Infections frequently develop because catheter insertion is a case of HAIs (Health Care Associated Infections) that occur as a result of non-compliant procedures and activities by healthcare providers. This research approach is a pre-post design model experiment. The sample was divided into two groups: the treatment group and the control group. Each consists of 20 respondents. An independent sample t-test was used to analyze the data to determine the impact of UTI prevention and control bundles on CAUTI in inpatients. The results showed that no bacterial growth was found in the control group who underwent urine culture examination at the beginning of the catheterization (pre-test), but bacterial growth was discovered after 72 hours (post-test), with candida albicans > 105 CFU/ml found by four respondents (20%), staphylococcus aureus 105 CFU/ml found by one respondent (5%), and Escherichia coli >105 CFU/ml found by one respondent (5%). During the pre-test and post-test, no evidence of bacterial growth was discovered in the treatment group. The findings of the independent sample t-test revealed that the prevention and control of UTI prevention and control bundles had a significant effect on CAUTI in inpatients, with a value of p = 0.000 (p