Prevalence Rates For Women Research Articles

Adult-Onset Still’s Disease Misdiagnosed as Acute Fibrinous and Organizing Pneumonia: A Case Report and Literature Review

Adult-onset Still’s disease (AOSD) is a rare condition that lies between autoinflammatory syndrome and autoimmune disease. The main clinical manifestations include fever, chills, rash, joint swelling and pain, peripheral blood leukocytosis, splenomegaly, etc. It is a systemic disease affecting between 1 and 34 people per million. The average age of onset is 35 years old, with a slightly higher prevalence rate in women. Since AOSD lacks early specific symptoms and signs, non-specialist doctors have limited understanding of the disease, and patients are prone to clinical misdiagnosis, mistreatment, and delayed disease progression. This paper reports a patient whose AOSD was misdiagnosed as acute fibrinous and organizing pneumonia.

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

BackgroundThe Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold:a) to describe a framework for identifying dementia in a cohort study.b) to report the age-specific incidence and prevalence of all-cause dementia and dementia subtypes in 865 individuals in the LBC1936.MethodsElectronic Health Records (EHR) of all participants were reviewed, and relevant information was extracted to form case vignettes for everyone with any record of cognitive dysfunction. The EHR data sources include hospital and clinic letters, general practitioner and hospital referrals, prescribed medications, imaging and laboratory results. Death certificate data were obtained separately. Clinician assessments were performed when there was concern about a participant's cognition. A diagnosis of probable dementia, possible dementia, or no dementia was agreed upon by a consensus diagnostic review board, comprised of a multidisciplinary team of clinical dementia experts who reviewed case vignettes and clinician assessment letters. For those with probable dementia, a subtype was also determined, where possible. We compared the agreement between our newly ascertained dementia diagnoses with the existing self-reported dementia diagnoses.ResultsSelf-reported dementia diagnoses were positive in only 17.8% of ascertained dementia diagnoses. The EHR review identified 163/865 (18.8%) individuals as having cognitive dysfunction. At the consensus diagnostic review board, 118/163 were diagnosed with probable all-cause dementia, a prevalence of 13.6%. Age-specific dementia prevalence increased with age from 0.8% (65–74.9 years) to 9.93% (85–89.9 years). Prevalence rates for women were higher in nearly all age groups. The most common subtype was dementia due to Alzheimer disease (49.2%), followed by mixed Alzheimer and cerebrovascular disease (17.0%), dementia of unknown or unspecified cause (16.1%), and dementia due to vascular disease (8.5%).ConclusionsWe present a robust systematic framework and guide for other cohort teams wanting to ascertain dementia diagnoses. The newly ascertained dementia diagnosis provides vital data for further analyses of LBC1936 to allow exploration of lifecourse predictors of dementia.

Abstract TP86: Systematic Review Of Aortic Atherosclerotic Plaque In Cryptogenic Stroke

Introduction: In patients with cryptogenic stroke (CS), complex aortic plaque may be a potential underlying etiology. We performed a systematic review to determine the prevalence of complex aortic plaque in CS patients. Methods: A systematic review and meta-analysis were performed according to PRISMA guidelines (PROSPERO: CRD42022300865). PubMed and EMBASE databases were searched from Jan 1980 to Nov 2021 for studies assessing aortic (ascending, arch, descending) plaque by transesophageal echocardiogram (TEE), CT/CTA, or MRI in at least 10 CS patients. Prevalence rates were pooled using a random-effects model. I 2 statistics assessed heterogeneity. An Egger’s test assessed publication bias. Results: From 2712 articles, 31 met inclusion criteria. Ascending, arch, and descending aorta were assessed in 65%, 100%, 55% of studies, respectively. Studies investigated aortic plaque by TEE (84%), CT/CTA (19%) and MRI (16%). The prevalence of complex aortic plaque in 4666 CS patients was heterogeneous across studies and yielded a summary prevalence of 30% (95% CI 23-38%, I 2 = 96%; Figure 1) contrasting with 11% (95% CI 5-20%, I 2 =83%) in 677 patients without stroke. Prevalence rates in women and men were 26% (95% CI 14%-43%, I 2 = 94%) and 35% (95% CI 21-52%, I 2 = 97%), respectively. To investigate geographic differences, 14 studies from Europe were pooled (32%, 95% CI 23-43%, I 2 =93%), 3 from the Middle East (34%, 95% CI 11-67%, I 2 =94%) and 3 from the US (28%, 95% CI 13-51%, I 2 =90%). No publication bias was detected (p=0.66). Sources of heterogeneity included patient selection, imaging technology (e.g, transducer frequency) and plaque measurement criteria. Conclusions: Studies suggest a prevalence rate of complex aortic plaque in approximately 30% of CS patients. However, significant heterogeneity in the results indicate a need for less variability in CS patient selection and more reproducible imaging methods/criteria for detecting complex aortic plaque.

