and lack of perceived strategies while middle-aged and older adults’ (lower) distress was predicted by acceptance of negative emotions and emotion regulation abilities; perceived social support was related to lower distress for all groups but mindfulness was unrelated. Results suggest that emotion regulation resources and skills are a promising prevention and intervention focus.

INVESTIGATING PSYCHOLOGICAL FACTORS AS A PREDICTOR OF FEAR OF FALLING AND FALL RISK IN OLDER ADULTS

Abstract Psychological factors related to appetitive and avoidant motivation, perceptions of aging, and regulatory focus (promotion focus on gains versus a prevention focus on non-losses) are likely to play an important role in predicting one’s fear of falling (FOF) and resulting impact on physical activity engagement. This pilot study aimed to investigate the gap in current research related to these psychological factors as predictors of older adults’ Fear of Falling and Fall Risk Appraisal (FRA). The study assessed positive and negative perceptions about aging in regards to control and consequences of aging (Brief Aging Perceptions Questionnaire [B-APQ]), motivation (Behavioral Inhibition System/Behavioral Activation system [BIS/BAS]), regulatory focus in goal achievement (Regulatory Focus Questionnaire [RFQ]), FOF (Fall-Efficacy Scale-International [FES-I]), and static balance levels (BTracks Balance system [BBS]). Participants (n=48) were categorized into four FRA groups: rational (low FOF/normal balance), irrational (high FOF/normal balance), incongruent (low FOF/poor balance), and congruent (high FOF/poor balance). A Spearman Rho correlation found that FOF was positively correlated with two of the BAPQ sub-domains of Control-Positive (ρ = 0.46, p<.001) and Consequences and Control Negative (ρ = 0.43, p =.002),. A Kruskal-Wallis test found the relationship between BAPQ Control Positive and the Irrational and Rational FRA group baselines to be significant. The results suggest that among other psychological factors, perceptions about aging may be predictive of FOF and FRA in aging. These results highlight the importance of clinicians addressing not only the physiological factors of fall risk, but also the psychological factors underlying fall risk in older adults.

Not all information security-related stresses are equal: the effects of challenge and hindrance stresses on employees’ compliance with information security policies

ABSTRACT Information security-related stresses (SRSs) are widely considered to play a negative role in the workplace, motivating employees' violation of information security policies (ISPs). However, researchers have neglected to challenge SRS and its role in promoting positive security actions. Therefore, this study aimed to explore the effect of both challenge and hindrance SRSs on employees' intention to comply with ISPs and the moderating mechanisms of regulatory focus in the relationship between SRSs and ISP compliance. Using survey data from 489 employees in Chinese enterprises, we applied a PLS-SEM method to test hypotheses. Our study found that the hindrance SRS had a negative effect on ISP compliance intention, differently, challenge SRS motivates employees to comply with ISPs. Our study also found prevention focus acted as a positive moderator in the relationship between hindrance SRS and compliance intention, while promotion focus had no effect on this relationship; Promotion focus positively moderated the relationship between challenge SRS and compliance intention, and prevention focus negatively moderated the relationship between challenge SRS and compliance intention. These findings provide new knowledge by examining the different effects and the boundary conditions to understand how two types of SRS influence employees' informaiton security dicisions.

Geographic distance in cross-border acquisitions: The impact of CEO's psychological attributes

This study examines the influence of acquiring firm CEOs' psychological attributes on the geographic distance of target firms in cross-border acquisitions. Drawing on the regulatory focus theory, we argue that CEOs with a higher dispositional prevention focus are more vigilant and loss-aversive, avoiding target firms at a greater geographic distance in cross-border acquisitions. Furthermore, building on the concept of regulatory misfit, we examine the moderating effect of acquiring firm CEOs' context-specific experience and the munificence of acquiring firms' industries in priming the dispositional prevention focus. In a sample of 218 cross-border acquisitions by public firms from the United Kingdom from 2006 to 2014, we find support for our hypotheses. This study emphasizes the role of micro-foundations in cross-border acquisitions and deepens the understanding of cross-border acquisition location choice decisions.

Safety of COVID-19 Vaccination in Patients With Breast Cancer: Cross-Sectional Study in China.

