Prevalence Of Syphilis Infection Research Articles

Prevalence and Factors Associated with Syphilis among Mothers with Missed Opportunities for Antenatal Syphilis Testing in Rural Western Uganda: A Cross-Sectional Study.

Early prenatal syphilis testing and treatment are essential preventative measures for maternal syphilis and associated adverse pregnancy outcomes of pregnancy; however, data shows that two-thirds of all cases are missed among women who visit prenatal care center at least once but are not tested for syphilis. This study determined the prevalence and factors associated with syphilis infection among mothers with missed opportunities for antenatal syphilis testing in rural western Uganda delivered at Fort Portal Regional Referral Hospital (FRRH). A cross-sectional study was done during the period from April 2022 to June 2022. A total of 124 participants had been recruited consecutively from postnatal ward of FRRH. Pretested questionnaires were used to obtain information on data required for analysis. Venous blood sampling (2 ml taken from the forearm using anticoagulant free vacutainer) was done for all mothers who missed opportunity for prenatal syphilis testing using both RPR and TPHA. Descriptive statistics followed by binary logistic regression analysis was done using SPSS version 22.0. The prevalence of syphilis infection was 27 (21.8%). After adjusted analysis, having more than one sexual partners in the past one year was associated with higher odds of syphilis infection (aOR = 24.922, 95% CI: 4.462-139.201, p < 0.001), and staying with the partner was found to be associated with lower odds of syphilis infection (aOR = 0.213, 95% CI: 0.040-1.142, p = 0.050). The study identified high prevalence of syphilis infection among mothers with missed opportunities for antenatal syphilis testing, and this was positively associated with having more than one sexual partners in the past one year and negatively associated with not staying with partner.

Risk factors and adverse outcomes associated with syphilis infection during pregnancy

The prevalence of syphilis infection in pregnancy is increasing at an alarming rate. This study aimed to evaluate sociodemographic risk factors and adverse pregnancy outcomes associated with syphilis infection during pregnancy in a current US population of live births. This was a retrospective analysis of the Centers for Disease Control and Prevention, Natality Live Birth database for the years 2016 to 2019. All live births were eligible for inclusion. Deliveries with missing data on syphilis infection were excluded. We analyzed the database comparing pregnancies complicated by maternal infection with syphilis with those without infection. Several maternal sociodemographic factors and adverse pregnancy and neonatal outcomes were compared between the 2 groups. Multivariable logistic regression was performed to evaluate the association of these factors with syphilis infection in pregnancy, and adverse pregnancy and neonatal outcomes while adjusting for potential confounders. Data were presented as adjusted odds ratios with 95% confidence intervals. Of the 15,341,868 births included, 17,408 (0.11%) were complicated by maternal infection with syphilis. Concurrent infection with gonorrhea was associated with the highest risk of syphilis in pregnancy (adjusted odds ratio, 7.24; 95% confidence interval, 6.79-7.72). Low educational attainment (less than high school: adjusted odds ratio, 4.40; 95% confidence interval, 3.93-4.92), non-Hispanic Black race/ethnicity (adjusted odds ratio, 3.81; 95% confidence interval, 3.65-3.98), and Medicaid insurance (adjusted odds ratio, 2.13; 95% confidence interval, 2.03-2.23) were also associated with a significantly increased risk of infection. Syphilis infection was associated with an increased risk for preterm birth (<37 weeks: adjusted odds ratio, 1.25; 95% confidence interval, 1.20-1.31; <32 weeks: adjusted odds ratio, 1.26; 95% confidence interval, 1.16-13.7), low birthweight (adjusted odds ratio, 1.34; 95% confidence interval, 1.28-1.40), congenital malformations (adjusted odds ratio, 1.43; 95% confidence interval, 1.14-1.78), low 5-minute Apgar scores (adjusted odds ratio, 1.29; 95% confidence interval, 1.19-1.41), neonatal intensive care unit admission (adjusted odds ratio, 2.19; 95% confidence interval, 2.11-2.28), immediate ventilation (adjusted odds ratio, 1.48; 95% confidence interval, 1.39-1.57), and prolonged ventilation (adjusted odds ratio, 1.58; 95% confidence interval, 1.44-1.73). We identified several risk factors and adverse pregnancy outcomes associated with syphilis infection in pregnancy. Given the concerning rise in prevalence of pregnancy infections, public health strategies aimed at infection prevention and access to timely screening and treatment to reduce associated adverse pregnancy outcomes are urgently needed.