Research progress in the treatment of Knee Osteoarthritis

Osteoarthritis in the knee is a disease that is chronic and degenerative. It occurs more frequently between the elderly and the obese populations, and the prevalence rate of women is higher than that of men. With the accelerated aging of the population, the prevalence of knee osteoarthritis has also increased, which has brought greater pressure to the patients themselves and society. In recent years, although through the efforts of researchers, there have been a variety of treatment methods for knee osteoarthritis in the clinic, researchers have not yet found a complete cure for knee osteoarthritis. This paper introduces the research status of therapeutic modalities, exercise therapy and traditional therapy in the therapy of knee osteoarthritis by investigating previous research, aiming to promote the level of knee osteoarthritis therapy.

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review.

Polycystic ovary syndrome (PCOS) is a common multisystem disease with reproductive, metabolic and psychological abnormalities. It is characterized by a high prevalence rate in women of childbearing age and highly heterogeneous clinical manifestations, which seriously harm women’s physical and mental health. Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants. It can intervene with the pathologic process of PCOS from multiple targets and channels and has few adverse reactions. It is mentioned in this review that QUR can improve ovulation disorder, relieve Insulin resistance (IR), reduce androgen, regulate lipid metabolism, regulate gut microbiota and improve vascular endothelial function, which is of great significance in the treatment of PCOS.

Епідеміологія переломів проксимального відділу стегнової кістки в Україні: результати дослідження стоп (cистема реєстрації остеопоротичних переломів)

Переломи проксимального відділу стегнової кістки (ППВСК) є одним із найбільш тяжких ускладнень остеопорозу, що має важливе медико-соціальне й економічне значення. Загальновідомо, що їх частота поступово збільшується з віком й залежить від статі, проте епідеміологічні дані в Україні обмежені. У статті наведено результати першого українського багатоцентрового епідеміологічного дослідження СТОП (Cистема реєсТрації Остеопоротичних Переломів) щодо частоти ППВСК у осіб віком 40 років і старше. Установлено, що частота ППВСК у населення України збільшується з віком. Продемонстровано більш високі показники частоти ППВСК у чоловіків молодше 55 років із подальшим переважанням показників у жінок. Загалом показник частоти ППВСК був подібним показнику сусідніх держав (Польща та Румунія). Оскільки ППВСК є серйозною проблемою охорони здоров’я в Україні та світі, регіональні епідеміологічні дані щодо їх частоти є важливим підґрунтям для розробки загальнонаціональної системи профілактики та лікування остеопорозу та його ускладнень.

Prediabetes Burden in Nigeria: A Systematic Review and Meta-Analysis.

Prediabetes is a borderline glycemic status associated with both higher incidence of cardiovascular disease as well as higher risk of progression to diabetes. There is a rising burden of diabetes and prediabetes globally. This study aims to estimate the burden of prediabetes in Nigeria. Online searches of Google Scholar, PubMed, and Scopus were conducted and studies were selected based on predefined criteria. A total of 15 studies consisting of 14,206 individuals conducted between 2000 and 2019 were included in the meta-analysis with studies using American Diabetic Association (ADA) and World Health Organization (WHO) criteria pooled separately. The pooled prevalence of prediabetes in Nigeria was found to be 13.2% (95% CI: 5.6–23.2%, I2 = 98.4%) using the ADA criteria and 10.4% (95% CI: 4.3–18.9%, I2 = 99.2%) using the WHO criteria. According to the latest data by the United Nations, this translates to an estimated 15.8 and 12.5 million adult prediabetic individuals in Nigeria using the ADA and WHO criteria, respectively. The prevalence rates for women and men were similar at 12.1% (95% CI: 5–21%). The pooled prevalence rates for urban and rural settlements were also similar at 9% (95% CI: 2–22%). In conclusion, the prevalence of prediabetes in Nigeria was almost two times higher than the 7.3% estimate by the International Diabetes Federation in 2003. The similar rates of prediabetes between men and women and between urban and rural settlements points toward narrowing of cardiovascular risk burden between the two sexes and the two settlements. This represents higher future cardiovascular disease burden in the country further pressurizing the overstretched healthcare system.