The widespread use of vaccines against the novel coronavirus disease (COVID-19) has become one of the most effective means to establish a population immune barrier. Patients with cancer are vulnerable to COVID-19 infection, adverse events, and high mortality, and should be the focus of epidemic prevention and treatment. However, real-world data on the safety of vaccines for patients with breast cancer are still scarce. This study aims to compare the safety of COVID-19 vaccines between patients vaccinated before or after being diagnosed with breast cancer. Patients with breast cancer who sought medical advice from October 2021 to December 2021 were screened. Those who received COVID-19 vaccines were enrolled in this study to analyze the safety of the vaccines. The primary outcome was patient-reported adverse events (AEs). All events after vaccine injection were retrospectively documented from the patients. A total of 15,455 patients with breast cancer from 41 hospitals in 20 provinces in China were screened, and 5766 patients who received COVID-19 vaccines were enrolled. Of those enrolled, 45.1% (n=2599) of patients received vaccines before breast cancer diagnosis, 41.3% (n=2379) were vaccinated after diagnosis, and 13.6% (n=784) did not known the accurate date of vaccination or cancer diagnosis. Among the patients vaccinated after diagnosis, 85.4% (n=2032) were vaccinated 1 year after cancer diagnosis and 95.4% (n=2270) were vaccinated during early-stage cancer. Of all 5766 vaccinated patients, 93.9% (n=5415) received an inactivated vaccine, 3.7% (n=213) received a recombinant subunit vaccine, and 2.4% (n=138) received other vaccines, including adenovirus and mRNA vaccines. In the first injection of vaccines, 24.4% (n=10, 95% CI 11.2-37.5) of patients who received an adenovirus vaccine reported AEs, compared to only 12.5% (n=677, 95% CI 11.6-13.4) of those who received an inactivated vaccine. Patients with metastatic breast cancer reported the highest incidence of AEs (n=18, 16.5%, 95% CI 9.5-23.5). Following the second injection, patients who received an inactivated vaccine (n=464, 8.7%, 95% CI 8.0-9.5) and those who received a recombinant vaccine (n=25, 8.7%, 95% CI 5.5-12.0) reported the same incidence of AEs. No significant differences in patient-reported AEs were found between the healthy population and patients with breast cancer (16.4% vs 16.9%, respectively); the most common AEs were local pain (11.1% vs 9.1%, respectively), fatigue (5.5% vs 6.3%, respectively), and muscle soreness (2.3% vs 3.6%, respectively). The type of vaccine and time window of vaccination had little impact on patient-reported AEs. Compared with patients vaccinated before breast cancer diagnosis, there were no significant differences in patient-reported AEs in the patients vaccinated after diagnosis. Thus, it is safe for patients with breast cancer, especially for those in the early stage, to receive COVID-19 vaccines. Chinese Clinical Trial Registry ChiCTR2200055509; https://tinyurl.com/33zzj882.

Trampoline Park Injury Trends.

Trampolines are an important cause of childhood injury and focus of injury prevention. Understanding and prevention of trampoline park injury is constrained by inadequate exposure data to estimate the at-risk population. This study aimed to measure trampoline park injury incidence and time trends using industry data. Cross-sectional study to retrospectively analyze reported injuries and exposure in 18 trampoline parks operating in Australia and the Middle East, from 2017 to 2019. Exposure was derived from ticket sales and expressed as jumper hours. Exposure-adjusted incidence was measured using marginalized 0-inflated Poisson modeling and time trends using Joinpoint regression. There were 13 256 injured trampoline park users reported from 8 387 178 jumper hours; 11% sustained significant injury. Overall, trampoline park injuries occurred at a rate of 1.14 injuries per 1000 jumper hours (95% confidence intervals 1.00 to 1.28), with rates highest for high-performance (2.11/1000 jumper hours, 1.66 to 2.56) and inflatable bag or foam pit (1.91/1000 jumper hours, 1.35 to 2.50) jumping. Significant injuries occurred at a rate of 0.11 injuries per 1000 jumper hours (0.10 to 0.13), with rates highest for high-performance (0.29/1000 jumper hours, 0.23 to 0.36), and parkour (0.22/1000 jumper hours, 0.15 to 0.28) jumping. Overall, injury rates decreased by 0.72%/month (-1.05 to -0.40) over the study period. Trampoline park injuries occur in important numbers with sometimes serious consequences. However, within these safety standard-compliant parks, exposure-adjusted estimates show injuries to be uncommon and injury rates to be declining. Further reductions are required, especially severe injuries, and this study can enhance injury prevention initiatives.

Investigating pre-professional dancer health status and preventative health knowledge.

Dance is a highly demanding physical pursuit coupled with pressure to conform to aesthetic ideals. Assessment of health status and preventative health knowledge of pre-professional dancers may help inform educational strategies promoting dancers' health and career longevity. The aim of this research was to establish a baseline understanding of dance students at a single pre-professional institution based on metrics focused on current health, nutrition, lifestyle, and wellbeing while also gauging knowledge of longer-term health implications. Adopting a cross-sectional study design, the Dance-Specific Energy Availability Questionnaire was tailored for Australian participants and administered online. The response rate was 59.5% (69/116 eligible students) and the survey was completed in full by 63 students. Mean BMI was 20 kg/m2, although among females, 47% had a BMI < 20 (range 16 to 25 kg/m2), and at their lowest reported weight BMI was 14 to 25 kg/m2. Over a third had either experienced (31%) or were currently experiencing (3.4%) secondary amenorrhea (period absence ≥ 3 consecutive months). Most dancers did not exclude food groups, however, 24% had been advised to exclude particular foods in the past, mostly by dance teachers. A large percentage used nutritional supplements (68%) with 60% supplementing with iron and more than half (53%) taking two or more supplements. Only 25% had ever utilised a qualified dietitian, although 16% reported a history of eating disorders and 25% reported vegetarian or vegan eating patterns. REDs risk scores ranged from -16 to +16 points with negative scores indicating LEA and higher risk of REDs. The mean score for males was 5.2 (SD = 3.9) and 2.1 (SD = 5.9) for females, with 33.3% producing a negative score. Results provide insight to health knowledge and particular issues pertinent for dancers and highlights the need for specific education strategies to promote a preventative health focus for those entering a pre-professional programme. This study also highlights the need for improved awareness of LEA and REDs among all practitioners working with dancers along with cultural and structural changes within the broader dance community to help protect and promote the wellbeing of dancers.

