Aim: This study aims to assess the prevalence of work-related stress and its impact on nurses’ work performance at King Abdullah Complex in Jeddah City. 
 Methods: A cross-sectional- study was conducted using a previously validated questionnaire distributed among nursing staff at King Abdullah Complex in Jeddah City.
 Duration of the Study: This study was conducted for some time from September 2022 until August 2023.
 Results: From a total of 263 nursing participants, the study findings reported that the prevalence of Work-related stress among nursing staff in the King Abdallah Complex at Jeddah City was 63.7% and most of the nurses feel that their job negatively impacts their physical or emotional health. Many nurses expressed that they have insufficient recognition or rewards for good performance at work.
 Conclusion: The findings of the study indicate that work-related stress is a pervasive concern among the nursing staff employed at King Abdullah Complex. A considerable percentage of nursing workers have reported encountering different levels of stress within their everyday work settings.
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