Aim: To determine whether pregnant women with HIV are at a greater risk of developing perinatal depression (PND). Method: a literature review identified relevant evidence surrounding the prevalence of depression in HIV-infected pregnant women. Inclusion and exclusion criteria were applied to 52 articles, of which five quantitative studies were applicable. Findings: social and psychological factors secondary to HIV infection were noted to be the main reason for an increase in the prevalence of PND. conclusion: Women with a complex psychosocial background are at a significantly higher risk of developing PND. suggestions have been made by the author to incorporate the findings into a care Pathway that allows for the routine screening of all women to help highlight those at a greater risk of developing PND. There is a need for further research to support the findings of the literature review as well as to broaden the current research available in high-income countries. This article focuses on the HIV-infected and HIV at-risk pregnant population of the USA. The prevalence of PND in this population is explored and risk factors acknowledged. Trending risk factors for PND in this population include HIV status, psychiatric history, stress and substance use. These findings are incorporated into a draft tool that could be integrated into current practice.