High seroprevalence of syphilis infection among pregnant women in Public Health facilities in Shashemene town, southern Ethiopia

BackgroundSyphilis infection is a major public health problem in developing countries including Ethiopia. Thus, this study aimed to assess the seroprevalence of syphilis and associated factors among pregnant women attending Antenatal Care (ANC) in Public health facilities in Shashemene town, southern Ethiopia. MethodAn institutional-based cross-sectional study design was conducted among 230 pregnant women from the 27th of August to the 30th of September 2018. Data were collected using a structured interviewer-administered questionnaire. Data were entered into Epi-Info 7 and analyzed with SPSS Version 21. A multivariate logistic regression model was used to investigate factors associated with syphilis infection. A p-value of <0.05 was considered statistically significant. ResultThe overall prevalence of syphilis infection was 22(9.6%)(95% CI, [6.1, 14.1%]). Pregnant mothers who had multiple sexual partners (AOR = 5.12, 95% CI 1.51, 17.44), abnormal vaginal discharge (AOR = 18.13 95%CI 3.66, 88.42), previous history of abortion (AOR = 5.6, 95%CI 2.03, 15.36) and previous history of stillbirth (AOR = 9.98, 95% CI: 2.85, 34.92) were among factors associated with syphilis infection. ConclusionAccording to this study, the magnitude of syphilis infection among pregnant mothers attending ANC was high. Pregnant mothers who had multiple sexual partners, previous history of abortion, previous history of stillbirth, and abnormal vaginal discharge were significantly associated with syphilis infection. Thus, health providers should provide comprehensive health education about syphilis transmission, signs and symptoms, and the methods of prevention as well as create awareness about the adverse outcome of getting syphilis infection.

Prevalence of Syphilis in Pregnant Women Living With Human Immunodeficiency Virus (HIV) From South Africa Using a Molecular-Based Assay.

Syphilis is one of the most common sexually transmitted infections (STIs), and it remains a significant public health concern, particularly in low-resource settings including sub-Saharan Africa. There are limited data on the prevalence of syphilis among pregnant women living with HIV in South Africa. This study determined the prevalence of syphilis infection in pregnant women living with HIV by the polymerase chain reaction (PCR). This was a cross-sectional study that included 385 pregnant women living with HIV recruited from the antenatal clinic at the King Edward VIII Hospital in Durban, South Africa between October 2020 and April 2021. Treponema pallidum was detected using the Applied BiosystemsTM TaqMan® Assays from stored DNA samples extracted from vaginal swabs. The prevalence of syphilis was 5.2% (20/385). The overall median (Q1-Q3) age of the women was 30.0 years (25.0-36.0). Of the women who tested positive for syphilis, 60.0% had reported STI symptoms (p = 0.030) and of those, 65.0% did not perceive themselves at risk of contracting STIs (p = 0.019). Women who reported having STI symptoms were more likely to test positive for syphilis when compared to women who reported not having any STI symptoms (OR: 2.810; 95% CI 1.119-7.052; p = 0.028). Women who perceived themselves as being at risk of contracting STIs were less likely to test positive for syphilis when compared to women who did not perceive themselves at risk of contracting STIs (OR: 0.328; 95% CI 0.128-0.842; p = 0.020). The study has indicated syphilis is prevalent among pregnant women living with HIV in Durban, South Africa however STI risk perception is low. Educational programs on STIs are essential among pregnant women attending antenatal care clinics in Durban.

Prevalence of Syphilis Infections Among Volunteer Blood Donors in Jinan Blood Center, China: A 15-Year Retrospective Study.

