Prevalence Of Marijuana Research Articles

Active methamphetamine use is associated with transmitted drug resistance to non-nucleoside reverse transcriptase inhibitors in individuals with HIV infection of unknown duration.

Background:Frequent methamphetamine use among recently HIV infected individuals is associated with transmitted drug resistance (TDR) to non-nucleoside reverse transcriptase inhibitors (NNRTI); however, the reversion time of TDR to drug susceptible HIV may exceed 3 years. We assessed whether recreational substance use is associated with detectable TDR among individuals newly diagnosed with HIV infection of unknown duration.Design:Cross-sectional analysis.Methods:Subjects were enrolled at the University California, San Diego Early Intervention Program. Demographic, clinical and substance use data were collected using structured interviews. Genotypic resistance testing was performed using GeneSeq™, Monogram Biosciences. We analyzed the association between substance use and TDR using bivariate analyses and the corresponding transmission networks using phylogenetic models.Results:Between April 2004 and July 2006, 115 individuals with genotype data were enrolled. The prevalence of alcohol, marijuana and methamphetamine use were 98%, 71% and 64% respectively. Only active methamphetamine use in the 30 days prior to HIV diagnosis was independently associated with TDR to NNRTI (OR: 6.6; p=0.002).Conclusion:Despite not knowing the duration of their HIV infection, individuals reporting active methamphetamine use in the 30 days prior to HIV diagnosis are at an increased risk of having HIV strains that are resistant to NNRTI.

The Association of Methamphetamine Use and Cardiomyopathy in Young Patients

Purpose Methamphetamine is the most widespread illegally used stimulant in the United States. Previously published case reports and series suggest a potential association between methamphetamine exposure and cardiomyopathy. The objective of this study is to demonstrate an association between methamphetamine use and cardiomyopathy. Subject and Methods Case-control study based on chart review of discharges from a tertiary care medical center from January 2001 to June 2004. Patients were ≤45 years old. Cases included patients with a discharge diagnosis of either cardiomyopathy or heart failure. Controls included hospitalized patients who had an echocardiographic assessment of left ventricular function with ejection fraction ≥55% and no wall motion abnormalities. Results One hundred and seven cases and 114 controls were identified. Both groups had similar gender distribution, length of hospital stay, rates of health insurance, prevalence of coronary artery disease, diabetes mellitus, hypertension, cigarette smoking, alcohol abuse, and marijuana and cocaine use. Cases were older than controls (mean age: 38 vs 35 years; P=.008), had higher body mass index (BMI) (mean BMI: 37 vs 30 kg/m 2; P<.001), and higher prevalence of renal failure (13% vs 4.4%; P=.03). Methamphetamine users had a 3.7-fold increased odds ratio [95% confidence interval, 1.8-7.8] for cardiomyopathy, adjusting for age, body mass index, and renal failure. Conclusions Methamphetamine use was associated with cardiomyopathy in young patients.

Substance Abuse Counseling Services in Secondary Schools: A National Study of Schools and Students, 1999-2003

ABSTRACT: This study focuses on (a) American 8th-. 10th-, and 12th-grade students' access to, and use of, substance abuse counseling services via schools and (b) associations between such access and student substance use prevalence. From 1999 through 2003, student data were obtained from the Monitoring the Future study; and school data were obtained through the Youth, Education, and Society study, resulting in nationally representative data from 113,008 students in 855 public and private schools. Results indicate that in contrast to relatively stable student heavy—drug use prevalence rates, internal counseling availability and participation decreased significantly over time, as did reported student referral to external counseling. Availability of internal counseling, as well as student participation in both internal and external referrals, differed significantly by school characteristics—school level, grade size, sector, population density, school socioeconomic status, majority student body race/ethnicity, and geographical region. Student use of counseling services did not show any relationships with school-level heavy drinking rates; however, student participation in external counseling referrals was positively associated with school-level prevalence rates for the use of illicit drugs other than marijuana and showed indications of a similar relationship with marijuana prevalence rates. The decreasing access to, and use of, counseling, the lower probability of counseling availability in middle schools, and the lack of association between heavy—alcohol use rates and counseling services, all suggest missed opportunities and a greater need for counseling services to reduce high-risk drug use.