Prevalence of empathy, anxiety and depression, and their association with each other and with sex and intended specialty in medical students

Abstract: Introduction: Empathy and mental health are crucial for medical students’ self-care and performance as well as for patient care. Objective: to assess the prevalence of empathy, anxiety and depression, and their association with each other and sex, intended specialty and course semester. Method: Cross-sectional study with 405 of 543 students (74.6%) from odd semesters and from the 12th semester of the medical course of two universities in southern Brazil. Data were collected using a self-administered questionnaire containing information on age, sex, medical course semester, intended specialty, Jefferson Scale of Empathy (JSE) and Beck Anxiety and Depression Inventories (BAI and BDI). The data were analyzed using descriptive statistics, Student’s t-tests, Chi-square, and bidirectional ANOVA between groups. The level of significance was set at p < 0.05. Results: The mean JSE score was 120.2 (SD = 10.6) [116.9 (SD = 11.0) in men and 123.4 (SD = 9.2) in women, p = 0.000], being higher among students who wanted to follow medical areas aimed at people [123.1 (SD = 10.1)], than among those whose intended areas aimed at techniques and procedures [118.5 (SD = 11.2)], p = .003. There was no difference between the course periods. The anxiety and depression mean rates were, respectively, 16.2 (SD = 11.3) and 11.9 (SD = 9.0) [13.1 (SD = 10.3) and 9.9 (SD = 8.3) in men and 19.1 (SD = 11.4), and 13.8 (SD = 9.4) in women, p = .000 for both]. The prevalence rate of moderate and high anxiety was 33.8% and, when including mild anxiety, it was 59%. The prevalence rate of dysphoria (BDI = 16 - 20) and depression (BDI > 20) was 26.4%, and 11.9% for suicidal ideation. An association was observed between severe anxiety and the JSE subscale ‘Walking in patient’s shoes’, more related to empathic stress. Conclusions: Empathy is high and stable throughout the medical course at the studied institutions and higher in women and students who want to follow people-oriented specialties. Anxiety and depression have higher prevalence rates in women. Severe anxiety is associated with the JSE subscale ‘Walking in patient’s shoes’.

Prevalence of empathy, anxiety and depression, and their association with each other and with sex and intended specialty in medical students

Abstract: Introduction: Empathy and mental health are crucial for medical students’ self-care and performance as well as for patient care. Objective: to assess the prevalence of empathy, anxiety and depression, and their association with each other and sex, intended specialty and course semester. Method: Cross-sectional study with 405 of 543 students (74.6%) from odd semesters and from the 12th semester of the medical course of two universities in southern Brazil. Data were collected using a self-administered questionnaire containing information on age, sex, medical course semester, intended specialty, Jefferson Scale of Empathy (JSE) and Beck Anxiety and Depression Inventories (BAI and BDI). The data were analyzed using descriptive statistics, Student’s t-tests, Chi-square, and bidirectional ANOVA between groups. The level of significance was set at p < 0.05. Results: The mean JSE score was 120.2 (SD = 10.6) [116.9 (SD = 11.0) in men and 123.4 (SD = 9.2) in women, p = 0.000], being higher among students who wanted to follow medical areas aimed at people [123.1 (SD = 10.1)], than among those whose intended areas aimed at techniques and procedures [118.5 (SD = 11.2)], p = .003. There was no difference between the course periods. The anxiety and depression mean rates were, respectively, 16.2 (SD = 11.3) and 11.9 (SD = 9.0) [13.1 (SD = 10.3) and 9.9 (SD = 8.3) in men and 19.1 (SD = 11.4), and 13.8 (SD = 9.4) in women, p = .000 for both]. The prevalence rate of moderate and high anxiety was 33.8% and, when including mild anxiety, it was 59%. The prevalence rate of dysphoria (BDI = 16 - 20) and depression (BDI > 20) was 26.4%, and 11.9% for suicidal ideation. An association was observed between severe anxiety and the JSE subscale ‘Walking in patient’s shoes’, more related to empathic stress. Conclusions: Empathy is high and stable throughout the medical course at the studied institutions and higher in women and students who want to follow people-oriented specialties. Anxiety and depression have higher prevalence rates in women. Severe anxiety is associated with the JSE subscale ‘Walking in patient’s shoes’.