Syphilis infections among volunteer blood donors increased rapidly in recent years. It is important to analyze the demographics of seropositive donor groups and help to recruit donors from low-risk population. The aim of this study was to analyze the syphilis prevalence among volunteer blood donors in Jinan Blood Center and give direction to blood recruitment. A cross-sectional study was conducted among blood donors in Jinan, China. Socio-demographic data and blood donation testing data from January 2007 to December 2021 were extracted from the database of blood management software of Jinan Blood Center for analysis. All blood samples were screened by ELISA, and those anti-TP-positive samples were counted and analyzed by sex, age, educational background, occupation and blood donation times. Logistic regression was used to explore risk factors associated with syphilis infection. Totally 700,757 blood samples were collected in the study during 2007 to 2021, 2290 cases were detected anti-TP positive with a positive rate of 0.33%. Female, 35-44 years old, with a lower education degree, farmers and first-time donors were the high-risk subgroups. Consultation and identification of high-risk population groups should be improved. Measures should be taken to make the donor recruitment more professional and detailed.

Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.

We investigated people with HIV (PWH) receiving combination antiretroviral therapy (cART) for latent syphilis infection prevalence, risk factors, treatment response, and neurosyphilis. A prospective follow-up study was conducted on PWH and latent syphilis. The cases were randomly assigned to receive either benzathine penicillin G (BPG) or doxycycline (DOXY), and the posttreatment response was evaluated after 12 and 24 months. The traditional algorithm was used for serodiagnosis, and a semi-quantitative rapid plasma reagin (RPR) test monitored disease activity and treatment effectiveness. Of the 823 participants, 64.8% were women, and the mean age was 41.7±10 years. Thirty-one (3.8%) of the participants (22 males and nine females) had latent syphilis. The risk factors were male sex (aOR = 3.14), increasing age (aOR = 1.04 per year), and cART duration (aOR = 1.01 per month). Baseline RPR titers were: ≤1:4 in 19 (61.3%), between 1:8 and 1:32 in 10 (32.2%), and >1:32 in 2 (6.4%). None of the seven cerebrospinal fluid analyses supported a neurosyphilis diagnosis. In the 12th month of treatment, 27 (87.1%) had adequate serological responses, three (9.7%) had serological nonresponse, and one (3.2%) had treatment failure. Syphilis treatment was repeated in the last four cases with the alternative drug. In terms of adequate serologic response, both therapies were comparable at the 12th month, p = 0.37. All cases responded to treatment in the 24th month. In PWH receiving cART, latent syphilis occurred more in men than women, suggesting an investigation of sexual practices and the impact of antenatal syphilis screening. Syphilis disease activity reduces in the latent stage. Therefore, the routine cerebrospinal fluid analysis contributes little to the diagnosis of asymptomatic neurosyphilis and the treatment success of latent syphilis. DOXY is an alternative to BPG, and cART improves serologic response to latent syphilis treatment.

Prevalence of Syphilis Infections among the Iranian Population: A Systematic Review and Meta-Analysis.

Background:Syphilis is one of the most important sexually transmitted infections (STI) and a public health problem, but the literature describing the true burden of syphilis is limited. In Iran, there are no accurate results on the prevalence of syphilis. This study aimed to conduct a systematic review and meta-analysis of syphilis in Iran.Methods:Following PRISMA guidelines, we conducted a systematic review and meta-analysis of studies published on the prevalence of Syphilis in Iran. We systematically reviewed the literature to identify eligible studies as of Sep 13, 2020, in international and national databases. The results are presented in the form of forest plots and tables. Pooled prevalence and 95% confidence intervals were calculated using Der Simonian and Laird method. Perform subgroup analysis through population, gender, city, and diagnostic tests to assess the source of heterogeneity.Results:We reviewed 1,229 papers and reports, and extracted data from 15 eligible records. The prevalence of combined syphilis in Iran is 0.1% (95% confidence interval [95% CI] 0.1–0.1%). The prevalence of syphilis was 0.4% in men (95% confidence interval [95% CI] −0.3, 1%) and 0.6% in women (95% confidence interval [95% CI] (0.1, 1%)). The cumulative meta-analysis showed a decline in the prevalence of syphilis between the years 1999 and 2015.Conclusion:The prevalence of syphilis in Iran is low. In the past few decades, the prevalence of syphilis across the country has declined. Syphilis infection is a small burden that needs to be revised in the implementation of high-cost screening programs.