Substance Abuse Counseling Services in Secondary Schools: A National Study of Schools and Students, 1999-2003

This study focuses on (a) American 8th-, 10th-, and 12th-grade students' access to, and use of, substance abuse counseling services via schools and (b) associations between such access and student substance use prevalence. From 1999 through 2003, student data were obtained from the Monitoring the Future study; and school data were obtained through the Youth, Education, and Society study, resulting in nationally representative data from 113,008 students in 855 public and private schools. Results indicate that in contrast to relatively stable student heavy-drug use prevalence rates, internal counseling availability and participation decreased significantly over time, as did reported student referral to external counseling. Availability of internal counseling, as well as student participation in both internal and external referrals, differed significantly by school characteristics--school level, grade size, sector, population density, school socioeconomic status, majority student body race/ethnicity, and geographical region. Student use of counseling services did not show any relationships with school-level heavy drinking rates; however, student participation in external counseling referrals was positively associated with school-level prevalence rates for the use of illicit drugs other than marijuana and showed indications of a similar relationship with marijuana prevalence rates. The decreasing access to, and use of, counseling, the lower probability of counseling availability in middle schools, and the lack of association between heavy-alcohol use rates and counseling services, all suggest missed opportunities and a greater need for counseling services to reduce high-risk drug use.

Obtaining sensitive information from a wary population: A comparison of telephone and face-to-face surveys of welfare recipients in the United States

Recent studies reveal the benefits of technological developments such as audio computer assisted self-interviewing (A-CASI) in interview methodology, especially for surveys of sensitive behavior and information. However, we believe that the selection of mode of administration depends not only on the technology available and the behavior of interest, but also on the specific population under study. We therefore assess survey mode effects on reported rates of alcohol and drug use among welfare recipients, an especially important group for scholars and public health agencies. The sample consisted of adult recipients of Temporary Assistance to Needy Families (TANF) in Oklahoma, January 2001. Adjusting for demographic characteristics, employment, and education, we employ odds ratios to compare 30-day, 1 year, and lifetime prevalence estimates from telephone and face-to-face surveys. Telephone methodology yields similar or higher estimates for lifetime prevalence of alcohol, marijuana, and hard drug use and abuse, though lower estimates of recent use. We discuss our findings in relation to underfunded public health agencies that must efficiently assess and respond to local levels of drug abuse and we conclude that mode selection may depend upon the population under study.

Recent Marijuana Blunt Smoking Impacts Carbon Monoxide as a Measure of Adolescent Tobacco Abstinence

Adolescent tobacco smokers have a higher prevalence of marijuana (MJ) smoking than adolescents who do not smoke tobacco. As part of an adolescent smoking cessation trial, we examined whether MJ smoking, and specifically “blunt” (gutted cigars filled with MJ) smoking, elevated participants' likelihood of a false indication of cigarette smoking on the basis of breath carbon monoxide (CO) testing. Using clinical data from 37 adolescents (mean age 15.1 ± 1.4 years, 78% female) who participated in a smoking-cessation trial in Baltimore between 1999 and 2002, and who on at least one occasion, reported abstinence from tobacco smoking for at least 7 days, we analyzed 146 cigarette-abstinent-visit exhaled CO concentrations classified into blunt occasions (12 participants, 33 visits), nonblunt MJ occasions (seven participants, 20 visits), and non-MJ occasions (27 paricipants, 93 visits). Repeated-measures logistic regression revealed that blunt occasions were associated with CO ≥ 8 ppm, compared to nonblunt occasions (p = 0.013). Blunt occasions also tended to be associated with the more youth-appropriate cutoff CO ≥ 6 ppm, compared to non-MJ occasions (p=0.054). Blunt smoking impacted the interpretation of measures of exhaled CO for tobacco cessation.

Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco.