A preliminary study on the immune responses of HPV16-E7 by combined intranasal immunization with lymphotoxin

Human papillomavirus (HPV) ranks the first cause of cervical cancer. Cervical cancer has high prevalence rates in women around the world. The HPV-E7 oncoprotein is expressed in cervical cancer and is a target of developing immunotherapies against HPV-associated tumors. However, the antigenicity of this protein is low. Due to this reason, potent adjuvants are required to enhance its therapeutic efficacy. This preliminary study aims to evaluate whether lymphotoxin (LT) could act as an effective immune adjuvant for HPV infection in mice models. Intranasal immunization was used to explore the effect of HPV-E7 and/or LT immune response. After the third intranasal immunization, the titer for the HPV-E7 antibody was detected in serum and vaginal washing fluid. Also, we assessed the expression of chemokine ligand 13 (CXCL13) and Peripheral Node Addressin (PNAd) in the lymph nodes after intranasal immunization with immunohistochemical analysis. compared to HPV-E7 immunization, intranasal immunization with HPV-E7 plus LT significantly increased HPV-E7-specific serum IgG and vaginal IgA titers. Furthermore, the combined use of HPV-E7 and LT strongly induced E7-specific CTL responses. LT can be effective for intranasal immunized HPV-E7 to improve E7-specific immune responses to HPV infection. It is new approach to eradicate chronic HPV infection capable of inducing an effective anti-infection method.

Prevalence, onset and course of anxiety disorders during pregnancy: A systematic review and meta analysis

BackgroundAnxiety disorders during pregnancy are associated with various adverse outcomes. Previous reviews of anxiety disorders during pregnancy have methodological limitations and were conducted without a meta-analysis. The present study is a systematic review and meta-analysis of the published research on the prevalence, onset and course of all anxiety disorders during pregnancy plus obsessive-compulsive disorder (OCD) and posttraumatic stress disorder. MethodsA comprehensive literature search was performed on a wide range of databases. A random effects model was used for the meta-analysis. ResultsThirty-six studies were included. Prevalence rates of anxiety disorders during pregnancy varied considerably. The pooled prevalence rate of each disorder during pregnancy was 3%, except for specific phobia, where it was 6%. Between 13% and 39% of pregnant OCD women had the onset of OCD during pregnancy, and this occurred mainly in the 2nd trimester. The onset of panic disorder (PD) was more common in the 1st and 2nd trimesters of pregnancy. LimitationsDifferent designs of the included studies, as well as different assessment tools and assessment times during pregnancy and the paucity of studies of the onset and course, preclude definitive conclusions. ConclusionsAnxiety disorders are common during pregnancy. Unlike prevalence rates of other anxiety disorders during pregnancy, prevalence rates of PD and OCD during pregnancy were higher than their lifetime prevalence rates in women in the general population. The onset of OCD during pregnancy is not rare and the course of PD and OCD during pregnancy is highly variable. These findings suggest that pregnancy may be a specific risk factor for the occurrence and/or exacerbation of PD and OCD and underscore the importance of their early diagnosis and management.

Time trends in diabetes mellitus in Jordan between 1994 and 2017.