Prevalence of syphilis infection and associated sociodemographic factors among antenatal-care attendees in Meghalaya, India: Revisiting HIV Sentinel Surveillance data

Despite relatively simple prevention and treatment, syphilis remains a major social and public health concern worldwide, particularly in developing nations. To estimate the prevalence and to determine the sociodemographic factors associated with syphilis infection among antenatal-care (ANC) attendees in Meghalaya, India. A facility-based cross-sectional study was conducted utilizing National HIV Sentinel Surveillance of Meghalaya, January-March 2017. Pregnant women aged 15-49years (n = 3015) were recruited consecutively, interviewed, and tested for syphilis by Venereal Disease Research Laboratory test in eight selected ANC sites representing all districts of Meghalaya. Prevalence of syphilis was found to be 1.03 % (95% CI = 0.67-1.39) (31/3015). Prevalence was maximum among illiterates with gradual lowering of adjusted odds ratio (AOR) with improvement of education. Women whose husbands had no income were associated with higher risk (AOR = 4.97, 95% CI = 1.11-22.20) of syphilis. Significant risk (OR = 2.42, 95% CI = 1.02-5.74) was also observed with Jaintia Hills residents as compared to Garo Hills. As high prevalence of gestational syphilis was identified in Meghalaya along with important sociodemographic predictors, evidence to policy translation is required at state and national level to scale up prevention, screening, and management of syphilis.

A cross-sectional descriptive study of clinical and serological prevalence of syphilis infection in people living with HIV and its effect on CD4+ T cells.

Context:The natural history of syphilis could be altered in the presence of HIV. It has been documented that syphilis infection increases the risk of HIV transmission by at least 3-fold.Aims:The aim of the study was (1) to study clinical presentation of syphilis in HIV individuals, (2) to estimate seroprevalence of syphilis in HIV individuals, and (3) to study the effect of syphilis infection on CD4+ T cells.Subjects and Methods:HIV-positive patients attending sexually transmitted infection clinic for a period of 1 year from June 2017 to May 2018 in the age group of 15–70 years were included in the study. A detailed history was taken; genital and dermatological examination was done. All patients were tested with VDRL and treponema pallidum hemagglutination assay (TPHA). Pearson's Chi-square test was used to compare categorical variables and Student's t-test was used to compare continuous variables.Results:Out of ninety study population, nine (10%) had clinical manifestations of syphilis. VDRL was positive with significant titers in all cases of syphilis. TPHA was positive in 88.9% of cases with clinical syphilis and 17.3% of cases without clinical manifestations of syphilis. Mean CD4 count was low among patients having syphilis infection compared to study population.Conclusion:This study shows high prevalence of syphilis in HIV and highlights the importance of preventing and promptly treating syphilis in people living with HIV, as the active infection is associated with fall in CD4 count, which leads to opportunistic infections.

Effect of syphilis infection on HIV acquisition: a systematic review and meta-analysis

ObjectivesCo-infection of syphilis and HIV remains hard to manage and its morbidity shows a rising tendency. Syphilis has been associated with increased risk of HIV acquisition in high-risk groups, especially...