Tobacco smoking has been observed to cause molecular alterations in bronchial epithelium that antedate the development of lung carcinoma. The rising prevalence of marijuana and cocaine use among young adults in the United States prompted us to investigate whether similar molecular and histopathologic alterations occur in habitual smokers of marijuana and/or cocaine who may or may not also smoke tobacco. Bronchoscopy was performed in 104 healthy volunteer subjects, including 28 nonsmokers and 76 smokers of one or more of the following substances: marijuana, tobacco, and/or cocaine. Bronchial mucosa biopsy specimens and brushings were analyzed for histopathologic changes, for immunohistopathologic expression of intermediate or surrogate end-point markers that are linked to an increased risk of cancer (Ki-67 [a marker of cell proliferation], epidermal growth factor receptor, p53, Her-2/neu [also known as erbB-2 and ERBB2], globular actin, and abnormal DNA ploidy). Reported P values are two-sided. Smokers of any one substance or of two or more substances exhibited more alterations than nonsmokers in five to nine of the 10 histopathologic parameters investigated (all P < .05), and they exhibited more molecular abnormalities than nonsmokers. Differences between smokers and nonsmokers were statistically significant (all P < or = .01) for Ki-67, epidermal growth factor receptor, globular actin, and DNA ploidy. There was general agreement between the presence of molecular abnormalities and histopathologic alterations; however, when disagreement occurred, the molecular abnormalities (e.g., Ki-67 and epidermal growth factor receptor) were more frequently altered (all P < or = .01). These findings suggest that smoking marijuana and/or cocaine, like tobacco smoking, exerts field cancerization effects on bronchial epithelium, which may place smokers of these substances at increased risk for the subsequent development of lung cancer.

Correlates of alcohol, tobacco and marijuana use among Scottish postsecondary helping-profession students.

There is limited information about the prevalence of recreational drug use over the postsecondary experience in Scotland. The purpose of this study was to investigate the patterns of alcohol, tobacco and marijuana use in postsecondary helping-profession students (medical, nursing, education and psychology) in Scotland in regards to gender, age and course of study. The Queensland Alcohol and Drug Study Questionnaire was completed by students enrolled in helping-profession courses from 22 departments at universities and colleges in five Scottish cities. The sample consisted of 717 male and 2,537 female students. A slightly (p < .05) higher percent of women (92.7%) consumed alcohol compared to men (90%), but men consumed significantly (p < .001) more drinks per week (26.7) compared to women (17.3). There was no difference between the two groups when U.K. recommendations of maximum limits for each gender were considered. About 50% of men and women consumed over 21 drinks and 14 drinks per week, respectively. A higher (p < .05) percent of men (42.5%) smoked compared to women (36.9%) and a higher (p < .001) percent of men (40.1%) consumed marijuana compared to women (24.1%). There was no difference in the quantity of tobacco consumed. For both men and women, the prevalence of alcohol and marijuana was highest 2 or 3 years before the maximum use of tobacco (students over 24 years of age). Male and female psychology students consumed the most marijuana. Psychology students, together with nursing students, also consumed the most tobacco. In view of the increasing prevalence of tobacco over the university experience, especially among nursing and psychology students, and heavier alcohol consumption among younger students, health education programs for Scottish postsecondary helping-profession students should expand from the recently introduced school programs.

Effects of Age on Perinatal Substance Abuse among Whites and African Americans

This descriptive study assessed age effects on perinatal use of alcohol, marijuana, and cocaine among African-American and white women. Data were derived from the California Perinatal Exposure Study, relying on a statistical probability sample (n = 29,494) of women who underwent anonymous urine toxicology screening in birthing hospitals. The central hypothesis was that there would be no difference in age effects on drug use among white and African-American women. Marital status and payment source were used as risk factors in order to create detailed age-risk profiles for both racial-ethnic groups. Logistic regression analyses were used and findings indicated that cocaine use peaked in early adulthood for whites and in mid-adulthood for African Americans who had higher prevalence levels with the same or fewer risk factors as whites. Over one third of African-American women in their mid-thirties who were not married and who had publicly assisted births tested positive for cocaine. In contrast, high risk whites had higher marijuana prevalence levels than African-American women, and prevalence increased with age. Alcohol prevalence increased with age for African-American and white women who were publicly assisted, but decreased with age for all others. Findings for alcohol and marijuana generally followed the same risk-adjusted patterns for African American and white women but with different prevalence levels; however, cocaine use had a unique pattern with higher prevalence among African-American women in mid-adulthood regardless of risk level.

