Prevalence Of Oral Clefts Research Articles

Prevalence and clinical characterization of oral clefts in patients with chromosome trisomy 18.

To verify the prevalence and perform the clinical characterization of oral clefts in a sample of patients with trisomy of chromosome 18 in Southern Brazil. This was a retrospective cross-sectional study, performed in a reference clinical genetic service in Southern Brazil. Theinitial sample consisted of 77 patients diagnosed in the neonatal period with trisomy 18 treated at the Clinical Genetics Service of a referral hospital at Federal University of Health Sciences of Porto Alegre (UFCSPA). The patients' diagnosis was confirmed by karyotype and care was provided during their stay in the intensive care unit (ICU) of the hospital that is a reference in Southern Brazil for care for malformed patients. The period covered was from 1975 to 2020. During the study period, 77 patients diagnosed with trisomy 18 were treated, most of them in the ICU. Of these, 13 individuals were excluded due to incomplete data. The final sample consisted of 64 patients with an average age of 2.4 years of life, ranging from one day to 16 years old, the majority of whom were female. Regarding face dysmorphisms identified in the sample, three (4,68%) patients had cleft lip and two (3,11%) had cleft lip and palate. This study contributed to the recognition of the characteristics and prevalence of oral clefts in individuals with trisomy 18 in a sample of patients from Southern Brazil. Inaddition, we described the clinical alterations found in patients with oral clefts, as well as other associated comorbidities, such as cardiac, neurological and pulmonary comorbidities, as well as cranial and facial dysmorphisms.

Prevalence of Lip and Palate Clefts and the Related Factors in Babies Born From 2014 to 2019 in Karaj, Iran

Background: Cleft lip and palate are the most common congenital anomalies in the head and neck region, which are affected by environmental and genetic factors. These defects can cause serious problems such as deformity, nutritional, respiratory and social interactions for patients. Objective: The current study was performed to investigate the frequency of cleft lip and palate and its related factors in infants born in Karaj’s hospitals during 2014 to 2018. Methods: This descriptive-analytical study was conducted on the case of newborns. The studied population included 91,563 cases of babies born between 1993 and 1997 in Kamali, Imam Ali (AS), Maryam and Qaim hospitals in Karaj. Of these, 46 babies were identified with various types of oral clefts. The information of the files was collected and analyzed with SPSS v24 statistical software.. Results: The prevalence of oral cleft was 0.5 per thousand live births. (26.08%) of infants had cleft lip, (52.17%) cleft palate, and (21.73%) cleft lip and palate (P = 0.024). 56.52% of male babies (P = 0.37), 76.08% of mothers in the age group of 20 to 30 years with an average age of 24.4 years, 58.69% of first pregnancy mothers, 13.03% of parents, history Family marriage (P< 0.001), and 37% of mothers had blood type A in the file (P = 0.11). Conclusion: The prevalence of oral clefts in Karaj is lower than the global statistics and other regions of the country.

Prevalence of Cleft Lip and Palate and Access to Rehabilitation Services in the South-West of Iran: A 10-Year Study

Background and Objectives: Cleft lip and or cleft palate (CL/P) is one of the most prevalent malformations in the head and neck region. The etiology of this malformation is multifactorial, and the incidence of clefts may be affected by ethnic, racial, geographic, and socioeconomic factors, therefore this study aimed to investigate the prevalence, risk factors of CL/P, and access to rehabilitation services for these children in the south-west of Iran. Methods: This cross-sectional study retrospectively analyzed birth data collected from hospitals (according to the International Classification of Diseases [ICD10] hospital registry code) in Shahrekord City, Iran, from 2011 to 2021. Frequency distribution and frequency of received rehabilitation services were analyzed. 76 children without this disorder were selected as a control group to evaluate the risk factors. Results: The overall prevalence was approximately 0.93 per 1000 live births. The prevalence of Cleft Lip (CL), cleft palate (CP), and Cleft Lip and Palate (CLP) were 0.17, 0.27, and 0.49, respectively. Of the 38 infants born with CL/P, 20 infants (52.63%) were boys and 18 (47.36%) were girls (P>0.05). The variables of cleft history, maternal disease, maternal medicine history, low infant weight, and child disease were significantly associated with CL/P (P<0.05). Also, the children with CL/P significantly delayed speech development (P<0.05). A total of 26.31% of them did not have early surgery, 10.52% had no surgery, and 34.21% had no history of speech and language treatment. Conclusion: Findings of this study showed that the overall prevalence of oral clefts was 0.93 per 1000 live births. However, some of these children did not have access to surgery and rehabilitation services in time; therefore it is necessary to plan to receive early surgery and rehabilitation services.