Prevalence of syphilis in people living with HIV/AIDS: A Hospital based Cross-Sectional Study

Introduction: Syphilis, a sexually transmitted disease is one of the oldest diseases caused by the bacterium Treponema pallidum, has been a major public health concern worldwide. The aim is to find out the prevalence of syphilis and its risk factors among people with HIV at Western Regional hospital in Nepal.&#x0D; Methods: A hospital-based cross-sectional study was conducted at one of the largest public hospitals in Western Region of Nepal. A consecutive 90 HIV-positive patients were recruited prospectively from December 2016 to February 2017. Blood samples and data on sociodemographic and risk factors were collected. Serum were diagnosed for syphilis using Rapid Plasma Reagin (RPR) test.&#x0D; Results: The prevalence of syphilis infection was 12.2% in HIV positive participants. Syphilis occurred exclusively in male 7 comparatively 4 in female. Seropositivity of syphilis was seen higher in married than unmarried HIV infected individuals. Syphilis prevalence seems to increase with increasing age, with the highest rate in the age group 35–50 years. A decreasing rate of syphilis was observed with increasing educational level, where illiterate HIV-positive participants had higher infection compared with those having at least a certificate.&#x0D; Conclusion: Higher prevalence of syphilis in people with HIV infection demands the need to target this people to prevent the transmission of both infections. Testing for all HIV-infected people for syphilis and management of the infected would have clinical and epidemiological importance.

Prevalence of Syphilis Infection in a Tertiary Rural Hospital: A Five Year Evaluation

Syphilis is a blood borne and sexually transmitted disease of global distribution. This study was aimed at determining the trend and prevalence of syphilis across the years among patients attending the Igbinedion University Teaching Hospital, Okada, Nigeria. A retrospective analysis of data of patients attending the Out patients department as well as those attending the anti natal clinic of Igbinedion University Teaching Hospital, Okada,Nigeria from January 2015 to December 2019.Sera samples were screened for Treponema palladium antibody using commercially available immunochromatic rapid Syphilis based test kits. Out of the 741 screened sera in the 2015 – 2019 study period, 8 (1.1%) were positive for Treponema pallidium antibodies. The prevalence are 0.4%, 1.3%, 0%, 3.8% and 2.8% respectively for the year 2015, 2016, 2017, 2018 and 2019 respectively. The gender related distribution for the study periods are not statistically significant with p- values all greater than 0.05. The prevalence of syphilis is low within this community which is an indication of adherence to preventive measures never the less public awareness remains a medium for eradication of syphilis.&#x0D; Keywords: Rapid Syphilis test kit, Immunochramatogenic, Treponema pallidium

Trend of Syphilis Infection among Voluntary Blood Donors in Foshan City from 2008 to 2017

To investigate the prevalence of syphilis infection in voluntary blood donors in Foshan City, so as to provide reference for improving the infusion blood safety strategy of city. A total of 657 382 voluntary blood donors in Foshan City from January 2008 to December 2017 were selected. The blood samples were tested for treponema pallidum. The prevalence trends, the detection rate of treponema pallidum infection and epidemiological data were statistically analyzed. Enzyme-linked immunosorbent assay (ELISA) was performed for antibody screening in blood samples. The two-hole retest was then performed for the samples which were positive in initial test, meanwhile, they were also confirmed by the treponema hemagglutination blood coagulation test (TPHA). First, the annual infection rate of treponema pallidum in Foshan City from January 2008 to December 2017 was 0.43%, 0.40%, 0.41%, 0.43%, 0.50%, 0.32%, 0.36%, 0.32%, 0.37% and 0.32%, respectively. A total of 2502 cases of treponema pallidum infection were detected, the overall infection rate was 0.38%, and the infection rate decreased year by year (x2=23.826, P＜0.05). Second, among the 657 382 samples of voluntary blood donors, 2 502 were showed the positive treponema pallidum antibody (0.38%). In 2015-2017, 791 donors were showed positive treponema pallidum antibody, 676 case out of which were confirmed positive, 0.34% with the positive coincidence rate of 85.46%. Third, this group of 676 syphilis infection cases were male-dominated (0.35%, 577/164 484). The age distribution was 18-53 years old, and the average age was 32 years, among which 35-44 years old accounted for 0.33% (138/41 858). The education level of in donors with treponema pallidom positive mainly ranked at low or lower levels under janior college (0.32%, 571/180 917). The occupation is mainly outside work and company staff (0.39%, 452/115 101). The marital status is mainly unmarried (0.29%, 377/130 905). The place of origin is mainly non-local (0.29%,570/198 063). The positive rate of treponema pallidum shows a downward trend in 2008-2017. Among the individuals with comfirmed TP antibody positive in 2015-2017, the non-local, unmarried and low educated males are main population, moreover more than half of them are migrant worker or company employeers.