The prevalence of diabetes has been increasing over the past few decades. The objective of this study is to assess the time trends in diabetes between 1994 and 2017 in Jordan. Surveys were conducted in 1994, 2004, 2009 and 2017 by the same investigators using generally similar methods. Fasting blood glucose was measured in all surveys. Variables were obtained using structured questionnaires designed specifically for the surveys. Crude and age-specific diabetes prevalence rates were derived for each sex, together with overall, crude and age-standardized prevalence rates. The prevalence of diabetes in men aged ≥25years increased from 14.2% in 1994 to 18.3% in 2004, 26.8% in 2009 and 32.4% in 2017. The corresponding prevalence rates in women were 12.3%, 16.9%, 18.8%, and 18.1%, respectively. The overall age-standardized prevalence rate increased from 13.0% in 1994 to 17.1% in 2004, 22.2% in 2009 and 23.7% in 2017. Known diabetes in the 2017 survey accounted for 82.6% of people with diabetes. A HbA1c of <59mmol/mol (7.5%) was observed in 41.4% of participants with known diabetes. The results showed a high prevalence of diabetes in Jordan among people aged ≥25years. Prevalence increased from 1994 to 2009, but slowed thereafter. The increase was greater in men than in women. Previously diagnosed diabetes accounted for a high percentage of people with diabetes in all surveys and was highest in 2017 survey, suggesting that the national strategy against diabetes has brought some benefits. Efforts should be made to improve glycaemic control in people with diabetes.

Contraceptive prevalence rate in women of reproductive age in a semi urban community of Islamabad

Objective: To determine the prevalence of utilization of family planning methods among married women of reproductive age in a semi urban community of Islamabad.&#x0D; Methodology: A cross-sectional survey was done using two stage sampling, including cluster and consecutive sampling techniques. A proportionate sample from each mohallas of Nurpur Shahan was taken to achieve our sample size. All married women of the reproductive age group (15-45 years) living with their husbands, not diagnosed as a case of infertility and permanent residents of Nurpur Shahan were included.&#x0D; Results: Total of 550 women were included in the study with mean age of 31.64 years. Majority of women 497 (94.7%) were currently married while 322 (59.9 %) were literate. Of all the women, 72 (13.2%) women were currently pregnant and only 62 (11.3%) had a planned pregnancy. Induced abortion was practiced once by 9 (1.8%) women and 21 (4.1%) had done it twice. 394 (72.8%) had knowledge of family planning methods and only 102 (19.5%) women were using family Planning methods currently.&#x0D; Conclusion: Miscellaneous challenges are involved to increase involvement of the women and their families in the use of family planning services. Health education campaigns at community level to increase awareness regarding different family planning methods are highly needed. Government needs to improve the LHWs services to increase the use of family planning methods and combat induced abortions as a method of contraception. Controlling population through sterilization after attaining a large family size should not be the preferred method of family Planning.

GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC.

Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 in GAD2 gene to changes in regional inhibition/excitation balance, anxiety-like traits, and related neural activity in both sexes. One hundred and five healthy individuals were examined with high-field (7T) multimodal magnetic resonance imaging (MRI); including resting-state functional MRI in combination with assessment of GABA and glutamate (Glu) levels via MR spectroscopy. Regional GABA/Glu levels in anterior cingulate cortex (ACC) subregions were assessed as mediators of gene-personality interaction for the trait harm avoidance and moderation by sex was tested. In AA homozygotes, with putatively lower GAD2 promoter activity, we observed increased intrinsic neuronal activity and higher inhibition/excitation balance in pregenual ACC (pgACC) compared with G carriers. The pgACC drove a significant interaction of genotype, region, and sex, where inhibition/excitation balance was significantly reduced only in female AA carriers. This finding was specific for rs2236418 as other investigated single nucleotide polymorphisms of the GABA synthesis related enzymes (GAD1, GAD2, and GLS) were not significant. Furthermore, only in women there was a negative association of pgACC GABA/Glu ratios with harm avoidance. A moderated-mediation model revealed that pgACC GABA/Glu also mediated the association between the genotype variant and level of harm avoidance, dependent on sex. Our data thus provide new insights into the neurochemical mechanisms that control emotional endophenotypes in humans and constitute predisposing factors for the development of anxiety disorders in women.SIGNIFICANCE STATEMENT Anxiety disorders are among the most common and burdensome psychiatric disorders, with higher prevalence rates in women. The causal mechanisms are, however, poorly understood. In this study we propose a neurobiological basis that could help to explain female bias of anxiety endophenotypes. Using magnetic resonance brain imaging and personality questionnaires we show an interaction of the genetic variation rs2236418 in the GAD2 gene and sex on GABA/glutamate (Glu) balance in the pregenual anterior cingulate cortex (pgACC), a region previously connected to affect regulation and anxiety disorders. The GAD2 gene polymorphism further influenced baseline neuronal activity in the pgACC. Importantly, GABA/Glu was shown to mediate the relationship between the genetic variant and harm avoidance, however, only in women.