Frequency of Cleft Lip with or Without Cleft Palate and Related Factors in a Group of Neonates in Three Hospitals in Sari, Iran, during 2004-2018

Introduction: Cleft lip with or without cleft palate (CLP) is one of the most common congenital defects in the orofacial region. Many factors are involved in the occurrence of cleft lip in newborns including genetic and environmental factors. The prevalence of this anomaly varies in different races and countries. Therefore, this study aimed to determine the prevalence of this disorder in newborns in Bu Ali, Hekmat, and Amir Mazandarani Hospitals in Sari, Iran, during 2004-2018. Materials and Methods: This descriptive-analytical study was carried out using information obtained from the records of patients in Imam, Hekmat, and Amir Mazandarani health centers in Sari, Iran. The number of patients with CLP was extracted from the information in the record files. Afterward, information related to infant and mother, such as gender, birth weight, maternal age, the cases of consanguine marriage, family history of CLP, history of drug use in the first trimester of pregnancy, the history of smoking and alcohol consumption were also recorded to investigate the factors related to CLP. Results: A total of 65,522 births were recorded at the three abovementioned health centers during 14 years, of which 80 infants were born with a variety of CLP anomalies. The overall CLP prevalence in this study was estimated at 1.2 per 1,000 births. It should be noted that 52.5% (n=42) and 47.5% (n=38) of these cases had CLP and CL, respectively. No cases of isolated cleft palate were observed. Furthermore, 71.3% (n=57) of all CLP cases occurred unilaterally. In total, 86.3% of the studied infants weighed over 2,500 gr at birth and 72.5% of mothers aged under 30 years at childbirth. Conclusion: Based on the obtained results, the overall prevalence of oral clefts in the studied population was 1.2 per 1,000 births and mostly occurred unilaterally.

Access to antenatal healthcare and the prevalence of oral clefts: a spatial analysis.

Congenital anomalies are caused by a variety of risk factors, including individual and environmental ones. This study estimated the prevalence of oral clefts and examined their area-level risk indicators using data from The National Congenital Anomaly Survey in South Korea. Disease mapping and ecological regression were used to assess the geographical variation and potential risk indicators for oral clefts, such as living in a rural area, material deprivation, and limited access to antenatal healthcare. In South Korea, 1.15 (95% CI, 1.08-1.23) children out of every 1,000 births were born with oral clefts during 2005 and 2006. The most common oral cleft type was cleft palate, followed by cleft lip, then cleft lip and palate. Disease mapping showed that the proportion of areas with a higher risk than the national average was relatively higher for oral clefts than for all congenital abnormalities among rural and healthcare underserved areas. The relative risk of oral cleft prevalence was higher in rural areas and healthcare underserved areas than in urban areas and areas with better access to healthcare. The findings suggest that access to antenatal healthcare as well as area-level risk indicators should be considered a priority when developing measures to decrease the occurrence of oral clefts.

Prevalence of Oral Clefts among Live Births in Gansu Province, China.

Background: Oral clefts (OCs) are common human birth defects. Children with OCs in underdeveloped regions are more likely to suffer from poverty and hardship in their future lives. Here, we attempted to estimate the prevalence of OCs among live births in Gansu Province in 2008 to understand the epidemiologic pattern of the disease. Methods: A cross-sectional study was conducted from January 2008 to December 2008 in Gansu Province. The live births delivered between January and December 2008 with OCs were investigated through face-to-face questionnaire survey. Results: A total of 468 infants with OCs were identified among 347,137 live births in 2008 in Gansu Province, which yielded a prevalence of 1.35 per 1000 live births. The majority of these cases were CL (cleft lip) (prevalence = 0.85 per 1000 live births), and the prevalence of CLP (cleft lip and palate) and CP (cleft palate) was 0.34 and 0.11 per 1000 live births, respectively. We also found that the prevalence of OCs in Jiayuguan (3.39 per 1000 live births) and Dingxi (2.71 per 1000 live births) was higher than those of other cities in Gansu Province. Additionally, we failed to detect significant correlation between economic conditions of the cities and the prevalence of OCs in our study. Conclusions: The prevalence of OCs among live births in Gansu Province in 2008 was higher than the prevalence of OCs in other provinces in China. The high prevalence may reflect the need for further etiological studies to explore the potential risk factors in this region. In addition, more subtype information needs to be collected in future prevalence studies for better understanding of the epidemiologic pattern of the disease.

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children-A National Survey.

Although the prevalence of oral clefts in China is among the highest worldwide, little is known about the prevalence of speech disability associated with cleft palate in Chinese children. The data for this study were collected from the Second China National Sample Survey on Disability, and identification of speech disability associated with cleft palate was based on consensus manuals. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A weighted number of 112,070 disabled children affected by cleft palate were identified, yielding a prevalence of 3.45 per 10,000 children (95% CI: 3.19–3.71). A history of speech disability in the mother (OR = 20.266, 95% CI 5.788–70.959, p < 0.0001), older paternal child-bearing age (OR = 1.061, 95% CI 1.017–1.108, p = 0.0065, per year increase in age), and lower parental education (maternal: OR = 3.424, 95% CI 1.082–10.837, p = 0.0363; paternal: OR = 2.923, 95% CI 1.245–6.866, p = 0.0138) were strongly associated with risk of speech disability associated with cleft palate in the offspring. Our results showed that maternal speech disability, older paternal child-bearing age, and lower levels of parental education were independent risk factors for speech disability associated with cleft palate for children in China. These findings may have important implications for health disparities and prevention.