Chlorophyllin attenuates the effects of benzo[a]pyrene in human hepatoma HepG2/C3A cells

Chlorophyllin, a semisynthetic compound derived from chlorophyll, has been a focus in cancer prevention because it exerts important biological activities, such as antigenotoxic, antioxidative and anticarcinogenic activities. The aim of this study was to evaluate the effect of chlorophyllin against benzo[a]pyrene toxicity in HepG2/C3A cells. Cells were co-treated (chlorophyllin plus benzo[a]pyrene) and the cell viability, cell growth kinetics, cell cycle, and apoptosis were evaluated. The mRNA levels of cell cycle and apoptotic genes were analyzed. Our results showed that chlorophyllin reduce the antiproliferative effects of benzo[a]pyrene in a multi-specific manner, restoring the normal distribution of the cell cycle and inhibiting the cell death induced by the xenobiotic. Gene expression analysis showed that benzo[a]pyrene decreased the mRNA levels of genes involved in cell cycle control (cyclins and cyclin-dependent kinases) and apoptosis. Cells co-treated with 200 µM of chlorophyllin and benzo[a]pyrene also showed a downregulation of mRNA levels of the genes, but the expression levels of the gene that encodes to tumor protein p53 were maintained near to control. Thus, chlorophyllin is a good candidate as a chemoprotective agent that mitigates the cytotoxic effects benzo[a]pyrene and, thus, might be a promising tool to prevent liver cancer.

The influencing mechanism of pro-environmental behaviors in the private domain on those in the public domain

From the perspective of regulatory focus theory, the influencing mechanism of pro-environmental behaviors (PEBs) in the private domain on behaviors in the public domain were analyzed by revealing the mediating effect of the status quo maintenance and the moderating effect of the prevention focus orientation. The study results show that PEBs in the private domain significantly promote individuals’ PEBs in the public domain. The status quo maintenance partially mediates the relationship between PEBs in the private and public domains. Specifically, individuals with a high-level prevention focus orientation strengthen the relationship between the PEBs in the private domain and the status quo maintenance, and that of the PEBs in the public domain. Therefore, individuals with high-level prevention focus will more likely engage in subsequent PEBs in the public domain after their initial PEBs in the private domain due to their increased status quo maintenance degree. Policymakers and practitioners should pay attention to the prevention-repetition effect and use the PEBs in the private domain to promote those in the public domain.

Examining Medical Staff Well-Being through the Application and Extension of the Job Demands-Resources Model: A Cross-Sectional Study.

For medical staff, job satisfaction is essential for advancement on an individual and organizational level. This study looked into the relationships between challenging job demands, job resources, personal resources, and well-being. Additionally, it examined the potential mediating effects of emotional exhaustion and work motivation within the framework of the job demands-resources (JD-R) model. Results from a cross-sectional study of 267 medical employees at a second-grade comprehensive hospital in Jiangsu, China's mainland, indicated that challenging job demands and job satisfaction were positively correlated and mediated via (decreasing) emotional exhaustion. The relationship between job resources and job satisfaction was found to be mediated via (decreasing) emotional exhaustion and (increasing) work motivation. The investigation also demonstrated that the two regulatory focuses serve different purposes. It was discovered that promotion focus had a favorable effect on work motivation but a negative effect on emotional exhaustion. Conversely, preventive focus only positively predicted emotional exhaustion. Thus, the JD-R model offers a valuable structure for clarifying the job satisfaction of health personnel. The implications for enhancing individual and job outcomes are discussed.

Time-of-day effects on speed and accuracy performance during simulated shiftwork

ABSTRACT Performance on tasks involving speed and accuracy fluctuate throughout the 24-h day negatively affecting shift workers and organizations. Two simulated work shifts common in occupational settings were used to assess performance on a vigilance and math task. In study 1, 33 sleep-deprived participants completed a nightshift. In study 2, 32 partially sleep-deprived participants completed a dayshift. These studies found that performance differed between the type of task and the type of simulated shift where performance during the nightshift was worse than during the dayshift. In addition, collapsing speed and accuracy on the math task into inverse efficiency scores provided a unique measure that captured the impact of circadian rhythms during shiftwork. The current study also indicated that participants adopted cognitive strategies including speed-accuracy tradeoff and regulatory foci regarding work motivation (prevention focus and promotion focus) when completing the tasks depending on time-of-day, type of shift, circadian rhythms, and amount of sleep deprivation. This suggests that researchers and organizations should consider cognitive strategies in addition to the physiological components of sleep deprivation and circadian rhythms when investigating and documenting the impact of time-of-day due to different types of shiftwork conditions on performance and safety.