Prevalence of glaucoma in the Israeli Arab population.

We describe the prevalence and treatment of glaucoma in a Muslim Arab population in Israel. Based on the medical records of 15 122 persons, the overall prevalence of glaucoma was 3.9%. Prevalence rates of primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) were 3.0% and 0.42%, respectively. Prevalence rates of women were 135% that of men considering all types of glaucoma, 143% for POAG, and 96% for PACG. Prostaglandin analogs and beta blockers, alone or combined with carbonic anhydrase inhibitors, were the preferred medications. Of 68 patients who underwent trabeculectomy, 27 (39.7%) required medications, postoperatively, for treatment of glaucoma; following Ex-Press shunt surgery, 3/11 (27.3%) required medications. During the last three years, 16 (1.3%) individuals with POAG were recorded as legally blind as a result of glaucoma.

The effect of black seed powder on blood glycaemia, blood lipidemia and body composition on adults at risk for cardiovascular diseases: A con-trolled, randomized, single blind, parallel-design study

Recently 42% of the population in the United Arab Emirates (UAE) was diagnosed with metabolic syndrome (MetS), while the prevalence of the MetS in the Gulf Cooperation Council Countries (GCC) is 10-15% higher than in the most developed countries, with generally higher prevalence rates for women. Recent studies proved that black seed may have an effect in reducing the metabolic syndrome factors as well as the cardiovascular diseases risk factors. More studies proved the anti-lipidemic and anti-glycemic effects of blackseed; therefore, it could be used for the management and prevention of the MetS problems. Objectives: To measure the effect of blackseed powder on fasting blood glucose (FBG), hemoglobin (Hb), hemoglobin A1c (HbA1c), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), blood pressure (BP), waist circumference (WC) and body composition in participants at risk for cardiovascular diseases. Methodology: The study is a controlled, randomized, single blind, parallel-design study. 60 participants who are at risk for cardiovascular diseases were randomly distributed into 2 treatment groups, the first group was the blackseed powder group while the second group was a placebo-control (corn starch) group. 3 grams per day of each treatment was ingested by the participants for 12 weeks. Results: 51 participants continued the study from both groups (29 black seed, 22 Placebo), there was a significant improvement in Cholesterol, HDL, LDL, Triglyceride levels, WC and the percent of body fat (P-value &lt; 0.05). While it showed no effect on systolic and diastolic blood pressure levels and blood glucose levels for the black seed group compared to the placebo group. Conclusion: Black seed powder has a significant effect on improving Blood lipids levels in blood, WC and percent of body fat while it showed no improvement in blood glucose levels as well as blood pressure levels for individuals at risk for CVD.

Cancer prevalence in Israeli men and women with schizophrenia

The aim of this cross–sectional study was to compare cancer prevalence rates among patients with schizophrenia to those of the non-schizophrenia population. The study population included members of Clalit Health Services aged 25 to 74 years and all data was taken from patients’ electronic health records. Of the 2,060,314 members who were included in the study, 32,748 had a diagnosis of schizophrenia. Cancer prevalence rates in women with and without schizophrenia were 491 per 10,000 and 439 per 10,000, respectively; in men, cancer prevalence rates were 226 per 10,000 and 296 per 10,000, respectively. The age-adjusted prevalence rate of all-type cancer was significantly lower among men with schizophrenia, compared to men without schizophrenia; specifically, men with schizophrenia had a lower rate of prostate cancer, and of cancers in the "other" category, compared to men without schizophrenia. Reduced cancer rates in men with schizophrenia may reflect under-diagnosis of some cancer types, likely due to insufficient medical attention. An effort to improve screening regimes should be made.