Prevalentie van schisis in Nederland en Noord-Nederland in 1997-2007

Objective. To investigate the prevalence of oral cleft live births in the Netherlands, we analyzed time-trends in the Netherlands and Northern Netherlands (NNL) over the period 1997-2007 and stratified these trends by cleft category (cleft lip/alveolus ± cleft palate: CL±P; cleft palate only: CP). Methods. Patients born alive with oral clefts in the Netherlands during 1997-2007 were included from three Dutch registries on congenital anomalies/oral clefts. The estimated annual percentage change (EAPC) in prevalence was calculated using Poisson regression. Results. The overall prevalence of oral clefts per 10,000 live births was 16.6 in the Netherlands and 21.4 in NNL. During 1997-2007, the live-birth prevalence of oral clefts in the Netherlands decreased significandy (EAPC -2.0%; 95% CI: -3.0% to -0.90%), as did the CL±P prevalence (EAPC -2.1%; 95% CI: -3.4% to -0.80%), while no significant trend in CP was found. The rates of the region NNL showed no significant trends. Discussion. The national decrease in prevalence may be explained by two hypotheses: 1) greater prenatal detection of congenital anomalies including oral clefts has led to more pregnancy terminations; and 2) increased periconceptional folic acid use has reduced the risk of oral clefts. Both hypotheses would mainly apply to the category CL±P, since, unlike CP, this category can be detected prenatally by 2D ultrasound and develops during the period recommended for folic acid use. Conclusion. Because the CL±P prevalence in the Netherlands decreased, that of all oral clefts decreased. Although the rates in the region NNL were higher, they showed no significant trends.

Time trends in oral clefts in Chinese newborns: Data from the Chinese National Birth Defects Monitoring Network

Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology. Data used in this study were collected from 1996 to 2005 using the nationwide hospital-based registry, the Chinese Birth Defects Monitoring Network. A total of 4,891,472 newborns (live or still births with 28 weeks of gestation or more) delivered in member hospitals were assessed for birth defects within 7 days following birth. The prevalence of nonsyndromic, syndromic, and overall clefts was 14.23, 2.40, and 16.63 per 10,000, respectively. An upward time trend in the prevalence of nonsyndromic cleft palate and nonsyndromic cleft lip was detected. Cleft lip with or without cleft palate showed a different pattern by gender, urban-rural classification, and geographic location when compared to cleft palate, particularly for nonsyndromic cases. Maternal age was associated with prevalence of all oral clefts. Neonates with oral clefts had increased rates of mortality. The observed complex patterns of prevalence of oral clefts from the Chinese national birth defects registry indicate that oral cleft subtypes by either cleft location or syndromic status should be considered in the development of intervention measures and in future analytical studies.

Prevalence of nonsyndromic oral clefts in Texas: 1995–1999

Nonsyndromic cleft lip with/without cleft palate (NSCLP) and nonsyndromic cleft palate only (NSCPO) are common complex birth defects affecting 4,000 newborns annually. We undertook a descriptive study of oral clefts in Texas, focusing on the effect of folic acid fortification and Hispanic ethnicity on the prevalence of oral clefts as these factors have not previously been described. Data on 896 infants with NSCLP and NSCPO born between 1995 and 1999 in Texas were compared to all births in Texas during the same period. Prevalence odds ratios (POR) were calculated for maternal ethnicity, race, age, parity, public health region of residence, highest level of education, and infant gender. The effect of folic acid fortification on oral clefts was also examined. Compared with whites, adjusted POR were 0.97 (95% CI = 0.77-1.23) and 0.90 (95% CI 0.72-1.14) for NSCLP and 0.46 (95% CI = 0.30-0.72) and 0.62 (95% CI = 0.42-0.90) for NSCPO in foreign-born and US-born Hispanics, respectively. After fortification was implemented, the rate of NSCLP did not decrease. However, there was a 13% decrease in the prevalence of NSCPO (adjusted POR = 0.87, 95% CI = 0.68-1.15). Compared to whites, the rates in US-born and foreign-born Hispanic women were similar for NSCLP and much lower for NSCPO. The small reduction of 13% in NSCPO after folic acid fortification is imprecise and should be interpreted cautiously. Overall, it appears that folic acid fortification has had very little or no effect on the prevalence of oral clefts in infants born in Texas.