IntroductionPressure injuries (PIs) are a significant issue in healthcare system: nursing students are recommended to be prepared to assess the risk, prevent and manage them. However, despite the coronavirus disease-2019 (COVID-19) pandemic significantly affected nursing students’ learning opportunities no data regarding their impact of PIs knowledge, attitudes and learning occasions have been documented to date. AimsTo describe the post-pandemic knowledge and attitudes regarding PI prevention and management and to compare clinical learning opportunities in the field of PIs before and after the COVID-19 pandemic. MethodA descriptive multi-method study involving students at the time of their graduation in the before (n=114) and after the pandemic (n=113). The Italian versions of the Pressure Ulcer Knowledge Assessment Tool (PUKAT-IT) and Attitude Toward Pressure Ulcer Prevention (APuP-IT) scales were used. Data regarding pre- and post-pandemic learning opportunities were retrospectively collected from the Student Portfolio of Skills. ResultsThe average PUKAT-IT score was 57.92% (cut-off 60%), which indicates insufficient knowledge; the average APuP-IT score was 78.19% (cut-off 75%), which shows positive attitudes towards PI. Comparing the pre- and the post-pandemic groups, learning opportunities in PI risk assessment and prevention significantly decreased (overall 38.90 vs 32.27 and 35.26 vs 25.97, respectively) while those regarding the PI management remained stable. ConclusionIn the post-pandemic times, nursing students’ knowledge about PIs remains insufficient while their attitudes are adequate; the pandemic significantly reduced students’ exposure to prevention and assessment learning opportunities during their internship, which suggests a need to update educational strategies to ensure appropriate knowledge and learning experiences in this field.