Drug Use Prevalence in a Rural School-Age Population: The New Hampshire Survey

Pre-adolescent and adolescent drug use is a major public health concern in the United States. Although we have good prevalence data on some adolescents, we have little information on pre-adolescents, young adolescents, and rural children. We conducted a survey of 4,406 children in grades 4-12 in rural New Hampshire in 1990. Students completed annual self-report surveys on demographic characteristics, drug use, and psychosocial risk factors. These children are initiating drug use in elementary school. Alcohol is the preferred drug for both genders at all grade levels, followed by cigarettes, marijuana, and spitting tobacco. Current use of these drugs escalates in the sixth through ninth grades. Lifetime prevalence and 30-day prevalence increase slowly through high school. Most children who are going to use drugs have begun by the tenth grade. In this rural state, children's drug preferences are similar to those of other pre-adolescents and adolescents. Rural students have equal, and in some cases higher, lifetime and current use prevalence of alcohol, marijuana, and tobacco in comparison with national samples.

The shifting importance of alcohol and marijuana as gateway substances among serious drug abusers.

Prior research based on representative samples drawn from the general population suggests persons tend to follow a common developmental pathway from use of alcohol as youths through possible use of marijuana as teens potentially leading to use of more serious substances as adults. Based on this model, alcohol and marijuana act as gateways, whereby persons who do not onset to alcohol rarely onset to marijuana; similarly, non-marijuana users rarely onset to more serious substance use and abuse. This study examines whether a sample of serious drug abusers recruited from New York City in 1988-89 followed the same developmental pathway as observed in general populations. The results suggest that alcohol is not a prerequisite for progression to marijuana, but marijuana use nearly always precedes use of more serious substances such as cocaine, crack and heroin. Furthermore, with the growing prevalence of marijuana (since 1965) the importance of alcohol as a gateway to marijuana use appears to have declined and marijuana's role as a gateway to serious drug use appears to have increased.

Tobacco, Alcohol, and Other Drug Use Among High School Students—United States, 1991

In the United States, use of tobacco, alcohol, and other drugs is associated with the leading causes of morbidity and mortality (e.g., motor-vehicle crashes, homicide, suicide, and cancer [1]), with lower educational achievement, and with school dropout (2-5). This report presents self-reported data about the prevalence of tobacco, alcohol, marijuana, and cocaine use among students in grades 9-12 from two school-based components of the Youth Risk Behavior Surveillance System (6): 1) state and local Youth Risk Behavior Surveys (YRBSs) conducted by departments of education in 23 states and 10 cities during the spring of 1991 and 2) the national YRBS conducted during the same period.

Alcohol and Other Drug Use Among High School Students—United States, 1990

Use of alcohol and other drugs is associated with the leading causes of death and injury (e.g., motor-vehicle crashes, homicides, and suicides) among teenagers and young adults; for example, nearly half of all deaths from motor-vehicle crashes in this age group involve alcohol use (1,2). This article presents self-reported data about the prevalence of alcohol, marijuana, and cocaine use among U.S. students in grades 9-12 during 1990.

Differential drug use patterns among sexually abused adolescent girls in treatment for chemical dependency.

A sample of 444 girls admitted to adolescent chemical dependency treatment was divided into four groups based on sexual abuse experiences. Girls who reported intrafamilial abuse, extrafamilial abuse, or both, were compared with nonvictims in terms of alcohol and drug use histories. Prevalence and frequency of alcohol, marijuana, and cocaine did not differ significantly among the groups. However, all sexual abuse victims were significantly more likely to regularly use stimulants, sedatives, tranquilizers, and hallucinogens. Sexual abuse victims also reported earlier onset of alcohol and drug use, more self-medication, and more use to escape family problems.

Inhalant, marijuana, and alcohol abuse among barrio children and adolescents.

Prevalence of inhalant, marijuana, and alcohol abuse was studied in a sample of 457 male and female Mexican-American children and adolescents between the ages of 9 and 17 years. Subjects interviewed resided in four housing projects located in East Los Angeles. All interviews were conducted by adolescents who resided in the same housing projects. Results indicated that compared to a national sample, Mexican-American adolescents were at least 14 times more likely to be currently abusing inhalants. The prevalence rate of marijuana was double the national rate, but the prevalence of alcohol was equal to that found nationally. Reasons for elevated substance abuse rates are explored.