Prevalence and Factors Affecting Women with Uterine Prolapse in Lekhnath, Kaski, Nepal

Background: Uterine prolapse is the main public health problem of reproductive age women in Nepal. Uterine prolapse (UP), which affects about 10% of women of reproductive age in Nepal, is the most frequently reported cause of poor health in women of reproductive age and postmenopausal women. Currently, women’s awareness of UP is unknown, and attempts to unravel the UP problem are inadequate.Objectives: The objectives of this study was to determine prevalence of uterine prolapse, to explore factors affecting women with uterine prolapse and to find association between selected variables and prevalence of uterine prolapse.Methods: A community based cross sectional study was conducted from 7th July, 2016 to 7th of August, 2016 among married women with at least one child in the Ritthepani, Ward No 2, Lekhnath. Participants were selected by purposive sampling techniques, and data were collected through structured interview schedule. Frequency, percentage, mean, SD and chi-square test was performed to identify factors associated with prevalence of uterine prolapse.Results: The major findings were majority 35 (35%) of women were in the age group of 20 to 30 years, followed by 89 (89%) Hindu religion, 48 (48%) belonged to janajati and religious minority which included Newar, Magar, Gurung, Tamang and Muslims. Most of the women 35 (35%) were Illiterate, 44 (44%) earn their living by working in agriculture, 57 (57%) respondents had ≥Rs1500 per month income in the family, 58 (58%) belonged to nuclear families, 76 (76%) of the respondents had knowledge about uterine prolapse and they got information mostly from 24 (24%) friends. The prevalence rate of women with uterine prolapse was found to be 13% whereas mean and standard deviation were 0.87 ±0.33. The findings of association between the prevalence of uterine prolapse with age at first child birth, abortion, sexual intercourse immediate after delivery and constipation were found to be significantly associated. Almost all respondents replied that uterine prolapse can be prevented by avoiding strenuous activities during antenatal and postnatal period followed by avoiding giving birth to too many babies, taking nutritious diet, deliver the baby in health institution by health personnel, avoiding long term coughing and chronic constipation.Conclusion: Uterine prolapse was observed among women of Ritthepani ward no 2; among them most of them were age group between 20 - 30 year early married Illiterate. The perceived service was taken by less number of eligible women. Women awareness towards the problem, limiting frequent pregnancies and provision of educational opportunities are recommended for the prevention of uterine prolapse. Journal of Gandaki Medical CollegeVolume, 09, Number 2, July December 2016, Page: 47-51

Contemporary prevalence estimates for giant cell arteritis and polymyalgia rheumatica, 2015.

There are no estimates of the prevalence of giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) in a US population in the current millennium. The purpose of this study was to estimate the 2015 prevalence of GCA and PMR in a US population-based setting. Cohorts of incident GCA in 1950-2009 and incident PMR in 1970-2014 were previously identified among residents of Olmsted County, Minnesota. Prevalence estimates were obtained from the age-, sex-, and calendar year-specific incidence rates and adjusted to the US white 2010 population aged ≥50 years. Confidence intervals (CI) were computed using bootstrap sampling. There were 248 incident cases of GCA in 1950-2009 and 790 cases of PMR in 1970-2014. The overall age- and sex-adjusted prevalence rate of GCA on January 1, 2015 was 204 (95% CI: 161-254) per 100,000 population aged ≥50 years. GCA prevalence rate in women was 304 (95% CI: 229-375) and in men was 91 (95% CI: 46-156) per 100,000 population. The overall age and sex adjusted prevalence rate of PMR on January 1, 2015 was 701 (95% CI: 651-750) per 100,000 population. PMR prevalence rate in women was 870 (95% CI: 787-957) and in men was 508 (95% CI: 426-589) per 100,000 population. Prevalence rates of GCA and PMR in 2015 are similar to previously published prevalence estimates in the late 1990s. The health burden of these diseases among older persons continues to be substantial and reflects the need for continued efforts to better manage it.

Post-traumatic stress disorder in women and their partners, following severe post-partum hemorrhage: A study protocol for a prospective cohort study

AbstractBackground: Post-traumatic stress disorder is a Trauma- and Stressor-Related Disorder resulting from exposure to an event that is considered as traumatic. It is recognized in relation to traumatic childbirth that both patient, partner and health-care provider can develop a post-traumatic stress disorder. The most important risk factors in women are depression during the pregnancy, fear of childbirth, severe pre-eclampsia, preterm premature rupture of membranes, and severe neonatal complications. The prevalence rate in women in Western countries is estimated between 1 and 3%. The prevalence in partners witnessing childbirth is unknown. Post-traumatic stress disorder in relation to severe post-partum haemorrhage, in either women or partners, has not been extensively researched yet. Methods/design: This is a prospective cohort study in a hospital setting, with the objective to evaluate whether women and their partners have a higher risk to develop a post-traumatic stress disorder or symptoms, followi...