Introduction: Postpartum depression (PPD) is a prevalent mental health issue affecting women post-childbirth, particularly primigravida mothers. This study aims to explore the prevalence and risk factors of PPD among primigravida mothers in Kabul, Afghanistan, a low- and middle-income country with limited research on PPD among primigravida mothers. Materials and Methods: A descriptive cross-sectional study design was employed, and data were collected from 200 primigravida mothers who gave birth in Rabia Balkhi and Malalai Hospitals in Kabul. A structured questionnaire was utilized to gather data on socio-demographic characteristics, PPD symptoms, and risk factors, which were analyzed using descriptive statistics and SPSS. Results: The study findings revealed that 42.5% of the primigravida mothers in Kabul experienced symptoms of PPD according to EPDS scores. This prevalence rate was higher than global estimates and previous studies in high-income countries. Risk factors associated with PPD among primigravida mothers in Kabul included a history of depression or mental health problems (55.5%), job loss or financial difficulties (74.5%), trauma related to natural disasters or war (63%), experiences of physical or verbal abuse (34.5%), lack of social support or feelings of isolation (23%), and difficulties adjusting to motherhood (48.5%). Conclusion: The study highlights the prevalence and risk factors of Postpartum Depression among primigravida mothers in Kabul, Afghanistan, emphasizing the need for interventions to support new mothers' mental health, including prioritizing screening, providing targeted support, and addressing socioeconomic and environmental challenges, through investment in mental health services and public health campaigns.
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