Factors associated with HIV and syphilis infection among female sex workers in three cities in Papua New Guinea: findings from Kauntim mi tu, a biobehavioral survey.

Respondent-driven sampling surveys among FSW in Port Moresby, Lae, and Mt. Hagen (2016-17) were conducted. FSW who were aged ≥12 years, who were born female, who spoke English or Tok Pisin and who had sold or exchanged vaginal sex in the past 6 months were eligible to participate. Participants were interviewed face-to-face and offered rapid HIV and syphilis testing. Survey logistic procedures were used to identify factors associated with HIV and syphilis infection, including modern contraception use, physical violence and having a casual male partner. Weighted data analysis was conducted. Overall, 2901 FSW (Port Moresby, 673; Lae, 709; and Mt. Hagen, 709) were enrolled in the study. HIV prevalence was 15.2% in Port Moresby, 11.9% in Lae and 19.6% in Mt. Hagen. Factors associated with HIV varied by city; for example, use of modern contraception in Port Moresby, experiences of physical violence in Lae and ever having tested for HIV in Mt. Hagen. No one variable was associated with HIV in all cities. Prevalence of syphilis infection was 7.1%, 7.0%, and 3.0% in Port Moresby, Lae, and Mt. Hagen, respectively. Factors associated with syphilis infection also varied by city and were only significant in Lae. The different factors associated with HIV and syphilis infection in each city highlight the complex HIV and syphilis epidemics among FSW and the importance of conducting surveys in multiple locations and developing local interventions.

Low prevalence of syphilis infection among key populations in Togo in 2017: a national cross-sectional survey

BackgroundThe World Health Organisation (WHO) recommends the screening of syphilis among populations highly exposed to HIV. However, data on the prevalence of syphilis in these populations are scarce in Togo. This study aimed at estimating the prevalence of syphilis among males who have sex with males (MSM), female sex workers (FSW) and drug users (DU) in Togo.MethodsA cross-sectional bio-behavioral study was conducted in August and September 2017 using a respondent-driven sampling (RDS) method in eight major cities in Togo. A standardized questionnaire was used to record socio-demographic data and sexual behavior patterns. A blood sample was taken and SD Bioline Duo VIH/Syphilis rapid test was used to test for HIV and syphilis.ResultsA total of 2158 key populations (678 MSM, 1003 FSW and 477 DU), with an average age of 27.6 years (standard deviation 8.8 years) participated in the study. Prevalence of syphilis was 0.6% (95% CI = [0.3–1.0]) with no statistical significance between the three groups: null among MSM, 0.8% among FSW (95% CI = [0.37–1.63]) and 1.1% among DU (95% CI = [0.39–2.57]). There was no relation between HIV status and syphilis (p = 0.236). Among the 298 HIV-positive people, none was diagnosed with syphilis.ConclusionsFindings from this study reveal a low prevalence rate of syphilis among key populations in Togo. Specific interventions into HIV prevention programs should be reinforced to eliminate syphilis in Togo.

Factors associated with syphilis infection: a cross-sectional survey among outpatients in Asikuma Odoben Brakwa District, Ghana

BackgroundSyphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. The disease affects all ages and both sexes but more prevalent among the sexually active age group of 15–49 years. The purpose of the current study was to determine the prevalence and factors associated with syphilis infection among outpatients 15–49 years in the Asikuma Odoben Brakwa District of Ghana where high levels of infection were earlier reported among antenatal women.MethodsA descriptive cross-sectional study was carried out in 13 randomly selected health facilities. Blood samples were collected and tested for syphilis infection and a questionnaire administered to determine factors associated with the disease.ResultsA total 277 patients aged 15–49 years participated in the study. The overall prevalence of syphilis infection was 3.2% (9/277), with 5.7% (6/105) and 1.7% (3/172) among males and females respectively. Significant factors associated with syphilis infection included sub-district of residence, (χ2 (4) = 31.20, p < 0.001) and history of coerced sexual intercourse (χ2 (1) =7.49, p = 0.006).ConclusionsThe prevalence of syphilis infection was high among male patients who lived in rural areas. Having a history of coerced sexual intercourse was a strong predictor for syphilis infection. Access to sexually transmitted infection control interventions in rural communities including health education may help control the disease.

PREVALENCE OF SYPHILIS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC OF BULCHANA HEALTH CENTER, SHASHEMENE, WEST ARSI ZONE, ETHIOPIA

Background: Syphilis is an important cause of morbidity and mortality in pregnancy and it is one of the greatest public health challenges. It is responsible for up to 30% of perinatal mortality. Ethiopia is one of the countries in which sexually transmitted infection (STIs) are highly prevalent. However, the data needed to present a realistic picture of the prevalence of syphilis are limited.&#x0D; Objective: To determine the prevalence of syphilis among pregnant mothers attending Antenatal Clinic of Bulchana health center, Shashemene, West Arsi Zone, Ethiopia, 2017.&#x0D; Materials and Methods: Health institution based retrospective cross sectional study was conducted from April 01 to June 01, 2017 among women attended Antenatal Clinic of Bulchana health center during the period of 2014 to 2016. Non probability sampling technique was used to recruit study participants. A total of 4346 pregnant women were included in this study. Data was captured by reviewing and observation of a recorded data at the ANC registration book using pre-tested structured check list. Data were entered and cleaned using EpiData version 3.0. and analyzed by SPSS version 21. Binary logistic regression was used and significant variables were further adjusted using multivariate analysis. A p-value &lt;0.05 was considered as level of significance.&#x0D; Result: In this study the prevalence of syphilis among pregnant women found to be 1.1% 95%CI [0.8-1.3]. Relatively high prevalence of syphilis 15(1.5%) was observed among age group of 15-19 years. The prevalence of syphilis was high among pregnant women living in rural area 35(1.1%). Being rural dwellers and those with multiple pregnancy, 2-4 and more than 5 pregnancies showed significant association with prevalence of syphilis infection. [(OR=0.68, 95%CI (5.33, 17.32), P=0.04)], [(OR=10, 95% CI(1.36, 74.42), p= 0.02] and [(OR=2.18, 95%CI(1.20, 3.95), p= 0.01], respectively.&#x0D; Conclusion: The observed seroprevalence of syphilis among women attending ANC still mandates effective health education campaigns to elucidate the risk factors and prevention of syphilis not only to pregnant women but also the public at large. Strengthening service delivery at the provider and facility level to improve prompt access to effective syphilis diagnostic and treatment services is mandatory.&#x0D; Keywords: syphilis, pregnant women, ANC, Shashemene Ethiopia.

2270. Frequency of Syphilis Annual Screening Testing, Prevalence of Infection and Re-infection and Associated Characteristics among People Receiving Care for HIV in an HIV/AIDS Care Clinic in Mexico City (2001–2017)

BackgroundSyphilis has increased among people living with HIV (PLWH), particularly in men who have sex with men (MSM). Syphilis screening test should be routinely offered as part of comprehensive care for PLWH. We assessed the annual frequency of syphilis testing and positive test results in patients actively receiving care for HIV in Mexico City and its associated factors.MethodsWe retrospectively analyzed cohort data of patients receiving care for HIV in our clinic (2001–2017). We estimated the annual proportion of PLWH receiving care that was tested for Syphilis and the annual prevalence of Syphilis infection among those tested. We performed annual, cross-sectional analysis in patients receiving care. We included patients with at least one registered visit to the clinic each year and defined those that were engaged in care, as those with at least two visits separated by at least 3 months in a given year. To identify factors associated with being tested and with being infected we used multivariate logistic regression models with random intercepts and GEE using sex, age, education, socioeconomic status (SES), year, time in care, use of ART, being naïve and having AIDS at enrollment, being engaged in care, and number of hospitalizations as independent variables.Results2896 patients were included. The proportion of patients tested for syphilis increased from 21% in 2001 to 81% in 2017. The prevalence of syphilis increased from 7% to 21% during the same period with an early peak in 2003–2004 (Figure 1). Over time, the prevalence of re-infections increased substantially and accounted for the most positive test from 2013 onwards. Men, younger age, MSM, increasing education, time receiving care, number of hospitalizations and being engaged in care during the year were positively associated with being tested (Figure 2). Men, younger age, MSM, patients not receiving ARTs, those with AIDS at enrollment, and not being engaged in care were at higher risk of infection (Figure 3). ConclusionAnnual VDRL testing increased over time, as did prevalence of syphilis, particularly after 2010 (9% vs. 21%). Re-infections were frequent. Efforts are needed to increase screening among women, those newly enrolled in care, and with low SES. Preventive strategies are needed for men, particularly MSM, early after enrollment.Disclosures All authors: No reported disclosures.

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Introduction: Syphilis has represented a major challenge to public health in Brazil for its prevalence and serious perinatal sequel. Objectives: To know the prevalence of syphilis infection and the occurrence of abortion in pregnant women, by age and spatial distribution in the state of Sergipe. Methodology: This is a cross sectional descriptive study, retrospective in which were analyzed 39.807 entries of users of the Program for the Protection of Pregnant women (PPP) in 73 municipalities of the state of Sergipe in a period of approximately two years. Results: We screened 39.807 pregnant women, these 7.538 (18,9%) said they have aborted, 544 (1,37%) had syphilis positive and 192 (0,48%) pregnant women had syphilis positive and abortion declared. The proportion rose from 25,7% in the number of women who aborted and had any type of change to 35,3% in women who aborted and confirmed positive syphilis, an increase of 1,37 in the number of cases. The municipality of Carmopolis had the highest percentage of cases 2,19%, followed by Malhador 1,30%, Malhada dos Bois 1,16%, Estância 1,15%, Barra dos Coqueiros 1,14%, Santa Luzia do Itanhy 1,04% e Pedrinhas 1%. Conclusion: It was found that was high the registration of abortions in pregnant women in the most part of the municipalities. The rates of prevalence and incidence of syphilis were higher than those accepted by OMS. Through the PPP can be verified that syphilis may be an associated factor to the occurrence of high incidence of abortion and perinatal morbidity and mortality in the state of Sergipe in Brazil.

The Prevalence of Syphilis Infection and Its Associated Factors in the General Population of Rwanda: A National Household-Based Survey.

Background. The prevalence of syphilis among HIV-infected people is a public health concern, but there is limited literature to describe the true burden of syphilis in resource-limited settings. We conducted this survey in 2013 to estimate the prevalence of syphilis. Methods. A cross-sectional survey. Participants were tested for syphilis and HIV. Factors associated with syphilis infection were identified. Results. The prevalence of syphilis was 0.9% (95% CI: 0.7–1.1). This prevalence was higher in the 25–49-year-old age (1.1% [95% CI: 0.8–1.3]) than in the 15–24-year-old age (0.6% (95% CI: 0.4–0.9)). Women with lower education had a higher prevalence of syphilis (1.2% (95% CI: 0.9–1.5)) compared to others (0.4% (95% CI: 0.2–0.8)). This prevalence among HIV-infected people was six times higher: 4.8% (95% CI: 2.9–7.9) compared to HIV-negative people (0.8% (95% CI: 0.6–1.0)). The prevalence of syphilis among HIV-infected females was 5.9% (95% CI: 3.4–10.0). HIV-infected or concurrent sexual partners was associated with increased syphilis prevalence with aOR = 4.2 (95% CI: 2.5–7.2) and aOR = 4.2 (95% CI: 2.8–6.5), respectively. Conclusions. The prevalence of syphilis was significantly higher among HIV-infected patients. HIV infection and concurrent sexual partners are associated with an increased prevalence of syphilis. Preventing HIV might help in preventing syphilis.